P21-activated kinase 4 (PAK4) is required for metaphase spindle positioning and anchoring

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Oncogene

• Publication date

  2013-02-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2012.98PMID 22450748
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Cohesion fatigue induces chromatid separation in cells delayed at metaphase.

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• Blebbing dynamics during endothelial cell spreading.

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• PAK4 is required for regulation of the cell‐cycle regulatory protein p21, and for control of cell‐cycle progression

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• Signalling to cancer cell invasion through PAK family kinases.

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• Uncoordinated Loss of Chromatid Cohesion Is a Common Outcome of Extended Metaphase Arrest

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• Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis

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• Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin αvβ5 Clustering and Turnover

  2010cited by this paper
• Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.

  2010cited by this paper
• p120‐catenin is a binding partner and substrate for Group B Pak kinases

  2010cited by this paper
• p21-activated Kinase 4 Phosphorylation of Integrin β5 Ser-759 and Ser-762 Regulates Cell Migration*

  2010cited by this paper
• The Dynactin Complex Maintains the Integrity of Metaphasic Centrosomes to Ensure Transition to Anaphase*

  2010cited by this paper
• Cell Cycle-Dependent Microtubule-Based Dynamic Transport of Cytoplasmic Dynein in Mammalian Cells

  2009cited by this paper
• Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.

  2009cited by this paper
• Dual Role of Cdc42 in Spindle Orientation Control of Adherent Cells

  2009cited by this paper
• Greatwall maintains mitosis through regulation of PP2A

  2009cited by this paper
• P21-activated kinase is required for mitotic progression and regulates Plk1

  2008cited by this paper
• The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

  2008cited by this paper
• LIM Kinase-mediated Cofilin Phosphorylation during Mitosis Is Required for Precise Spindle Positioning*

  2008cited by this paper
• Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis

  2008cited by this paper
• A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF.

  2008cited by this paper
• Blebs lead the way: how to migrate without lamellipodia

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• Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint.

  2007cited by this paper
• A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin β interactions

  2007cited by this paper
• The spindle-assembly checkpoint in space and time

  2007cited by this paper
• PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.

  2007cited by this paper
• The Drosophila p21 activated kinase Mbt regulates the actin cytoskeleton and adherens junctions to control photoreceptor cell morphogenesis.

  2007cited by this paper
• HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture

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• Reassembly of contractile actin cortex in cell blebs

  2006cited by this paper
• Analysis of a RanGTP-regulated gradient in mitotic somatic cells

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• Ran at kinetochores.

  2006cited by this paper
• A mammalian NudC-like protein essential for dynein stability and cell viability.

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• Activated cofilin colocalises with Arp2/3 complex in apoptotic blebs during programmed cell death.

  2005cited by this paper
• Interplay between components of a novel LIM kinase–slingshot phosphatase complex regulates cofilin

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• The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

  2005cited by this paper
• Temporal and spatial control of nucleophosmin by the Ran–Crm1 complex in centrosome duplication

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• Mechanisms for focusing mitotic spindle poles by minus end–directed motor proteins

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• Cortical control of microtubule stability and polarization.

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• Dynamic Microtubules Lead the Way for Spindle Positioning

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• Importin β is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells

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• Rac-induced increase of phosphorylation of myosin regulatory light chain in HeLa cells.

  2004cited by this paper
• Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles

  2004cited by this paper
• Mammalian RanBP1 regulates centrosome cohesion during mitosis

  2003cited by this paper
• Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines*

  2002cited by this paper
• Assembly of centrosomal proteins and microtubule organization depends on PCM-1

  2002cited by this paper
• p21‐activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

  2002cited by this paper
• Cytoskeletal Changes Regulated by the PAK4 Serine/Threonine Kinase Are Mediated by LIM Kinase 1 and Cofilin*

  2001cited by this paper
• A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization

  2001cited by this paper
• Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth

  2001cited by this paper
• Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly

  2001cited by this paper
• Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.

  2001cited by this paper
• Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos

  2000cited by this paper
• Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion.

  2000cited by this paper
• Construction of Centrosomes and Spindle Poles by Molecular Motor‐Driven Assembly of Protein Particles

  2000cited by this paper
• Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2*

  2000cited by this paper
• A Role for P21-Activated Kinase in Endothelial Cell Migration

  1999cited by this paper
• Inhibition of myosin light chain kinase by p21-activated kinase.

  1999cited by this paper
• Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

  1998cited by this paper
• Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells.

  1998cited by this paper
• Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (γ-PAK)

  1998cited by this paper
• Microtubules Orient the Mitotic Spindle in Yeast through Dynein-dependent Interactions with the Cell Cortex

  1997cited by this paper
• Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

  1996cited by this paper

• PAK4 promotes the cytoskeletal organization and meiotic maturation via phosphorylating DDX17 in oocyte

  2025cites this paper
• PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation

  2024cites this paper
• PAK4-relevant proliferation reduced by cell autophagy via p53/mTOR/p-AKT signaling

  2023cites this paper
• The significance of PAK4 in signaling and clinicopathology: A review

  2022cites this paper
• Fine-tuning cell organelle dynamics during mitosis by small GTPases

  2022cites this paper
• p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5.

  2020cites this paper
• PAK6 promotes cervical cancer progression through activation of the Wnt/β-catenin signaling pathway

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• Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells

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• PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway*

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• Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer.

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• PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/ (cid:2) -Catenin Pathway *

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• microRNA-126 suppresses PAK4 expression in ovarian cancer SKOV3 cells.

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• Structure-based virtual screening and ADME/T-based profiling for low molecular weight chemical starting points as p21-activated kinase 4 inhibitors

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• Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis

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• Role of p-21-activated kinases in cancer progression.

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• A quantum chemical analysis of the relationships between electronic structure, PAK1 inhibition and MEK phosphorylation in a series of 2-arylamino-4-aryl-pyrimidines.

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• Liver kinase B1 regulates the centrosome via PLK1

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• Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics*

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• PAK signalling during the development and progression of cancer

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• P21-activated kinase 4--not just one of the PAK.

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• Molecular pathways regulating mitotic spindle orientation in animal cells

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• Spindle Angle Measurements.

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• p21-activated kinase 4 regulates mitotic spindle positioning and orientation

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