Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease

Summary Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. Here, we found that oral administration of the polysaccharides and water extract from G. lucidum promoted neural progenitor cell (NPC) proliferation to enhance neurogenesis and alleviated cognitive deficits in transgenic AD mice. G. lucidum polysaccharides (GLP) also promoted self-renewal of NPC in cell culture. Further mechanistic study revealed that GLP potentiated activation of fibroblast growth factor receptor 1 (FGFR1) and downstream extracellular signal-regulated kinase (ERK) and AKT cascades. Consistently, inhibition of FGFR1 effectively blocked the GLP-promoted NPC proliferation and activation of the downstream cascades. Our findings suggest that GLP could serve as a regenerative therapeutic agent for the treatment of cognitive decline associated with neurodegenerative diseases.

• Publication year

  2017

• Venue

  Stem Cell Reports

• Publication date

  2017-01-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.stemcr.2016.12.007PMID 28076758PMCID 5233449
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR

  2016cited by this paper
• A herbal medicine for Alzheimer’s disease and its active constituents promote neural progenitor proliferation

  2015cited by this paper
• Plos One

  2015cited by this paper
• Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

  2015cited by this paper
• Regenerative medicine in Alzheimer's disease.

  2014cited by this paper
• Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease.

  2014cited by this paper
• A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42.

  2014cited by this paper
• Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats

  2013cited by this paper
• BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

  2013cited by this paper
• Mobilizing endogenous stem cells for repair and regeneration: are we there yet?

  2012cited by this paper
• Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus.

  2011cited by this paper
• Treatment of Alzheimer disease.

  2011cited by this paper
• Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury.

  2011cited by this paper
• Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

  2010cited by this paper
• Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice

  2010cited by this paper
• Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

  2010cited by this paper
• A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis

  2010cited by this paper
• [Ganoderma lucidum extract protects dopaminergic neurons through inhibiting the production of inflammatory mediators by activated microglia].

  2010cited by this paper
• Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

  2010cited by this paper
• Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

  2009cited by this paper
• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Macrophage receptors of polysaccharide isolated from a marine filamentous fungus Phoma herbarum YS4108

  2009cited by this paper
• Ganoderma lucidum: a potent pharmacological macrofungus.

  2009cited by this paper
• Isolating, expanding, and infecting human and rodent fetal neural progenitor cells.

  2008cited by this paper
• Antagonizing β-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum

  2008cited by this paper
• Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice

  2008cited by this paper
• Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

  2008cited by this paper
• Regenerative Medicine in Alzheimer's Disease

  2008cited by this paper
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment.

  2008cited by this paper
• Mechanisms and functional implications of adult neurogenesis.

  2008cited by this paper
• Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.

  2007cited by this paper
• Growth Factor-Stimulated Generation of New Cortical Tissue and Functional Recovery after Stroke Damage to the Motor Cortex of Rats

  2007cited by this paper
• Isolation and culture of adult neurons and neurospheres

  2007cited by this paper
• Alzheimer's disease drugs promote neurogenesis.

  2006cited by this paper
• Brain‐derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI‐3Kinase signalling mechanism

  2005cited by this paper
• Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury.

  2004cited by this paper
• Neurogenesis in the adult brain: new strategies for central nervous system diseases.

  2004cited by this paper
• Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.

  2004cited by this paper
• Alzheimer病トランスジェニック(PDGF‐APPSw,Ind)マウス

  2004cited by this paper
• Increased hippocampal neurogenesis in Alzheimer's disease

  2003cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells

  2000cited by this paper
• Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

  1997cited by this paper
• Developments of a water-maze procedure for studying spatial learning in the rat.

  1984cited by this paper

• Neuroprotection in the age of emerging infections: The untapped power of medicinal mushrooms.

  2026cites this paper
• Immunomodulatory Effects of Ganoderma lucidum on NK Cells: From Traditional Use to Modern Immunotherapy

  2025cites this paper
• Ganoderma lucidum polysaccharides target the gut-brain axis: Unveiling a novel mechanism for ameliorating aging-induced cognitive impairment and oxidative stress.

  2025cites this paper
• Morphology, anticancer and neurological activities of Hericium erinaceus.

  2025cites this paper
• Ganoderma lucidum triterpenes ameliorate age-related cognitive impairment via regulating Eubacterium lentum-mediated serine metabolism.

  2025cites this paper
• Research Progress on the Mechanisms of Traditional Chinese Medicine in the Treatment of Alzheimer’s Disease and Its Clinical Applications

  2025cites this paper
• Mass Spectrometry Imaging: Applications and Advances in Analyzing Bioactive Components in Foods

  2025cites this paper
• Investigating the Neuroprotective, Hepatoprotective, and Antimicrobial Effects of Mushroom Extracts

  2025cites this paper
• Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells

  2025cites this paper
• Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer’s disease

  2025cites this paper
• Unlocking the therapeutic potential of bioactive compounds in Ganoderma lucidum: a new frontier in natural medicine

  2025cites this paper
• Reishi Mushroom (Ganoderma lucidum): pharmacology of a potent healer in traditional Chinese medicine.

