Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Human Molecular Genetics

• Publication date

  2002-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/11.20.2409PMID 12351576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prediction and statistical analysis of alternatively spliced exons.

  2003cited by this paper
• An extensive network of coupling among gene expression machines

  2002cited by this paper
• Alternative Splicing and Neuritic mRNA Translocation Under Long-Term Neuronal Hypersensitivity

  2002cited by this paper
• The mRNA assembly line: transcription and processing machines in the same factory.

  2002cited by this paper
• Profiling alternative splicing on fiber-optic arrays

  2002cited by this paper
• SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1.

  2002cited by this paper
• Defects in Pre-mRNA Processing as Causes of and Predisposition to Diseases

  2002cited by this paper
• Messenger-RNA-binding proteins and the messages they carry

  2002cited by this paper
• Inhibition of the Splicing of Glucose-6-phosphate Dehydrogenase Precursor mRNA by Polyunsaturated Fatty Acids*

  2002cited by this paper
• Ischemia Induces a Translocation of the Splicing Factor tra2-β1 and Changes Alternative Splicing Patterns in the Brain

  2002influential reference
• Alternative splicing: multiple control mechanisms and involvement in human disease.

  2002cited by this paper
• A genomic view of alternative splicing

  2002cited by this paper
• A question of size: the eukaryotic proteome and the problems in defining it.

  2002cited by this paper
• Splicing regulation as a potential genetic modifier.

  2002cited by this paper
• Listening to silence and understanding nonsense: exonic mutations that affect splicing

  2002cited by this paper
• Synaptic Activity-Induced Conversion of Intronic to Exonic Sequence in Homer 1 Immediate Early Gene Expression

  2002cited by this paper
• A conserved mRNA export machinery coupled to pre-mRNA splicing.

  2002cited by this paper
• Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

  2002cited by this paper
• Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol.

  2001cited by this paper
• The sequence of the human genome (abstract only)

  2001cited by this paper
• Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.

  2001cited by this paper
• Regulation of murine survival motor neuron (Smn) protein levels by modifying Smn exon 7 splicing.

  2001cited by this paper
• Treatment of spinal muscular atrophy by sodium butyrate

  2001cited by this paper
• Identification of genes expressed in the amygdala during the formation of fear memory.

  2001cited by this paper
• Regulation of the Processing of Glucose-6-phosphate Dehydrogenase mRNA by Nutritional Status*

  2001cited by this paper
• Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.

  2001cited by this paper
• Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer

  2001cited by this paper
• Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors.

  2001cited by this paper
• Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.

  2001cited by this paper
• Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients.

  2001cited by this paper
• Coordination between transcription and pre‐mRNA processing

  2001cited by this paper
• Insulin Regulates Alternative Splicing of Protein Kinase C βII through a Phosphatidylinositol 3-Kinase-dependent Pathway Involving the Nuclear Serine/Arginine-rich Splicing Factor, SRp40, in Skeletal Muscle Cells*

  2001cited by this paper
• The Sequence of the Human Genome

  2001cited by this paper
• Initial sequencing and analysis of the human genome

  2001cited by this paper
• A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels

  2001influential reference
• Coordination between transcription and pre-mRNA processing

  2001cited by this paper
• Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors.

  2001cited by this paper
• Polypyrimidine Track-binding Protein Binding Downstream of Caspase-2 Alternative Exon 9 Represses Its Inclusion*

  2001cited by this paper
• Pre-mRNA splicing in the new millennium.

  2001cited by this paper
• Regulation of alternative pre‐mRNA splicing by the ERK MAP‐kinase pathway

  2001cited by this paper
• Genome-wide detection of alternative splicing in expressed sequences of human genes

  2001cited by this paper
• Spliceosomal UsnRNP biogenesis, structure and function.

  2001cited by this paper
• Alternative RNA splicing in the nervous system.

  2001cited by this paper
• RNA processing and human disease

  2000cited by this paper
• Sorting out the complexity of SR protein functions.

