IRF4 variants have age-specific effects on nevus count and predispose to melanoma.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  American Journal of Human Genetics

• Publication date

  2010-07-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ajhg.2010.05.017PMID 20602913PMCID PMC2896771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males.

  2010cited by this paper
• Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma.

  2010cited by this paper
• Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma

  2009cited by this paper
• Common Gene Variants in the Tumor Necrosis Factor (TNF) and TNF Receptor Superfamilies and NF-kB Transcription Factors and Non-Hodgkin Lymphoma Risk

  2009cited by this paper
• Nevus density and melanoma risk in women: A pooled analysis to test the divergent pathway hypothesis

  2009cited by this paper
• Melanoma epidemiology.

  2009cited by this paper
• IRF4: Immunity. Malignancy! Therapy?

  2009cited by this paper
• Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  2009cited by this paper
• Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi

  2009cited by this paper
• Genome-wide association study identifies three loci associated with melanoma risk

  2009influential reference
• A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes

  2009cited by this paper
• Serum 25-hydroxyvitamin D3 levels are associated with breslow thickness at presentation and survival from melanoma.

  2009cited by this paper
• A population-based study of Australian twins with melanoma suggests a strong genetic contribution to liability.

  2009cited by this paper
• Molecular genetics of human pigmentation diversity.

  2009cited by this paper
• Personal genomes: The case of the missing heritability

  2008cited by this paper
• Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study

  2008cited by this paper
• ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma

  2008cited by this paper
• The Queensland Study of Melanoma: Environmental and Genetic Associations (Q-MEGA); Study Design, Baseline Characteristics, and Repeatability of Phenotype and Sun Exposure Measures

  2008cited by this paper
• The Wellcome Trust Case Control Consortium, U.K.

  2008cited by this paper
• A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation

  2008cited by this paper
• WOMBAT—A tool for mixed model analyses in quantitative genetics by restricted maximum likelihood (REML)

  2007cited by this paper
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

  2007cited by this paper
• Family-based association tests for genomewide association scans.

  2007cited by this paper
• Human pigmentation variation: evolution, genetic basis, and implications for public health.

  2007cited by this paper
• A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions

  2007cited by this paper
• Genetic determinants of hair, eye and skin pigmentation in Europeans

  2007cited by this paper
• Principal components analysis corrects for stratification in genome-wide association studies

  2006cited by this paper
• Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort.

  2006cited by this paper
• KRAS variation and risk of endometriosis.

  2006cited by this paper
• Risk Factors for Melanoma by Body Site

  2005cited by this paper
• Association testing with Mendel

  2005cited by this paper
• Familial aggregation of melanoma risks in a large population-based sample of melanoma cases

  2004cited by this paper
• Analysis of melanoma onset: assessing familial aggregation by using estimating equations and fitting variance components via Bayesian random effects models.

  2004cited by this paper
• Familial aggregation of melanoma risks in a large population-based sample of melanoma cases

  2004cited by this paper
• Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma.

  2003cited by this paper
• Expression of the B-Cell Proliferation Marker MUM1 by Melanocytic Lesions and Comparison with S100, gp100 (HMB45), and MelanA

  2003cited by this paper
• Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish family‐cancer database

  2002cited by this paper
• Heritability and gene-environment interactions for melanocytic nevus density examined in a U.K. adolescent twin study.

  2001cited by this paper
• Analysis of MUM1/IRF4 Protein Expression Using Tissue Microarrays and Immunohistochemistry

  2001cited by this paper
• Genetics of risk factors for melanoma: an adult twin study of nevi and freckles.

  2000cited by this paper
• A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs.

  1999cited by this paper
• The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia.

  1998cited by this paper
• Melanoma epidemiology.

  1997cited by this paper
• Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.

  1996cited by this paper
• Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: systematic overview of 10 case-control studies. The International Melanoma Analysis Group (IMAGE).

  1995cited by this paper
• Risk of cutaneous melanoma associated with pigmentation characteristics and freckling: Systematic overview of 10 case‐control studies

  1995cited by this paper
• Naevi in schoolchildren in Scotland and Australia

  1994cited by this paper
• Heterogeneity of melanoma risk in families of melanoma patients.

