Regulation of Parkin E3 ubiquitin ligase activity

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cellular and Molecular Life Sciences

• Publication date

  2012-04-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00018-012-0978-5PMID 22527713PMCID PMC11115052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Toward understanding Machado-Joseph disease.

  2012cited by this paper
• Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin.

  2012influential reference
• Regulation of parkin and PINK1 by neddylation.

  2012cited by this paper
• Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential.

  2012cited by this paper
• Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

  2012cited by this paper
• 1.1.2 AUTOSOMAL RECESSIVE PARKINSONISM

  2012cited by this paper
• Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation

  2012cited by this paper
• Autosomal recessive parkinsonism.

  2012cited by this paper
• Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

  2012influential reference
• Linear ubiquitination prevents inflammation and regulates immune signalling

  2011cited by this paper
• Policing Parkin with a UblD

  2011cited by this paper
• Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

  2011cited by this paper
• Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

  2011cited by this paper
• PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.

  2011cited by this paper
• Parkinson's disease and cancer: two wars, one front

  2011cited by this paper
• SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

  2011cited by this paper
• UbcH7 reactivity profile reveals Parkin and HHARI to be RING/HECT hybrids

  2011cited by this paper
• DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.

  2011cited by this paper
• The Emerging Role of Linear Ubiquitination in Cell Signaling

  2011cited by this paper
• Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

  2011cited by this paper
• Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination

  2011influential reference
• Mitophagy and Parkinson's disease: The PINK1–parkin link

  2011cited by this paper
• Structural regulation of cullin-RING ubiquitin ligase complexes.

  2011cited by this paper
• The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.

  2011cited by this paper
• The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

  2011cited by this paper
• Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

  2011cited by this paper
• Parkin, A Top Level Manager in the Cell’s Sanitation Department

  2011cited by this paper
• Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

  2011cited by this paper
• PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.

  2011cited by this paper
• Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson’s disease

  2011cited by this paper
• Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation

  2011cited by this paper
• Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)

  2011influential reference
• Parkin Interacts with Ambra1 to Induce Mitophagy

  2011cited by this paper
• Mutant ataxin-3 promotes the autophagic degradation of parkin

  2011cited by this paper
• Posttranslational modifications as versatile regulators of parkin function.

  2011cited by this paper
• Autoregulation of Parkin activity through its ubiquitin‐like domain

  2011influential reference
• SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

  2011cited by this paper
• Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme*

  2011cited by this paper
• Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

  2010cited by this paper
• Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1

  2010cited by this paper
• The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

  2010cited by this paper
• Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy.

  2010cited by this paper
• PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

  2010cited by this paper
• Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

  2010cited by this paper
• Mechanisms of mitophagy

  2010cited by this paper
• The diversity of ubiquitin recognition: hot spots and varied specificity.

  2010cited by this paper
• PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

  2010cited by this paper
• Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy*

  2010cited by this paper
• Genetic Analysis of Pathways to Parkinson Disease

  2010cited by this paper
• Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

  2010cited by this paper
• Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

  2010cited by this paper
• Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

  2010cited by this paper
• Genetic Etiology of Parkinson Disease Associated with Mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 Genes: A Mutation Update

  2010cited by this paper
• Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling.

  2010cited by this paper
• The role of parkin in familial and sporadic Parkinson's disease

  2010cited by this paper
• Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.

  2010cited by this paper
• Ubiquitin signalling in DNA replication and repair

  2010cited by this paper
• Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

  2010cited by this paper
• PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

  2010cited by this paper
• The emerging complexity of protein ubiquitination.

  2009cited by this paper
• Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

  2009cited by this paper
• Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin*

  2009cited by this paper
• Programmed cell death‐2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease

  2009cited by this paper
• SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.

  2009cited by this paper
• Nonproteolytic functions of ubiquitin in cell signaling.

  2009cited by this paper
• Building ubiquitin chains: E2 enzymes at work

  2009cited by this paper
• Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

  2009cited by this paper
• DNA damage induces nuclear translocation of parkin

  2009cited by this paper
• Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation*

  2009cited by this paper
• Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.

  2009cited by this paper
• PINK1 function in health and disease

  2009cited by this paper
• Breaking the chains: structure and function of the deubiquitinases

  2009cited by this paper
• Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

  2009cited by this paper
• S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

  2009cited by this paper
• S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

  2009cited by this paper
• Faculty Opinions recommendation of S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.

