Prognostic importance of survivin in breast cancer

Survivin is a member of the inhibitor of apoptosis (IAP) family, and is also involved in the regulation of cell division. Survivin is widely expressed in foetal tissues and in human cancers, but generally not in normal adult tissue. This study examined the expression of surviving protein in a series of 293 cases of invasive primary breast carcinoma. Survivin immunoreactivity was assessed using two different polyclonal antibodies, and evaluated semiquantitatively according to the percentage of cells demonstrating distinct nuclear and/or diffuse cytoplasmic staining. Overall, 60% of tumours were positive for survivin: 31% demonstrated nuclear staining only, 13% cytoplasmic only, and 16% of tumour cells demonstrated both nuclear and cytoplasmic staining. Statistical analysis revealed that survivin expression was independent of patient's age, tumour size, histological grade, nodal status, and oestrogen receptor status. In multivariate analysis, nuclear survivin expression was a significant independent prognostic indicator of favourable outcome both in relapse-free and overall survival (P<0.001 and P=0.01, respectively). In conclusion, our results show that survivin is frequently overexpressed in primary breast cancer. Nuclear expression is most common and is an independent prognostic indicator of good prognosis.

• Publication year

  2003

• Venue

  British Journal of Cancer

• Publication date

  2003-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.bjc.6600776PMID 12671708PMCID 2376388
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TNM Classification of Malignant Tumours, 7th Edition

  2009cited by this paper
• Expert Commentary.

  2002influential reference
• Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function.

  2002cited by this paper
• Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression

  2002cited by this paper
• Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa.

  2001cited by this paper
• Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors

  2001cited by this paper
• Expression of Survivin, YB-1, and KI-67 in Sporadic Adenomas and Dysplasia-Associated Lesions or Masses in Ulcerative Colitis

  2001cited by this paper
• The survivin:fas ratio in pediatric renal tumors.

  2001cited by this paper
• The Survivin saga goes in vivo.

  2001cited by this paper
• An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7.

  2001cited by this paper
• Survivin expression in tumor cell nuclei is predictive of a favorable prognosis in gastric cancer patients.

  2001cited by this paper
• Neuroendocrine cells in human prostate over‐express the anti‐apoptosis protein survivin

  2001cited by this paper
• Role of survivin, whose gene is mapped to 17q25, in human neuroblastoma and identification of a novel dominant-negative isoform, survivin-beta/2B.

  2000cited by this paper
• Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.

  2000cited by this paper
• Survivin promotes cell proliferation in human hepatocellular carcinoma

  2000influential reference
• Expression and prognostic significance of survivin in de novo acute myeloid leukaemia

  2000cited by this paper
• Prognostic significance of survivin expression in diffuse large B-cell lymphomas.

  2000cited by this paper
• High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma

  2000cited by this paper
• Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases.

  2000cited by this paper
• Expression of survivin and Bcl-2 in the normal human endometrium.

  2000cited by this paper
• Role ofsurvivin, whose gene is mapped to 17q25, in human neuroblastoma and identification of a novel dominant-negative isoform,survivin-?/2B

  2000cited by this paper
• Expression of survivin and its relationship to loss of apoptosis in breast carcinomas.

  2000cited by this paper
• Expression of the antiapoptosis gene,Survivin, predicts death from recurrent colorectal carcinoma

  2000cited by this paper
• A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers.

  1999cited by this paper
• IAP family proteins--suppressors of apoptosis.

  1999cited by this paper
• Tumor content of the antiapoptosis molecule survivin and recurrence of bladder cancer.

  1999cited by this paper
• Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties.

  1999cited by this paper
• Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis

  1999cited by this paper
• Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

  1999cited by this paper
• Pathological prognostic factors in breast cancer.

  1999cited by this paper
• Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer.

  1998cited by this paper
• The inhibitors of apoptosis (IAPs) and their emerging role in cancer

  1998cited by this paper
• IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

  1998cited by this paper
• Control of apoptosis and mitotic spindle checkpoint by survivin

  1998cited by this paper
• Induction of Apoptosis and Inhibition of Cell Proliferation bysurvivin Gene Targeting*

  1998cited by this paper
• Molecular basis of spontaneous regression of neuroblastoma: role of neurotrophic signals and genetic abnormalities.

