Catalytic Mesoporous Janus Nanomotors for Active Cargo Delivery

We report on the synergy between catalytic propulsion and mesoporous silica nanoparticles (MSNPs) for the design of Janus nanomotors as active cargo delivery systems with sizes <100 nm (40, 65, and 90 nm). The Janus asymmetry of the nanomotors is given by electron beam (e-beam) deposition of a very thin platinum (2 nm) layer on MSNPs. The chemically powered Janus nanomotors present active diffusion at low H2O2 fuel concentration (i.e., <3 wt %). Their apparent diffusion coefficient is enhanced up to 100% compared to their Brownian motion. Due to their mesoporous architecture and small dimensions, they can load cargo molecules in large quantity and serve as active nanocarriers for directed cargo delivery on a chip.

• Publication year

  2015

• Venue

  Journal of the American Chemical Society

• Publication date

  2015-04-06

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1021/jacs.5b02700PMID 25844893PMCID 4440854
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemically powered micro- and nanomotors.

  2015cited by this paper
• Soft Matter

  2014cited by this paper
• Self-Propelling Nanomotors in the Presence of Strong Brownian Forces

  2014cited by this paper
• Selecting the swimming mechanisms of colloidal particles: bubble propulsion versus self-diffusiophoresis.

  2014cited by this paper
• Redox-Responsive Mesoporous Silica Nanoparticles: A Physiologically Sensitive Codelivery Vehicle for siRNA and Doxorubicin

  2014cited by this paper
• The environmental impact of micro/nanomachines: a review.

  2014cited by this paper
• Synthetic micro/nanomotors in drug delivery.

  2014cited by this paper
• Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo

  2014cited by this paper
• In situ synthesis of ultra-small platinum nanoparticles using a water soluble polyphenolic polymer with high catalytic activity

  2014cited by this paper
• Synthesis, Characterization, and Application of Ultrasmall Nanoparticles

  2014cited by this paper
• Preparation of size-controlled monodisperse colloidal mesoporous silica nanoparticles and fabrication of colloidal crystals

  2014cited by this paper
• Self-propelled Janus mesoporous silica nanomotors with sub-100 nm diameters for drug encapsulation and delivery.

  2014cited by this paper
• Nanohelices by shadow growth.

  2014cited by this paper
• Enzymatically induced motion at nano- and micro-scales.

  2014cited by this paper
• Nano/micromotors in (bio)chemical science applications.

  2014cited by this paper
• Nanopropellers and their actuation in complex viscoelastic media.

  2014cited by this paper
• Ionic effects in self-propelled Pt-coated Janus swimmers.

  2013cited by this paper
• Emergent cometlike swarming of optically driven thermally active colloids.

  2013cited by this paper
• Chemotactic behavior of catalytic motors in microfluidic channels.

  2013cited by this paper
• Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo.

  2013cited by this paper
• Intelligent, self-powered, drug delivery systems.

  2013cited by this paper
• Clusters, asters, and collective oscillations in chemotactic colloids.

  2013cited by this paper
• Assembly, disassembly, and anomalous propulsion of microscopic helices.

  2013cited by this paper
• Small power: Autonomous nano- and micromotors propelled by self-generated gradients

  2013cited by this paper
• Enzyme molecules as nanomotors.

  2013cited by this paper
• Electrokinetic effects in catalytic platinum-insulator Janus swimmers

  2013cited by this paper
• Self-propelled polymer-based multilayer nanorockets for transportation and drug release.

  2013cited by this paper
• The pH taxis of an intelligent catalytic microbot.

  2013cited by this paper
• Synthesis of mesoporous silica nanoparticles.

  2013cited by this paper
• Theranostic applications of mesoporous silica nanoparticles and their organic/inorganic hybrids.

  2013cited by this paper
• Self-propelled nanojets via template electrodeposition.

  2013cited by this paper
• Fantastic voyage: designing self-powered nanorobots.

  2012cited by this paper
• Functional mesoporous silica nanoparticles for photothermal-controlled drug delivery in vivo.

  2012cited by this paper
• Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

  2012cited by this paper
• Controlling physical features of mesoporous silica nanoparticles (MSNs) for emerging applications

  2012cited by this paper
• Transport of cargo by catalytic Janus micro-motors

  2012cited by this paper
• Mesoporous silica nanoparticles in biomedical applications.

  2012cited by this paper
• Catalytic Janus motors on microfluidic chip: deterministic motion for targeted cargo delivery.

  2012cited by this paper
• Autonomous movement of platinum-loaded stomatocytes.