  2000cited by this paper
• The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

  2000cited by this paper
• Heterogeneous Ribonucleoprotein A1 Is Part of an Exon-specific Splice-silencing Complex Controlled by Oncogenic Signaling Pathways*

  2000cited by this paper
• Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development.

  2000cited by this paper
• Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

  2000cited by this paper
• Cold shock induces the insertion of a cryptic exon in the neurofibromatosis type 1 (NF1) mRNA.

  2000cited by this paper
• Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.

  2000cited by this paper
• Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases.

  2000cited by this paper
• Misregulation of pre-mRNA splicing that causes human diseases

  2000cited by this paper
• An update of the mutation spectrum of the survival motor neuron gene (SMN1) in autosomal recessive spinal muscular atrophy (SMA)

  2000cited by this paper
• Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2).

  2000cited by this paper
• Alternative pre-mRNA splicing: the logic of combinatorial control.

  2000cited by this paper
• An Alternative-Exon Database and Its Statistical Analysis

  2000cited by this paper
• A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras

  2000cited by this paper
• A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy.

  1999cited by this paper
• mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription.

  1999cited by this paper
• Cloning and characterization of two neural‐salient serine/arginine‐rich (NSSR) proteins involved in the regulation of alternative splicing in neurones

  1999cited by this paper
• Regulation of alternative splicing by RNA editing

  1999cited by this paper
• Developmental regulation of SR protein phosphorylation and activity.

  1999cited by this paper
• Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis

  1999cited by this paper
• Activity‐dependent regulation of alternative splicing patterns in the rat brain

  1999cited by this paper
• SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation

  1999cited by this paper
• Increase in syntaxin 1B and glutamate release in mossy fibre terminals following induction of LTP in the dentate gyrus: a candidate molecular mechanism underlying transsynaptic plasticity

  1998cited by this paper
• Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site selection.

  1998cited by this paper
• Control of alternative splicing of potassium channels by stress hormones.

  1998cited by this paper
• Acidic stimulation induces a negative regulatory factor that affects alternative exon selection in vitro in human ATP synthase gamma-subunit pre-mRNA.

  1998cited by this paper
• Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

  1998cited by this paper
• Exon III splicing switch of fibroblast growth factor (FGF) receptor-2 and -3 can be induced by FGF-1 or FGF-2

  1998cited by this paper
• Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors.

  1998cited by this paper
• Coupling of signal transduction to alternative pre‐mRNA splicing by a composite splice regulator

  1998influential reference
• A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm.

  1998cited by this paper
• Induction of Long‐Term Potentiation In Vivo Regulates Alternate Splicing to Alter Syntaxin 3 Isoform Expression in Rat Dentate Gyrus

  1998cited by this paper
• Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

  1998cited by this paper
• Acute stress facilitates long-lasting changes in cholinergic gene expression

  1998cited by this paper
• Expression and RNA Splicing of the Maize Glutathione S-Transferase Bronze2 Gene Is Regulated by Cadmium and Other Stresses

  1997cited by this paper
• The molecular basis of partial penetrance of splicing mutations in cystic fibrosis.

  1997cited by this paper
• Selective Regulation of Agrin mRNA Induction and Alternative Splicing in PC12 Cells by Ras-dependent Actions of Nerve Growth Factor*

  1997cited by this paper
• Effect of heat shock treatment on the production of variant testosterone‐repressed prostate message‐2 (TRPM‐2) mRNA in culture cells

  1997cited by this paper
• Functional association between promoter structure and transcript alternative splicing.

  1997cited by this paper
• HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver

  1997cited by this paper
• Alternative Splicing of Human Inducible Nitric-Oxide Synthase mRNA

  1996cited by this paper
• NF1 mRNA isoform expression in PC12 cells: modulation by extrinsic factors.

  1996cited by this paper
• Change in plasma membrane Ca2(+)-ATPase splice-variant expression in response to a rise in intracellular Ca2+.

  1996cited by this paper
• Insulin regulated PKC isoform mRNA in rat adipocytes.