  1998cited by this paper
• A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

  1997cited by this paper
• Analysis of bcl‐2 in sporadic breast carcinoma

  1997cited by this paper
• Analysis of bcl-2 in sporadic breast carcinoma.

  1997cited by this paper
• bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer.

  1994cited by this paper
• pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up

  1991cited by this paper

• IAPs in cancers: molecular mechanisms, clinical prognostic value, and translational therapeutic potential

  2026cites this paper
• Targeting Survivin: Now I Become Death, the Destroyer of Cells

  2025cites this paper
• Survivin recombinant overlapping peptide (ROP) vaccine in advanced solid tumours: a first-in-human, multicentre, open-label, phase 1a dose-escalation study

  2025cites this paper
• Engineered Nanoparticles for μPAD Nucleic Acid Detection

  2025cites this paper
• Whole Genome Expression Analysis Identifies Multiple Targeted Integrative Effects of Polyphenol-Rich Propolis on HER-2-Positive Breast Cancer Cell Line

  2024cites this paper
• The impact of quercetin and paclitaxel combination on ovarian cancer cells

  2024cites this paper
• Intensity of survivin expression linked to features of aggressive relapsed/refractory diffuse large B-cell lymphoma

  2024cites this paper
• A Comprehensive Evaluation Framework for Benchmarking Multi-Objective Feature Selection in Omics-Based Biomarker Discovery

  2024cites this paper
• Doubly self-assembled dermatan sulfate/chitosan nanoparticles for targeted siRNA delivery in cancer therapy.

  2024cites this paper
• The prognostic role of survivin expression in breast cancer: A systematic review and meta-analysis

  2024cites this paper
• Survivin as a Therapeutic Target for the Treatment of Human Cancer

  2024cites this paper
• Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner

  2023cites this paper
• A combinatorial delivery of survivin targeted siRNA using cancer selective nanoparticles for triple negative breast cancer therapy

  2023cites this paper
• Survivin and p53 expression in benign and malignant lesions of breast

  2023cites this paper
• Evaluation of Tumor-Suppressive Properties and Apoptotic Functions of Mad Honey and Vincristine Applications in a Rat Model of Breast Cancer

  2023cites this paper
• Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?

  2023cites this paper
• Significance of combined TGF-β1 and survivin expression on the prognosis of patients with triple-negative breast cancer

  2022cites this paper
• Influence of Paclitaxel and Doxorubicin Therapy of ßIII-Tubulin, Carbonic Anhydrase IX, and Survivin in Chemically Induced Breast Cancer in Female Rat

  2021cites this paper
• The Unique Biology behind the Early Onset of Breast Cancer

  2021cites this paper
• The BIRC Family Genes Expression in Patients with Triple Negative Breast Cancer

  2021cites this paper
• Prognostic Significance of BIRC5/Survivin in Breast Cancer: Results from Three Independent Cohorts

  2021cites this paper
• The abnormal expression of chromosomal region maintenance 1 (CRM1)-survivin axis in ovarian cancer and its related mechanisms regulating proliferation and apoptosis of ovarian cancer cells

  2021cites this paper
• Synergistic Effect of Doxorubicin and siRNA-Mediated Silencing of Mcl-1 Using Cationic Niosomes against 3D MCF-7 Spheroids

  2021cites this paper
• Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda

  2020cites this paper
• Survivin and Telomerase as Radiotherapeutic Response Predictors of Subjects with Stage IIIB Cervical Squamous Cell Carcinoma

  2020cites this paper
• Performing Data Mining to Explain the Correlation between the BIRC5 Gene and Prognosis in Breast Cancer Patients

  2020cites this paper
• Identification of potential key genes for HER-2 positive breast cancer based on bioinformatics analysis

  2020cites this paper
• Extracellular vesicles in blood: are they viable as diagnostic and predictive tools in breast cancer?

