Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Molecular Cell Biology

• Publication date

  2013-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/jmcb/mjs066PMID 23329852
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• RNF8‐ and RNF168‐dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

  2012cited by this paper
• ORC1 BAH domain links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome

  2012cited by this paper
• Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

  2011cited by this paper
• The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

  2011cited by this paper
• ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation

  2011cited by this paper
• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.

  2011cited by this paper
• Developing histone deacetylase inhibitors as anti-cancer therapeutics.

  2011cited by this paper
• NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

  2011cited by this paper
• Coupling mitosis to DNA replication: the emerging role of the histone H4-lysine 20 methyltransferase PR-Set7.

  2011cited by this paper
• Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast

  2011cited by this paper
• The DNA damage response: making it safe to play with knives.

  2010cited by this paper
• MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

  2010cited by this paper
• The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

  2010cited by this paper
• 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

  2010cited by this paper
• MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1

  2010cited by this paper
• Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

  2010cited by this paper
• Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.

  2010cited by this paper
• The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

  2010cited by this paper
• ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.

  2010cited by this paper
• The DNA-damage response in human biology and disease

  2009cited by this paper
• 53BP1: function and mechanisms of focal recruitment.

  2009cited by this paper
• A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

  2009cited by this paper
• The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate

  2009cited by this paper
• Solving the RIDDLE of 53BP1 recruitment to sites of damage

  2009cited by this paper
• Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay

  2009cited by this paper
• Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development

  2009cited by this paper
• Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells

  2008cited by this paper
• A combinatorial H4 tail library for exploring the histone code.

  2008cited by this paper
• SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

  2008cited by this paper
• Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20*

  2008cited by this paper
• 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

  2008cited by this paper
• A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

  2008cited by this paper
• The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more?

  2008cited by this paper
• The γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more?

  2008cited by this paper
• SIRT1 promotes DNA repair activity and deacetylation of Ku70

  2007cited by this paper
• The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

  2007cited by this paper
• Certain and Progressive Methylation of Histone H4 at Lysine 20 during the Cell Cycle

  2007cited by this paper
• SIRT1 regulates the function of the Nijmegen breakage syndrome protein.

  2007cited by this paper
• DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007cited by this paper
• Positional stability of single double-strand breaks in mammalian cells

  2007cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007cited by this paper
• Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation.

  2007cited by this paper
• Androgen receptor activity is inhibited in response to genotoxic agents in a p53-independent manner

  2006cited by this paper
• Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions

  2006cited by this paper
• Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

  2006cited by this paper
• Tudor, MBT and chromo domains gauge the degree of lysine methylation

  2006cited by this paper
• Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer.

  2006cited by this paper
• Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

  2006cited by this paper
• Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest.

  2006cited by this paper
• Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.

  2005cited by this paper
• Localized Histone Acetylation and Deacetylation Triggered by the Homologous Recombination Pathway of Double-Strand DNA Repair

  2005cited by this paper
• MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

  2005cited by this paper
• Involvement of Human MOF in ATM Function

  2005cited by this paper
• Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair.

  2004cited by this paper
• Acetylation of yeast histone H4 lysine 16: a switch for protein interactions in heterochromatin and euchromatin.

  2004cited by this paper
• Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.

  2004cited by this paper
• Histone H4 Hyperacetylation Precludes Histone H4 Lysine 20 Trimethylation*

  2004cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions

  2004cited by this paper
• Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

  2004cited by this paper
• Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

  2003cited by this paper
• Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA.

  2003cited by this paper
• Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair

  2002cited by this paper
• Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.

  2002cited by this paper
• Negative Control of p53 by Sir2 Promotes Cell Survival under Stress

  2001cited by this paper
• Negative control of p53 by Sir2alpha promotes cell survival under stress.

  2001cited by this paper
• Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.

  2000cited by this paper
• p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

  1999cited by this paper
• Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

  1999cited by this paper
• Histone H4 and the maintenance of genome integrity.

  1995cited by this paper
• Patterns of histone acetylation.

  1990cited by this paper
• The uptake and turnover of acetate in HeLa cell histone fractions.

