DOCOSAHEXAENOIC ACID‐INDUCED PROTECTIVE EFFECT AGAINST IMPAIRED LEARNING IN AMYLOID β‐INFUSED RATS IS ASSOCIATED WITH INCREASED SYNAPTOSOMAL MEMBRANE FLUIDITY

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Clinical and Experimental Pharmacology and Physiology

• Publication date

  2006-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1440-1681.2006.04467.xPMID 17002670
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane order.

  2004influential reference
• Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress.

  2002cited by this paper
• LIPID PEROXIDATION AND PROTEIN OXIDATION IN ALZHEIMER'S DISEASE BRAIN: POTENTIAL CAUSES AND CONSEQUENCES INVOLVING AMYLOID -PEPTIDE-ASSOCIATED FREE RADICAL OXIDATIVE STRESS

  2002influential reference
• Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

  2002influential reference
• Lipid peroxidation and protein oxidation in Alzheimer's disease brain: Potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

  2002cited by this paper
• Intracellular Calcium Changes in Neuronal Cells Induced by Alzheimer's ß-Amyloid Protein Are Blocked by Estradiol and Cholesterol

  2001influential reference
• Alzheimer's disease: genes, proteins, and therapy.

  2001influential reference
• Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain.

  2001influential reference
• Conjunctive representations in learning and memory: principles of cortical and hippocampal function.

  2001influential reference
• Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

  2001influential reference
• Effects of docosahexaenoic acid on annular lipid fluidity of the rat bile canalicular plasma membrane.

  2001influential reference
• Lectin cytochemistry of rat cerebral and cerebellar neuronal cells

  2001cited by this paper
• Endogenous GLP-1 is involved in β-amyloid protein-induced memory impairment and hippocampal neuronal death in rats

  2000influential reference
• Correlation of beta-amyloid aggregate size and hydrophobicity with decreased bilayer fluidity of model membranes.

  2000influential reference
• Cholesterol Modulates the Membrane- Disordering Effects of Beta-Amyloid Peptides in the Hippocampus: Specific Changes in Alzheimer’s Disease

  2000influential reference
• Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity.

  2000cited by this paper
• Amyloid β Protein (Aβ) Starts to Deposit As Plasma Membrane‐Bound Form in Diffuse Plaques of Brains from Hereditary Cerebral Hemorrhage with Amyloidosis‐Dutch Type, Alzheimer Disease and Nondemented Aged Subjects

  2000influential reference
• Antioxidative Effects of Docosahexaenoic Acid in the Cerebrum Versus Cerebellum and Brainstem of Aged Hypercholesterolemic Rats

  1999influential reference
• Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells

  1999influential reference
• Distribution and Fluidizing Action of Soluble and Aggregated Amyloid β-Peptide in Rat Synaptic Plasma Membranes*

  1999influential reference
• Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats.

  1999influential reference
• Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity.

  1999influential reference
• Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration.

  1998influential reference
• A detergent-insoluble membrane compartment contains A beta in vivo.

  1998influential reference
• Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet.

  1998influential reference
• A detergent-insoluble membrance compartment contains Aβ in vivo

  1998cited by this paper
• CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains.

  1998cited by this paper
• Cl−-ATPase and Na+/K+-ATPase activities in Alzheimer's disease brains

  1998cited by this paper
• Amyloid β‐Peptides Increase Annular and Bulk Fluidity and Induce Lipid Peroxidation in Brain Synaptic Plasma Membranes

  1997influential reference
• Dysfunction of cholinergic and dopaminergic neuronal systems in β-amyloid protein-infused rats

  1997influential reference
• 17β‐Estradiol attenuates oxidative impairment of synaptic Na+/K+‐ATPase activity, glucose transport, and glutamate transport induced by amyloid β‐peptide and iron

  1997influential reference
• Oxidative injury of synapse and alteration of antioxidative defense systems in rats, and its prevention by vitamin E.

