Amyloid β Protein (Aβ) Starts to Deposit As Plasma Membrane‐Bound Form in Diffuse Plaques of Brains from Hereditary Cerebral Hemorrhage with Amyloidosis‐Dutch Type, Alzheimer Disease and Nondemented Aged Subjects

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Neuropathology and Experimental Neurology

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/JNEN/59.8.723PMID 10952062
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated byβ protein immunostaining

  2004cited by this paper
• New sensitive light microscopical detection of colloidal gold on ultrathin sections by reflection contrast microscopy

  2004cited by this paper
• Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated byβ protein immunostain

  2004cited by this paper
• Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer β-amyloid deposition

  2004cited by this paper
• Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques

  2004cited by this paper
• Morphology of cerebral plaque-like lesions in hereditary cerebral hemorrhage with amyloidosis (Dutch)

  2004cited by this paper
• Intraneuronal Aβ42 Accumulation in Human Brain

  2000cited by this paper
• Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease.

  2000cited by this paper
• Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease

  2000cited by this paper
• Age-related plaque morphology and C-terminal heterogeneity of amyloid β in Dutch-type hereditary cerebral hemorrhage with amyloidosis

  2000cited by this paper
• Intraneuronal Abeta42 accumulation in human brain.

  2000cited by this paper
• Ultrastructural evidence of early non-fibrillar Aβ42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type

  1999cited by this paper
• The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells.

  1998cited by this paper
• Presenilin 1 regulates the processing of β-amyloid precursor protein C- terminal fragments and the generation of amyloid β-protein in endoplasmic reticulum and Golgi

  1998influential reference
• Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

  1998cited by this paper
• Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells.

  1998cited by this paper
• A detergent-insoluble membrane compartment contains A beta in vivo.

  1998cited by this paper
• A detergent-insoluble membrance compartment contains Aβ in vivo

  1998cited by this paper
• Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

  1998cited by this paper
• Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques

  1998influential reference
• Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

  1997cited by this paper
• In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies

  1997cited by this paper
• Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42*

  1997cited by this paper
• Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

  1997cited by this paper
• Acceleration of Amyloid Fibril Formation by Specific Binding of Aβ-(1–40) Peptide to Ganglioside-containing Membrane Vesicles*

  1997cited by this paper
• Early-onset dementias: clinical, neuropathological and genetic characteristics

  1996cited by this paper
• Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

  1996cited by this paper
• Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains.

  1996cited by this paper
• Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.

  1996cited by this paper
• 609 Aβ and its associated proteins with aging: comparison between senile plaques and amyloid angiopathy

  1996cited by this paper
• Alzheimer's disease : biology, diagnosis, and therapeutics

  1996cited by this paper
• Immunohistochemical analysis of COOH-termini of amyloid beta protein (Aβ) using end-specific antisera for Aβ40 and Aβ42 in Alzheimer's disease and normal aging

  1995cited by this paper
• Diffuse senile plaques: amorphous or fibrous?

  1995cited by this paper
• GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease

  1995cited by this paper
• GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

  1995cited by this paper
• Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

  1994cited by this paper
• Polyclonals to β-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

  1994cited by this paper
• Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

  1994cited by this paper
• Reflection contrast microscopy of ultrathin sections in immunocytochemical localization studies: a versatile technique bridging electron microscopy with light microscopy

  1993cited by this paper
• The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.

  1993cited by this paper
• Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

  1993cited by this paper
• Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?

  1993cited by this paper
• Ultrastructural Characterization of Cerebellar Diffuse Plaques in Alzheimer's Disease

  1992cited by this paper
• Pathological changes in the brain of a patient with familial Alzheimer's disease having a missense mutation at codon 717 in the amyloid precursor protein gene.

  1992cited by this paper
• Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study.

  1992cited by this paper
• Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

  1992cited by this paper
• Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

  1990cited by this paper
• Immunoelectron microscopic localization of amyloid β protein in the diffuse plaques of Alzheimer-type dementia

  1990cited by this paper
• Immunoelectron microscopic localization of amyloid beta protein in the diffuse plaques of Alzheimer-type dementia.