  1996cited by this paper
• The Alternative Splicing Pattern of the Tenascin-C Pre-mRNA Is Controlled by the Extracellular pH (*)

  1995cited by this paper
• Regulation of alternative splicing of the fibronectin IIICS domain by cytokines.

  1994cited by this paper
• Expression and modulation of CD44 variant isoforms in humans

  1994cited by this paper
• Alternative splicing of class Ib major histocompatibility complex transcripts in vivo leads to the expression of soluble Qa-2 molecules in murine blood.

  1994cited by this paper
• Alternative 5' splice site selection induced by heat shock

  1994cited by this paper
• Construction of a novel database containing aberrant splicing mutations of mammalian genes.

  1994cited by this paper
• Insulin-inducible changes in insulin receptor mRNA splice variants.

  1994cited by this paper
• Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells.

  1993cited by this paper
• Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA.

  1993cited by this paper
• Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock

  1993cited by this paper
• The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences

  1992cited by this paper
• Hippocampal kindling increases the expression of glutamate receptor-A Flip and -B Flip mRNA in dentate granule cells.

  1992cited by this paper

• REVEILLE2 Thermosensitive Splicing: A Molecular Basis for the Integration of Nocturnal Temperature Information by the Arabidopsis Circadian Clock

  2023cites this paper
• lncRNA ZFAS1 Promotes HMGCR mRNA Stabilization via Binding U2AF2 to Modulate Pancreatic Carcinoma Lipometabolism

  2022cites this paper
• ADAM10 as a biomarker of mild cognitive impairment but not of cognitive frailty.

  2021cites this paper
• Mutations in cis that affect mRNA synthesis, processing and translation.

  2021cites this paper
• Targeting the splice factor kinase CLK1 in prostate cancer cells

  2020cites this paper
• Functional significance of U2AF1 S34F mutations in lung adenocarcinomas

  2019cites this paper
• C 6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1

  2019cites this paper
• Binding of SRSF4 to a novel enhancer modulates splicing of exon 6 of Fas pre-mRNA.

  2018cites this paper
• Quantitative proteome analyses of phosphorylated proteins and alternative splice variants in human cell lines and urine

  2018cites this paper
• Marine-derived protein kinase inhibitors for neuroinflammatory diseases

  2018cites this paper
• The posterior pituitary expresses the serotonin receptor 2C.

  2018cites this paper
• Presence of Androgen Receptor Variant in Neuronal Lipid Rafts

  2017cites this paper
• A tale of two paralogs: human Transformer2 proteins with differential RNA-binding affinities

  2016cites this paper
• [Cytokine-mediated regulation of expression of Gfi1 and U2afll4 genes activated by T-cells with different differentiation status in vitro].

  2016cites this paper
• Global intron retention mediated gene regulation during CD4+ T cell activation

  2016cites this paper
• Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins.

  2016cites this paper
• ROLE OF HNRNP H IN A REVERSIBLE FINE-TUNING MECHANISM OFSPLICING RESPONSE UPON TRANSCRIPTIONAL PAUSING

  2016cites this paper
• Cytokine-mediated regulation of expression of Gfi1 and U2afll4 genes by activated T-cells with various differentiation status in vitro

  2015cites this paper
• mRNA Variants of a Neuronal Sodium Channel in Rat Cardiac Myocytes

  2015cites this paper
• submaximal exercise expression in human skeletal muscle following VEGF-A splice variants and related receptor

  2015cites this paper
• Transcription, Signaling Receptor Activity, Oxidative Phosphorylation, and Fatty Acid Metabolism Mediate the Presence of Closely Related Species in Distinct Intertidal and Cold-Seep Habitats

  2015cites this paper
• Third Report on Chicken Genes and Chromosomes 2015

  2015cites this paper
• ARH-seq: identification of differential splicing in RNA-seq data

  2014cites this paper
• Structural Basis for Regulation of RNA-Binding Proteins by Phosphorylation

  2014cites this paper
• Illuminating the Transcriptome through the Genome

  2014cites this paper
• GFAP variants in health and disease: stars of the brain… and gut

  2014cites this paper
• Aberrant regulation of alternative pre-mRNA splicing in hepatocellular carcinoma.