  1997influential reference
• Dysfunction of Cholinergic and Dopaminergic Neuronal Systems in β‐Amyloid Protein‐Infused Rats

  1996cited by this paper
• Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

  1996influential reference
• Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

  1995cited by this paper
• Effect of a high alpha-linolenate and high linoleate diet on membrane-associated enzyme activities in rat brain--modulation of Na+, K+- ATPase activity at suboptimal concentrations of ATP.

  1995influential reference
• beta-Amyloid peptide decreases membrane fluidity.

  1995influential reference
• β-amyloid peptide decreases membrane fluidity

  1995cited by this paper
• β-Amyloid protein-induced Alzheimer's disease animal model

  1994cited by this paper
• Cell membrane fatty acid composition in Type 1 (insulin-dependent) diabetic patients: relationship with sodium transport abnormalities and metabolic control

  1993influential reference
• Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

  1991influential reference
• Brain Aging: Neuropathology and Neuropharmacology , edited by J. Cervos-Navarro and H.-I. Sarkander, Aging Series, Volume 21, Raven Press, New York, 1983 (454 pages; U.S. $64.00).

  1983cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review

  2024cites this paper
• Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease

  2023cites this paper
• Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment

  2023cites this paper
• Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function.

  2023cites this paper
• The synaptic lipidome in health and disease.

  2022cites this paper
• Maternal and Neonatal Polyunsaturated Fatty Acid Intake and Risk of Neurodevelopmental Impairment in Premature Infants

  2022cites this paper
• Esterification of Docosahexaenoic Acid Enhances Its Transport to the Brain and Its Potential Therapeutic Use in Brain Diseases

  2022cites this paper
• Unsaturated fatty acids in mental disorders: An umbrella review of meta-analyses.

  2022cites this paper
• Docosahexaenoic Acid (DHA)

  2021cites this paper
• Docosahexaenoic acid modulates oxidative stress and monoamines levels in brain of streptozotocin-induced diabetic rats

  2021cites this paper
• Why Have the Benefits of DHA Not Been Borne Out in the Treatment and Prevention of Alzheimer’s Disease? A Narrative Review Focused on DHA Metabolism and Adipose Tissue

  2021cites this paper
• Supplementation of Catfish (Clarias gariepinus) Oil Enriched with Omega-3 Soft Capsule Improves Oxidative Stress and Cognitive Function in Elderly.

  2020cites this paper
• Use of phytochemicals for the treatment of insulin resistance–linked visceral and neurological disorders

  2020cites this paper
• Retinoid X Receptor α Regulates DHA-Dependent Spinogenesis and Functional Synapse Formation In Vivo.

  2020cites this paper
• The Effect of Dietary Supplementation of Vitamin E, Selenium, Zinc, Folic Acid, and N-3 Polyunsaturated Fatty Acids on Sperm Motility and Membrane Properties in Dogs

  2019cites this paper
• Omega-3 fatty acids and cognitive decline: a systematic review.

  2019cites this paper
• Docosahexaenoic Acid (DHA, C22:6, ω-3) Composition of Milk and Mammary Gland Tissues of Lactating Mother Rats Is Severely Affected by Lead (Pb) Exposure

  2019cites this paper
• The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice.

  2019cites this paper
• Omega-3 fatty acids as adjunctive therapeutics: prospective of nanoparticles in its formulation development.

  2019cites this paper
• A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial

  2019cites this paper
• Whole transcriptome sequencing analyses of DHA treated glioblastoma cells.

  2019cites this paper
• Consequences of early-life stress for microglia throughout life : Relevance for the hippocampus in aging and Alzheimer’s disease

  2018cites this paper
• Fatty Acids: From Membrane Ingredients to Signaling Molecules

  2018cites this paper
• Consequences of early-life stress for microglia throughout life

  2018cites this paper
• A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress

  2018cites this paper
• Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease

  2017cites this paper
• Eicosapentaenoic Acid in Myelinogenesis: Prospective in Multiple Sclerosis Treatment

  2017cites this paper
• Molecular Mechanisms behind the Beneficial Activity of Polyunsaturated Fatty Acids in Alzheimer's Disease and Related Conditions

  2017cites this paper
• Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases.