  2020cites this paper
• Loss of cytoplasmic survivin expression is an independent predictor of poor prognosis in radically operated prostate cancer patients

  2020cites this paper
• Unraveling survivin expression in chronic myeloid leukemia: Molecular interactions and clinical implications.

  2020cites this paper
• The multiple roles of the IAP super-family in cancer.

  2020cites this paper
• Polymorphisms in Survivin (BIRC5 Gene) Are Associated with Age of Onset in Breast Cancer Patients

  2019cites this paper
• Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1/p-STAT3 Signaling in Human Breast Cancers

  2019cites this paper
• Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO).

  2019cites this paper
• The role of Survivin as a biomarker and potential prognostic factor for breast cancer.

  2019cites this paper
• Performance of survivin mRNA as a biomarker for breast cancer among Vietnamese women

  2019cites this paper
• Prognostic value of XIAP and survivin expression in locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy

  2019cites this paper
• Molecular Carcinogenesis

  2019influential citation
• WITHDRAWN: Performance of survivin mRNA as a biomarker for breast cancer among Vietnamese women.

  2019cites this paper
• Sono and photo stimulated Chlorine E6 nanocomposite in tumor-bearing mice: upcoming cancer treatment

  2019cites this paper
• Expression of survivin does not appear to influence breast cancer recurrence risk

  2018cites this paper
• EXPRESSION OF SURVIVIN AND p53 IN BREAST CANCER

  2018cites this paper
• Expression Analysis of Survivin and XIAP in Gallbladder Cancer: a Case-control Study in Indo-Gangetic Plain

  2018cites this paper
• Is serum survivin expression a predictive biomarker in locally advanced gastric cancer patients treated with neoadjuvant chemotherapy?

  2018cites this paper
• Prognostic Significance of Survivin and Livin Expression in the Primary Breast Cancer and Their Lymph Node Metastases

  2018cites this paper
• Extracellular vesicles and anti-cancer drug resistance.

  2018cites this paper
• Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response

  2018cites this paper
• Survivin in breast lesions: immunohistochemical analysis of 196 cases.

  2017cites this paper
• Nuclear Survivin as a Prognostic Factor in Squamous-Cell Carcinoma of the Oral Cavity

  2017cites this paper
• P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway.

  2017cites this paper
• Characterization of hormonal receptors and human epidermal growth factor receptor-2 in tissues of women with breast cancer at Muhimbili National Hospital, Dar es salaam, Tanzania

  2017cites this paper
• Targeting survivin suppresses proliferation and invasion of retinoblastoma cells in vitro and in vivo.

  2017cites this paper
• The impact of Survivin , WRAP 53 ! , and Hypoxia on treatment response in Head and Neck Cancer

  2017cites this paper
• Nuclear survivin promoted by acetylation is associated with the aggressive phenotype of oral squamous cell carcinoma

  2017cites this paper
• Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma

  2016cites this paper
• Title BRCA 1 positively regulates FOXO 3 expression by restricting FOXO 3 gene methylation and epigenetic silencing through targeting EZH 2 in breast cancer

  2016cites this paper
• BIRC5 (survivin): a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy

  2016cites this paper
• BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer

  2016cites this paper
• SURVIVIN AND Ki67 PROLIFERATIVE INDEX IN BREAST CARCINOMA

  2016influential citation
• Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer

  2016cites this paper
• Nuclear and Cytoplasmic Expression of Survivin in Breast Carcinoma: Correlation with Clinicopathological Parameters

  2016cites this paper
• Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer

  2016cites this paper
• The pattern of prognostic and risk indicators among women with breast cancer undergoing modified radical mastectomy in Dar es Salaam, Tanzania

  2016cites this paper
• Assessment of combined vaccination and immune modulation as an anti-tumour therapy

  2016cites this paper
• Sequestering survivin to functionalized nanoparticles: a strategy to enhance apoptosis in cancer cells.

