NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II

This study identified matrix metalloproteinase-2 (MMP2) as a novel target gene of Forkhead box O transcription factor FoxO3a in the response to urotensin-II and the NADPH oxidase NOX4 and showed that FoxO3a activated by this pathway promotes vascular growth in vitro and in vivo.

• Publication year

  2011

• Venue

  Molecular Biology of the Cell

• Publication date

  2011-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E10-12-0971PMID 21965295PMCID 3216667
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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