  1970cited by this paper

• C8orf33 dictates DNA double-strand break repair choice by modulating KAT8-mediated H4K16 acetylation

  2025cites this paper
• HDAC2 inhibition restores H4K16 Acetylation and Rescues Cellular Senescence in Hutchinson-Gilford progeria syndrome

  2025cites this paper
• Interplay and Dynamics of Chromatin Architecture and DNA Damage Response: An Overview

  2025cites this paper
• Epigenetic drug screening identifies enzyme inhibitors A-196 and TMP-269 as novel regulators of sprouting angiogenesis

  2025cites this paper
• Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress.

  2025cites this paper
• How histone modifications influence cellular radiosensitivity: Pharmaceutically targeting epigenetic regulators as a promising avenue to overcome radioresistance

  2025cites this paper
• New facets in the chromatin-based regulation of genome maintenance.

  2024cites this paper
• HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair

  2024cites this paper
• Progeria‐based vascular model identifies networks associated with cardiovascular aging and disease

  2024cites this paper
• Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease

  2023cites this paper
• Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

  2023cites this paper
• SIRT2 inhibition as the Achilles' heel of ATRX-deficient gliomas.

  2023cites this paper
• Multiple DNA repair pathways contribute to MMS-induced post-replicative DNA synthesis in S. pombe .

  2023cites this paper
• CMAR_A_346052 259..271

  2022cites this paper
• 53BP1: Keeping It under Control, Even at a Distance from DNA Damage

  2022cites this paper
• Quantification of protein enrichment at site-specific DNA double-strand breaks by chromatin immunoprecipitation in cultured human cells

  2022cites this paper
• Early recruitment of PARP-dependent m8A RNA methylation at DNA lesions is subsequently accompanied by active DNA demethylation

  2022cites this paper
• Role of NAD+ and FAD in Ischemic Stroke Pathophysiology: An Epigenetic Nexus and Expanding Therapeutic Repertoire

  2022influential citation
• Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells

  2022cites this paper
• The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways

  2022cites this paper
• The Functional Roles and Regulation of Circular RNAs during Cellular Stresses

  2022cites this paper
• Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress

  2022cites this paper
• New insights into the DNA repair pathway choice with NuA4/TIP60.

  2022cites this paper
• Roles for the methyltransferase SETD8 in DNA damage repair

  2022cites this paper
• Histone variants: The unsung guardians of the genome.

  2022cites this paper
• Targeted Cancer Therapy Based on Acetylation and Deacetylation of Key Proteins Involved in Double-Strand Break Repair

  2022cites this paper
• CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway

  2022cites this paper
• RNF8‐ubiquitinated KMT5A is required for RNF168‐induced H2A ubiquitination in response to DNA damage

  2021cites this paper
• PARP dependent recruitment of RNA methylated at 8-adenosine is linked to base excision repair mechanism

  2021cites this paper
• Role of Histone Methylation in Maintenance of Genome Integrity

  2021cites this paper
• ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication

  2021cites this paper
• Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy

  2021cites this paper
• Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription

  2021cites this paper
• Transcriptional Analyses of Acute Exposure to Methylmercury on Erythrocytes of Loggerhead Sea Turtle

  2021cites this paper
• Transcription-coupled DNA double-strand break repair.

  2021cites this paper
• To Join or Not to Join: Decision Points Along the Pathway to Double-Strand Break Repair vs. Chromosome End Protection

  2021cites this paper
• The Role of Histone Lysine Methylation in the Response of Mammalian Cells to Ionizing Radiation

  2021cites this paper
• The human VRK1 chromatin kinase in cancer biology.

  2021cites this paper
• Substrate Scope for Human Histone Lysine Acetyltransferase KAT8

  2021cites this paper
• TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double‐strand breaks in vertebrate cells

  2020cites this paper
• Methylation of Histone 4's Lysine 20: A critical analysis of the state of the field.

  2020cites this paper
• Cancer-associated 53BP1 mutations induce DNA damage repair defects.

  2020cites this paper
• Age-associated deficient recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection

  2020cites this paper
• Transcriptional Regulation at DSBs: Mechanisms and Consequences.

  2020cites this paper
• H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres

  2020cites this paper
• Control of the chromatin response to DNA damage: Histone proteins pull the strings.