  2012cited by this paper
• Controlling Particle Size and Structural Properties of Mesoporous Silica Nanoparticles Using the Taguchi Method

  2011cited by this paper
• Hybridization of Photoactive Titania Nanoparticles with Mesoporous Silica Nanoparticles and Investigation of Their Photocatalytic Activity

  2011cited by this paper
• Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility

  2011cited by this paper
• Highly efficient catalytic microengines: template electrosynthesis of polyaniline/platinum microtubes.

  2011cited by this paper
• Bull. Chem. Soc. Jpn. への投稿のすすめ

  2011cited by this paper
• Phoretic motion of spheroidal particles due to self-generated solute gradients

  2010cited by this paper
• Label-free DNA sensor based on surface charge modulated ionic conductance.

  2009cited by this paper
• Size-specific catalytic activity of platinum clusters enhances oxygen reduction reactions.

  2009cited by this paper
• Can man-made nanomachines compete with nature biomotors?

  2009cited by this paper
• Catalytic microtubular jet engines self-propelled by accumulated gas bubbles.

  2009cited by this paper
• Life at Low Reynolds Number

  2008cited by this paper
• Colloidal suspensions of functionalized mesoporous silica nanoparticles.

  2008cited by this paper
• Colloidal Suspensions of Nanometer‐Sized Mesoporous Silica

  2007cited by this paper
• Chemotaxis of nonbiological colloidal rods.

  2007cited by this paper
• Self-motile colloidal particles: from directed propulsion to random walk.

  2007cited by this paper
• Bipolar electrochemical mechanism for the propulsion of catalytic nanomotors in hydrogen peroxide solutions.

  2006cited by this paper
• Propulsion of a molecular machine by asymmetric distribution of reaction products.

  2005cited by this paper
• Synthetic self-propelled nanorotors.

  2005cited by this paper
• Catalytic nanomotors: autonomous movement of striped nanorods.

  2004cited by this paper
• Redox signaling

  2004cited by this paper
• A new family of mesoporous molecular sieves prepared with liquid crystal templates

  1992cited by this paper
• The preparation of alkyltrimethylammonium-kanemite complexes and their conversion to microporous materials.

  1990cited by this paper

• Clustering Dynamics of SiO2-Pt Active Janus Colloids

  2026cites this paper
• Structurally Dependent Self-Propulsion Behaviors of Pt-SiO2 Micromotors

  2026cites this paper
• Accuracy Comes at a Cost: Optimal Localisation Against a Flow

  2026cites this paper
• Self-navigated NIR-II thermophoretic liposome nanomotors for directed tumor delivery and enhanced chemotherapy

  2026cites this paper
• Biohybrid miniature robots using living organisms

  2026cites this paper
• Light-induced directed self-propulsion of active nanosized particles in a three-dimensional Brownian environment probed by heterodyne photon correlation laser spectroscopy.

  2025cites this paper
• Differentiation of Back-and-Forth Motion in Self-Propulsion Emerging via Complex Formation.

  2025cites this paper
• Polymersome-based nanomotors: preparation, motion control, and biomedical applications

  2025cites this paper
• Technology Roadmap of Micro/Nanorobots

  2025cites this paper
• A roadmap for next-generation nanomotors

  2025cites this paper
• Navigating the future of oncology: the transformative role of microrobots in precision cancer therapy.

  2025cites this paper
• Amino acid coating enables micromotor operation in physiological conditions

  2025cites this paper
• Self‑Propelled Nanomotor Probe Enabled Lateral Flow Immunoassay for Sensitive Detection of Inflammatory Factors

  2025cites this paper
• Manipulating Liquid‐Liquid Interphase Solute Diffusion for the Construction of Non‐Symmetric Metal‐Quinone Network Nanoarchitectonics and Nano‐Motorization

  2025cites this paper
• Inertial active particles in a Poiseuille flow: Upstream swimming and particle separation.

  2025cites this paper
• Injectable nanorobots for precision cancer therapy: motion-enhanced drug delivery.

  2025cites this paper
• Janus-Structured Micro/Nanomotors: Self-Propelled Mechanisms and Biomedical Applications

  2025cites this paper
• Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine

  2025cites this paper
• Fuel-driven filamentous phage nanomotors.

  2025cites this paper
• NIR‐II Fluorescent Thermophoretic Nanomotors for Superficial Tumor Photothermal Therapy

  2025cites this paper
• Recent Advancements in Near-Infrared Light-Propelled Nanomotors for Biomedical Applications.

  2025cites this paper
• Recent Advances in Micro/Nanomotor for the Therapy and Diagnosis of Atherosclerosis.