  2009cited by this paper
• Parkin occurs in a stable, non-covalent, ∼110-kDa complex in brain

  2008cited by this paper
• An Integrated Genomic Analysis of Human Glioblastoma Multiforme

  2008cited by this paper
• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

  2008cited by this paper
• PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.

  2008cited by this paper
• Combined kinase inhibition modulates parkin inactivation

  2008cited by this paper
• Of Parkin and Parkinson's: light and dark sides of a multifaceted E3 ubiquitin–protein ligase

  2007cited by this paper
• Silencing of the Pink1 Gene Expression by Conditional RNAi Does Not Induce Dopaminergic Neuron Death in Mice

  2007cited by this paper
• Characterizing the cancer genome in lung adenocarcinoma

  2007cited by this paper
• Parkin Mediates Neuroprotection through Activation of IκB Kinase/Nuclear Factor-κB Signaling

  2007cited by this paper
• Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

  2007cited by this paper
• Update on the genetics of Parkinson's disease

  2007cited by this paper
• Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

  2007cited by this paper
• Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

  2007cited by this paper
• Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.

  2007cited by this paper
• Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels.

  2007cited by this paper
• Phosphorylation of Parkin by the Cyclin-dependent Kinase 5 at the Linker Region Modulates Its Ubiquitin-Ligase Activity and Aggregation*

  2007cited by this paper
• Functional modulation of parkin through physical interaction with SUMO‐1

  2006influential reference
• Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

  2006cited by this paper
• Parkin Ubiquitinates and Promotes the Degradation of RanBP2*

  2006cited by this paper
• Identification of Far Upstream Element-binding Protein-1 as an Authentic Parkin Substrate*

  2006cited by this paper
• Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

  2006cited by this paper
• Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

  2006cited by this paper
• A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling

  2006cited by this paper

• Synergism of IP3R and Parkin mutants identifies mitochondrial stress as an early feature of Parkinson's disease

  2025cites this paper
• E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

  2025influential citation
• PRKN-linked familial Parkinson’s disease: cellular and molecular mechanisms of disease-linked variants

  2024cites this paper
• MANF facilitates breast cancer cell survival under glucose-starvation conditions via PRKN-mediated mitophagy regulation

  2024cites this paper
• Effects and mechanisms of bisphenols exposure on neurodegenerative diseases risk: A systemic review.

  2024cites this paper
• Pathogenetic factors in Parkinson disease and novel experimental therapies

  2022cites this paper
• Mdm2 enhances ligase activity of parkin and facilitates mitophagy

  2020cites this paper
• Computer-aided Analysis of Selective Phytochemicals as Potent Inhibitors of Parkin: Major Biological Target of Parkinson’s disease

  2020cites this paper
• Promoter DNA Hypermethylation-Implications for Alzheimer's Disease.

  2019cites this paper
• Autophagy in Neurodegenerative Diseases

  2019cites this paper
• Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma

  2019cites this paper
• Neuronal Proteomic Analysis of the Ubiquitinated Substrates of the Disease-Linked E3 Ligases Parkin and Ube3a

  2018cites this paper
• The M458L missense mutation disrupts the catalytic properties of Parkin

  2018cites this paper
• PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect

  2018cites this paper
• Differential expression of PARK2 splice isoforms in an in vitro model of dopaminergic‐like neurons exposed to toxic insults mimicking Parkinson's disease

  2018cites this paper
• Phosphorylation of Arabidopsis SINA2 by CDKG1 affects its ubiquitin ligase activity

  2018cites this paper
• Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease

  2018cites this paper
• Mechanisms, pathophysiological roles and methods for analyzing mitophagy – recent insights

  2018cites this paper
• Parkin-phosphoubiquitin complex reveals a cryptic ubiquitin binding site required for RBR ligase activity

  2017cites this paper
• Glutaredoxin-1 As A Therapeutic Target In Neurodegenerative Inflammation

  2017cites this paper
• Chapter 5 – Mitophagy

  2017cites this paper
• Parkinson’s Disease-associated proteins: studying their role in mitophagy with cellular and Drosophila models

  2017influential citation
• Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

  2017cites this paper
• Ubiquitin and Parkinson's disease through the looking glass of genetics

  2017cites this paper
• How Studies of the Serotonin System in Macaque Models of Menopause Relate to Alzheimer’s Disease

  2016cites this paper
• Specificity and disease in the ubiquitin system

  2016cites this paper
• Expression Profile of Human PARK2 Splicing Isoforms in Peripheral Blood Cells and Isolated Lymphomonocytes

  2016cites this paper
• Synaptic functions of the ubiquitin ligase TRIM3

  2016cites this paper
• Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G

  2016cites this paper
• Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

  2016cites this paper
• Targeting Pink1-Parkin-mediated mitophagy for treating liver injury.

