Downregulation of Protein Kinase C Inhibits Activation of Mitochondrial KATP Channels by Diazoxide

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Circulation

• Publication date

  2001-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/01.CIR.104.1.85PMID 11435343
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial function.

  2000cited by this paper
• Cardiotrophic Effects of Protein Kinase C ε Analysis by In Vivo Modulation of PKCε Translocation

  2000cited by this paper
• Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.

  2000cited by this paper
• Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation.

  2000cited by this paper
• Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway.

  1999cited by this paper
• Opening of mitochondrial KATPchannel induces early and delayed cardioprotective effect: role of nitric oxide.

  1999cited by this paper
• Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium.

  1999cited by this paper
• Responses of cardiac protein kinase C isoforms to distinct pathological stimuli are differentially regulated.

  1999cited by this paper
• Activation of mitochondrial ATP-sensitive K(+) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity.

  1999cited by this paper
• Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.

  1999cited by this paper
• Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect : role of nitric oxide

  1999cited by this paper
• Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes.

  1999cited by this paper
• Protein Kinase C- ξ is Responsible for the Protection of Preconditioning in Rabbit Cardiomyocytes

  1999cited by this paper
• Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation

  1999cited by this paper
• Role of Protein Kinase C in Mitochondrial KATP Channel–Mediated Protection Against Ca2+ Overload Injury in Rat Myocardium

  1999cited by this paper
• Oxidant stress with hydrogen peroxide attenuates calcium paradox injury: role of protein kinase C and ATP-sensitive potassium channel.

  1998cited by this paper
• Ischemic preconditioning translocates PKC-δ and -ε, which mediate functional protection in isolated rat heart.

  1998cited by this paper
• Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C.

  1998cited by this paper
• Activation of alpha1-adrenergic receptor during Ca2+ pre-conditioning elicits strong protection against Ca2+ overload injury via protein kinase C signaling pathway.

  1998cited by this paper
• Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function.

  1998cited by this paper
• Mitochondrial ATP-sensitive K1 channels modulate cardiac mitochondrial function

  1998cited by this paper
• Implication of protein kinase C-alpha, delta, and epsilon isoforms in ischemic preconditioning in perfused rat hearts.

  1997cited by this paper
• The ATP-regulated K+ channel in mitochondria: five years after its discovery.

  1996cited by this paper
• The Mitochondrial K Channel as a Receptor for Potassium Channel Openers (*)

  1996cited by this paper
• Regulation of ATP-sensitive potassium channels by phosphorylation.

  1996cited by this paper
• Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase Cɛ, but not p42/44MAPK

  1996cited by this paper
• Protein kinase C activates ATP-sensitive K+ current in human and rabbit ventricular myocytes.

  1996cited by this paper
• Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts.

  1996cited by this paper
• Differential sensitivity of venular and arteriolar alpha-adrenergic receptor constriction to inhibition by hypoxia. Role of receptor subtype and coupling heterogeneity.

  1996cited by this paper
• Preconditioning of isolated rat heart is mediated by protein kinase C.

  1995cited by this paper
• Two Closely Related Isoforms of Protein Kinase C Produce Reciprocal Effects on the Growth of Rat Fibroblasts

  1995cited by this paper
• Protein kinase C V3 domain mutants with differential sensitivities to m-calpain are not resistant to phorbol-ester-induced down-regulation.

  1994cited by this paper
• KATP channels in ischaemic preconditioning.

  1994cited by this paper
• Regular Physical Exercise and Low‐Fat Diet: Effects on Progression of Coronary Artery Disease

  1992cited by this paper
• Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to alpha 1-adrenergic and phorbol ester stimulation.

  1988cited by this paper
• Down-regulation of protein kinase C is due to an increased rate of degradation.

  1987cited by this paper
• Determination of the isoenzyme levels of lactate dehydrogenase.

  1975cited by this paper
• Subcellular localization and properties of 5'-nucleotidase in the rat liver.

  1967cited by this paper

• KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury

  2023cites this paper
• The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

  2022cites this paper
• Postoperative Cognitive Dysfunction and Delirium

  2022cites this paper
• The roles of PKC-δ and PKC-ε in myocardial ischemia/reperfusion injury.

  2021cites this paper
• TASK-5, a potential mitochondrial channel characterised by planar patch-clamp electrophysiology

  2018cites this paper
• The cardioprotective effect of sildenafil is mediated by the activation of malate dehydrogenase and an increase in the malate‐aspartate shuttle in cardiomyocytes

  2017cites this paper
• PHARMACOLOGICAL PRECONDITIONING OF ENDOTHELIAL PROGENITOR CELLS FOR THE REPAIR OF DIABETIC CARDIOMYOPATHY

  2016cites this paper
• Review of remote ischemic preconditioning: from laboratory studies to clinical trials

  2016cites this paper
• Diazoxide Attenuates Postresuscitation Brain Injury in a Rat Model of Asphyxial Cardiac Arrest by Opening Mitochondrial ATP-Sensitive Potassium Channels

  2016cites this paper
• Risk Factors Associated with Cognitive Decline after Cardiac Surgery: A Systematic Review