  1990cited by this paper
• Electron micrograph of diffuse plaques. Initial stage of senile plaque formation in the Alzheimer brain.

  1989cited by this paper
• Alzheimer patients and Down patients: cerebral preamyloid deposits differ ultrastructurally and histochemically from the amyloid of senile plaques.

  1989cited by this paper
• Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals.

  1988cited by this paper
• The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

  1987cited by this paper
• Ultrastructural studies of vascular lesions in experimental amyloidosis of mice.

  1985cited by this paper
• Secondary amyloidosis of the gastrointestinal tract: an electron microscopic study.

  1985cited by this paper
• Familial Amyloidosis A Histopathological Study

  1984cited by this paper
• Localization of gold in biological tissue

  1981cited by this paper
• The Fine Structure of the Nervous System

  1971cited by this paper
• The Fine Structure of the Nervous System.

  1970cited by this paper
• ON THE PATHOLOGY OF SENILE PSYCHOSIS THE DIFFERENTIAL DIAGNOSTIC SIGNIFICANCE OF REDLICH‐FISCHER'S MILIARY PLAQUES

  1923cited by this paper
• Die presbyophrene demenz, deren anatomische grundlage und klinische Abgrenzung

  1910cited by this paper

• Structural Changes of Amyloid β-Protein Fibrils on Neuronal Cells.

  2025cites this paper
• The Determinant of Tau Spreading in Alzheimer’s Disease: Dependent on Senile Plaque, Neural Circuits, or Spatial Proximity?

  2025cites this paper
• Amyloid Fibril Formation on Neuronal Cells in the Coexistence of Aβ40 and Aβ42

  2024cites this paper
• Sugar distributions on gangliosides guide the formation and stability of amyloid-β oligomers.

  2023cites this paper
• Sugar distributions on gangliosides guide the formation and stability of amyloid-β oligomers

  2023cites this paper
• The association of lipids with amyloid fibrils

  2022cites this paper
• Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer’s Disease

  2021cites this paper
• Assessing Reproducibility in Amyloid β Research: Impact of Aβ Sources on Experimental Outcomes

  2020cites this paper
• Three-dimensional real time imaging of amyloid β aggregation on living cells

  2020cites this paper
• Applications of reflection‐contrast microscopy, including the sensitive detection of the results of in situ hybridisation a review

  2019cites this paper
• Short-term aromatase inhibition induces prostatic alterations in adult wistar rat: A biochemical, histopathological and immunohistochemical study.

  2019cites this paper
• Neuropathological correlates of amyloid PET imaging in Down syndrome

  2019cites this paper
• Cause and consequence of Aβ - Lipid interactions in Alzheimer disease pathogenesis.

  2018cites this paper
• Ultrastructural Pathology of Plasma and Endoplasmic Reticulum Membranes of Nerve and Glial Cells: A Review

  2018cites this paper
• Amylin in Alzheimer's disease: Pathological peptide or potential treatment?

  2017cites this paper
• CADASIL: Ultrastructural insights into the morphology of granular osmiophilic material

  2017cites this paper
• Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.

  2017cites this paper
• Amyloid beta peptides inside a reconstituted cell-like liposomal system: aggregation, FRET, fluorescence oscillations and solvation dynamics.

  2016cites this paper
• Fibrillation of β amyloid peptides in the presence of phospholipid bilayers and the consequent membrane disruption.

  2015cites this paper
• Lipids in Amyloid-β Processing, Aggregation, and Toxicity.

  2015cites this paper
• Ca(2+) Interacts with Glu-22 of Aβ(1-42) and Phospholipid Bilayers to Accelerate the Aβ(1-42) Aggregation Below the Critical Micelle Concentration.

