In Brief

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Nature Reviews Neuroscience

• Publication date

  2003-07-31

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/nrn1210PMID 12895421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional analysis of an archaebacterial voltage-dependent K+ channel

  2003cited by this paper
• X-ray structure of a voltage-dependent K+ channel

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• Voltage Sensor Movements

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• What can be deduced about the structure of Shaker from available data?

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• Interactions between S4-S5 Linker and S6 Transmembrane Domain Modulate Gating of HERG K+ Channels*

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• Crystal structure and mechanism of a calcium-gated potassium channel

  2002influential reference
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• Flexibility of the Kir6.2 inward rectifier K+ channel pore

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• Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents.

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• S4 Charges Move Close to Residues in the Pore Domain during Activation in a K Channel

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• Histidine Scanning Mutagenesis of Basic Residues of the S4 Segment of the Shaker K+ Channel

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• Three-dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution.

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• Induction, assembly, maturation and maintenance of a postsynaptic apparatus

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• Molecular dynamics of the KcsA K(+) channel in a bilayer membrane.

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• Mg2+ Modulates Voltage-Dependent Activation in Ether-à-Go-Go Potassium Channels by Binding between Transmembrane Segments S2 and S3

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• The voltage sensor in voltage-dependent ion channels.

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• Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

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• Tethered blockers as molecular ‘tape measures’ for a voltage-gated K+ channel

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• α-Helical Structural Elements within the Voltage-Sensing Domains of a K+ Channel

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• Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites.

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• A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel.

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• Voltage-Dependent Structural Interactions in the Shaker K+ Channel

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• Helical Structure and Packing Orientation of the S2 Segment in the Shaker K+ Channel

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• Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter

  1999cited by this paper
• The Lipid – Protein Interface of a Shaker K 1 Channel

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• Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy

  1999influential reference
• Mutations in the S4 Region Isolate the Final Voltage-dependent Cooperative Step in Potassium Channel Activation

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• The Activation Gate of a Voltage-Gated K 1 Channel Can Be Trapped in the Open State by an Intersubunit Metal Bridge

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  1998cited by this paper
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  1998cited by this paper
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  1997influential reference
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  1997cited by this paper
• Potassium Channel α and β Subunits Assemble in the Endoplasmic Reticulum*

  1997cited by this paper
• Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits.

  1997cited by this paper
• Gated access to the pore of a voltage-dependent K+ channel.

  1997cited by this paper
• Contribution of the S4 segment to gating charge in the Shaker K+ channel.

  1996cited by this paper
• Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel

  1996cited by this paper
• Intersubunit interaction between amino- and carboxyl-terminal cysteine residues in tetrameric shaker K+ channels.

  1996influential reference
• Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel.

  1996cited by this paper
• Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.

  1995cited by this paper
• Electrostatic interactions of S4 voltage sensor in Shaker K+ channel.

  1995cited by this paper
• Engineering a metal binding site within a polytopic membrane protein, the lactose permease of Escherichia coli.

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding.

  1994cited by this paper
• Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites.

  1994cited by this paper
• Glycosylation of shaker potassium channel protein in insect cell culture and in Xenopus oocytes.

  1994cited by this paper
• A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels.

  1992cited by this paper
• The aromatic binding site for tetraethylammonium ion on potassium channels.

  1992cited by this paper
• Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping.

  1992cited by this paper
• Determination of the subunit stoichiometry of a voltage-activated potassium channel

  1991cited by this paper
• Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel

  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  2023cites this paper
• A Common Kinetic Property of Mutations Linked to Episodic Ataxia Type 1 Studied in the Shaker Kv Channel

  2020cites this paper
• Tracking the movement of discrete gating charges in a voltage-gated potassium channel

  2020cites this paper
• The trajectory of discrete gating charges in a voltage-gated potassium channel

  2020cites this paper
• Metal bridge in S4 segment supports helix transition in Shaker channel

  2019influential citation
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  2018cites this paper
• Nonsensing residues in S3–S4 linker’s C terminus affect the voltage sensor set point in K+ channels

  2018cites this paper
• The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel

  2016cites this paper
• Mechanism of Inactivation in Voltage-Gated Na(+) Channels.

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• Metal bridges to probe membrane ion channel structure and function

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• Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels

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• Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6

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• Erythromelalgia Mutation Q875E Stabilizes the Activated State of Sodium Channel Nav1.7*

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• Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain

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• Long α helices projecting from the membrane as the dimer interface in the voltage-gated H+ channel

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• 10.04 – Ion Channels in the Cell Membrane: Structure, Function, and Modeling

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• Molecular mechanisms of the coupling of gating to voltage sensing in transmembrane proteins

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• Études de type structure fonction des mutations causant l’ataxie épisodique de type I sur les canaux potassiques dépendants du voltage

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• Energetic role of the paddle motif in voltage gating of Shaker K+ channels

  2013cites this paper
• Fine-tuning of Voltage Sensitivity of the Kv1.2 Potassium Channel by Interhelix Loop Dynamics*

  2013cites this paper
• Vitamin A Transport and the Transmembrane Pore in the Cell-Surface Receptor for Plasma Retinol Binding Protein

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• Stabilization of the Conductive Conformation of a Voltage-gated K+ (Kv) Channel

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• A conformational intermediate in glutamate receptor activation.

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• Cooperative Activation of the T-type CaV3.2 Channel

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• Tethered spectroscopic probes estimate dynamic distances with subnanometer resolution in voltage-dependent potassium channels.

  2013cites this paper
• A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb

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• Orientations and Proximities of the Extracellular Ends of Transmembrane Helices S0 and S4 in Open and Closed BK Potassium Channels

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• Inter-Subunit Interactions across the Upper Voltage Sensing-Pore Domain Interface Contribute to the Concerted Pore Opening Transition of Kv Channels

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• Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations.

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• Mechanism of Voltage Gating in Potassium Channels

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• Voltage Sensor Inactivation in Potassium Channels

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• Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels

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• R1 in the Shaker S4 occupies the gating charge transfer center in the resting state

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• An electrostatic potassium channel opener targeting the final voltage sensor transition

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• Mechanisms of closed‐state inactivation in voltage‐gated ion channels

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• Epileptic Channelopathies and Dysfunctional Excitability - From Gene Mutations to Novel Treatments

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• In search of a consensus model of the resting state of a voltage-sensing domain.

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• Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel.

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• Position and motions of the S4 helix during opening of the Shaker potassium channel

  2010cites this paper
• Transfer of ion binding site from ether-à-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening

  2010influential citation
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• The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channel

  2009cites this paper
• Dynamic Coupling of Voltage Sensor and Gate Involved in Closed-State Inactivation of Kv4.2 Channels

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• Structure-function studies on the voltage-gated sodium channel.

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• Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination

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  2008cites this paper
• Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer.

  2008cites this paper
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• PROBING THE BINDING SITES AND MECHANISMS OF ACTION OF TWO hERG CHANNEL ACTIVATORS, NS1643 AND PD307243

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• Chapter 13 A Brief Introduction to Voltage-Gated K+ Channels

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• Modeling and simulation of ion channels

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• Ion channels: from conductance to structure.

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  2006cites this paper
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• Role of Charged Residues in the S1–S4 Voltage Sensor of BK Channels

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