  1993cited by this paper
• The number and distribution of benign pigmented moles (melanocytic naevi) in a healthy British population

  1985cited by this paper
• The pubic scars of gestation and parturition in a group of pre‐Columbian and colonial Peruvian mummies

  1976cited by this paper
• The American journal of human genetics in the 1970s.

  1970cited by this paper

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  2025cites this paper
• An Anthropometric Study of Total Body Nevus Counts, Height, Sex, and Age Differences

  2025cites this paper
• Assessment of the Influence of UVR in Cutaneous Melanoma

  2025cites this paper
• Genetic Landscape of Familial Melanoma

  2025cites this paper
• Interferon regulatory factor 4 modulates epigenetic silencing and cancer‐critical pathways in melanoma cells

  2024cites this paper
• Exploring the Germline Genetics of In Situ and Invasive Cutaneous Melanoma: A Genome-Wide Association Study Meta-Analysis.

  2024cites this paper
• The Complex Interplay between Nevi and Melanoma: Risk Factors and Precursors

  2023cites this paper
• Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick.

  2023cites this paper
• Biology and genetics of acquired and congenital melanocytic naevi.

  2022cites this paper
• A review of nevus‐associated melanoma: What is the evidence?

  2022cites this paper
• Association of Melanoma-Risk Variants with Primary Melanoma Tumor Prognostic Characteristics and Melanoma-Specific Survival in the GEM Study

  2021cites this paper
• On Naevi and Melanomas: Two Sides of the Same Coin?

  2021cites this paper
• A multicentre study of naevus‐associated melanoma vs. de novo melanoma, tumour thickness and body site differences *

  2021cites this paper
• Different Pigmentation Risk Loci for High-Risk Monosomy 3 and Low-Risk Disomy 3 Uveal Melanomas

  2021cites this paper
• Examining Evidence For A Causal Association Between Telomere Length & Nevus Count.

  2021cites this paper
• A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.

  2021cites this paper
• Germline variants are associated with increased primary melanoma tumor thickness at diagnosis

  2020cites this paper
• Influence of germline genetic variants on dermoscopic features of melanoma

  2020cites this paper
• Nevi and Breslow thickness in melanoma: sex differences?

  2020cites this paper
• Genes determining nevus count and dermoscopic appearance in Australian melanoma cases and controls.

  2020cites this paper
• Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma.

  2020cites this paper
• Environmental UVR Levels and Skin Pigmentation Gene Variants Associated with Folate and Homocysteine Levels in an Elderly Cohort

  2020cites this paper
• Genome-wide association meta-analyses combining multiple risk phenotypes provides insights into the genetic architecture of cutaneous melanoma susceptibility

  2020cites this paper
• Genome-Wide Association Study Identifies Genetic Associations with Perceived Age

  2020cites this paper
• It’s Not All Sunshine: Non-sun-related Melanoma Risk-factors

  2020cites this paper
• Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma

  2020cites this paper
• Gene Discovery Using Twins

  2020cites this paper
• The role of MC1R gene variants and phenotypical features in predicting high nevus count.

  2020cites this paper
• Association of Known Melanoma Risk Factors with Primary Melanoma of the Scalp and Neck

  2020cites this paper
• Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: Increased carriage of TYR and OCA2 variants

  2020cites this paper
• High naevus count and MC1R red hair alleles contribute synergistically to increased melanoma risk

  2019cites this paper
• Melanocytic Naevi

  2019cites this paper
• Body site‐specific genetic effects influence naevus count distribution in women

  2019cites this paper
• The Genetics of Human Skin and Hair Pigmentation.

  2019cites this paper
• Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, MX2, in melanoma promotion

  2019cites this paper
• Prediction of skin color, tanning and freckling from DNA in Polish population: linear regression, random forest and neural network approaches

  2019cites this paper
• Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact

  2018cites this paper
• Combining common genetic variants and non‐genetic risk factors to predict risk of cutaneous melanoma

  2018cites this paper
• Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes.

