Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Free Radical Biology & Medicine

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0891-5849(02)01179-6PMID 12498977
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Methods of Enzymatic Analysis

  2019cited by this paper
• Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.

  2003cited by this paper
• Xanthine oxidase contributes to preconditioning's preservation of left ventricular developed pressure in isolated rat heart: developed pressure may not be an appropriate end-point for studies of preconditioning

  2002cited by this paper
• The cardioprotection of calcitonin gene-related peptide-mediated preconditioning.

  2002cited by this paper
• Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.

  2002cited by this paper
• The Chemical Biology of Nitric Oxide

  2002cited by this paper
• Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling

  2001influential reference
• Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable manner.

  2001cited by this paper
• Unique Oxidative Mechanisms for the Reactive Nitrogen Oxide Species, Nitroxyl Anion*

  2001cited by this paper
• Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts.

  2001cited by this paper
• Ischemic and anesthetic preconditioning reduces cytosolic [Ca2+] and improves Ca(2+) responses in intact hearts.

  2001cited by this paper
• Diazoxide induced cardioprotection: what comes first, K(ATP) channels or reactive oxygen species?

  2001cited by this paper
• Nitroxyl anion regulation of the NMDA receptor

  2001cited by this paper
• Ischemic preconditioning: from the first to the second window of protection.

  2001cited by this paper
• Acetylcholine, Bradykinin, Opioids, and Phenylephrine, but not Adenosine, Trigger Preconditioning by Generating Free Radicals and Opening Mitochondrial KATP Channels

  2001cited by this paper
• The KATP channel opener diazoxide protects cardiac myocytes during metabolic inhibition without causing mitochondrial depolarization or flavoprotein oxidation

  2001cited by this paper
• Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.

  2001cited by this paper
• Diazoxide-Induced Cardioprotection Requires Signaling Through a Redox-Sensitive Mechanism

  2001cited by this paper
• Mitochondrial K(ATP) channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation.

  2001cited by this paper
• Downregulation of Protein Kinase C Inhibits Activation of Mitochondrial KATP Channels by Diazoxide

  2001cited by this paper
• Role of Oxidants in the Signaling Pathway of Preconditioning

  2001cited by this paper
• Nitroglycerin Induces Late Preconditioning Against Myocardial Infarction in Conscious Rabbits Despite Development of Nitrate Tolerance

  2001cited by this paper
• Preconditioning decreases ischemia/reperfusion-induced peroxynitrite formation.

  2001cited by this paper
• Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts.

  2000cited by this paper
• Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts

  2000cited by this paper
• Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of delta-isoform of protein kinase C in rat ventricular myocardium.

  2000cited by this paper
• Opening of Mitochondrial KATP Channels Triggers the Preconditioned State by Generating Free Radicals

  2000cited by this paper
• cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.

  2000cited by this paper
• Role of nitric oxide in myocardial function.

  2000cited by this paper
• Inhibition of nitric oxide synthase augments the positive inotropic effect of nitric oxide donors in the rat heart

  2000cited by this paper
• Differential actions of L‐cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta

  2000cited by this paper
• Activation of mitochondrial ATP-dependent potassium channels by nitric oxide.

  2000influential reference
• Chapter 2 – The Chemical Properties of Nitric Oxide and Related Nitrogen Oxides

  2000cited by this paper
• Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning.

  2000cited by this paper
• Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart.

  1999cited by this paper
• Ischaemic preconditioning changes the pattern of coronary reactive hyperaemia in the goat: role of adenosine and nitric oxide.

  1999cited by this paper
• The cardioprotective effects of nitroglycerin-induced preconditioning are mediated by calcitonin gene-related peptide.

  1999cited by this paper
• Signal Transduction in Ischemic Preconditioning:

  1999cited by this paper
• Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury.

  1999cited by this paper
• Opening of mitochondrial KATPchannel induces early and delayed cardioprotective effect: role of nitric oxide.

  1999cited by this paper
• Low concentrations of adenosine receptor blocker decrease protection by hypoxic preconditioning in ischemic rat hearts.

  1998cited by this paper
• Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart.

  1998cited by this paper
• Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism.