  2015cites this paper
• Title Role of mitochondrial ATP-sensitive potassium channel-mediated PKC-ε in delayed protection against myocardial ischemia / reperfusion injury in isolated hearts of sevoflurane-preconditioned rats Permalink

  2015cites this paper
• The effect of levosimendan on myocardial ischemia–reperfusion injury in streptozotocin-induced diabetic rats

  2015cites this paper
• Role of mitochondrial ATP-sensitive potassium channel-mediated PKC-ε in delayed protection against myocardial ischemia/reperfusion injury in isolated hearts of sevoflurane-preconditioned rats

  2015cites this paper
• Impaired PI3K/Akt signaling as a potential cause of failure to precondition rat hearts under conditions of simulated hyperglycemia.

  2015cites this paper
• Diazoxide preconditioning of endothelial progenitor cells improves their ability to repair the infarcted myocardium

  2015cites this paper
• Diazoxide preconditioning of endothelial progenitor cells from streptozotocin-induced type 1 diabetic rats improves their ability to repair diabetic cardiomyopathy

  2015cites this paper
• B-dependent miR-146 a expression by targeting Fas κ NF-Diazoxide potentiates mesenchymal stem cell survival via

  2014cites this paper
• Mitochondrial channels: ion fluxes and more.

  2014cites this paper
• Myocardial remote ischemic preconditioning: from pathophysiology to clinical application.

  2013cites this paper
• Cardioprotection techniques: preconditioning, postconditioning and remote conditioning (basic science).

  2013influential citation
• Protein kinase C inhibitors: a patent review (2010 – present)

  2013cites this paper
• Myocardial remote ischemic preconditioning: from pathophysiology to clinical application.

  2013cites this paper
• Is oxytocin a therapeutic factor for ischemic heart disease?

  2013cites this paper
• Preconditioning in the Heart

  2013cites this paper
• Normothermic cardiopulmonary bypass increases cerebral tissue oxygenation during combined valve surgery: a single-centre, randomized trial.

  2013cites this paper
• Effects of diazoxide on rat isolated atria

  2012cites this paper
• Normothermic cardiopulmonary bypass increases cerebral oxygenation during combined valve surgery: 4AP7-1

  2012cites this paper
• Preconditioning of stem cells for the treatment of myocardial infarction.

  2012cites this paper
• Activation of IL-11/STAT3 pathway in preconditioned human skeletal myoblasts blocks apoptotic cascade under oxidant stress.

  2012cites this paper
• Preconditioning approach in stem cell therapy for the treatment of infarcted heart.

  2012cites this paper
• Cardioprotection by Remote Ischemic Preconditioning Exhibits a Signaling Pattern Different From Local Ischemic Preconditioning

  2011cites this paper
• Remodeling of atrial ATP-sensitive K⁺ channels in a model of salt-induced elevated blood pressure.

  2011cites this paper
• Modulation of the Protein Kinase Cδ Interaction with the “d” Subunit of F1F0-ATP Synthase in Neonatal Cardiac Myocytes

  2010cites this paper
• MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts.

  2010cites this paper
• Signaling pathways involved in postconditioning-induced cardioprotection of human myocardium, in vitro

  2010cites this paper
• Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

  2010cites this paper
• Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection

  2010cites this paper
• Preconditioning Promotes Survival and Angiomyogenic Potential of Mesenchymal Stem Cells in the Infarcted Heart via NF-κB Signaling

  2010cites this paper
• Adenosine A1 receptor activation reduces opening of mitochondrial permeability transition pores in hypoxic cardiomyocytes

  2010cites this paper
• Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas.

  2010cites this paper
• Preconditioning and Stem Cell Survival

  2010cites this paper
• Closure of prosthetic paravalvular leaks: a long way to go

  2010cites this paper
• Cardioprotection à la phase aiguë de l'infarctus

  2010cites this paper
• Chloride Channel 2 and Protein Kinase C Epsilon Protein Module in Ischemic Preconditioning of Rabbit Cardiomyocytes

  2010cites this paper
• Loss of cardioprotection with ageing.

  2009cites this paper
• Interventional treatment of structural heart disease

  2009cites this paper
• Possible role of JAK-2 in attenuated cardioprotective effect of ischemic preconditioning in hyperhomocysteinemic rat hearts.

  2009cites this paper
• Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation.

  2008cites this paper
• Effect of diazoxide on flavoprotein oxidation and reactive oxygen species generation during ischemia-reperfusion: a study on Langendorff-perfused rat hearts using optic fibers.

  2008cites this paper
• Sevoflurane improves myocardial ischaemic tolerance in a closed‐chest porcine model

  2008cites this paper
• Isoflurane Activates Human Cardiac Mitochondrial Adenosine Triphosphate-Sensitive K+ Channels Reconstituted in Lipid Bilayers

  2007cites this paper
• Images in cardiovascular medicine. Late device dislodgement after percutaneous closure of mitral prosthesis paravalvular leak with Amplatzer muscular ventricular septal defect occluder.

