p21‐activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

No abstract is available for this paper.

• Publication year

  2002

• Venue

  EMBO Reports

• Publication date

  2002-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/embo-reports/kvf157PMID 12151336PMCID PMC1084211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Translating the Histone Code

  2001cited by this paper
• Differential regulation of CENP-A and histone H3 phosphorylation in G2/M.

  2001cited by this paper
• Chromosomal passengers and the (aurora) ABCs of mitosis.

  2001cited by this paper
• The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition

  2001cited by this paper
• Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes

  2000cited by this paper
• Temporal and Spatial Distribution of Activated Pak 1 in Fibroblasts

  2000cited by this paper
• Core histone N‐termini play an essential role in mitotic chromosome condensation

  2000cited by this paper
• Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins.

  2000cited by this paper
• Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts

  2000cited by this paper
• Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells*

  2000cited by this paper
• Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor

  2000cited by this paper
• p21-activated protein kinase: a crucial component of morphological signaling?

  1999cited by this paper
• The nucleosome: a powerful regulator of transcription.

  1998cited by this paper
• Signaling to chromatin through histone modifications: how clear is the signal?

  1998cited by this paper
• Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

  1997cited by this paper
• MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

  1997cited by this paper
• Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

  1997cited by this paper
• Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.

  1997cited by this paper
• Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

  1996cited by this paper
• Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells.

  1994cited by this paper
• Chromosomal passengers: Toward an integrated view of mitosis

  1991cited by this paper
• Localization of cytoplasmic dynein to mitotic spindles and kinetochores

  1990cited by this paper

• RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance

  2025cites this paper
• Hyperactivation of p21-Activated Kinases in Human Cancer and Therapeutic Sensitivity

  2023cites this paper
• Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair

  2022cites this paper
• The P21-Activated Kinase 1 and 2 As Potential Therapeutic Targets for the Management of Cardiovascular Disease.

  2022cites this paper
• Minor Kinases with Major Roles in Cytokinesis Regulation

  2022cites this paper
• p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond

  2022cites this paper
• The Role of p21-Activated Kinases in Cancer and Beyond: Where Are We Heading?

  2021cites this paper
• Group I PAKs in myelin formation and repair of the central nervous system: what, when, and how

  2021influential citation
• Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases

  2020cites this paper
• P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer

  2020cites this paper
• A three layered histone epigenetics in breast cancer metastasis

  2020cites this paper
• p21-activated kinases in thyroid cancer.

  2020cites this paper
• Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells.

  2020cites this paper
• Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers.

  2020cites this paper
• The PAK1-Stat3 Signaling Pathway Activates IL-6 Gene Transcription and Human Breast Cancer Stem Cell Formation

  2019cites this paper
• MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition.

  2019cites this paper
• Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7–PAK1 complex

  2019cites this paper
• p21 Activated kinase 1: Nuclear activity and its role during DNA damage repair.

  2018cites this paper
• Upregulation of P21-Activated Kinase 1 (PAK1)/CREB Axis in Squamous Non-Small Cell Lung Carcinoma

  2018cites this paper
• Regulation of glucose metabolism by P21-Activated Kinases (PAKs), Ste20 and Cla4: using the budding yeast Saccharomyces cerevisiae as a model organism

  2018cites this paper
• p21-activated kinase 1 activity is required for histone H3 Ser10 phosphorylation and chromatin condensation in mouse oocyte meiosis.

  2017cites this paper
• Structure, biochemistry, and biology of PAK kinases.

  2017cites this paper
• Targeting Rho, Rac, CDC42 GTPase Effector p21 Activated Kinases in Mutant K-Ras-Driven Cancer

  2017cites this paper
• Signaling coupled epigenomic regulation of gene expression

  2017cites this paper
• Recent Advances in Substrate Identification of Protein Kinases in Plants and Their Role in Stress Management

  2017cites this paper
• NOTCH1 intracellular domain negatively regulates PAK1 signaling pathway through direct interaction.

  2016cites this paper
• PAKs in Human Cancer Progression: From Inception to Cancer Therapeutic to Future Oncobiology.

  2016cites this paper
• PAK1 translocates into nucleus in response to prolactin but not to estrogen.

  2016cites this paper
• A Catalogue of Altered Salivary Proteins Secondary to Invasive Ductal Carcinoma: A Novel In Vivo Paradigm to Assess Breast Cancer Progression

  2016cites this paper
• Rac1/p21‐activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes

  2016cites this paper
• Therapeutic Potential of Targeting PAK Signaling.

  2015cites this paper
• Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

  2015cites this paper
• Recent Advances in Prolactin Research

  2015influential citation
• The role of tyrosyl phosphorylated PAK1 in the synergetic effect of estrogen and prolactin in breast cancer cells

  2015cites this paper
• Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice

  2015cites this paper
• The role of β1-integrin in normal and oncogene-mediated proliferation in breast epithelia

  2015cites this paper
• Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.

  2015cites this paper
• Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins.

  2015cites this paper
• Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer

  2014cites this paper
• Expression and functionality of histone H2A variants in cancer

  2014cites this paper
• p21-Activated protein kinases and their emerging roles in glucose homeostasis.

  2014cites this paper
• The Role of p21-activated Protein Kinase 1 in Metabolic Homeostasis

  2014cites this paper
• Prolactin Regulates Cyclin D 1 Promoter Activity via Serine-threonine Kinase PAK 1 and Adapter Protein Nck

  2014cites this paper
• Roles for DSCAM and DSCAML1 in central nervous system development and disease.

