Pathophysiological and Clinical Evidence of the Effectiveness of Antioxidant Compounds as a Single or Adjunct Therapy for Hypertension

High blood pressure is a highly prevalent condition affecting 1.13 billion people worldwide. Its pathophysiology is not yet fully understood, but evidence shows an important role of oxidative stress in its development and maintenance, being responsible for phenotypic changes in blood vessels that increase blood pressure. Focusing therapy on reducing oxidative stress has been an objective tested in both animal and human models with diverse and sometimes contradictory results. The origin of this controversy lies, among other things, in the different antioxidant doses, inclusion methods, and criteria present in the studies. A deep analysis of these antioxidant compounds could generate evidence for their combined and targeted use in key regulators of ROS production. Moreover, analyzing current evidence from already existing studies, with a focus on those performed in humans, can elucidate the suitability of this treatment. We present the pathophysiological bases and existing evidence for a new proposal aimed to improve the effectiveness of antihypertensive therapy based on the use of widely known and used antioxidants compounds as a single or adjunct therapy with other antihypertensive drugs.

• Publication year

  2021

• Venue

  International Journal of Clinical Studies and Medical Case Reports

• Publication date

  2021-11-22

• Fields of study

  Not labeled

• Identifiers
  DOI 10.46998/ijcmcr.2021.15.100337
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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