The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Chemistry and Biology

• Publication date

  2000-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S1074-5521(00)00123-XPMID 10873833
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.

  1999cited by this paper
• Changes in caspase expression in Alzheimer's disease: comparison with development and aging.

  1999cited by this paper
• Irreversible caspase inhibitors: tools for studying apoptosis.

  1999cited by this paper
• The atomic-resolution structure of human caspase-8, a key activator of apoptosis.

  1999cited by this paper
• Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.

  1999cited by this paper
• Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

  1999cited by this paper
• Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

  1999cited by this paper
• Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

  1999cited by this paper
• Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death.

  1999cited by this paper
• Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor.

  1998cited by this paper
• Caspase 7‐induced cleavage of kinectin in apoptotic cells

  1998cited by this paper
• Properties of the caspases.

  1998cited by this paper
• Different Subcellular Distribution of Caspase-3 and Caspase-7 following Fas-induced Apoptosis in Mouse Liver*

  1998cited by this paper
• Chapter 18 – Blocking lnterleukin-1 Action

  1998cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.

  1998cited by this paper
• Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors*

  1998cited by this paper
• Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

  1998cited by this paper
• Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

  1998cited by this paper
• Caspases: key mediators of apoptosis.

  1998cited by this paper
• Caspases: the proteases of the apoptotic pathway

  1998cited by this paper
• Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract*

  1998cited by this paper
• A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

  1997cited by this paper
• Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

  1997cited by this paper
• Caspases: the executioners of apoptosis.

  1997cited by this paper
• Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone*

  1997cited by this paper
• Practical Application of Computer-Aided Drug Design

  1997cited by this paper
• The role of the Caspase family of cysteine proteases in apoptosis.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Expression and purification of human interleukin-1beta converting enzyme from Trichoplusia ni insect cells using a baculovirus expression system.

  1997cited by this paper
• Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases*

  1997cited by this paper
• Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzyme

  1997cited by this paper
• Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death

  1996cited by this paper
• Processing and Activation of CMH-1 by Granzyme B (*)

  1996cited by this paper
• The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

  1996cited by this paper
• Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32 (*)

  1996cited by this paper
• Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice.

  1996cited by this paper
• INTERLEUKIN-1β CONVERTING ENZYME INHIBITION BLOCKS PROGRESSION OF TYPE II COLLAGEN-INDUCED ARTHRITIS IN MICE

  1996cited by this paper
• Structure and mechanism of interleukin-1 beta converting enzyme.

  1994cited by this paper
• Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

  1994cited by this paper
• AMoRe: an automated package for molecular replacement

  1994cited by this paper
• Structure and mechanism of interleukin-lβ converting enzyme

  1994cited by this paper
• Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer.

  1994cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• The α/β hydrolase fold

  1992cited by this paper
• X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

  1992cited by this paper
• The alpha/beta hydrolase fold.

  1992cited by this paper
• A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

  1992cited by this paper
• RIBBONS 2.0

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• Structural and genetic analysis of electrostatic and other interactions in bacteriophage T4 lysozyme.

  1991cited by this paper
• The anatomy and taxonomy of protein structure.

  1981cited by this paper
• Solvent content of protein crystals.

  1968cited by this paper

• 10 things you wish you knew about inflammatory caspases: A holistic review of their biochemistry, activation, and signalling

  2025cites this paper
• In-silico analysis of papain fibrinolytic mechanism from Carica papaya

  2025cites this paper
• Mapping the Binding Interactions between Human Gasdermin D and Human Caspase-1 Using Carbene Footprinting

  2023cites this paper
• Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

  2023cites this paper
• Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.

  2023cites this paper
• Interleukin-1β converting enzyme (ICE): A comprehensive review on discovery and development of caspase-1 inhibitors.

  2023cites this paper
• Proapoptotic Effect and Molecular Docking Analysis of Curcumin–Resveratrol Hybrids in Colorectal Cancer Chemoprevention

  2022cites this paper
• Caspase Activation and Inhibition.