  2015cites this paper
• Tjernberg peptide: a double edged sword in Alzheimer’s disease

  2015cites this paper
• Age-related changes in membrane fluidity and fluorescence intensity by tachykinin neuropeptide NKB and Aβ (25-35) with 17β estradiol in female rat brain

  2014cites this paper
• The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes

  2014cites this paper
• Membrane-Anchored Aβ Accelerates Amyloid Formation and Exacerbates Amyloid-Associated Toxicity in Mice

  2013cites this paper
• Lipid interaction triggering Septin2 to assembly into β-sheet structures investigated by Langmuir monolayers and PM-IRRAS.

  2013cites this paper
• Hereditary and sporadic beta-amyloidoses.

  2013cites this paper
• The Role of Aβ in Alzheimer's Disease

  2013cites this paper
• Synapses, spines, zinc and pathology of Alzheimer's disease.

  2013cites this paper
• Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment.

  2012cites this paper
• Characterisation of different amyloid-ß aggregates in Alzheimer's disease

  2012cites this paper
• Pathology of nerve cell membranes in complicated and severe human brain traumatic injuries. An electron microscopic study using cortical biopsies..

  2012cites this paper
• Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain*♦

  2011cites this paper
• Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.

  2011cites this paper
• Lipid membranes and beta-amyloid: a harmful connection.

  2010cites this paper
• Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

  2010cites this paper
• Role of Oxidatively Stressed Lipids in Amyloid Formation and Toxicity

  2010cites this paper
• CHOLESTEROL AND NEURONAL SUSCEPTIBILITY TO BETA-AMYLOID TOXICITY.

  2010cites this paper
• Lipid-Induced Conformational Transition of Amyloid β Peptide Fragments

  2010cites this paper
• A kinetic model for beta-amyloid adsorption at the air/solution interface and its implication to the beta-amyloid aggregation process.

  2009cites this paper
• Small molecule inhibitors of Aβ‐aggregation and neurotoxicity

  2009cites this paper
• Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification

  2009cites this paper
• Alzheimer's disease: from pathology to therapeutic approaches.

  2009cites this paper
• Structural and Kinetic Characterization of Cell Surface and Internalized Alzheimer Amyloid Peptides in Neuronal Cells

  2009cites this paper
• Die Alzheimer‐Demenz: von der Pathologie zu therapeutischen Ansätzen

  2009cites this paper
• Cerebral amyloidosis: postmortem detection with human 7.0-T MR imaging system.

  2009cites this paper
• Effects of human apolipoprotein E isoforms on the amyloid β‐protein concentration and lipid composition in brain low‐density membrane domains

  2007cites this paper
• Neuroglobin attenuates β-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo

  2007cites this paper
• Angiotensin-II-Rezeptorantagonisten und endotheliale Progenitorzellen: ein neuer therapeutischer Ansatz?

  2007cites this paper
• Dense-core and diffuse Abeta plaques in TgCRND8 mice studied with synchrotron FTIR microspectroscopy.

  2007cites this paper
• The Cerebral β‐Amyloid Angiopathies: Hereditary and Sporadic

  2006cites this paper
• DOCOSAHEXAENOIC ACID‐INDUCED PROTECTIVE EFFECT AGAINST IMPAIRED LEARNING IN AMYLOID β‐INFUSED RATS IS ASSOCIATED WITH INCREASED SYNAPTOSOMAL MEMBRANE FLUIDITY

  2006influential citation
• Membrane Associated Functions of Neurokinin B (NKB) on Aβ (25–35) Induced Toxicity in Aging Rat Brain Synaptosomes

  2006cites this paper
• The cerebral beta-amyloid angiopathies: hereditary and sporadic.

  2006cites this paper
• Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain.

  2005cites this paper
• Alternatives Fehlspleißen von Tau Exon 10, Htra2-ß und Clk2 in post mortem Hirngewebe von Alzheimer-Patienten

  2005cites this paper
• Cholesterol and Amyloid β Fibrillogenesis

  2005cites this paper
• Hereditary cerebral hemorrhage with amyloidosis‐Dutch type

  2005cites this paper
• Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.

