A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nature Immunology

• Publication date

  2012-01-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ni.2210PMID 22267219PMCID PMC4028049
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling

  2011cited by this paper
• Regulation of FOXO protein stability via ubiquitination and proteasome degradation.

  2011cited by this paper
• The SYK tyrosine kinase: a crucial player in diverse biological functions

  2010cited by this paper
• A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates the B cell fate

  2010cited by this paper
• Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.

  2010cited by this paper
• The cunning little vixen: Foxo and the cycle of life and death

  2009cited by this paper
• Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development

  2009cited by this paper
• Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling

  2009cited by this paper
• Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

  2009cited by this paper
• Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6.

  2008cited by this paper
• PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway.

  2008cited by this paper
• Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling.

  2008influential reference
• Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros

  2008cited by this paper
• Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells.

  2008cited by this paper
• SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway

  2008cited by this paper
• Distinct roles for Foxo1 at multiple stages of B cell differentiation

  2008cited by this paper
• Transcriptional repression mediated by repositioning of genes to the nuclear lamina

  2008cited by this paper
• Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

  2008cited by this paper
• PKC h directs induction of IRF-4 expression and Ig k gene rearrangement in pre-BCR signaling pathway

  2008cited by this paper
• The pathways to tumor suppression via route p38.

  2007cited by this paper
• Basal B Cell Receptor-Directed Phosphatidylinositol 3-Kinase Signaling Turns Off RAGs and Promotes B Cell-Positive Selection1

  2007cited by this paper
• Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

  2007cited by this paper
• Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.

  2007cited by this paper
• Bone-marrow haematopoietic-stem-cell niches

  2006cited by this paper
• Pre-BCR signals and the control of Ig gene rearrangements.

  2006cited by this paper
• Microenvironmental niches in the bone marrow required for B-cell development

  2006cited by this paper
• Foxp1 is an essential transcriptional regulator of B cell development

  2006cited by this paper
• Supplemental Data Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates

  2006cited by this paper
• Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation.

  2006cited by this paper
• MAPK p38 alpha is dispensable for lymphocyte development and proliferation.

  2005cited by this paper
• MAPK p38α Is Dispensable for Lymphocyte Development and Proliferation1

  2005cited by this paper
• Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells

  2005cited by this paper
• Both the pre‐BCR and the IL‐7Rα are essential for expansion at the pre‐BII cell stage in vivo

  2005cited by this paper
• Regulation of interleukin 7–dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5

  2005cited by this paper
• Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

  2003cited by this paper
• Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation.

  2003cited by this paper
• Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome*

  2003cited by this paper
• IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development.

  2003cited by this paper
• Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene.

  2002cited by this paper
• Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway.

  2001cited by this paper
• BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.

  1999cited by this paper
• BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

  1999cited by this paper
• A R T I C L E S COSMOLOGY AND GENESIS: THE ROAD TO HARMONY AND THE NEED FOR COSMOLOGICAL ALTERNATIVES

  1992cited by this paper

• BET bromodomain inhibition: a potential therapeutic avenue in MEF2D-HNRNPUL1-rearranged B-cell acute lymphoblastic leukaemia.

  2026cites this paper
• Decoding human B cell ontogeny in prenatal and adult bone marrow and in vitro models via single-cell multiomics

  2025cites this paper
• Feedback loops in B-cell chromatin regulation as a therapeutic target for modulating antibody production and malignancies: insights from BACH2.

  2025cites this paper
• Chromatin Remodulator CHD4: A Potential Target for Cancer Interception

  2025cites this paper
• Lineage- and stage-specific activity of antigen receptor gene enhancers during lymphocyte development

  2024cites this paper
• Hypoxia-adenosinergic regulation of B cell responses

  2024cites this paper
• Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus

  2024cites this paper
• Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease.

  2024cites this paper
• Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions

  2024cites this paper
• Kidins220 regulates the development of B cells bearing the λ light chain

  2024cites this paper
• IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression.

  2024cites this paper
• Spi-C and PU.1 Counterregulate Rag1 and Igκ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells.

  2023cites this paper
• Mature B cells and mesenchymal stem cells control emergency myelopoiesis

  2023cites this paper
• IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion

  2023cites this paper
• Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia

  2023cites this paper
• Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells.

  2023cites this paper
• Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia

  2023cites this paper
• Puppet masters of B‐cell progenitor acute lymphoblastic leukemia: The preB cell receptor and the interleukin 7 receptor α

  2023cites this paper
• The discrete roles of individual FOXO transcription factor family members in B-cell malignancies

  2023cites this paper
• Human and mouse early B cell development: so similar but so different.

  2023cites this paper
• INPP5K controls the dynamic structure and signaling of wild type and mutated, leukemia-associated IL7 receptors.

  2023cites this paper
• The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression

  2022cites this paper
• Assessing DNA Damage Responses Using B Lymphocyte Cultures.

  2022cites this paper
• The miR-26 family regulates early B cell development and transformation

  2022cites this paper
• RETRACTED ARTICLE: The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination

  2022influential citation
• Transcriptome sequencing reveals improved ammonia nitrogen tolerance in Zebra II strain of the Manila clam Ruditapes philippinarum.