  2014cites this paper
• When chromatin structure meets CD6 exon 5 alternative splicing: an encounter triggered by T cell activation

  2014cites this paper
• Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing

  2013cites this paper
• Genetics and Philosophy: An Introduction

  2013cites this paper
• Alternative splicing regulation in programmed cell death and neurological disorders: A systems biology approach

  2013cites this paper
• Alterations of Alternative Splicing Patterns of Ser/Arg-Rich (SR) Genes in Response to Hormones and Stresses Treatments in Different Ecotypes of Rice (Oryza sativa)

  2013cites this paper
• Analysis strategy of protein-protein interaction networks.

  2013cites this paper
• Inference of alternative splicing from tiling array data.

  2013cites this paper
• Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms

  2013cites this paper
• Transcription control of DAPK

  2013cites this paper
• Mechanism of action of GGA, a targeted oligonucleotide enhancer of splicing developed for the treatment of spinal muscular atrophy

  2013cites this paper
• MEF2C exon α: role in gene activation and differentiation.

  2013cites this paper
• Changes in Cell Morphology and the Cellular Localization of Protein Kinase Dsk1 in Schizosaccharomyces pombe in Response to Butylated Hydroxyanisole

  2013cites this paper
• Modulation of Pre-mRNA Splicing Patterns with Synthetic Chemicals and Their Clinical Applications

  2012cites this paper
• AMPA receptor assembly: atomic determinants and built-in modulators.

  2012cites this paper
• Alternative splicing in plants – coming of age

  2012cites this paper
• Characterization of [gamma]' fibrinogen as a cardiovascular risk marker

  2012cites this paper
• Effect of hyperglycaemia on VEGF-A splice variants, junctional integrity and vascular leakage in human feto-placental vessels from normal and type 1 diabetic pregnancies

  2012cites this paper
• Novel approaches to understanding Hent2 and hENT2-related proteins: From novelnuclear variants to global networks / Nuevos enfoques sobre el estudio de hENT2 y proteínas relacionadas: desde nuevas variantes nucleares a redes globales

  2012cites this paper
• How does Tra2β protein regulate tissue-specific RNA splicing?

  2012cites this paper
• Longins and the longin domain: pivotal elements in subcellular trafficking and neuronal differentiation

  2012cites this paper
• Use of single molecule methods to reveal the mechanisms of splice site selection

  2012cites this paper
• Genome-wide activation of latent donor splice sites in stress and disease

  2012cites this paper
• Splicing of mouse p53 pre-mRNA does not always follow the “first come, first served” principle and may be influenced by cisplatin treatment and serum starvation

  2012cites this paper
• Post-transcriptional regulation in cancer progression

  2012cites this paper
• Alternative Splicing of a Novel Inducible Exon Diversifies the CASK Guanylate Kinase Domain

  2012cites this paper
• Alternative splicing of the human gene SYBL1 modulates protein domain architecture of longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms

  2011cites this paper
• C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1

  2011cites this paper
• RNA splicing: disease and therapy.

  2011cites this paper
• Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development

  2011cites this paper
• Signaling from depolarization to alternative splicing: Identification of molecular links mediating inducible exon skipping

  2011cites this paper
• A study to investigate the expression, structure and function of alternatively spliced progesterone receptor variants in breast cancer cells

  2011cites this paper
• The emerging role of pre-messenger RNA splicing in stress responses: Sending alternative messages and silent messengers

  2011cites this paper
• Identification and Characterization of Alternative Promoters, Transcripts and Protein Isoforms of Zebrafish R2 Gene

  2011cites this paper
• Kainate promotes alterations in neuronal RNA splicing machinery.

  2011cites this paper
• Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.