  2015cites this paper
• Molecular characterization of the Parkinson's associated protein DJ-1

  2015cites this paper
• Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation

  2015cites this paper
• Mitochondrial Dynamics, Mitophagy and Mitochondrial Spheroids in Drug-Induced Liver Injury

  2015cites this paper
• Expression profile of parkin isoforms in human gliomas.

  2015cites this paper
• Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases

  2015cites this paper
• Parkin Is Dispensable for Mitochondrial Function, but Its Ubiquitin Ligase Activity Is Critical for Macroautophagy and Neurotransmitters: Therapeutic Potential beyond Parkinson's Disease

  2015cites this paper
• Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

  2015cites this paper
• Parkin Regulates Mitosis a nd Genomic Stability through Cdc 20 / Cdh 1 Graphical Abstract Highlights

  2015cites this paper
• Linking microtubules to Parkinson's disease: the case of parkin.

  2015cites this paper
• Inflammation is genetically implicated in Parkinson's disease.

  2015cites this paper
• Keeping the immune system in check: a role for mitophagy

  2015cites this paper
• Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques

  2015cites this paper
• Structural and Functional Impact of Parkinson Disease‐Associated Mutations in the E3 Ubiquitin Ligase Parkin

  2015cites this paper
• DUBs counteract parkin for efficient mitophagy

  2014cites this paper
• INCREASE OF BASAL OXIDATIVE STRESS LEVELS AND IMPAIRMENT OF HEME OXYGENASE-1/BILIVERDIN REDUCTASE POST-TRANSLATIONAL MODIFICATION BY THE DEFECT OF PARKINSON-RELATED GENE OF PINK1

  2014cites this paper
• New insights into ubiquitin E3 ligase mechanism

  2014cites this paper
• Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

  2014cites this paper
• PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

  2014cites this paper
• RBR E3 ubiquitin ligases: new structures, new insights, new questions

  2014cites this paper
• Cell-Permeable Parkin Proteins Suppress Parkinson Disease-Associated Phenotypes in Cultured Cells and Animals

  2014cites this paper
• Parkin and PINK1: much more than mitophagy.

  2014cites this paper
• A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

  2014cites this paper
• Role of the Innate and Adaptive Immune System in the Pathogenesis of PD

  2014cites this paper
• Regulation in Cell Cycle via p53 and PTEN Tumor Suppressors

  2014cites this paper
• Behavioral characterization of C. elegans homologs of Parkinson's disease associated genes

  2014cites this paper
• DNAJ proteins: more than just “co-chaperones”

  2014cites this paper
• Protéine impliquée dans la réplication de l'adn, et modulation de son activité

  2014cites this paper
• Posttranslational modification and quality control.

  2013cites this paper
• Structure of the human Parkin ligase domain in an autoinhibited state

  2013cites this paper
• Insights into NEDD8 function and the regulation of its conjugation system

  2013cites this paper
• A Whole Genome RNAi Screen to Identify Novel Promoters of PINK1/Parkin-mediated Mitophagy

  2013cites this paper
• The Role of Innate and Adaptive Immunity in Parkinson's Disease

  2013cites this paper
• Functions of autophagy in normal and diseased liver

  2013cites this paper
• Linear ubiquitination-mediated NF-κB regulation and its related disorders.

  2013cites this paper
• Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

  2013cites this paper
• Genetik von Bewegungsstörungen

  2013cites this paper
• Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer?

  2013cites this paper
• Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver☆

  2013cites this paper
• An emerging role of PARK2 in cancer

  2013cites this paper
• A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

  2013cites this paper
• GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

  2013influential citation
• ubiquitin-proteasome system Posttranslational Modification and Quality Control

  2013cites this paper
• JB Review Linear ubiquitination-mediated NF-iB regulation and its related disorders

  2013cites this paper
• Análise de redes de interação transcricional na substância nigra, locus cerúleo e núcleo dorsal do nervo vago na Doença de Parkinson

  2013cites this paper