Voxel-based mapping of irreversible ischaemic damage with PET in acute stroke.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Brain : a journal of neurology

• Publication date

  1999-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/BRAIN/122.12.2387PMID 10581231
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 15O continuous-inhalation method: Correction for intravascular signal using C15O

  2004cited by this paper
• Diffusion MRI in patients with transient ischemic attacks.

  1999cited by this paper
• Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra

  1999influential reference
• Resolution of early diffusion-weighted and FLAIR MRI abnormalities in a patient with TIA

  1999cited by this paper
• Instrumental Diagnosis and Treatment of Acute Ischemic Stroke: The Clinician’s Perspective

  1999cited by this paper
• Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators.

  1998cited by this paper
• Tissue at Risk of Infarction Rescued by Early Reperfusion: A Positron Emission Tomography Study in Systemic Recombinant Tissue Plasminogen Activator Thrombolysis of Acute Stroke

  1998cited by this paper
• Identifying hypoxic tissue after acute ischemic stroke using PET and 18F-fluoromisonidazole

  1998cited by this paper
• Human herpesvirus 8 variants.

  1998cited by this paper
• Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI

  1998cited by this paper
• Magnetic resonance imaging in acute stroke

  1998cited by this paper
• Dichotomized efficacy end points and global end-point analysis applied to the ECASS intention-to-treat data set: post hoc analysis of ECASS I.

  1998cited by this paper
• Dichotomized Efficacy End Points and Global End-Point Analysis Applied to the ECASS Intention-to-Treat Data Set

  1998cited by this paper
• Advantages and Disadvantages of Neurological Scales

  1998influential reference
• Magnetic Resonance Imaging of Acute Stroke

  1998influential reference
• Evaluation of the ratio of cerebral blood flow to cerebral blood volume as an index of local cerebral perfusion pressure.

  1998cited by this paper
• Early computed-tomography abnormalities in acute stroke.

  1997cited by this paper
• Early computed-tomography abnormalities in acute stroke.

  1997cited by this paper
• Early reperfusion in the anesthetized baboon reduces brain damage following middle cerebral artery occlusion: a quantitative analysis of infarction volume.

  1997influential reference
• Enlargement of human cerebral ischemic lesion volumes measured by diffusion‐weighted magnetic resonance imaging

  1997influential reference
• Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis.

  1996influential reference
• Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra

  1996influential reference
• Do changes in oxygen metabolism in the unaffected cerebral hemisphere underlie early neurological recovery after stroke? A positron emission tomography study.

  1996cited by this paper
• Early spontaneous hyperperfusion after stroke. A marker of favourable tissue outcome?

  1996cited by this paper
• Cerebral white matter is highly vulnerable to ischemia.

  1996cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1996cited by this paper
• Good clinical outcome in a patient with a large CT scan hypodensity treated with intra-arterial urokinase after an embolic stroke

  1996cited by this paper
• Ischemic stroke and incomplete infarction.

  1996influential reference
• How time dependent is the threshold for cerebral infarction?

  1996cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.

  1995cited by this paper
• Sequential studies of severely hypometabolic tissue volumes after permanent middle cerebral artery occlusion. A positron emission tomographic investigation in anesthetized baboons.

  1995influential reference
• Value of acute-stage positron emission tomography in predicting neurological outcome after ischemic stroke: further assessment.

  1995cited by this paper
• Magnetic resonance versus computed tomographic imaging in acute stroke.

  1995cited by this paper
• Viability thresholds and the penumbra of focal ischemia

  1994cited by this paper
• PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome.

  1993cited by this paper
• Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging.

  1992influential reference
• Histochemical and morphometric investigation of the pathogenesis of acute brain infarction in primates.

  1992influential reference
• Progressive Derangement of Periinfarct Viable Tissue in Ischemic Stroke

  1992influential reference
• Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia.

  1991influential reference
• Physical characteristics of TTV03, a new high spatial resolution time-of-flight positron tomograph

  1990cited by this paper
• Local brain haemodynamics and oxygen metabolism in cerebrovascular disease. Positron emission tomography.

  1989cited by this paper
• Neurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats.

  1986influential reference
• A Stereotactic Method of Anatomical Localization for Positron Emission Tomography

  1985cited by this paper
• Cerebral Blood Flow and Cerebral Metabolic Rate of Oxygen Requirements for Cerebral Function and Viability in Humans

  1985influential reference
• Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion.

  1984cited by this paper
• Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion.

  1984cited by this paper
• Transient Focal Ischemia in Subhuman Primates: Neuronal Injury as a Function of Local Cerebral Blood Flow

  1983influential reference
• Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts

  1983cited by this paper
• Differential regional vulnerability in transient focal cerebral ischemia.

  1982cited by this paper
• Incomplete cerebral infarction‐‐focal incomplete ischemic tissue necrosis not leading to emollision.

  1982cited by this paper
• Thresholds of focal cerebral ischemia in awake monkeys.

  1981influential reference
• Thresholds in cerebral ischemia - the ischemic penumbra.