  2005cites this paper
• Membrane disordering effects of beta-amyloid peptides.

  2005cites this paper
• Soluble Aβ oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

  2005cites this paper
• Proteomic analysis of inflammatory protein expression patterns in cell culture and transgenic animal models for Alzheimer ’ s disease

  2005cites this paper
• Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats.

  2005cites this paper
• Statin treatment and a disease-specific pattern of β-amyloid peptides in Alzheimer’s disease

  2005cites this paper
• Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain.

  2005cites this paper
• Interactions of Aβ(1–40) with Glycerophosphocholine and Intact Erythrocyte Membranes: Fluorescence and Circular Dichroism Studies

  2004cites this paper
• Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.

  2004cites this paper
• Interactions of Alzheimer amyloid peptides with cultured cells and brain tissue, and their biological consequences.

  2004cites this paper
• Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.

  2004cites this paper
• Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

  2004cites this paper
• Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine

  2004cites this paper
• Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

  2004cites this paper
• Reflection contrast microscopy

  2004cites this paper
• Glial reactions and the clearance of amyloid β protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type

  2004cites this paper
• Proteomic analysis of inflammatory protein expression patterns in cell culture and transgenic animal models for Alzheimer's disease

  2004cites this paper
• Cholesterol Modulates Amyloid Beta-peptide’s Membrane Interactions

  2003cites this paper
• Cholesterol, a Modulator of Membrane-associated Aβ-fibrillogenesis

  2003cites this paper
• Dietary Lipids in the Aetiology of Alzheimer’s Disease

  2003cites this paper
• Early Synergy between Aβ42 and Oxidatively Damaged Membranes in Promoting Amyloid Fibril Formation by Aβ40*

  2003cites this paper
• Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease.

  2003cites this paper
• Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment.

  2003cites this paper
• Early synergy between Abeta42 and oxidatively damaged membranes in promoting amyloid fibril formation by Abeta40.

  2003cites this paper
• Cholesterol modulates amyloid beta-peptide's membrane interactions.

  2003cites this paper
• Cholesterol Trafficking and Amyloid Beta Peptides

  2003cites this paper
• Aβ42-Peptide Assembly on Lipid Bilayers

  2002cites this paper
• βAPP and Furin mRNA Concentrates in Immature Senile Plaques in the Brain of Alzheimer Patients

  2002cites this paper
• Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.

  2002cites this paper
• Alzheimer beta-amyloid peptides: normal and abnormal localization.

  2002cites this paper
• Cholesterol attenuates the membrane perturbing properties of β-amyloid peptides

  2002cites this paper
• Cholesterol attenuates the membrane perturbing properties of beta-amyloid peptides.

  2002cites this paper
• Review Alzheimer ß-amyloid peptides: normal and abnormal localization

  2002cites this paper
• Enhanced Aβ40 Deposition Was Associated with Increased Aβ42/43 in Cerebral Vasculature with Dutch‐Type Hereditary Cerebral Hemorrhage with Amyloidosis (HCHWA‐D)

  2002cites this paper
• Abeta42-peptide assembly on lipid bilayers.

  2002cites this paper
• Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.

  2002cites this paper
• Alzheimer's disease: β‐Amyloid protein and tau

  2002cites this paper
• Cholesterol, a Modulator of Membrane‐Associated Aβ‐Fibrillogenesis

  2002cites this paper
• Amyloid deposition in diffuse plaques may or may not start at the neuronal cell surface membrane.

  2001cites this paper
• Alzheimer β Amyloid Deposition Enhanced by ApoE ϵ4 Gene Precedes Neurofibrillary Pathology in the Frontal Association Cortex of Nondemented Senior Subjects

  2001cites this paper
• Neuropathologie der Demenzen

  2001cites this paper
• Comparison of the aggregation properties, secondary structure and apoptotic effects of wild‐type, Flemish and Dutch N‐terminally truncated amyloid β peptides

  2001cites this paper