The Prominent Role of Neutrophils during the Initial Phase of Infection by Leishmania Parasites

Neutrophils are rapidly and massively recruited to the site of Leishmania inoculation, where they phagocytose the parasites, some of which are able to survive within these first host cells. Neutrophils can thus provide a transient safe shelter for the parasites, prior to their entry into macrophages where they will replicate. In addition, neutrophils release and synthesize rapidly several factors including cytokines and chemokines. The mechanism involved in their rapid recruitment to the site of parasite inoculation, as well as the putative consequences of their massive presence on the microenvironment of the focus of infection will be discussed in the context of the development of the Leishmania-specific immune response.

• Publication year

  2009

• Venue

  Journal of Biomedicine and Biotechnology

• Publication date

  2009-10-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2010/719361PMID 19884987PMCID 2768872
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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