Endocytosis of plasma membrane proteins in Saccharomyces cerevisiae requires their ubiquitination by the ART-Rsp5 ubiquitin ligase complex. Little is known about how the complex engages substrates. The Art1 C-terminus recognizes Mup1 via a tripartite ART sorting signal: an acidic patch, in proximity to the membrane and substrate lysines.
Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex
Evan L. Guiney,Till Klecker,S. Emr
Published 2016 in Molecular Biology of the Cell
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- Publication year
2016
- Venue
Molecular Biology of the Cell
- Publication date
2016-12-15
- Fields of study
Biology, Medicine, Chemistry
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Semantic Scholar, PubMed
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