  2017cites this paper
• Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy.

  2017cites this paper
• Targeting synaptic dysfunction in Alzheimer ’ s disease by administering a specific nutrient combination Chapter

  2017cites this paper
• Premature or pathological aging: longevity

  2017cites this paper
• Docosahexaenoic acid: one molecule diverse functions

  2017cites this paper
• Docosahexaenoic Acid and Omega 3 Fatty Acids

  2017cites this paper
• Erythrocytes as Potential Link between Diabetes and Alzheimer’s Disease

  2017cites this paper
• The Protective Role of Omega-3 and Melatonin Against AlCl3 Induced some Biochemical Changes in Albino Rats

  2017influential citation
• Dietary Crude Lecithin Increases Systemic Availability of Dietary Docosahexaenoic Acid with Combined Intake in Rats

  2016cites this paper
• Dietary n-6:n-3 ratio and Vitamin E improve motility characteristics in association with membrane properties of boar spermatozoa

  2016cites this paper
• The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease.

  2016cites this paper
• Caractérisation de métabolites oxygénés dérivés des acides arachidonique et docosahexaénoïque dans le cerveau de rat

  2016cites this paper
• REVIEWS: CURRENT TOPICS The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease

  2016cites this paper
• Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease

  2016cites this paper
• Biochemical Aspects of n-6 and n-3 Fatty Acid-Derived Lipid Mediators in the Brain

  2016cites this paper
• Nourishing the brain from cradle to grave: The role of nutrients in neural development and neurodegeneration

  2015cites this paper
• Rats given linseed oil in microemulsion forms enriches the brain synaptic membrane with docosahexaenoic acid and enhances the neurotransmitter levels in the brain

  2015cites this paper
• The binding of Aβ1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease.

  2015cites this paper
• Electrophilic Derivatives of Omega-3 Fatty Acids for the Cure and Prevention of Neurodegenerative Disorders

  2015cites this paper
• nanostructure and function in neurons Effects of hyperbaric gases on membrane

  2015cites this paper
• Cyclic Intermittent Fasting Influences the Structure of Hepatocyte Nuclear Membrane in Young and Old Rats

  2015cites this paper
• Cellular Membrane Fluidity in Amyloid Precursor Protein Processing

  2014cites this paper
• Resolution of inflammation in Alzheimer’s disease

  2014cites this paper
• Impact of DHA on Metabolic Diseases from Womb to Tomb

  2014cites this paper
• Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: the influence of LCPUFA on neural development, aging, and neurodegeneration.

  2014cites this paper
• Neuroprotective Properties of the Marine Carotenoid Astaxanthin and Omega-3 Fatty Acids, and Perspectives for the Natural Combination of Both in Krill Oil

  2014cites this paper
• n-3 LCPUFA improves cognition: the young, the old and the sick.

  2014cites this paper
• Docosahexaenoic Acid Supplementation during Pregnancy: A Potential Tool to Prevent Membrane Rupture and Preterm Labor

  2014cites this paper
• Modulation des lipides du cerveau par l’alimentation : études chez des modèles animaux de maladies neurodégénératives

  2014cites this paper
• The Omega-6/Omega-3 Ratio and Dementia or Cognitive Decline: A Systematic Review on Human Studies and Biological Evidence

  2013cites this paper
• Mediterranean diet and dementia of the Alzheimer type.

  2013cites this paper
• Enhancement of cognitive function in models of brain disease through environmental enrichment and physical activity.

  2013cites this paper
• Metabolic Syndrome

  2013cites this paper
• Cognitive enhancement by omega-3 fatty acids from child-hood to old age: findings from animal and clinical studies.

