Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Cell

• Publication date

  2001-01-12

• Fields of study

  Biology

• Identifiers
  DOI 10.1016/S0092-8674(01)00194-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Motor function in the mitotic spindle.

  2000cited by this paper
• Tpx2, a Novel Xenopus Map Involved in Spindle Pole Organization

  2000cited by this paper
• GTP hydrolysis by Ran is required for nuclear envelope assembly.

  2000cited by this paper
• Spindles get the ran around.

  2000cited by this paper
• Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts.

  2000cited by this paper
• The role of Ran in nuclear function.

  2000cited by this paper
• Centrosome-independent mitotic spindle formation in vertebrates.

  2000cited by this paper
• Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

  1999cited by this paper
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  1999cited by this paper
• The ran GTPase regulates mitotic spindle assembly.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis.

  1999cited by this paper
• Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran.

  1999cited by this paper
• The direction of transport through the nuclear pore can be inverted.

  1999cited by this paper
• Transport between the cell nucleus and the cytoplasm.

  1999cited by this paper
• Snurportin1, an m3G‐cap‐specific nuclear import receptor with a novel domain structure

  1998cited by this paper
• Importin β, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

  1998cited by this paper
• NTF2 mediates nuclear import of Ran

  1998cited by this paper
• Nucleocytoplasmic transport and cell proliferation.

  1998cited by this paper
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  1998cited by this paper
• Nucleocytoplasmic transport: the soluble phase.

  1998cited by this paper
• XCTK2: A Kinesin-related Protein That Promotes Mitotic Spindle Assembly in Xenopus laevis Egg Extracts

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  1997cited by this paper
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  1997cited by this paper
• A Novel Class of RanGTP Binding Proteins

  1997cited by this paper
• Dominant‐negative mutants of importin‐β block multiple pathways of import and export through the nuclear pore complex

  1997cited by this paper
• A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.

  1997cited by this paper
• Different Binding Domains for Ran-GTP and Ran-GDP/RanBP1 on Nuclear Import Factor p97*

  1997cited by this paper
• Nuclear import of U snRNPs requires importin β

  1997cited by this paper
• Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein

  1996cited by this paper
• A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.

  1996cited by this paper
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  1996cited by this paper
• A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

  1996cited by this paper
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  1996cited by this paper
• Influence of M-phase chromatin on the anisotropy of microtubule asters

  1996cited by this paper
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  1996cited by this paper
• The conserved amino‐terminal domain of hSRP1 alpha is essential for nuclear protein import.

  1996cited by this paper
• A 41 amino acid motif in importin‐alpha confers binding to importin‐beta and hence transit into the nucleus.

  1996cited by this paper
• Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

  1996cited by this paper
• XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly.

  1996cited by this paper
• NuMA is required for the organization of microtubules into aster-like mitotic arrays

  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
• A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles

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• Cell cycle extracts.

  1991cited by this paper
• Preparation of marked microtubules for the assay of the polarity of microtubule-based motors by fluorescence

  1991cited by this paper
• Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

  1991cited by this paper
• Chapter 30 Cell Cycle Extracts

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• The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

  1989cited by this paper
• The polarity and stability of microtubule capture by the kinetochore

  1988cited by this paper
• Beyond self-assembly: from microtubules to morphogenesis.

  1986cited by this paper
• The total length of spindle microtubules depends on the number of chromosomes present

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• Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell.

  1980cited by this paper

• Spindle morphology changes between meiosis and mitosis driven by CK2 regulation of the Ran pathway.

  2025cites this paper
• Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in Tetrahymena.

  2025cites this paper
• Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

  2025cites this paper
• NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends

  2024cites this paper
• Ibetazol, a novel inhibitor of importin β1-mediated nuclear import

  2024cites this paper
• CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation

  2024cites this paper
• siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells

  2024cites this paper
• HURP localization in metaphase is the result of a multi-step process requiring its phosphorylation at Ser627 residue

  2023cites this paper
• Ran GTPase and Its Importance in Cellular Signaling and Malignant Phenotype

  2023cites this paper
• Suppression of classical nuclear import pathway by importazole and ivermectin inhibits rotavirus replication.

  2022cites this paper
• Arabidopsis RAN GTPases are critical for mitosis during male and female gametogenesis

  2022cites this paper
• Dual control of formin-nucleated actin assembly by the chromatin and ER in mouse oocytes.

  2022cites this paper
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  2022cites this paper
• Multiple mechanisms prevent ectopic condensation of FG nucleoporins in the cytoplasm

  2022cites this paper
• β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila.

  2022cites this paper
• Flavors of Non-Random Meiotic Segregation of Autosomes and Sex Chromosomes

  2021cites this paper
• RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization

  2021cites this paper
• Mud binds the kinesin-14 Ncd in Drosophila

  2021cites this paper
• The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning

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  2020cites this paper
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  2020cites this paper
• Complementary functions for the Ran gradient during division

  2020cites this paper
• Exportins can inhibit major mitotic assembly events in vitro: membrane fusion, nuclear pore formation, and spindle assembly

  2020cites this paper
• Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.

  2020cites this paper
• Ca2+-binding protein from Entamoeba histolytica (EhCaBP6) is a novel GTPase.

  2020cites this paper
• Microtubule Organization in Striated Muscle Cells

  2020cites this paper
• Phosphorylation of importin-α1 by CDK1–cyclin B1 controls mitotic spindle assembly

  2019cites this paper
• RanGTP and importin β regulate meiosis I spindle assembly and function in mouse oocytes

  2019influential citation
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  2019cites this paper
• The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules

  2019cites this paper
• RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking

  2019influential citation
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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• The Ran-GTP gradient spatially regulates XCTK2 in the spindle.

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  2014influential citation
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