53BP1: function and mechanisms of focal recruitment.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biochemical Society Transactions

• Publication date

  2009-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BST0370897PMID 19614615
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response.

  2009cited by this paper
• The Direct Interaction between 53BP1 and MDC1 Is Required for the Recruitment of 53BP1 to Sites of Damage*

  2009cited by this paper
• ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

  2008cited by this paper
• Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20*

  2008cited by this paper
• 53BP1 facilitates long-range DNA end-joining during V(D)J recombination

  2008cited by this paper
• 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

  2008cited by this paper
• DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

  2008cited by this paper
• Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis

  2008cited by this paper
• The MRN complex.

  2008cited by this paper
• A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

  2008cited by this paper
• Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint

  2008cited by this paper
• NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway

  2008cited by this paper
• An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

  2008cited by this paper
• Living on a break: cellular senescence as a DNA-damage response.

  2008cited by this paper
• Living on a break: cellular senescence as a DNA-damage response

  2008cited by this paper
• DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

  2007cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007cited by this paper
• Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain

  2007cited by this paper
• Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

  2007cited by this paper
• DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

  2007cited by this paper
• New nomenclature for chromatin-modifying enzymes.

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

  2007cited by this paper
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007cited by this paper
• Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR.

  2007cited by this paper
• Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

  2007cited by this paper
• Tying the loose ends together in DNA double strand break repair with 53BP1

  2006cited by this paper
• gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.

  2006cited by this paper
• The role of double-strand break repair — insights from human genetics

  2006cited by this paper
• 53BP1 contributes to survival of cells irradiated with X‐ray during G1 without Ku70 or Artemis

  2006cited by this paper
• Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

  2006cited by this paper
• Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks.

  2006cited by this paper
• Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

  2006cited by this paper
• Chromatin modulation and the DNA damage response.

  2006cited by this paper
• The Tandem BRCT Domain of 53BP1 Is Not Required for Its Repair Function*

  2006cited by this paper
• Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

  2006cited by this paper
• MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

  2006cited by this paper
• Surviving the breakup: the DNA damage checkpoint.

  2006cited by this paper
• Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation.

  2006cited by this paper
• Signal transduction: how rad53 kinase is activated.

  2005cited by this paper
• Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteins

  2005cited by this paper
• Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells

  2005cited by this paper
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

  2005cited by this paper
• 53BP1 Oligomerization is Independent of its Methylation by PRMT1

  2005cited by this paper
• The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1*

  2005cited by this paper
• Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

  2005cited by this paper
• The 8-kDa Dynein Light Chain Binds to p53-binding Protein 1 and Mediates DNA Damage-induced p53 Nuclear Accumulation*

  2005cited by this paper
• Role of Dot1-Dependent Histone H3 Methylation in G1 and S Phase DNA Damage Checkpoint Functions of Rad9

  2005cited by this paper
• The GAR Motif of 53BP1 is Arginine Methylated by PRMT1 and is Necessary for 53BP1 DNA Binding Activity

  2005cited by this paper
• Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

  2005cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

  2004cited by this paper
• Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.

  2004cited by this paper
• A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

  2004cited by this paper
• 53BP1 is required for class switch recombination

  2004cited by this paper
• A domain of Rad9 specifically required for activation of Chk1 in budding yeast

  2004cited by this paper
• Homo-oligomerization Is the Essential Function of the Tandem BRCT Domains in the Checkpoint Protein Crb2*

  2004cited by this paper
• Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

  2004cited by this paper
• ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

  2004cited by this paper
• The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding.

  2004cited by this paper
• 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination

  2004cited by this paper
• Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX*

  2003cited by this paper
• Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

  2003cited by this paper
• Potential Role for 53BP1 in DNA End-joining Repair through Direct Interaction with DNA*

  2003cited by this paper
• p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

  2003cited by this paper
• Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability*

  2003cited by this paper
• 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

  2003cited by this paper
• NFBD1, Like 53BP1, Is an Early and Redundant Transducer Mediating Chk2 Phosphorylation in Response to DNA Damage*

  2003cited by this paper
• MDC1 is a mediator of the mammalian DNA damage checkpoint

  2003cited by this paper
• 53BP1, a Mediator of the DNA Damage Checkpoint

  2002cited by this paper
• Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.

  2002cited by this paper
• 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

  2002cited by this paper
• Genomic Instability in Mice Lacking Histone H2AX

  2002cited by this paper
• Toward maintaining the genome: DNA damage and replication checkpoints.

  2002cited by this paper
• DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

  2002cited by this paper
• The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation*

  2001cited by this paper
• Phosphorylation and Rapid Relocalization of 53BP1 to Nuclear Foci upon DNA Damage

  2001cited by this paper
• Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1*

  2001cited by this paper
• Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

  2001cited by this paper
• Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.

  2001cited by this paper
• Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress*

  2001cited by this paper
• The DNA damage response: putting checkpoints in perspective

  2000cited by this paper
• P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

  2000cited by this paper
• The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non‐homologous end joining

  2000cited by this paper
• Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

  1999cited by this paper
• The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage.

  1999cited by this paper
• A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

  1997cited by this paper
• Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

  1997cited by this paper
• BRCA1 protein products ... Functional motifs...

  1996cited by this paper
• …Functional motifs…

  1996cited by this paper
• The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.

  1988cited by this paper

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