  1998cited by this paper
• Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry.

  1998cited by this paper
• The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO.

  1998influential reference
• Characterisation of the infarct-limiting effect of delayed preconditioning: timecourse and dose-dependency studies in rabbit myocardium

  1997cited by this paper
• Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide.

  1997cited by this paper
• Direct measurement of nitric oxide generation from nitric oxide synthase.

  1997cited by this paper
• Signal transduction in ischemic preconditioning.

  1997cited by this paper
• No .NO from NO synthase.

  1996cited by this paper
• Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite.

  1996cited by this paper
• Time course of late preconditioning against myocardial stunning in conscious pigs.

  1996cited by this paper
• A redox-based mechanism for cardioprotection induced by ischemic preconditioning in perfused rat heart.

  1995cited by this paper
• Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase.

  1995cited by this paper
• Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts.

  1995cited by this paper
• Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury.

  1995cited by this paper
• Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism.

  1995cited by this paper
• Endogenous catecholamines are not necessary for ischaemic preconditioning in the isolated perfused rat heart.

  1995cited by this paper
• Signal transduction in ischemic preconditioning.

  1995cited by this paper
• Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.

  1994cited by this paper
• Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteine.

  1994cited by this paper
• Inhibition of nitric oxide limits infarct size in the in situ rabbit heart.

  1993cited by this paper
• Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

  1993cited by this paper
• Complexes of Nitric Oxide with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide: Hemodynamic Effect in the Rabbit

  1993cited by this paper
• Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.

  1991cited by this paper
• Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

  1986cited by this paper

• Oxidative HNO Formation Mechanisms from NH2OH via Two Different Heme Proteins and Effects from Hemes, Nearby Residues, and Protein Environments

  2025cites this paper
• Reusable HNO Sensors Derived from Cu Cyclam: A DFT Study on the Mechanistic Origin of High Reactivity and Favorable Conformation Changes and Potential Improvements

  2024cites this paper
• Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies

  2024cites this paper
• Platelets and Cardioprotection: The Role of Nitric Oxide and Carbon Oxide

  2023cites this paper
• Synthesis and nitroxyl (HNO) donating properties of benzoxadiazole-based Piloty's acids.

  2023cites this paper
• Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming

  2023cites this paper
• A lysosome-targeting ratiometric fluorescent probe used to detect Nitroxyl (HNO) in a Parkinson's disease model

  2023cites this paper
• Stabilization of a Heme-HNO Model Complex Using a Bulky Bis-Picket Fence Porphyrin and Reactivity Studies with NO.

  2023cites this paper
• Clinical Applications for Gasotransmitters in the Cardiovascular System: Are We There Yet?

  2023cites this paper
• Pro-luciferin probes containing (2-diphenylphosphino)benzoate and 2-thiolo-2-methylpropionate moieties: Synthesis, characterization, and reactivity toward nitroxyl

  2023cites this paper
• Modification of Ischemia/Reperfusion-Induced Alterations in Subcellular Organelles by Ischemic Preconditioning

  2022cites this paper
• Ratiometric Determination of Nitroxyl Utilizing a Novel Fluorescence Resonance Energy Transfer-Based Fluorescent Probe Based on a Coumarin-Rhodol Derivative

  2022cites this paper
• A near-infrared fluorescent probe with ultra-large Stokes shift for the detection of HNO in cells and mice

  2022cites this paper
• Mechanistic Origin of Favorable Substituent Effects in Excellent Cu Cyclam Based HNO Sensors

  2022cites this paper
• HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

  2022cites this paper
• When NO . Is not Enough: Chemical Systems, Advances and Challenges in the Development of NO . and HNO Donors for Old and Current Medical Issues

  2021cites this paper
• Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds

  2021cites this paper
• Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology.

  2021cites this paper
• Azanone (HNO): generation, stabilization and detection

  2021cites this paper
• HNO to NO Conversion Mechanism via Copper Zinc Superoxide Dismutase (CuZnSOD), Comparison with Heme Protein Mediated Conversions, and Origin of the Questionable Reversibility.