  2022cites this paper
• The Ancient Origins of Death Domains Support the ‘Original Sin’ Hypothesis for the Evolution of Programmed Cell Death

  2022cites this paper
• Characterization of caspase-7 interaction with RNA.

  2021cites this paper
• Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7.

  2021cites this paper
• Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3

  2020cites this paper
• Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats

  2020cites this paper
• Engineering caspase 7 as an affinity reagent to capture proteolytic products

  2020cites this paper
• MOLECULAR DOCKING ANALYSIS OF APIGENIN AS A NATURAL ANTICANCER COMPUND

  2020cites this paper
• Caspases from scleractinian coral show unique regulatory features

  2019cites this paper
• Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11

  2019cites this paper
• Molecular Designing of Small-Molecule Inhibitors for Apoptosis Regulation

  2018cites this paper
• 8.20 – Apoptosis☆

  2018cites this paper
• Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

  2018cites this paper
• Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis

  2018cites this paper
• Caspase -1, -3, -8 and antioxidant enzyme genes are key molecular effectors following Vibrio parahaemolyticus and Aeromonas veronii infection in fish leukocytes.

  2018cites this paper
• ВЛИЯНИЯ СУБСТАНЦИЙ РАЗЛИЧНОЙ ПРИРОДЫ НА АКТИВНОСТЬ КАСПАЗ (ОБЗОР)

  2018cites this paper
• Identification of FDA-approved drugs as novel allosteric inhibitors of human executioner caspases

  2018cites this paper
• Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors.

  2018cites this paper
• Structural biology of the separase-securin complex with crucial roles in chromosome segregation.

  2018cites this paper
• Nanoclays: A Review of Their Toxicological Profiles and Risk Assessment Implementation Strategies

  2017cites this paper
• Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding*

  2017cites this paper
• Characterization of Chemical Probes for Therapeutic Intervention of Innate Immune Signaling

  2017cites this paper
• Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT)

  2017cites this paper
• Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.

  2017cites this paper
• Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

  2017cites this paper
• Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered Regions.

  2017cites this paper
• Structural basis for alpha fetoprotein‐mediated inhibition of caspase‐3 activity in hepatocellular carcinoma cells

  2017influential citation
• Exploitation and Regulation of Apoptotic Caspases

  2017cites this paper
• Multifunctional murrel caspase 1, 2, 3, 8 and 9: Conservation, uniqueness and their pathogen-induced expression pattern.

  2016cites this paper
• Phage display and structural studies reveal plasticity in substrate specificity of caspase‐3a from zebrafish

  2016cites this paper
• Caspase Allostery and Conformational Selection.

  2016cites this paper
• Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.

  2016cites this paper
• Conserved molecular mechanisms underlying the effects of small molecule xenobiotic chemotherapeutics on cells.

  2016cites this paper
• Cell death controlling complexes and their potential therapeutic role

  2015cites this paper
• Small Molecule Active Site Directed Tools for Studying Human Caspases.

  2015cites this paper
• Comparative structural analysis of the caspase family with other clan CD cysteine peptidases

  2015cites this paper
• Life, career, and structural biology

  2014cites this paper
• Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies

  2014cites this paper
• Different apoptotic effects of [Pt(O,O′‐acac)(γ‐acac)(DMS)] and cisplatin on normal and cancerous human epithelial breast cells in primary culture

  2014cites this paper
• Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity.

  2014cites this paper
• Specificity of a protein–protein interface: Local dynamics direct substrate recognition of effector caspases

  2014cites this paper
• Turning on caspases with genetics and small molecules.

  2014cites this paper
• Caspase substrates and inhibitors.

  2013cites this paper
• The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells.

  2013cites this paper
• The Role of Caspase-7 during Infection with Listeria monocytogenes and during Intoxication with Listeriolysin O.

