Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Journal of Neurology Neurosurgery & Psychiatry

• Publication date

  1981-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/jnnp.44.11.991PMID 6801211PMCID PMC491202
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of an aldose reductase inhibitor on diabetic peripheral neuropathy. Preliminary report.

  1981cited by this paper
• Variability of sensory threshold determination in clinical use.

  1981cited by this paper
• Early peripheral nerve abnormalities in diabetes: an animal model.

  1980cited by this paper
• Relation between hemoglobin AI and determinations of glucose in diabetics treated with and without insulin.

  1980cited by this paper
• Diabetic Neuropathy in the Mutant Mouse [C57BL/ks(db/db)]: A Morphometric Study

  1980cited by this paper
• Sympathetic reflex latencies and conduction velocities in patients with polyneuropathy.

  1980cited by this paper
• Diabetic Neuropathy—New Concepts of Its Etiology

  1979cited by this paper
• Aldose reductase inhibition: studies with alrestatin.

  1979cited by this paper
• Increased endoneurial fluid pressure in galactose neuropathy

  1979cited by this paper
• Standardised method of determining vibratory perception thresholds for diagnosis and screening in neurological investigation.

  1979cited by this paper
• Dietary myo-inositol intake and peripheral nerve function in diabetic neuropathy.

  1979cited by this paper
• Nerve conduction abnormalities in untreated maturity-onset diabetes: relation to levels of fasting plasma glucose and glycosylated hemoglobin.

  1979cited by this paper
• Myoinositol and function of peripheral nerves in human diabetics A CONTROLLED CLINICAL TRIAL

  1978cited by this paper
• Effect of myo-inositol on peripheral-nerve function in diabetes.

  1978cited by this paper
• Influence of dietary myoinositol on nerve conduction and inositol phospholipids in normal and diabetic rats.

  1978cited by this paper
• Peripheral Nerve Fiber Size in Experimental Diabetes

  1977cited by this paper
• Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes.

  1977cited by this paper
• Peripheral and Autonomic Nerve Function in Newly Diagnosed Diabetes Mellitus

  1977cited by this paper
• Alloxan diabetic neuropathy

  1977cited by this paper
• [Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (2nd part) (author's transl)].

  1977cited by this paper
• [Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (author's transl)].

  1977cited by this paper
• [Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (3rd and last part) (author's transl)].

  1977cited by this paper
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  1976cited by this paper
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  1976cited by this paper
• Mortality in diabetic autonomic neuropathy.

  1976cited by this paper
• ALLOXAN DIABETIC NEUROPATHY: ELECTRON MICROSCOPIC STUDIES

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  1975cited by this paper
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  1975cited by this paper
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  1975cited by this paper
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  1974cited by this paper
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  1974cited by this paper
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  1974cited by this paper
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  1973cited by this paper
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  1973cited by this paper
• Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase Inhibitor

  1973cited by this paper
• Role of sorbitol pathway in neuropathy.

  1973cited by this paper
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  1973cited by this paper
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  1973cited by this paper
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  1972cited by this paper
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  1972cited by this paper
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  1971cited by this paper
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  1971cited by this paper
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  1970cited by this paper
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  1970cited by this paper
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  1968cited by this paper
• [Diabetic neuropathy. Pathologic anatomy, pathophysiology and pathogenesis on the basis of electron microscopic studies].

  1968cited by this paper
• Diabetische Neuropathie

  1968cited by this paper
• The Sorbitol Pathway: Enzyme Localization and Content in Normal and Diabetic Nerve and Cord

  1968cited by this paper
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  1967cited by this paper
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  1967cited by this paper
• Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes

  1966cited by this paper
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  1965cited by this paper
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  1962cited by this paper
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  1959cited by this paper
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  1953cited by this paper
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  1951cited by this paper
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  1945cited by this paper

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  2026cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Comparative analysis of electrophysiological parameters of sural nerve in normal and type-2 diabetic subjects

  2017cites this paper
• A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy.

  2016cites this paper
• Aldose Reductase Inhibitors in Clinical Practice

  2012cites this paper
• Sorbitol, Myo-Inositol and Sodium-Potassium ATPase in Diabetic Peripheral Nerve

  2012cites this paper
• Diabetic neuropathy: still a challenge in pharmacology.

  2010cites this paper
• Diabetic peripheral neuropathies.

  2010cites this paper
• From a dull enzyme to something else: facts and perspectives regarding aldose reductase.

  2008cites this paper
• Aldose reductase, still a compelling target for diabetic neuropathy.

  2008cites this paper
• Aldose Reductase Inhibitors for the Treatment of Diabetic Neuropathy

  2007cites this paper
• Aldose reductase inhibitors for the treatment of diabetic polyneuropathy.

  2007cites this paper
• Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential component.

  2006cites this paper
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  2006cites this paper
• Clinical Potential of Aldose Reductase Inhibitors in Diabetic Neuropathy

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998influential citation
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  1997cites this paper
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  1996cites this paper
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  1996cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1988cites this paper
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  1988cites this paper
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  1988cites this paper
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  1988cites this paper
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  1988cites this paper
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  1988cites this paper
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  1988cites this paper
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  1987cites this paper
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  1987cites this paper
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  1987cites this paper
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  1987cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1985cites this paper
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  1985cites this paper
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  1985cites this paper
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  1985cites this paper
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  1985cites this paper