  1981influential reference
• Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values

  1980cited by this paper
• Clinical equivalents of cerebral oxygen consumption in coma

  1972influential reference

• Simulated ischemia in cerebral slices is mimicked by opening the Na+/K+ pump: clues to the generation of spreading depolarization.

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• The Brush Sign Is Associated with a More Severe Oxygen Metabolic Impairment of the Ischemic Penumbra: An MRI-Based Study in Patients with Acute Stroke

  2025cites this paper
• Large-Core Paradox.

  2025cites this paper
• Fifty Years of Deciphering Stroke Pathophysiology.

  2025cites this paper
• The Imaging-Neuropathological Gap in Acute Large Vessel Occlusive Stroke.

  2024cites this paper
• Quantification of Infarct Core Volume in Patients with Acute Ischemic Stroke Using Cerebral Metabolic Rate of Oxygen in CT Perfusion

  2024cites this paper
• Clinical Imaging of the Penumbra in Ischemic Stroke: From the Concept to the Era of Mechanical Thrombectomy

  2022cites this paper
• The core/penumbra model: implications for acute stroke treatment and patient selection in 2021

  2021cites this paper
• Imaging Acute Stroke: From One-Size-Fit-All to Biomarkers

  2021cites this paper
• Neurological Applications of Positron Emission Tomography Imaging in Healthcare and Research

  2021cites this paper
• Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI

  2020cites this paper
• Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics

  2020cites this paper
• Tissue no-reflow despite full recanalization following thrombectomy for anterior circulation stroke with proximal occlusion: A clinical study

  2020cites this paper
• Neuroimaging

  2019cites this paper
• Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis.

  2019cites this paper
• Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression.

  2018cites this paper
• Nest‐building activity as a reproducible and long‐term stroke deficit test in a mouse model of stroke

  2018cites this paper
• Tissue Is More Important than Time in Stroke Patients Being Assessed for Thrombolysis

  2018cites this paper
• PET imaging of the neurovascular interface in cerebrovascular disease

  2017cites this paper
• Levosimendan in Cardiac Surgery.

  2017cites this paper
• Oxygen metabolism in acute ischemic stroke

  2017cites this paper
• Dosage Calculation for Intravenous Thrombolysis of Ischemic Stroke: To Weigh or to Estimate

  2017cites this paper
• Metabolic Imaging of the Neurovascular Interface in Cerebrovascular Disease using Positron Emission Tomography

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
• 54 – Critical Care of the Patient with Acute Stroke

  2016cites this paper
• 3 – Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease

  2015cites this paper
• Investigating the pathophysiology of acute ischaemic stroke using magnetic resonance imaging

  2015cites this paper
• Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke

  2015cites this paper
• PET Scans Obtained for Evaluation of Cognitive Dysfunction

  2015cites this paper
• Imaging of cerebral ischemia: from acute stroke to chronic disorders.

  2014cites this paper
• Vessel Occlusion, Penumbra, and Reperfusion – Translating Theory to Practice

  2014cites this paper
• The Modulation of the Cystic Fibrosis Transmembrane Conductance Regulator Protein by Sphingosine-1-Phosphate in the Cerebral Microvascular System

  2014cites this paper
• Integrated PET and MRI Scanners

  2014cites this paper
• Predicting the ischemic infarct volume at the first minute after occlusion in rodent stroke model by laser speckle imaging of cerebral blood flow

  2013cites this paper
• Use of PET in Neurology and Psychiatry

  2013cites this paper
• Redefining the Pericontusional Penumbra following Traumatic Brain Injury: Evidence of Deteriorating Metabolic Derangements Based on Positron Emission Tomography

  2013cites this paper
• Multiparametric MRI and CT Models of Infarct Core and Favorable Penumbral Imaging Patterns in Acute Ischemic Stroke

  2013cites this paper
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  2012cites this paper
• Refining the Mismatch Concept in Acute Stroke: Lessons Learned from PET and MRI

  2012influential citation
• Absolute Oxygenation Metabolism Measurements Using Magnetic Resonance Imaging

  2011cites this paper
• The Clinical Ischemic Penumbra

  2011cites this paper
• Cerebral Blood Flow and Metabolism in Human Cerebrovascular Disease

  2011cites this paper
• Predicting Infarction Within the Diffusion-Weighted Imaging Lesion: Does the Mean Transit Time Have Added Value?

  2011cites this paper
• Cerebrovascular diseases: do perfusion single photon emission computed tomography and metabolic PET provide the same clinical information?

  2011cites this paper
• Nuclear neuroimaging in acute and subacute ischemic stroke

  2010cites this paper
• PET in Cerebrovascular Disease.

  2010cites this paper
• Gestione dell'infarto cerebrale acuto

  2010cites this paper
• PET in Cerebrovascular Disease.

  2010cites this paper
• Perfusion computed tomography in prediction of functional outcome in patients with acute ischaemic stroke.

  2009cites this paper
• Cerebral blood flow and the ischemic penumbra.

  2009cites this paper
• Early Metabolic Characteristics of Lesion and Nonlesion Tissue after Head Injury

  2009cites this paper
• Positron emission tomography scans obtained for the evaluation of cognitive dysfunction.

