Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Clinical science

• Publication date

  2008-05-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1042/CS20070343PMID 17999638
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)

  2007cited by this paper
• Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

  2007cited by this paper
• Relationship between (Na + K)-ATPase activity, lipid peroxidation and fatty acid profile in erythrocytes of hypertensive and normotensive subjects

  2007cited by this paper
• Clinical pharmacology and therapeutic use of antioxidant vitamins

  2007cited by this paper
• The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

  2007cited by this paper
• Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients.

  2007cited by this paper
• Local ascorbate administration augments NO- and non-NO-dependent reflex cutaneous vasodilation in hypertensive humans.

  2007cited by this paper
• Redox signaling in hypertension.

  2006cited by this paper
• Antioxidants and endothelial nitric oxide synthesis

  2006cited by this paper
• Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace

  2006cited by this paper
• Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension

  2006cited by this paper
• Effect of Salt on Isoprostanes in Salt-Sensitive Essential Hypertension

  2006cited by this paper
• HYPERTENSION AND OXIDATIVE STRESS

  2006cited by this paper
• Effects of Ascorbic Acid on Ambulatory Blood Pressure in Elderly Patients with Refractory Hypertension

  2006cited by this paper
• Controversy of free radical hypothesis: reactive oxygen species--cause or consequence of tissue injury?

  2005cited by this paper
• Pathophysiological basis for the prophylaxis of preeclampsia through early supplementation with antioxidant vitamins.

  2005cited by this paper
• Urinary metabolites of workers exposed to nitrotoluenes

  2005cited by this paper
• Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension.

  2005cited by this paper
• F2-Isoprostanes as markers of oxidative stress in vivo: An overview

  2005cited by this paper
• Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

  2005cited by this paper
• Comparing Self-Management of Oral Anticoagulant Therapy with Clinic Management

  2005cited by this paper
• Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.

  2005cited by this paper
• The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial

  2005cited by this paper
• EFFECT OF POTENTIALLY MODIFIABLE RISK FACTORS ASSOCIATED WITH MYOCARDIAL INFARCTION IN 52 COUNTRIES (THE INTERHEART STUDY): CASE-CONTROL STUDY

  2005cited by this paper
• New algorithm for the diagnosis of hypertension.

  2005cited by this paper
• New Algorithm for the Diagnosis of Hypertension: Canadian Hypertension Education Program Recommendations (2005)

  2005cited by this paper
• The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals.

  2004cited by this paper
• Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study.

  2004cited by this paper
• Diagnosis and classification of diabetes mellitus.

  2004cited by this paper
• Reactive oxygen species in hypertension; An update.

  2004cited by this paper
• New concepts in reactive oxygen species and cardiovascular reperfusion physiology.

  2004cited by this paper
• A Randomized, Placebo-Controlled Trial of the Health Effects of Antioxidant Vitamins and Minerals

  2004cited by this paper
• Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?

  2004cited by this paper
• Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use

  2004cited by this paper
• European Society of Hypertension – European Society of Cardiology guidelines for the management of arterial hypertension

  2003cited by this paper
• Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities

  2003cited by this paper
• Lipid Peroxidation Is Not Increased in Patients With Untreated Mild-to-Moderate Hypertension

  2003cited by this paper
• Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.

  2003cited by this paper
• Current concepts in the use of antioxidants for the treatment of preeclampsia.

  2003cited by this paper
• Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study

  2003cited by this paper
• 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension.

  2003cited by this paper
• Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention

  2003cited by this paper
• Implications of Oxidative Stress and Homocysteine in the Pathophysiology of Essential Hypertension

  2003cited by this paper
• Convective and diffusive losses of vitamin C during haemodiafiltration session: a contributive factor to oxidative stress in haemodialysis patients.

  2002cited by this paper
• Vitamin E can reduce blood pressure in mild hypertensives.

  2002cited by this paper
• Ascorbic Acid Reduces Blood Pressure and Arterial Stiffness in Type 2 Diabetes

  2002cited by this paper
• Lack of Long-Term Effect of Vitamin C Supplementation on Blood Pressure

  2002cited by this paper
• Vitamin E can Reduce Blood Pressure in Mild Hypertensives

  2002cited by this paper
• NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat

  2001cited by this paper
• Relative deficiency of nitric oxide-dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions

  2001cited by this paper
• Plasma ascorbic acid: measurement, stability and clinical utility revisited.

  2001cited by this paper
• Effects of vitamin E on lipid peroxidation in healthy persons.