  2025cites this paper
• Preparation of bilobalide nanoemulsions and its neural-repairs effect on aluminum trichloride-induced Alzheimer’s disease mice

  2025cites this paper
• Advances in Research on Tibetan Medicine for Improving Cognitive Dysfunction

  2025cites this paper
• Mushrooms: Potential Agents for the Prevention and Slowdown of Alzheimer's Disease: A Review.

  2025cites this paper
• Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation

  2025influential citation
• Prospects of Ganoderma polysaccharides: Structural features, structure-function relationships, and quality evaluation.

  2025cites this paper
• Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging.

  2025cites this paper
• Ganoderma lucidum: An Emerging Nutritional Approach to Manage Depression

  2025influential citation
• A glucan from Ganoderma lucidum: structural characterization and the anti-inflammatory effect on Parkinson's Disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway.

  2025cites this paper
• Harnessing the power of ginger leaf polysaccharide: A potential strategy to combat Aβ-induced toxicity through the Wnt/β-catenin pathway.

  2025cites this paper
• Ganoderma Lucidum Polysaccharides: A Comprehensive Overview of Pharmacological Effects and Future Perspectives

  2025cites this paper
• Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.

  2025cites this paper
• Synergistic effects of plant polysaccharides and exercise on depression alleviation from the microbiota-gut-brain axis

  2025cites this paper
• Liquid-State Fermented Ganoderma lucidum GANO99 Regulates Gut Microbiota and Concomitantly Modulates the Behavioral Deficits and Neurohistopathological Hallmarks of Alzheimer’s Disease in a Preclinical Transgenic Mouse Model of Alzheimer’s Disease

  2024cites this paper
• Unveiling the medicinal potential of edible mushroom polysaccharides: Structure, function, and therapeutic insights

  2024cites this paper
• Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review.

  2024cites this paper
• Food Functional Factors in Alzheimer’s Disease Intervention: Current Research Progress

  2024influential citation
• UnCOT-AD: Unpaired Cross-Omics Translation Enables Multi-Omics Integration for Alzheimer’s Disease Prediction

  2024cites this paper
• Unraveling the web of defense: the crucial role of polysaccharides in immunity

  2024cites this paper
• Single-Vesicle Electrochemistry Reveals Polysaccharide from Glochidion eriocarpum Champ. Regulates Vesicular Storage and Exocytotic Release of Dopamine.

  2024cites this paper
• New insights into signaling pathways of cancer prevention effects of polysaccharides from edible and medicinal mushrooms.

  2024cites this paper
• Pharmacological Effects and Related Mechanisms of Ganoderma Lucidum Polysaccharides at the Cellular Level

  2024cites this paper
• Potential therapeutic natural compounds for the treatment of Alzheimer's disease.

  2024cites this paper
• Integrative medicinal approaches towards Alzheimer's disease model animals–A new hope

  2024cites this paper
• The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks

  2024cites this paper
• Protective Role of Ganoderma lucidum Polysaccharides Against Stress Induced by Heavy Metals in Caenorhabditis elegans

  2024influential citation
• Optimization of the Preparation Process of Glucuronomannan Oligosaccharides and Their Effects on the Gut Microbiota in MPTP-Induced PD Model Mice

  2024cites this paper
• Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or β-amyloid-induced damage in human neuronal SH-SY5Y cells

  2024cites this paper
• Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms

  2024cites this paper
• Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study.

  2024cites this paper
• Rapid Discovery of Aβ42 Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.

  2024cites this paper
• Water extract of sporoderm-broken spores of Ganoderma lucidum elicits dual antitumor effects by inhibiting p-STAT3/PD-L1 and promoting ferroptosis in castration-resistant prostate cancer

  2024cites this paper
• Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease.

  2024cites this paper
• Medium composition optimization and characterization of polysaccharides extracted from Ganoderma boninense along with antioxidant activity.

  2024cites this paper
• Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo

  2023cites this paper
• Unveiling the neuroprotective potential of dietary polysaccharides: a systematic review

  2023cites this paper
• The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s Disease

  2023cites this paper
• Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review.

  2023cites this paper
• Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

  2023cites this paper
• Polysaccharides: potential bioactive macromolecules for Alzheimer’s disease

  2023cites this paper
• Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure

  2023cites this paper
• The Role of Dietary Ingredients in Mental Energy - A Scoping Review of Randomized Controlled Trials.

  2023cites this paper
• Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease

  2023cites this paper
• Mannose‐rich exopolysaccharide from Agaricus sinodeliciosus var. Chaidam: Purification, chemical characterization, and neuroprotective activity

  2023cites this paper
• Multiple Metabolites Derived from Mushrooms and Their Beneficial Effect on Alzheimer’s Diseases

  2023cites this paper
• Ganoderma lucidum polysaccharide alleviates Cd toxicity in common carp (Cyprinus carpio): Neuropeptide, growth performance and lipid accumulation.