  2014cites this paper
• Role of p-21-activated kinases in cancer progression.

  2014cites this paper
• Role of ERK signaling in activity-dependent modifications of histone proteins.

  2014cites this paper
• The Akt/mTOR Pathway and Estrogen Receptor Phosphorylations : a crosstalk with potential to predict tamoxifen resistance in breast cancer

  2013cites this paper
• Phosphorylation of histone H3 on Ser10 by auto-phosphorylated PAK1 is not essential for chromatin condensation and meiotic progression in porcine oocytes

  2013influential citation
• Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.

  2013cites this paper
• Protein kinase CK2 phosphorylates and activates p21-activated kinase 1

  2013cites this paper
• Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats

  2013cites this paper
• P21-activated kinase 4 (PAK4) is required for metaphase spindle positioning and anchoring

  2013cites this paper
• Identification of Novel Gene Targets and Functions of p21-Activated Kinase 1 during DNA Damage by Gene Expression Profiling

  2013cites this paper
• Investigation into AMPK phosphatases and identification and characterisation of the interaction between AMPK and PAK1

  2013cites this paper
• Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines

  2013cites this paper
• Regulation of pancreatic and intestinal endocrine cell differentiation and function : roles of Pak3 and Rfx6

  2012cites this paper
• PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation

  2012cites this paper
• The Role of Centrosomes in Multiple Myeloma

  2012cites this paper
• PAKs in human disease.

  2012cites this paper
• p21-activated Kinase-1 Signaling Regulates Transcription of Tissue Factor and Tissue Factor Pathway Inhibitor*♦

  2012cites this paper
• [P21-activated kinases and their role in the nervous system].

  2012cites this paper
• Developmental Biology: Frontiers for Clinical Genetics

  2012cites this paper
• p21-activated kinase 4 regulates mitotic spindle positioning and orientation

  2012cites this paper
• From oncogene to tumor suppressor

  2012cites this paper
• PAK signaling in cancer

  2012cites this paper
• Signaling-dependent Phosphorylation of Mitotic Centromere-associated Kinesin Regulates Microtubule Depolymerization and Its Centrosomal Localization*

  2012cites this paper
• Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer—Opportunities, Challenges, and Limitations

  2012cites this paper
• Untangling the complexity of PAK1 dynamics

  2012cites this paper
• Treatment of doxorubicin-resistant MCF7/Dx cells with nitric oxide causes histone glutathionylation and reversal of drug resistance.

  2011cites this paper
• PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin.

  2011cites this paper
• Signalling to cancer cell invasion through PAK family kinases.

  2011cites this paper
• Carcinoembryonic antigen interacts with TGF-{beta} receptor and inhibits TGF-{beta} signaling in colorectal cancers.

  2010cites this paper
• PAK1 as a therapeutic target

  2010cites this paper
• Cancer esearch or and Stem Cell Biology cinoembryonic Antigen Interacts with TGF-β Receptor and R bits TGF-β Signaling in Colorectal Cancers

  2010cites this paper
• Purification and proteomic identification of putative upstream regulators of polo‐like kinase‐1 from mitotic cell extracts

  2010cites this paper
• An emerging role for p21-activated kinases (Paks) in viral infections.

  2010cites this paper
• Actin cytoskeleton dynamics and the cell division cycle.

  2010cites this paper
• Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations.

  2010cites this paper
• Integrin-interacting proteins in human cancer progression

  2010cites this paper
• PAK1-Nck interaction represents a novel mechanism to regulate cyclin D1 transcription in response to prolactin

  2010influential citation
• THE ROLE OF PAK4 IN TUMORIGENESIS IN VIVO By

  2010cites this paper
• Contents lists available at ScienceDirect The International Journal of Biochemistry & Cell Biology

  2010cites this paper
• CD24‐dependent MAPK pathway activation is required for colorectal cancer cell proliferation

  2010cites this paper
• Section Editors:Jacques L. Michaud, email: jacques.michaud@recherchestejustine.qc.caOlivier Pourqui, email: pourquie@igbmc.fr: Hippocampus development and function: role of epigenetic factors and implications for cognitive disease

  2010cites this paper
• Carcinoembryonic Antigen Interacts with TGF- β Receptor and Inhibits TGF- β Signaling in Colorectal Cancers

  2010cites this paper
• PAKing up to the endothelium.

  2009cites this paper
• PAK signalling in neuronal physiology.

  2009cites this paper
• Roles and regulation of «Saccharomyces cerevisiae» Rho-type GTPases Rho5p and Cdc42p

  2009cites this paper
• Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse

  2009cites this paper
• Characterisation of gene expression profiles of yeast cells expressing BRCA1 missense variants.

  2009cites this paper
• Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression

  2009cites this paper
• CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.

  2009cites this paper
• Downregulation of p21‐activated kinase‐1 inhibits the growth of gastric cancer cells involving cyclin B1

  2009cites this paper
• Pak protein kinases and their role in cancer

  2009influential citation
• Role of p21‐activated kinase in cell polarity and directional mesendoderm migration in the Xenopus gastrula

  2009cites this paper
• Epigenetic Mechanisms of Ovarian Gene Regulation

  2009cites this paper
• PAK Signaling in Oncogenesis

  2009influential citation
• Convergance of Cytoskeletal Signaling at p21-Activated Kinases

  2008cites this paper
• Integrins as regulators of the mitotic machinery.

  2008cites this paper
• Aurora-A kinase Ser349 phosphorylation is required during Xenopus laevis oocyte maturation.

  2008cites this paper