  2001cited by this paper
• Antioxidant Effects of Vitamins C and E Are Associated With Altered Activation of Vascular NADPH Oxidase and Superoxide Dismutase in Stroke-Prone SHR

  2001cited by this paper
• Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension.

  2001cited by this paper
• Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons

  2000cited by this paper
• Vitamin E supplementation and cardiovascular events in high-risk patients.

  2000cited by this paper
• Decreased endogenous antioxidant enzymatic status in essential hypertension

  2000cited by this paper
• Treatment of hypertension with ascorbic acid.

  1999cited by this paper
• Anti‐oxidant status and lipid peroxidation in patients with essential hypertension

  1998cited by this paper
• Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations.

  1998cited by this paper
• Vitamin C and blood pressure–an overview

  1997cited by this paper
• Combination oral antioxidant supplementation reduces blood pressure.

  1997cited by this paper
• The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.

  1996cited by this paper
• The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide.

  1995cited by this paper
• Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol.

  1993cited by this paper
• Evaluation of noninvasive blood pressure monitoring devices Spacelabs 90202 and 90207 versus resting and ambulatory 24-hour intra-arterial blood pressure.

  1992cited by this paper
• Accuracy of the SpaceLabs 90207 determined by the British Hypertension Society protocol.

  1991cited by this paper
• Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay.

  1985cited by this paper
• Assays of glutathione peroxidase.

  1984cited by this paper
• A short questionnaire for the measurement of habitual physical activity in epidemiological studies.

  1982cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

  1979cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• A fluorometric method for determination of oxidized and reduced glutathione in tissues.

  1976cited by this paper
• J Am Soc Nephrol 12: 2585–2593, 2001 Vitamin E Alleviates Renal Injury, but Not Hypertension, during Chronic Nitric Oxide Synthase Inhibition in Rats

  year unknowncited by this paper

• Oxidative Stress Biomarkers in Hypertension.

  2025cites this paper
• The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression

  2025cites this paper
• Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study

  2025cites this paper
• Advanced Glycation End Products, Advanced Oxidation Protein Products, and Ferric Reducing Ability of Plasma Are Correlates of Uncontrolled Hypertension in Patients With Type 2 Diabetes

  2025cites this paper
• Nutritional predictors of lymphatic filariasis progression: Insights from a machine learning approach

  2025cites this paper
• The Efficacy of Vitamins in the Prevention and Treatment of Cardiovascular Disease

  2024cites this paper
• Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

  2024cites this paper
• Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

  2023cites this paper
• Vitamin C supplementation lowers advanced glycation end products (AGEs) and malondialdehyde (MDA) in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled clinical trial

  2023cites this paper
• Dietary Antioxidant Quality Score (DAQS), serum lipids, markers of glucose homeostasis, blood pressure and anthropometric features among apparently metabolically healthy obese adults in two metropolises of Iran (Tabriz and Tehran): a cross-sectional study

  2023cites this paper
• Effect of antioxidant on tooth sensitivity after bleaching.

  2023cites this paper
• Beyond the Bottle: Exploring Health-Promoting Compounds in Wine and Wine-Related Products—Extraction, Detection, Quantification, Aroma Properties, and Terroir Effects

  2023cites this paper
• Oxidative Stress, Antioxidants and Hypertension

  2023cites this paper
• Hypertension Induces Pro-arrhythmic Cardiac Connexome Disorders: Protective Effects of Treatment

  2023cites this paper
• Dietary food antioxidants and their radical scavenging activity: A review

  2023cites this paper
• Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders

  2022cites this paper
• Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity - A narrative review.

  2022cites this paper
• Cereals as a Source of Bioactive Compounds with Anti-Hypertensive Activity and Their Intake in Times of COVID-19

  2022cites this paper
• Extraction and characterization of phenolic compounds and their potential antioxidant activities

  2022cites this paper
• Novel Combined Antioxidant Strategy against Hypertension, Acute Myocardial Infarction and Postoperative Atrial Fibrillation

  2021influential citation
• Pathophysiological and Clinical Evidence of the Effectiveness of Antioxidant Compounds as a Single or Adjunct Therapy for Hypertension

  2021cites this paper
• Antioxidant enzymes and vascular diseases

  2021cites this paper
• Effectiveness of Some Vitamins in the Prevention of Cardiovascular Disease: A Narrative Review

  2021cites this paper
• Purification of Angiotensin-Converting Enzyme (ACE) from Sheep Kidney and Inhibition Effect of Reduced Nicotinamide Adenine Dinucleotide (NADH) on Purified ACE Activity

  2021cites this paper
• Vitamins as primary or adjunctive treatment in infertile men with varicocele: A systematic review

  2021cites this paper
• Extrusion Process as an Alternative to Improve Pulses Products Consumption. A Review

  2021cites this paper
• [Analysis of the biochemical, anthropometric profile, and of antioxidant micronutrient ingestion in patients with resistant arterial hypertension].