  2020cites this paper
• The Role of Methyltransferase NSD2 as a Potential Oncogene in Human Solid Tumors

  2020cites this paper
• OTT_A_259873 6837..6846

  2020influential citation
• Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance

  2020cites this paper
• VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage

  2020cites this paper
• A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair

  2019cites this paper
• GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival

  2019cites this paper
• Treatment May Be Harmful: Mechanisms/Prediction/Prevention of Drug-Induced DNA Damage and Repair in Multiple Myeloma

  2019cites this paper
• Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate its Catalytic Activity.

  2019cites this paper
• Preserving genome integrity and function: the DNA damage response and histone modifications

  2019cites this paper
• One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4

  2019cites this paper
• Histone 4 Lysine 20 Methylation: A Case for Neurodevelopmental Disease

  2019cites this paper
• Induction and repair of clustered DNA damage sites after exposure to ionizing radiation

  2019cites this paper
• JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells

  2019cites this paper
• 53BP1: A key player of DNA damage response with critical functions in cancer.

  2019cites this paper
• PIE-1, SUMOylation, and Epigenetic Regulation of Germline Specification in Caenorhabditis elegans

  2018cites this paper
• Étude comparative des effets moléculaires et cellulaires induits par des rayonnements X de différentes énergies

  2018cites this paper
• Understanding the Histone DNA Repair Code: H4K20me2 Makes Its Mark

  2018influential citation
• The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance

  2018cites this paper
• Histone methylation in DNA repair and clinical practice: new findings during the past 5-years

  2018cites this paper
• The relationship between histone posttranslational modification and DNA damage signaling and repair

  2018cites this paper
• Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

  2018cites this paper
• Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites

  2018cites this paper
• H3K9me3 and H4K20me3 represent the epigenetic landscape for 53BP1 binding to DNA lesions

  2018cites this paper
• Title Chromatin modification and NBS 1 : Their relationship in DNAdouble-strand break repair

  2018cites this paper
• Alterations in histone acetylation following exposure to 60Co γ-rays and their relationship with chromosome damage in human lymphoblastoid cells

  2018cites this paper
• Regulation of Nucleosome Stacking and Chromatin Compaction by the Histone H4 N-Terminal Tail-H2A Acidic Patch Interaction.

  2017cites this paper
• Epigenetic regulation of the pathological process in endometriosis

  2017cites this paper
• Transcription-associated events affecting genomic integrity

  2017cites this paper
• The tale of a tail: histone H4 acetylation and the repair of DNA breaks

  2017cites this paper
• Reading chromatin signatures after DNA double-strand breaks

  2017cites this paper
• Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration

  2017cites this paper
• Sirtuins and DNA damage repair: SIRT7 comes to play

  2017cites this paper
• Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.

  2017influential citation
• Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair

  2017cites this paper
• Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma

  2017cites this paper
• The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

  2017cites this paper
• Mechanisms of Histone Modifications

  2017cites this paper
• DYNAMIC BINDING OF RAD9/53BP1 ON DNA LESIONS PROMOTES ACCURATE REPAIR AND GENOME STABILITY

  2017cites this paper
• Histone methylation and the DNA damage response.

  2017cites this paper
• MYCN, proliferative heterogeneity and treatment responsein neuroblastoma

  2017cites this paper
• PROTEOMIC IDENTIFICATION OF HISTONE POST-TRANSLATIONAL MODIFICATIONS INDUCED BY DNA DOUBLE-STRAND BREAKS AND NOVEL PROTEINS INVOLVED IN THE DNA DAMAGE RESPONSE

  2017cites this paper
• The nucleosome: orchestrating DNA damage signaling and repair within chromatin.

  2016cites this paper
• A potential role for protein palmitoylation and zDHHC16 in DNA damage response

  2016cites this paper
• Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair

  2016cites this paper
• Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair

  2016cites this paper
• TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function

  2016cites this paper
• Nuclear compartmentalization of DNA repair.

  2016cites this paper
• The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii

  2016cites this paper
• Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage.

  2016cites this paper
• H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development.

  2016cites this paper
• Solar Simulated Ultraviolet Radiation Induces Global Histone Hypoacetylation in Human Keratinocytes

  2016cites this paper
• Role of phosphorylation in the regulation of PRMT5

  2016influential citation
• SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

  2016cites this paper
• Chapter 11 – Variation, Modification, and Reorganization of Broken Chromatin

  2016cites this paper