  2023cites this paper
• The Potential of Edible and Medicinal Resource Polysaccharides for Prevention and Treatment of Neurodegenerative Diseases

  2023cites this paper
• Neuroprotective, neurogenic, and anticholinergic evidence of Ganoderma lucidum cognitive effects: Crucial knowledge is still lacking

  2023influential citation
• Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases

  2023cites this paper
• Biopharmaceutical applications of microbial polysaccharides as materials: A review.

  2023cites this paper
• A New Sesquiterpenoid from the Fruiting Bodies of Amauroderma amoiensis

  2023cites this paper
• Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review.

  2023cites this paper
• Neuroprotection of Food Bioactives in Neurodegenerative Diseases: Role of the Gut Microbiota and Innate Immune Receptors.

  2023cites this paper
• Update on new trend and progress of the mechanism of polysaccharides in the intervention of Alzheimer's disease, based on the new understanding of relevant theories: A review.

  2022cites this paper
• Plant polysaccharides utilized by gut microbiota: New players in ameliorating cognitive impairment

  2022cites this paper
• Edible mushrooms: Nutritional composition and medicinal benefits for improvement in quality life

  2022cites this paper
• Potential for non-starch polysaccharides in the prevention and remediation of cognitive impairment: A comprehensive review.

  2022cites this paper
• Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer‐like mice

  2022cites this paper
• A monomeric polysaccharide from Polygonatum sibiricum improves cognitive functions in a model of Alzheimer's disease by reshaping the gut microbiota.

  2022cites this paper
• The Intervention of Prebiotics on Depression via the Gut–Brain Axis

  2022influential citation
• Antimelanoma effect of a fucoxylomannan isolated from Ganoderma lucidum fruiting bodies.

  2022cites this paper
• Protective Effects of Polysaccharides in Neurodegenerative Diseases

  2022cites this paper
• Advances in polysaccharides of natural source of the anti-Alzheimer's disease effect and mechanism.

  2022cites this paper
• Structural Characterization of a Pleurotus sajor-caju Polysaccharide and Its Neuroprotection Related to the Inhibition of Oxidative Stress

  2022cites this paper
• Plant-derived bioactive components regulate gut microbiota to prevent depression and depressive-related neurodegenerative diseases: Focus on neurotransmitters

  2022cites this paper
• Mushroom Polysaccharides as Potential Candidates for Alleviating Neurodegenerative Diseases

  2022cites this paper
• Promoting Endogenous Neurogenesis as a Treatment for Alzheimer’s Disease

  2022cites this paper
• A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase inhibitor for the treatment of Alzheimer's disease.

  2022cites this paper
• A novel promising neuroprotective agent: Ganoderma lucidum polysaccharide.

  2022cites this paper
• Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1.

  2021cites this paper
• Bioactive components of mushrooms: Processing effects and health benefits.

  2021cites this paper
• Development of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery system loaded with curcumin and quercetin to improve their dissolution rate and permeability: State of the art.

  2021cites this paper
• Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties

  2021cites this paper
• Sterols from the Fruiting Bodies of Haddowia longipes

  2021cites this paper
• Polysaccharide from Ganoderma lucidum ameliorates cognitive impairment by regulating the inflammation of the brain-liver axis in rats.

  2021cites this paper
• Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer’s Disease (Mouse Model) through Autophagy Induced by Activating Axl

  2021cites this paper
• Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

  2021cites this paper
• Modifications of polysaccharide-based biomaterials under structure-property relationship for biomedical applications.

  2021cites this paper
• MAJOR BIOACTIVE PROPERTIES OF GANODERMA POLYSACCHARIDES: A REVIEW

  2021cites this paper
• Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases.

  2021cites this paper
• Structural elucidation of three novel oligosaccharides from Kunlun Chrysanthemum flower tea and their bioactivities.

  2021cites this paper
• Available Chemical Constituents and Activities of Ganoderma Lucidum (Lingzhi or Red Reishi) Utilizing in Disease Treatment: A mini review

  2021cites this paper
• New insights into the role of fibroblast growth factors in Alzheimer’s disease

  2021cites this paper
• CREB1K292 and HINFPK330 as Putative Common Therapeutic Targets in Alzheimer’s and Parkinson’s Disease

  2021cites this paper
• Ganoderma lucidum: A rational pharmacological approach to surmount the cancer.

  2020cites this paper
• Ganoderma lucidum aqueous extract prevents hypobaric hypoxia induced memory deficit by modulating neurotransmission, neuroplasticity and maintaining redox homeostasis

  2020cites this paper
• Connection of Ganoderma Lucidum with Health

  2020cites this paper
• The Interaction of EphA4 With PDGFRβ Regulates Proliferation and Neuronal Differentiation of Neural Progenitor Cells in vitro and Promotes Neurogenesis in vivo

  2020cites this paper
• Ganoderma

  2020cites this paper