The Effect of Calcium on Sodium Transport by Frog Skin

Calcium added to the solution bathing the outside of isolated frog skin caused a reversible decrease in net sodium transport across the skin. At constant sodium concentration, the inhibition of transport increased with increasing calcium concentration, but approached a limiting value. This maximum degree of inhibition was found to depend on sodium concentration; sodium transport could be inhibited by 60 per cent at 96 mM sodium, but by only 18 per cent at 19 mM sodium. The relative effectiveness of a given calcium concentration was also greater the higher the sodium concentration. The unidirectional flux of chloride across the short-circuited skin was decreased by calcium to approximately the same degree as active sodium transport. The results have been interpreted in terms of a relatively non-specific decrease in permeability of the outward facing membrane of the transporting cells. The resulting decrease in sodium permeability apparently causes a decrease in active sodium transport by reducing the availability of sodium to the transporting system.

• Publication year

  1962

• Venue

  The Journal of General Physiology

• Publication date

  1962-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1085/JGP.45.4.625PMID 13882704PMCID 2195197
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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