  2020cites this paper
• Honey: A Powerful Natural Antioxidant and Its Possible Mechanism of Action

  2020cites this paper
• Therapeutic Applications of Honey and its Phytochemicals: Vol.1

  2020cites this paper
• The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature.

  2020cites this paper
• Antioxidant Blueberry Anthocyanins Induce Vasodilation via PI3K/Akt Signaling Pathway in High-Glucose-Induced Human Umbilical Vein Endothelial Cells

  2020cites this paper
• Nutrients and bioactive components from vinegar: A fermented and functional food

  2020cites this paper
• Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome

  2020cites this paper
• Nicotinamide nucleotide transhydrogenase (NNT) regulates mitochondrial ROS and endothelial dysfunction in response to angiotensin II

  2020cites this paper
• Derepression of glomerular filtration, renal blood flow and antioxidant defence in patients with type 2 diabetes at high-risk of cardiorenal disease.

  2020cites this paper
• A systematic review and meta-analysis

  2020cites this paper
• Independent and Additive Effects of Coenzyme Q10 and Vitamin E on Cardiometabolic Outcomes and Visceral Adiposity in Women With Polycystic Ovary Syndrome.

  2019cites this paper
• In vitro effect of oxidized and reduced glutathione peptides on angiotensin converting enzyme purified from human plasma.

  2019cites this paper
• Effects of physical exercise on oxidative stress biomarkers in hypertensive animals and non-diabetic subjects with prehypertension/hypertension: a review

  2019cites this paper
• Comparison Effect of Tranexamic Acid (TA) and Tranexamic Acid Combined with Vitamin C (TXC) on Drainage Volume and Atrial Fibrillation Arrhythmia in Patients Undergoing Cardiac Bypass Surgery: Randomized Clinical Trial

  2019cites this paper
• Oxidative Stress in Hypertension and Cardiovascular-Renal Remodeling: Focus on the Renin-Angiotensin-Aldosterone System

  2019cites this paper
• Genetic Polymorphisms Associated with Reactive Oxygen Species and Blood Pressure Regulation

  2019cites this paper
• Targeting oxidative stress through antioxidants in diabetes mellitus

  2018cites this paper
• Effects of vitamin C supplementation on blood pressure and hypertension control in response to ambient temperature changes in patients with essential hypertension

  2018cites this paper
• Chapter 3 Oxidative Stress and Essential Hypertension

  2018cites this paper
• Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

  2018cites this paper
• Effects of resistance training on oxidative stress-related biomarkers in metabolic diseases: a review

  2018cites this paper
• Emerging Evidence on Neutrophil Motility Supporting Its Usefulness to Define Vitamin C Intake Requirements

  2017cites this paper
• New concepts of the pro-atherogenetic mechanism of vascular oxidative stress . Protective and harmful roles of NADPH oxidase * *

  2017cites this paper
• Association between dietary fibre intake and fruits , vegetables or whole grain consumption and the risk of cardiovascular disease . Results from the PREDIMED trial

  2017cites this paper
• Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease

  2017cites this paper
• Telferia Occidentalis and Vitamin C Attenuate Phenylhydrazine-Induced Haemolytic Anaemia and Associated Cardio-renal Dysfunctions via Inhibition of Oxidative Stress and Proapoptotic -Protein (Bax) Expressions

  2017cites this paper
• The Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side

  2017cites this paper
• Antioxidant-Based Eutectics of Irbesartan: Viable Multicomponent Forms for the Management of Hypertension

  2017cites this paper
• Gallbladder Disease: Relevance of Oxidative Stress

  2017cites this paper
• Total polyphenol content, carotenoid, tocopherol and fatty acid composition of commonly consumed Canadian pulses and their contribution to antioxidant activity

  2017cites this paper
• L-Name Hipertansif Ratlarda Ace İnhibitörü ile Birlikte L-Karnitin ve Co-enzim Q10 Verilmesinin Total Oksidan ve Antioksidan Düzeyleri Üzerine Etkileri

  2017cites this paper
• Vitamin E intake, serum tocopherols and blood pressure in UK adolescents

  2016cites this paper
• Antioxidants and Cardiovascular Risk Factors

  2016cites this paper
• Mediterranean diets supplemented with virgin olive oil and nuts enhance plasmatic antioxidant capabilities and decrease xanthine oxidase activity in people with metabolic syndrome: The PREDIMED study.