  2007cites this paper
• Opening of microglial KATP channels inhibits rotenone-induced neuroinflammation

  2007cites this paper
• Pharmacologically Preconditioned Skeletal Myoblasts Are Resistant to Oxidative Stress and Promote Angiomyogenesis via Release of Paracrine Factors in the Infarcted Heart

  2007cites this paper
• Intrinsic defensive mechanisms in the heart: a potential novel approach to cardiac protection against ischemic injury.

  2007cites this paper
• Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.

  2007cites this paper
• Proteomics and metabolomics combined in cardiovascular research.

  2007cites this paper
• Post–conditioning induced cardioprotection requires signaling through a redox–sensitive mechanism, mitochondrial ATP–sensitive K+ channel and protein kinase C activation

  2006cites this paper
• How the body controls brain temperature: the temperature shielding effect of cerebral blood flow.

  2006cites this paper
• Percutaneous Closure of Paravalvular Leaks

  2006cites this paper
• Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro.

  2006influential citation
• Diazoxide acts more as a PKC‐ɛ activator, and indirectly activates the mitochondrial KATP channel conferring cardioprotection against hypoxic injury

  2006cites this paper
• Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.

  2006cites this paper
• Tissue protection mediated by mitochondrial K+ channels.

  2006cites this paper
• Gαq-coupled receptors in human atrium function through protein kinase C ε and δ

  2005cites this paper
• Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury

  2005cites this paper
• SARCOPLASMIC RETICULUM CALCIUM CYCLING AND CARDIAC DISEASE

  2005cites this paper
• Mechanisms by which K(ATP) channel openers produce acute and delayed cardioprotection.

  2005cites this paper
• Characterisation and Application of the Isolated Perfused Murine Heart Model and the Role of Adenosine and Substrate During Ischaemia-Reperfusion

  2005cites this paper
• Diazoxide ameliorates microcirculatory disturbances through PKC-dependent pathway in I/R-injured rat cremaster muscles.

  2005cites this paper
• STRESS signaling pathways that modulate cardiac myocyte apoptosis.

  2005cites this paper
• Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria

  2005cites this paper
• Adenosine-mediated cardioprotection in the aging myocardium.

  2005cites this paper
• Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes

  2005influential citation
• Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits.

  2004cites this paper
• Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice.

  2004cites this paper
• Preconditioning delays Ca 2 +-induced mitochondrial permeability transition

  2004cites this paper
• Brain injury after adult cardiac surgery

  2004cites this paper
• KR-31378, a novel benzopyran analog, attenuates hypoxia-induced cell death via mitochondrial KATP channel and protein kinase C-epsilon in heart-derived H9c2 cells.

  2004cites this paper
• Reactive Oxygen Species Precede Protein Kinase C-&dgr; Activation Independent of Adenosine Triphosphate–sensitive Mitochondrial Channel Opening in Sevoflurane-induced Cardioprotection

  2004cites this paper
• PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium.

  2004cites this paper
• Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia.

  2004cites this paper
• Preconditioning delays Ca2+-induced mitochondrial permeability transition.

  2004cites this paper
• Ischemic preconditioning exaggerates cardiac damage in PKC-δ null mice

  2004cites this paper
• Diazoxide provides protection to human myocardium in vitro that is concentration dependent.

  2004cites this paper
• PKC-ε is upstream and PKC-α is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium

  2004cites this paper
• Contradictory effects of short- and long-term hyperglycemias on ischemic injury of myocardium via intracellular signaling pathway.

  2004cites this paper
• KR-31466, a benzopyranylindol analog, attenuates hypoxic injury through mitochondrial K(ATP) channel and protein kinase C activation in heart-derived H9c2 cells.

  2003cites this paper
• Pathogenesis and protection of ischemia and reperfusion injury in myocardium.

  2003cites this paper
• Translocation of Protein Kinase C Isoforms to Subcellular Targets in Ischemic and Anesthetic Preconditioning

  2003cites this paper
• Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery.

  2003cites this paper
• Targeted Inhibition of Ca2+/Calmodulin-dependent Protein Kinase II in Cardiac Longitudinal Sarcoplasmic Reticulum Results in Decreased Phospholamban Phosphorylation at Threonine 17*

  2003cites this paper
• Mechanisms of Delayed Electrical Uncoupling Induced by Ischemic Preconditioning

  2003cites this paper
• Preconditioning the myocardium: from cellular physiology to clinical cardiology.

  2003cites this paper
• The Effect of Isoflurane and Sevoflurane on Cerebrocortical Presynaptic Ca2+ and Protein Kinase C Activity

  2003cites this paper
• ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel.

  2003cites this paper
• Cellular uptake of a catechol iron chelator and chloroquine into Plasmodium falciparum infected erythrocytes.

  2003cites this paper
• Different influences of hyperglycemic duration on phosphorylated extracellular signal-regulated kinase 1/2 in rat heart.

  2003cites this paper
• Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ in the rat heart as revealed by κ‐opioid receptor stimulation with U50,488H

  2003cites this paper
• Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning.

  2003cites this paper