  2011cites this paper
• Characterization of the mechanisms behind the alternative splicing of the mutually exclusive exons 18N and 18A in the sodium channel gene SCN8A and mutually exclusive exons 5N and 5A in the soldium channel gene SCN9A

  2011cites this paper
• Role of Alternative Splicing of the 5-HT 2C Receptor in the Prader–Willi Syndrome

  2011cites this paper
• Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer.

  2011cites this paper
• Quantitative phosphoproteomics reveals link between Helicobacter pylori infection and RNA splicing modulation in host cells

  2011cites this paper
• Identification and Analysis of Two Splice Variants of Human G2A Generated by Alternative Splicing

  2010cites this paper
• Splice factor SFRS5: Regulation by p53 and effect on IL-24 splicing

  2010cites this paper
• Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes

  2010cites this paper
• Alternative splicing and breast cancer

  2010cites this paper
• Régulation de l’épissage alternatif de l’exon 16 du pré-messager 4.1R au cours de la différenciation érythroïde : implication de la voie de signalisation PI3- Kinase

  2010cites this paper
• A comprehensive survey of human polymorphisms at conserved splice dinucleotides and its evolutionary relationship with alternative splicing

  2010cites this paper
• A conserved unusual posttranscriptional processing mediated by short, direct repeated (SDR) sequences in plants.

  2010cites this paper
• IL-10 alters prolactin receptor activity emulating that during breast cancer.

  2010cites this paper
• A comparative approach for the investigation of biological information processing: An examination of the structure and function of computer hard drives and DNA

  2010influential citation
• Alternative splicing of genes during neuronal differentiation of NT2 pluripotential human embryonal carcinoma cells

  2010cites this paper
• Splicing Systems for Studying Signaling to the Spliceosome

  2010cites this paper
• Exhaustive Analysis of the Modular Structure of the Spliceosomal Assembly Network: A Petri Net Approach

  2010cites this paper
• Role of Alternative Splicing of the Serotonin Receptor 2 C in the Prader – Willi Syndrome

  2010cites this paper
• Vitamin A Metabolite, All-trans-retinoic Acid, Mediates Alternative Splicing of Protein Kinase C δVIII (PKCδVIII) Isoform via Splicing Factor SC35*

  2010cites this paper
• Child and adolescent psychiatric genetics

  2010cites this paper
• DARPP-32 binds to tra2-beta1 and influences alternative splicing.

  2010cites this paper
• Alternative splicing and disease.

  2009cites this paper
• Activin A selectively represses expression of the membrane-bound isoform of Kit ligand in human fetal ovary.

  2009cites this paper
• Regulation of alternative splicing of the small GTPase Rac1

  2009influential citation
• Alternative splicing and biological heterogeneity in prostate cancer

  2009cites this paper
• Control of Alternative Splicing by Signal-dependent Degradation of Splicing-regulatory Proteins*

  2009cites this paper
• Global Analysis of Allele-Specific Expression in Arabidopsis thaliana

  2009cites this paper
• Computational analysis of alternative splicing in human and mice

  2009cites this paper
• Identification and Functional Analyses of 11 769 Full-length Human cDNAs Focused on Alternative Splicing

  2009cites this paper
• Differenzielle Regulation des Zytokin-induzierten alternativen Spleißens des TF Gens in humanen Endothelzellen

  2009cites this paper
• Nuclear phosphoinositide signaling regulates messenger RNA export

  2009cites this paper
• The Heterogeneous Nuclear Ribonucleoprotein L Is an Essential Component in the Ca2+/Calmodulin-dependent Protein Kinase IV-regulated Alternative Splicing through Cytidine-Adenosine Repeats*

  2009cites this paper
• UvA-DARE ( Digital Academic Repository ) Alternative splicing of thyroid hormone receptor alpha transcripts during health and disease

  2009cites this paper
• Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma

  2008cites this paper
• A G-tract element in apoptotic agents-induced alternative splicing

  2008cites this paper
• A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

  2008cites this paper
• Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.

  2008cites this paper
• Substances that can change alternative splice-site selection.

  2008cites this paper
• Alternative pre-mRNA Splicing: Signals and Evolution

  2008cites this paper