  2016cites this paper
• Blood Pressure Reduction is Associated With the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy

  2016cites this paper
• Hypertension as an autoimmune and inflammatory disease

  2016cites this paper
• Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial

  2016cites this paper
• 5. Vitamins C and E supplementation in sickle cell anaemia

  2016cites this paper
• Oxidative Stress and Essential Hypertension

  2016cites this paper
• Modulation of endogenous antioxidant defense and the progression of kidney disease in multi-heritage groups of patients with type 2 diabetes: PRospective EValuation of Early Nephropathy and its Treatment (PREVENT)

  2016cites this paper
• Increased Levels of Modified Advanced Oxidation Protein Products Are Associated with Central and Peripheral Blood Pressure in Peritoneal Dialysis Patients

  2015cites this paper
• Oxidative stress in hypertension: mechanisms and therapeutic opportunities.

  2015cites this paper
• Endothelial Cell Function and Hypertension: Interactions Among Inflammation, Immune Function, and Exercise

  2015cites this paper
• A STUDY OF SERUM CALCIUM, MAGNESIUM AND COPPER LEVELS IN PATIENTS OF ESSENTIAL HYPERTENSION

  2015cites this paper
• Hypertension and the Fat-Soluble Vitamins A, D and E

  2015cites this paper
• The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review).

  2015cites this paper
• Oxidative stress in chronic vascular disease: From prediction to prevention.

  2015cites this paper
• The Investigation of the Impact of Antioxidant Vitamin C on Changes in Estrogen and Progesterone Hormones in the Treated Mice with DELTAMETHRIN

  2014cites this paper
• Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants

  2014cites this paper
• Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E.

  2014cites this paper
• Multimarker Screening of Oxidative Stress in Aging

  2014cites this paper
• Homocysteine, antioxidant micronutrients and late onset dementia

  2014cites this paper
• Effects of Simvastatin and Vitamin E on Diet-induced Hypercholesterolemia in Rats

  2014cites this paper
• The association between vitamin E intake and hypertension: results from the re-analysis of the National Health and Nutrition Survey.

  2014cites this paper
• Administration of ascorbic acid to prevent bleaching-induced tooth sensitivity: a randomized triple-blind clinical trial.

  2014cites this paper
• [Role of renal inflammation in the physiopathology of salt-sensitive hypertension].

  2014cites this paper
• Modulation of (Na,K)-ATPase activity by membrane fatty acid composition: therapeutic implications in human hypertension

  2014cites this paper
• Antioxidant Modulation of F2-Isoprostanes in Humans: A Systematic Review

  2014influential citation
• Essential hypertension and oxidative stress: New insights.

  2014cites this paper
• Polyphenol Consumption and Blood Pressure

  2014cites this paper
• Altérations cardiaques et vasculaires induites par le syndrome d'apnées obstructives du sommeil : role de HIF-1 et d'un de ses gènes-cibles, l'endothéline-1

  2014cites this paper
• Papel de la inflamación renal en la fisiopatología de la hipertensión sensible a sal

  2014cites this paper
• 2: Dyslipidemia and Atherosclerosis

  2014cites this paper
• The effect of polyphenol consumption on blood pressure.

  2013cites this paper
• Investigation of oxidative stress markers in essential hypertension.

  2013cites this paper
• Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage

  2013cites this paper
• Antioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: a randomized, double‐blind, placebo‐controlled trial

  2013cites this paper
• Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension

  2013cites this paper
• Influence of Acute Coffee Consumption on Postprandial Oxidative Stress

  2013cites this paper
• Bioactive Natural Constituents from Food Sources—Potential Use in Hypertension Prevention and Treatment

  2013influential citation
• Rationale for Antioxidant Supplementation in Sarcopenia

  2012cites this paper
• Do Apo-Lycopenoids Have Antioxidant Activities In Vitro?

  2012cites this paper
• Estrés oxidativo en hijos masculinos de hipertensos

  2012cites this paper
• D-α-tocopherol reduces renal damage in hypertensive rats

  2012cites this paper