  2013cites this paper
• Targeting Synaptic Dysfunction in Alzheimer's Disease by Administering a Specific Nutrient Combination

  2013cites this paper
• The influence of exercise on cognitive abilities.

  2013cites this paper
• The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer's Disease

  2013cites this paper
• Effect of Dietary Phytochemicals on Metabolic Syndrome and Neurological Disorders

  2013cites this paper
• Simultaneous Effects of Green Tea Extracts and Fish Oil on Mercury Accumulation and Antioxidant Defenses in Methylmercury-exposed Adult Mice

  2013cites this paper
• Prostaglandins, Leukotrienes and Essential Fatty Acids

  2013cites this paper
• Omega-3 Fatty Acids Enhance Phagocytosis of Alzheimer's Disease-Related Amyloid-β42 by Human Microglia and Decrease Inflammatory Markers

  2013cites this paper
• Improved Spatial Learning Strategy and Memory in Aged Alzheimer AβPPswe/PS1dE9 Mice on a Multi-Nutrient Diet

  2013cites this paper
• The role of n-3 dietary polyunsaturated fatty acids in brain function and ameliorating Alzheimer's disease: Opportunities for biotechnology in the development of nutraceuticals

  2012cites this paper
• Effects of Diet and/or Exercise in Enhancing Spinal Cord Sensorimotor Learning

  2012cites this paper
• The Effects of Long-Term Omega-3 Fatty Acid Supplementation on Cognition and Alzheimer's Pathology in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-Analysis

  2012cites this paper
• Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment.

  2012cites this paper
• Dietary intervention with DHA and curcumin enhance spinal cord sensory motor learning

  2012cites this paper
• DHA supplementation enhances high-frequency, stimulation-induced synaptic transmission in mouse hippocampus.

  2012cites this paper
• Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: implication of fatty acid-binding proteins (FABP) and G protein-coupled receptor 40 (GPR40) in adult neurogenesis.

  2011cites this paper
• ALUMINIUM-INDUCED BRAIN OXIDATIVE STRESS IN MALE RATS AND THE POSSIBLE AMELIORATING ROLE OF OMEGA-3 -

  2011cites this paper
• Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease.

  2011cites this paper
• The effect of dietary omega-3 polyunsaturated fatty acids and curcumin on cognition and pathology in a mouse model of amyloid pathology

  2011cites this paper
• Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing.

  2011cites this paper
• Endogenous Conversion of Omega-6 into Omega-3 Fatty Acids Improves Neuropathology in an Animal Model of Alzheimer's Disease

  2011cites this paper
• O papel do óleo de peixe sobre receptores 5-HT1A e a expressão do BDNF no hipocampo e córtex de ratos : um possível mecanismo antidepressivo

  2011cites this paper
• Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing.

  2011cites this paper
• Alzheimer’s Disease, Schizophrenia and Depression

  2011cites this paper
• Docosahexaenoic Acid and Cognitive Dysfunction

  2011cites this paper
• Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease

  2010cites this paper
• Why Pleiotropic Interventions are Needed for Alzheimer's Disease

  2010cites this paper
• Dietary fatty acids and the aging brain.

  2010cites this paper
• Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids

  2010cites this paper
• of Alzheimer ’ s Disease Neuroinflammation , AD , and Dementia

  2010cites this paper
• Potential Therapeutic Strategies for Neurodegenerative Diseases

  2010cites this paper
• Omega-3 Fatty Acids and Cognitive Function in Women

  2010cites this paper
• Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice.

  2010cites this paper
• Omega‐3, 6 and 9 Fatty Acids, Inflammation and Neurodegenerative Diseases

  2010cites this paper
• Control of Fatty Acid Intake and the Role of Essential Fatty Acids in Cognitive Function and Neurological Disorders

  2010cites this paper
• Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats.

  2010cites this paper
• A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma.

  2010cites this paper
• Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems.

  2010cites this paper
• Gene and protein expression profiling of the fat-1 mouse brain.

  2009cites this paper