  2022cites this paper
• Kidins220 regulates the development of B cells bearing the λ light chain

  2022cites this paper
• FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis

  2022cites this paper
• Spi-C and PU.1 counterregulate Rag1 and Igκ transcription to effect immunoglobulin kappa recombination in small pre-B cells

  2022cites this paper
• Signaling networks in B cell development and related therapeutic strategies

  2021cites this paper
• B Cell Metabolism and Autophagy in Autoimmunity

  2021cites this paper
• Radiofrequency EMF irradiation effects on pre-B lymphocytes undergoing somatic recombination

  2021cites this paper
• Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination *

  2021cites this paper
• C/EBPβ induces B‐cell acute lymphoblastic leukemia and cooperates with BLNK mutations

  2021cites this paper
• IRF4 Has a Unique Role in Early B Cell Development and Acts Prior to CD21 Expression to Control Marginal Zone B Cell Numbers

  2021cites this paper
• Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice

  2021cites this paper
• Signal-transducing adaptor protein-1 and -2 in hematopoiesis and diseases.

  2021cites this paper
• c-Myb expression is critical to maintain proliferation and glucose metabolism of large pre-B cells

  2020cites this paper
• CD83 expression regulates antibody production in response to influenza A virus infection

  2020cites this paper
• Dynamical modeling predicts an inflammation-inducible CXCR7+ B cell precursor with potential implications in lymphoid blockage pathologies

  2020influential citation
• B Cell Metabolism: An Understudied Opportunity to Improve Immune Therapy in Autoimmune Type 1 Diabetes

  2020cites this paper
• It Takes Three Receptors to Raise a B Cell.

  2020influential citation
• An Erg-driven transcriptional program controls B cell lymphopoiesis

  2020cites this paper
• Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.

  2020influential citation
• Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling

  2020cites this paper
• EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism

  2020influential citation
• Involvement of Blnk and Foxo1 in tumor suppression in BCR-ABL1-transformed pro-B cells

  2020cites this paper
• Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4.

  2020cites this paper
• New insights into the development of B cell responses: Implications for solid organ transplantation.

  2019cites this paper
• RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex

  2019influential citation
• Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma

  2019cites this paper
• The identification of immune responses required for durable control of childhood acute lymphoblastic leukemia

  2019cites this paper
• FoxO1 controls the expansion of pre-B cells by regulating the expression of interleukin 7 receptor α chain and its signal pathway.

  2019cites this paper
• CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas

  2019cites this paper
• CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis

  2019cites this paper
• RNAi Transfection Optimized in Primary Naïve B Cells for the Targeted Analysis of Human Plasma Cell Differentiation

  2019cites this paper
• Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation

  2019influential citation
• Cell circuits and niches controlling B cell development

  2019cites this paper
• FOXO genes in channel catfish and their response after bacterial infection

  2019cites this paper
• Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions

  2019cites this paper
• An Erg driven transcriptional program controls B-lymphopoiesis

  2019cites this paper
• At the intersection of DNA damage and immune responses

  2019cites this paper
• Exploring the Pre-B receptor checkpoint as a therapeutic target in acute lymphoblasic leukaemia

  2018cites this paper
• Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis

  2018cites this paper
• VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation

  2018cites this paper
• Molecular Regulation of Differentiation in Early B-Lymphocyte Development

  2018cites this paper
• Regulation of Energy Metabolism during Early B Lymphocyte Development

  2018influential citation
• Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development

  2018cites this paper
• BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

  2018cites this paper
• Changes in bursal B cells in chicken during embryonic development and early life after hatching

  2018cites this paper
• TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

  2018cites this paper
• Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.

  2018cites this paper
• Heterogeneity of memory B cells

  2018cites this paper
• The Role Of Spi-B And Pu.1 Transcription Factors In B Cell Development And In Suppression Of Leukemogenesis

  2018cites this paper
• PI3K induces B-cell development and regulates B cell identity

  2018cites this paper
• FOXO in B-cell lymphopoiesis and B cell neoplasia.

  2017cites this paper
• Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination

  2017cites this paper
• The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes

  2017cites this paper
• A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors.

  2017cites this paper
• Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation

  2017influential citation
• Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7

  2017cites this paper
• A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes.

  2017cites this paper
• Cell cycle RNA regulons coordinating early lymphocyte development

  2017cites this paper
• Retraction for Lee et al., “The BCL11A Transcription Factor Directly Activates RAG Gene Expression and V(D)J Recombination”

  2017influential citation
• A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1

  2017cites this paper
• Mechanisms of central tolerance for B cells

  2017cites this paper
• The miR‐15 family reinforces the transition from proliferation to differentiation in pre‐B cells

  2017cites this paper
• Activation-induced cytidine deaminase prevents pro-B cell acute lymphoblastic leukemia by functioning as a negative regulator in Rag1 deficient pro-B cells

  2017cites this paper
• Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation

  2017cites this paper
• The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation

  2017cites this paper
• Total cellular protein presence of the transcription factor IRF8 does not necessarily correlate with its nuclear presence.

  2017cites this paper
• Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription

  2017influential citation
• Regulation of B cell fate, survival, and function by mitochondria and autophagy.

  2017cites this paper
• The Ikaros family of zinc-finger proteins

  2016cites this paper
• Essential control of early B-cell development by Mef2 transcription factors.

  2016cites this paper
• Metabolic gatekeeper function of B-lymphoid transcription factors

  2016cites this paper
• orchestrate B cell fate.

  2016cites this paper
• Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3*

  2016cites this paper
• RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

  2016influential citation
• RAG-mediated DNA double-strand breaks activate a cell type–specific checkpoint to inhibit pre–B cell receptor signals

  2016influential citation