  2016cites this paper
• Targeting Survivin Enhances Chemosensitivity in Retinoblastoma Cells and Orthotopic Tumors

  2016cites this paper
• Differential Effect of Phosphorylation-Defective Survivin on Radiation Response in Estrogen Receptor-Positive and -Negative Breast Cancer

  2015cites this paper
• Survivin Hakkinda Bilinenler: Survivin ile İlgili Türkiye'de Yapilmiş Olan Çalişmalar

  2015cites this paper
• Correlation of carbonic anhydrase IX expression with clinico-morphological parameters, hormonal receptor status and HER-2 expression in breast cancer.

  2015cites this paper
• Serum Survivin Levels and Outcome of Chemotherapy in Patients with Malignant Mesothelioma

  2015cites this paper
• Survivin Hakkında Bilinenler: Survivin ile İlgili Türkiye’de Yapılmış Olan Çalışmalar

  2015cites this paper
• Targeting survivin using a combination of miR-494 and survivin shRNA has synergistic effects on the suppression of prostate cancer growth

  2015cites this paper
• Expression of IAP family proteins and its clinical importance in breast cancer patients.

  2015cites this paper
• Retraction Note to: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis

  2015cites this paper
• Prophylactic Cranial Irradiation Reduces the Incidence of Brain Metastasis in a Mouse Model of Metastatic Breast Cancer

  2015cites this paper
• Prognostic and Clinicopathological Value of Survivin in Diffuse Large B-cell Lymphoma

  2015cites this paper
• A Bioresponsive and Multifunctional Polymer Based Nanodevice for Cancer Nanotheranostics

  2015cites this paper
• Carbonic anhydrase IX: a promising diagnostic and prognostic biomarker in breast carcinoma.

  2014cites this paper
• D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells.

  2014cites this paper
• Clinical significance of Smac and survivin expression in breast cancer patients treated with anthracycline‑based neoadjuvant chemotherapy.

  2014cites this paper
• Luminal (Her2 negative) prognostic index and survival of breast cancer patients.

  2014cites this paper
• XPO1 (CRM1) Inhibition Represses STAT3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer

  2014cites this paper
• Effect of propranolol on IL-10, visfatin, Hsp70, iNOS, TLR2, and survivin in amelioration of tumor progression and survival in Solid Ehrlich Carcinoma-bearing mice

  2014cites this paper
• Prognostic Significance of Survivin in Breast Cancer: Meta‐analysis

  2014cites this paper
• Differential Expression of Survivin in Mammary Gland Diseases

  2014cites this paper
• An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer, in vitro and in vivo

  2014cites this paper
• RETRACTED ARTICLE: The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis

  2014cites this paper
• Significance of intracellular localization of survivin in cervical squamous cell lesions: Correlation with disease progression

  2014cites this paper
• Cancer Biology and Signal Transduction XPO 1 ( CRM 1 ) Inhibition Represses STAT 3 Activation to Drive a Survivin-Dependent Oncogenic Switch in Triple-Negative Breast Cancer

  2014cites this paper
• Prognostic value of survivin and EGFR protein expression in triple-negative breast cancer (TNBC) patients

  2014cites this paper
• Prognostic Significance of Survivin and Nuclear Morphometry in Nasopharyngeal Carcinoma

  2014cites this paper
• Transcriptional Expression Analysis of Survivin Splice Variants Reveals Differential Expression of Survivin-3α in Breast Cancer

  2013cites this paper
• HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage.

  2013cites this paper
• [Obtaining of the affinity purified antibodies against survivin for the structure functional study of the protein].

  2013cites this paper
• Strong expression of survivin is associated with positive response to radiotherapy and improved overall survival in head and neck squamous cell carcinoma patients

  2013cites this paper
• Survivin expression in breast lobular carcinoma: correlations with normal breast tissue and clinicomorphological parameters.

  2013cites this paper
• Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases

  2013cites this paper
• Prognostic value of proliferation markers expression in breast cancer

  2013cites this paper
• Survivin expression can predict the effect of chemoradiotherapy for advanced lower rectal cancer

  2013cites this paper
• Overexpression of survivin levels in circulation and tissue samples of lung cancer patients.

  2013cites this paper