  2024cites this paper
• The overall‐process dynamic mass transfer research of surfactant at the three‐phase emulsions interface

  2024cites this paper
• Phase separation of chemokinetic active particles

  2024cites this paper
• Design and batch fabrication of anisotropic microparticles toward small-scale robots using microfluidics: recent advances.

  2024cites this paper
• Nanoscopic Imaging of Self-Propelled Ultrasmall Catalytic Nanomotors.

  2024cites this paper
• Janus Micromotors Based on Fe3O4 and Fe3O4-OH for miRNA-21 Biosensing

  2024cites this paper
• The separation of active chiral particles with different diffusion coefficients

  2024cites this paper
• Navigating Therapeutic Opportunities and Challenges with Micro/Nanomotors in Translational Medicine: A Review

  2024cites this paper
• Multi-functional Hollow Structures for Intelligent Drug Delivery

  2024cites this paper
• Smart delivery vehicles for cancer: categories, unique roles and therapeutic strategies

  2024cites this paper
• Recent progresses on Janus electrocatalysts for water electrolysis: A critical review

  2024cites this paper
• Janus mesoporous organosilica/platinum nanomotors for active treatment of suppurative otitis media.

  2024cites this paper
• Miniature Robots for Battling Bacterial Infection.

  2024cites this paper
• Enzymatic micro/nanomotors in biomedicine: from single motors to swarms.

  2024cites this paper
• Design and Control of the Magnetically Actuated Micro/Nanorobot Swarm toward Biomedical Applications

  2024cites this paper
• Ultrafast light-activated polymeric nanomotors

  2024cites this paper
• Boosting the Efficiency of Photoactive Rod-Shaped Nanomotors via Magnetic Field-Induced Charge Separation

  2024cites this paper
• Propulsion mechanism of artificial flagellated micro-swimmers actuated by acoustic waves—theory and experimental verification

  2024cites this paper
• Interfacial templating strategy for asymmetric mesoporous materials: Synthesis and typical applications

  2024cites this paper
• Accelerating and breaking adaptive nano-colloids (<100 nm) into unsteady state operation via push-pull effects.

  2024cites this paper
• A general strategy for designing complex brush architecture using star‐like polymeric grafts

  2023cites this paper
• Algae-like Artificial Organic Phototactic Micro-swimmers

  2023cites this paper
• Development of 3D‐Printed Magnetic Micro‐Nanorobots for Targeted Therapeutics: the State of Art

  2023cites this paper
• Portable Electrochemical Sensor for Micromotor Speed Monitoring.

  2023cites this paper
• Engineered Polypeptides as a Tool for Controlling Catalytic Active Janus Particles

  2023cites this paper
• Clustering of chemically propelled nanomotors in chemically active environments.

  2023cites this paper
• Role of single particle motility statistics on efficiency of targeted delivery of micro-robot swarms

  2023cites this paper
• Controlling the transport of the mixture involving active and passive rods in confined channel.

  2023cites this paper
• A Survey for Possible Technologies of Micro/Nanomachines Used for Molecular Communication Within 6G Application Scenarios

  2023cites this paper
• Bioinspired Jellyfish-like Carbon/Manganese nanomotors with H2O2 and NIR light Dual-propulsion for enhanced tumor penetration and chemodynamic therapy

  2023cites this paper
• Biomembrane‐inspired design of medical micro/nanorobots: From cytomembrane stealth cloaks to cellularized Trojan horses

  2023cites this paper
• Polymeric Janus nanorods via anodic aluminum oxide templating.

  2023cites this paper
• Versatile synthesis of metal-compound based mesoporous Janus nanoparticles

  2023cites this paper
• On The Approach to Nanoscale Robots: Understanding the Relationship between Nanomotor's Architecture and Active Motion

  2023cites this paper
• Chemical Logic Gates on Active Colloids

  2023cites this paper
• Advances in Finite Element Analysis of External Field‐Driven Micro/Nanorobots: A Review

  2023cites this paper
• Intelligent micro/nanorobots for improved tumor therapy

  2023cites this paper
• Advancements in artificial micro/nanomotors for nucleic acid biosensing: a review of recent progress.

  2023cites this paper
• Complex Polymer Nanoparticle Synthesis and Morphology Control Using an Inkjet Mixing System

  2023cites this paper
• Antimicrobial micro/nanorobotic materials design: From passive combat to active therapy

  2023cites this paper
• Bioinspired microrobots: Opportunities and challenges in targeted cancer therapy.