  2021cites this paper
• Design and tuning of ionic liquid–based HNO donor through intramolecular hydrogen bond for efficient inhibition of tumor growth

  2020cites this paper
• Alkylamine-Substituted Perthiocarbamates: Dual Precursors to Hydropersulfide and Carbonyl Sulfide with Cardioprotective Actions.

  2020cites this paper
• Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.

  2020cites this paper
• Updating NO•/HNO interconversion under physiological conditions: A biological implication overview.

  2020cites this paper
• Role of nitroxyl (HNO) in cardiovascular system: From biochemistry to pharmacology.

  2020cites this paper
• Redox Aspects of Myocardial Ischemia/Reperfusion Injury and Cardioprotection

  2019cites this paper
• Engineering of a bioluminescent probe for imaging nitroxyl in live cells and mice.

  2019cites this paper
• Phoenixin-14: detection and novel physiological implications in cardiac modulation and cardioprotection

  2018cites this paper
• A recent history of nitroxyl chemistry, pharmacology and therapeutic potential

  2018cites this paper
• Notch1 Mediates Preconditioning Protection Induced by GPER in Normotensive and Hypertensive Female Rat Hearts

  2018cites this paper
• Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

  2018cites this paper
• A selenoprotein T‐derived peptide protects the heart against ischaemia/reperfusion injury through inhibition of apoptosis and oxidative stress

  2018cites this paper
• Apelin‐induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src

  2018influential citation
• The nitroxyl donor Angeli's salt ameliorates Staphylococcus aureus‐induced septic arthritis in mice

  2017cites this paper
• Hidden complexities in the reaction of H2O2 and HNO revealed by ab initio quantum chemical investigations.

  2017cites this paper
• Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin.

  2017cites this paper
• The chemical biology of HNO signaling.

  2017cites this paper
• Chromogranins: from Cell Biology to Physiology and Biomedicine

  2017cites this paper
• From Heaven to Heart: Nitroxyl (HNO) in the Cardiovascular System and Beyond

  2017cites this paper
• Role of Irisin in Ischaemia-Reperfusion Injury in Isolated Heart of Albino Rats

  2017cites this paper
• Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress.

  2017cites this paper
• Chromogranin A-Derived Peptides in Cardiac Pre- and Post-conditioning

  2017cites this paper
• Cardioprotective effects of calcitonin gene-related peptide in isolated rat heart and in H9c2 cells via redox signaling.

  2017cites this paper
• Is Azanone Endogenously Produced in Mammals

  2017cites this paper
• Protective Role of GPER Agonist G‐1 on Cardiotoxicity Induced by Doxorubicin

  2017cites this paper
• Yang of MI Therapy

  2016cites this paper
• Photochemical locking and unlocking of an acyl nitroso dienophile in the Diels–Alder reaction

  2016cites this paper
• HNO suppresses LPS-induced inflammation in BV-2 microglial cells via inhibition of NF-κB and p38 MAPK pathways.

  2016cites this paper
• Photocontrol of NO, H2S, and HNO Release in Biological Systems by Using Specific Caged Compounds.

  2016cites this paper
• Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.

  2016cites this paper
• Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

  2016cites this paper
• Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents

  2016cites this paper
• HNO/Thiol Biology as a Therapeutic Target

  2016cites this paper
• The HNO donor Angeli's salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia-reperfusion injury in the rat heart ex vivo.

  2016cites this paper
• Biological signaling by small inorganic molecules.

  2016cites this paper
• Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells

  2016cites this paper
• Retracted: Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties

  2016cites this paper
• A mitochondria-targetable near-infrared fluorescent probe for imaging nitroxyl (HNO) in living cells

  2016cites this paper
• EFFECT OF NESFATIN-1 ON ISCHAEMIA-REPERFUSION INJURY IN ISOLATED HEART OF ALBINO RATS

  2016cites this paper
• A FRET-based ratiometric two-photon fluorescent probe for dual-channel imaging of nitroxyl in living cells and tissues.

  2016cites this paper
• activationide 3-kinase and protein kinase C isolated rat heart akin to ischemic preconditioning: role Platelet-activating factor induces cardioprotection in

  2016cites this paper
• Protective Effect of Apigenin on Ischemia/Reperfusion Injury of the Isolated Rat Heart

  2015cites this paper
• The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

  2015cites this paper
• Apigenin attenuates myocardial ischemia/reperfusion injury via the inactivation of p38 mitogen‑activated protein kinase.