  2018cites this paper
• Molecular Epidemiology of Melanoma

  2018cites this paper
• Identification of 12 genetic loci associated with human healthspan

  2018cites this paper
• PUBLISHED VERSION

  2018cites this paper
• Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case–control study

  2018cites this paper
• Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon‐gamma response in melanocytic cells

  2018cites this paper
• Neurological Complications of Malignant Melanoma

  2018cites this paper
• Skin Pigmentation Genetics for the Clinic

  2017cites this paper
• Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4

  2017cites this paper
• Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

  2017cites this paper
• Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes

  2017cites this paper
• Phenotypes and genotypes of melanoma patients

  2017cites this paper
• IRF4 rs12203592 functional variant and melanoma survival

  2017influential citation
• Melanoma asociado a nevo melanocítico

  2017cites this paper
• The effect of patient and tumour genetics on survival from melanoma

  2017cites this paper
• Genome-Wide Association Reveals Pigmentation Genes Play a Role in Skin Aging

  2017cites this paper
• Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging.

  2017cites this paper
• Endometriosis and the risk of skin cancer: a prospective cohort study

  2017cites this paper
• Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma

  2016cites this paper
• From melanocytes to melanomas

  2016cites this paper
• The role of germline alterations in the DNA damage response genes BRIP1 and BRCA2 in melanoma susceptibility

  2016cites this paper
• Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: a cross‐sectional study

  2016cites this paper
• Prediction of the engendering mechanism and specific genes of primary melanoma by bioinformatics analysis

  2016cites this paper
• Prevalence of MITF p.E318K in Patients With Melanoma Independent of the Presence of CDKN2A Causative Mutations.

  2016cites this paper
• Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma.

  2016influential citation
• Further evidence for population specific differences in the effect of DNA markers and gender on eye colour prediction in forensics

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways.

  2016cites this paper
• Genetic Determinants of Skin Color, Aging, and Cancer

  2015cites this paper
• Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants

  2015cites this paper
• The TERT variant rs 2736100 is associated with colorectal cancer risk

  2015influential citation
• Evidence of CNIH3 involvement in opioid dependence

  2015cites this paper
• High nevus counts confer a favorable prognosis in melanoma patients

  2015cites this paper
• Cross‐species models of human melanoma

  2015influential citation
• Update on melanocytic nevi in children.

  2015cites this paper
• Epidemiological and genetic factors underlying melanoma development in Italy.

  2015cites this paper
• Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

  2015cites this paper
• Genetics of Eye Colour

  2015cites this paper
• Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects

  2014cites this paper
• Obesity gene NEGR1 associated with white matter integrity in healthy young adults

  2014cites this paper
• Investigation of a putative melanoma susceptibility locus at chromosome 3q29.

  2014cites this paper
• Comparison of melanoma guidelines in the U.S.A., Canada, Europe, Australia and New Zealand: a critical appraisal and comprehensive review

  2014cites this paper
• Gene Expression Profiling Identifies IRF4-Associated Molecular Signatures in Hematological Malignancies

  2014cites this paper
• Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients.

  2014cites this paper
• Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions

  2014cites this paper
• Emerging trends in the epidemiology of melanoma

  2014cites this paper
• Pigmentary traits, family history of melanoma and the risk of endometriosis: a cohort study of US women.

  2014cites this paper
• Sun‐induced freckling: ephelides and solar lentigines

  2014cites this paper
• Clinical and dermoscopic characteristics of new naevi in adults: results from a cohort study

  2013cites this paper
• Update on the Epidemiology of Melanoma

  2013cites this paper
• Received Date : 20-Jan-2013 Revised

  2013cites this paper
• Chapter 149 – Skin Cancer

  2013cites this paper
• The Epidemiology of Melanoma of the Skin

  2013cites this paper
• Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population

  2013influential citation
• Genetic variation at KIT locus may predispose to melanoma

  2013cites this paper
• Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors

  2013cites this paper
• Identification of anaplastic lymphoma kinase break points and oncogenic mutation profiles in acral/mucosal melanomas

  2013cites this paper
• Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.

  2013cites this paper
• COHORT PROFILE Cohort Profile : TwinsUK and Healthy Ageing Twin Study

  2013cites this paper
• Colorful DNA polymorphisms in humans.

  2013cites this paper
• Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer

  2013cites this paper