  2013cites this paper
• Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2

  2013cites this paper
• Caspase-3 and caspase-7

  2013cites this paper
• Structural asymmetry of procaspase-7 bound to a specific inhibitor.

  2013influential citation
• Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation

  2013cites this paper
• Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis

  2012cites this paper
• Mechanisms of Caspase-3 Regulation in the Execution of Cell Death

  2012cites this paper
• Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury.

  2012cites this paper
• Crystal structure of a Trypanosoma brucei metacaspase

  2012cites this paper
• Structure based study of caspase-3 and D-arginine dehydrogenase

  2012cites this paper
• Regulation of Caspase-9 by Natural and Synthetic Inhibitors

  2012cites this paper
• Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7.

  2012cites this paper
• Molecular determinants involved in activation of caspase 7.

  2011cites this paper
• A Short Caspase-3 Isoform Inhibits Chemotherapy-Induced Apoptosis by Blocking Apoptosome Assembly

  2011cites this paper
• Substrate-induced conformational changes occur in all cleaved forms of caspase-6.

  2011cites this paper
• The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies.

  2011cites this paper
• Exploring the role of caspases and RIPK4 during Xenopus development

  2011cites this paper
• A designed redox‐controlled caspase

  2011cites this paper
• Apoptosis: Human Caspases – Apoptosis and Inflammation Signaling Proteases

  2011cites this paper
• A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.

  2011cites this paper
• Caspase-7 loop conformations as a means of allosteric control

  2011cites this paper
• Apoptosis: Physiology and Pathology

  2011cites this paper
• 2.28 – Apoptosis

  2010cites this paper
• Chemical Regulation of the Apoptosome: New Alternative Treatments for Cancer

  2010cites this paper
• Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

  2010cites this paper
• Caspase-7: a protease involved in apoptosis and inflammation.

  2010cites this paper
• Identification of Functional Regions Defining Different Activity in Caspase-3 and Caspase-7 within Cells

  2010cites this paper
• Computational evidence for the catalytic mechanism of caspase-7. A DFT investigation.

  2010cites this paper
• Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity

  2010cites this paper
• Update 1 of: Proteases universally recognize beta strands in their active sites.

  2010cites this paper
• Mechanistic insights into apoptosome dependent caspase-9 processing and activation

  2010cites this paper
• Caspases: evolutionary aspects of their functions in vertebrates

  2009cites this paper
• Caspases: Activation, Regulation, and Function

  2009cites this paper
• Chemical Regulation of the Apoptosome : New Alternative Treatments for Cancer

  2009cites this paper
• Chapter 1 Caspases : Activation , Regulation , and Function

  2009cites this paper
• The crystal structure of caspase-6, a selective effector of axonal degeneration.

  2009cites this paper
• VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

  2009cites this paper
• Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7 Versus Caspase-3 Specificity*

  2009cites this paper
• Structural Biology of Programmed Cell Death

  2009cites this paper
• REVIEW PAPER Caspases: evolutionary aspects of their functions

  2009cites this paper
• Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7

  2009cites this paper
• Dissecting an Allosteric Switch in Caspase-7 Using Chemical and Mutational Probes*

  2009cites this paper
• Small-Molecule Activators of a Proenzyme

  2009cites this paper
• L2′ loop is critical for caspase‐7 active site formation

  2009cites this paper
• Leptosphaeria maculans elicits apoptosis coincident with leaf lesion formation and hyphal advance in Brassica napus.

  2008cites this paper
• [Pt(O,O′‐acac)(γ‐acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF‐7 breast cancer cells via the mitochondrial apoptotic pathway

  2008cites this paper
• Rôle de l'amphiréguline dans la résistance du cancer du poumon non-à petites cellules au gefitinib

  2008cites this paper
• FRET evidence that an isoform of caspase-7 binds but does not cleave its substrate.

  2008cites this paper
• Structural basis for executioner caspase recognition of P5 position in substrates

  2008cites this paper