  2015cites this paper
• Redox signalling and cardioprotection: translatability and mechanism

  2015influential citation
• Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties

  2015cites this paper
• Studies on the Reaction of Reduced Vitamin B12 Derivatives with the Nitrosyl Hydride (HNO) Donor Angeli's Salt: HNO Oxidizes the Transition-Metal Center of Cob(I)alamin

  2015cites this paper
• Comparison of the chemical reactivity of synthetic peroxynitrite with that of the autoxidation products of nitroxyl or its anion.

  2015cites this paper
• Nitrite Confers Preconditioning and Cytoprotection After Ischemia/Reperfusion Injury Through the Modulation of Mitochondrial Function

  2015cites this paper
• Chromofungin, CgA47-66-derived peptide, produces basal cardiac effects and postconditioning cardioprotective action during ischemia/reperfusion injury.

  2015cites this paper
• pGlu-serpinin protects the normotensive and hypertensive heart from ischemic injury.

  2015cites this paper
• Nitroxyl (HNO) for Treatment of Acute Heart Failure

  2014cites this paper
• Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer.

  2014cites this paper
• Catestatin Increases the Expression of Anti-Apoptotic and Pro-Angiogenetic Factors in the Post-Ischemic Hypertrophied Heart of SHR

  2014cites this paper
• Nitroxyl inhibits overt pain-like behavior in mice: Role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

  2014cites this paper
• Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways.

  2014cites this paper
• β‐Sitosterol Enhances Cellular Glutathione Redox Cycling by Reactive Oxygen Species Generated From Mitochondrial Respiration: Protection Against Oxidant Injury in H9c2 Cells and Rat Hearts

  2014cites this paper
• Mechanistic studies of oxidative decomposition of Angeli's salt and PAPA NONOate.

  2014cites this paper
• Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors.

  2014cites this paper
• Analysis of the HNO and NO donating properties of alicyclic amine diazeniumdiolates.

  2014cites this paper
• Protein S-nitrosylation in preconditioning and postconditioning

  2014cites this paper
• Kinetic and mechanistic studies on the reaction of the vitamin B12 complex aquacobalamin with the HNO donor Angeli's salt: Angeli's salt and HNO react with aquacobalamin.

  2014cites this paper
• The role of gasotransmitters

  2014cites this paper
• Malvidin, a red wine polyphenol, modulates mammalian myocardial and coronary performance and protects the heart against ischemia/reperfusion injury.

  2013cites this paper
• A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies.

  2013cites this paper
• Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE

  2013influential citation
• A singular value decomposition approach for kinetic analysis of reactions of HNO with myoglobin.

  2013cites this paper
• Piloty's acid derivative with improved nitroxyl-releasing characteristics.

  2013cites this paper
• Controlled release of HNO from chemical donors for biological applications.

  2013cites this paper
• Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.

  2013cites this paper
• The effect of hyperoside on the functional recovery of the ischemic/reperfused isolated rat heart: potential involvement of the extracellular signal-regulated kinase 1/2 signaling pathway.

  2013cites this paper
• Redox balance and cardioprotection

  2013cites this paper
• Developing Detection Methods for Nitroxyl

  2013cites this paper
• Nitroglycerine and sodium trioxodinitrate: from the discovery to the preconditioning effect.

  2013cites this paper
• Catestatin reduces myocardial ischaemia/reperfusion injury: involvement of PI3K/Akt, PKCs, mitochondrial KATP channels and ROS signalling

  2013cites this paper
• Discriminative EPR detection of NO and HNO by encapsulated nitronyl nitroxides

  2013cites this paper
• Synthesis and characterization of lithium oxonitrate (LiNO).

  2013cites this paper
• Quantitative detection of nitroxyl upon trapping with glutathione and labeling with a specific fluorogenic reagent.

  2013cites this paper
• Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia/reperfusion injury

  2012cites this paper
• O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies.

  2012cites this paper