  2008cites this paper
• PATHOPHYSIOLOGY OF ACUTE ISCHEMIC STROKE

  2008cites this paper
• White matter thresholds for ischemic penumbra and infarct core in patients with acute stroke: CT perfusion study.

  2008cites this paper
• Bioenergetics of cerebral ischemia: a cellular perspective.

  2008cites this paper
• Cerebral blood flow thresholds predicting new hypoattenuation areas due to macrovascular ischemia during the acute phase of severe and complicated aneurysmal subarachnoid hemorrhage. A preliminary study.

  2008cites this paper
• Predicting the Fate of Acute Ischemic Lesions Using Perfusion Computed Tomography

  2008cites this paper
• Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery

  2008influential citation
• Statistical mapping of effects of middle cerebral artery occlusion (MCAO) on blood flow and oxygen consumption in porcine brain.

  2007cites this paper
• Hyperventilation following head injury: Effect on ischemic burden and cerebral oxidative metabolism*

  2007cites this paper
• Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps

  2007cites this paper
• Clinical review: Imaging in ischaemic stroke – implications for acute management

  2007cites this paper
• Quantitative Perihematomal Blood Flow in Spontaneous Intracerebral Hemorrhage Predicts In-Hospital Functional Outcome

  2007cites this paper
• The implications of cerebral ischemia and metabolic dysfunction for treatment strategies in neurointensive care

  2006cites this paper
• Intrinsic Activated Microglia Map to the Peri-infarct Zone in the Subacute Phase of Ischemic Stroke

  2006cites this paper
• How affected is oxygen metabolism in DWI lesions?

  2006cites this paper
• Local Relationships Between Restricted Water Diffusion and Oxygen Consumption in the Ischemic Human Brain

  2006cites this paper
• Imaging of acute stroke.

  2006cites this paper
• Ischemic Stroke : A Systematic Review Cerebral Blood Flow Threshold of Ischemic Penumbra and Infarct Core in Acute

  2006cites this paper
• Cerebral Blood Flow Threshold of Ischemic Penumbra and Infarct Core in Acute Ischemic Stroke: A Systematic Review

  2006cites this paper
• Hypotension and mortality in septic shock: the "golden hour".

  2006cites this paper
• Brain tissue oxygen monitoring: a measure of supply and demand.

  2006cites this paper
• Cerebral Blood Flow Threshold of Ischemic Penumbra and Infarct Core in Acute Ischemic Stroke

  2006cites this paper
• Recovery of gait after stroke

  2006cites this paper
• Consumption in the Ischemic Human Brain Local Relationships Between Restricted Water Diffusion and Oxygen

  2006cites this paper
• Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.

  2005influential citation
• PET imaging in the assessment of normal and impaired cognitive function.

  2005cites this paper
• Xenon CT cerebral blood flow in acute stroke.

  2005cites this paper
• Astrocytic contributions to bioenergetics of cerebral ischemia

  2005cites this paper
• Therapeutic hypothermia for stroke: do new outfits change an old friend?

  2005cites this paper
• Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study

  2005influential citation
• Stroke Research in the Modern Era: Images versus Dogmas

  2005cites this paper
• Does the Mismatch Match the Penumbra?: Magnetic Resonance Imaging and Positron Emission Tomography in Early Ischemic Stroke

  2005cites this paper
• The Diffusion-Weighted Lesion in Acute Stroke: Heterogeneous Patterns of Flow/Metabolism Uncoupling as Assessed by Quantitative Positron Emission Tomography

  2005cites this paper
• Regional is Chaemia following Acute Head Injury

  2005cites this paper
• Molecular Imaging of Biological Processes with PET: Evaluating Biologic Bases of Cerebral Function

  2004cites this paper
• The resistance to ischemia of white and gray matter after stroke

  2004cites this paper
• Imaging the ischaemic penumbra

  2004cites this paper
• Diffusion- and perfusion-weighted magnetic resonance imaging in patients with acute ischemic stroke: can diffusion/perfusion mismatch predict outcome?

  2004cites this paper
• Does the Acute Diffusion-Weighted Imaging Lesion Represent Penumbra as Well as Core? A Combined Quantitative PET/MRI Voxel-Based Study

  2004cites this paper
• Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury

  2004influential citation
• Incidence and Mechanisms of Cerebral Ischemia in Early Clinical Head Injury

  2004cites this paper
• Chapter 52 – Critical Care of the Patient with Acute Stroke

  2004cites this paper
• Defining Ischemic Burden after Traumatic Brain Injury Using 15O PET Imaging of Cerebral Physiology

  2004cites this paper
• Chapter 40 – Cerebral Blood Flow and Metabolism in Human Cerebrovascular Disease

  2004cites this paper
• Regional ischemia after head injury

  2004cites this paper
• Voxel‐Based Mapping of Cortical Ischemic Damage Using Tc 99M L, L‐Ethyl Cysteinate Dimer Spect in Acute Stroke

  2004cites this paper
• Understanding the pattern of functional recovery after stroke: Facts and theories

  2004influential citation
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  2004cites this paper