  2023cites this paper
• Dynamics of Active SiO2–Pt Janus Colloids in Dilute Poly(ethylene oxide) Solutions

  2023cites this paper
• Mesoporous Nano-Badminton with Asymmetric Mass Distribution: How Nanoscale Architecture Affects the Blood Flow Dynamics.

  2023cites this paper
• Photothermal-driven micro/nanomotors: from structural design to potential applications.

  2023cites this paper
• A multiscale approach to uncover the self-assembly of ligand-covered palladium nanocubes.

  2023cites this paper
• Activity-Driven Emulsification of Phase-Separating Binary Mixtures.

  2023cites this paper
• Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

  2023cites this paper
• Visualizing Facets Asymmetry Induced Directional Movement of Cadmium Chloride Nanomotor.

  2023cites this paper
• Non-Stokesian dynamics of magnetic helical nanoswimmers under confinement

  2023cites this paper
• Rolling Helical Microrobots for Cell Patterning

  2023cites this paper
• Platinum Janus Nanoparticles as Peroxidase Mimics for Catalytic Immunosorbent Assay

  2022cites this paper
• Recent Progress on Asymmetric Carbon- and Silica-Based Nanomaterials: From Synthetic Strategies to Their Applications

  2022cites this paper
• Nanomachines and nanorobotics: improving cancer diagnosis and therapy

  2022cites this paper
• Active Brownian particles in external force fields: Field-theoretical models, generalized barometric law, and programmable density patterns.

  2022cites this paper
• Designing Sites in Heterogeneous Catalysis: Are We Reaching Selectivities Competitive With Those of Homogeneous Catalysts?

  2022cites this paper
• Fast fabrication of micron-sized Janus particles with controlled morphology via seed-swelling photoinitiated polymerization and their application in Cu (II) ion removal

  2022cites this paper
• Janus Micro/Nanorobots in Biomedical Applications

  2022cites this paper
• Biohybrid Magnetic Microrobots for Tumor Assassination and Active Tissue Regeneration.

  2022cites this paper
• Self‐Propelled Nanomotors with an Alloyed Engine for Emergency Rescue of Traumatic Brain Injury

  2022cites this paper
• Multiphysics numerical investigation of photothermal self-driving characteristics of SiO2@Au Janus microparticles for drug delivery

  2022cites this paper
• Small‐Scale Robotics with Tailored Wettability

  2022cites this paper
• Enhanced manipulation of tumor microenvironments by nanomotor for synergistic therapy of malignant tumor.

  2022cites this paper
• Highly sensitive aptasensor for the detection of SARS-CoV-2-RBD using aptamer-gated methylene blue@mesoporous silica film/laser engraved graphene electrode

  2022cites this paper
• Bionic morphological design and interface-free fabrication of halfmoon microrobots with enhanced motion performance

  2022cites this paper
• Paclitaxel-conjugated phenylboronic acid-enriched catalytic robots as smart drug delivery systems

  2022cites this paper
• Nanoswimmers Based on Capped Janus Nanospheres

  2022cites this paper
• Synthesis of Candida Antarctica Lipase B (CALB) enzyme-powered magnetite nanomotor based on PCL/Chitosan Janus nanostructure

  2022cites this paper
• Self-propelled Janus nanomotor as active probe for detection of pepsinogen by lateral flow immunoassay

  2022cites this paper
• Pt-TiO2 Bilayered Hemispherical Nanoshells with Tunable Pt Distribution for Chemically Self-Propelled Colloidal Motors

  2022cites this paper
• Self-Locomotive Composites Based on Asymmetric Micromotors and Covalently Attached Nanosorbents for Selective Uranium Recovery

  2022cites this paper
• Research progress in the application of colloidal motors for precision medicine.

  2022cites this paper
• Modulating drift dynamics of circle swimmers by periodic potentials.

  2022cites this paper
• Enzyme-Powered Micro/Nanomotors for Cancer Treatment.

  2022cites this paper
• Active colloidal molecules in activity gradients.

  2022cites this paper
• Nitric oxide-propelled nanomotors for bacterial biofilm elimination and endotoxin removal to treat infected burn wounds.

  2022cites this paper
• The importance of being a cube: active cubes in a microchannel

  2022cites this paper
• Azobenzene-bearing polymer engine powered organic nanomotors for light-driven cargo transport

  2022cites this paper
• Twin-Engine Janus Supramolecular Nanomotors with Counterbalanced Motion

  2022cites this paper
• Explaining chemical clues of metal organic framework-nanozyme nano-/micro-motors in targeted treatment of cancers: benchmarks and challenges

  2022cites this paper