Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Current topics in behavioral neurosciences

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/7854_2015_376PMID 26026289
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing

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• The motivation and pleasure dimension of negative symptoms: neural substrates and behavioral outputs.

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• Do people with schizophrenia have difficulty anticipating pleasure, engaging in effortful behavior, or both?

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• Immediate affective motivation is not impaired in schizophrenia.

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  2014cited by this paper
• Intolerance of uncertainty mediates reduced reward anticipation in major depressive disorder.

  2014cited by this paper
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• Reinforcement learning deficits in people with schizophrenia persist after extended trials.

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• The influence of anhedonia on feedback negativity in major depressive disorder.

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• Striatal response to reward anticipation: evidence for a systems-level intermediate phenotype for schizophrenia.

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• Amotivation in schizophrenia: integrated assessment with behavioral, clinical, and imaging measures.

  2014cited by this paper
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  2014cited by this paper
• Cognitive effort avoidance and detection in people with schizophrenia

  2014cited by this paper
• Motivational deficits in individuals at-risk for psychosis and across the course of schizophrenia.

  2014cited by this paper
• Neural response to reward anticipation in those with depression with and without panic disorder.

  2014cited by this paper
• Working Memory Contributions to Reinforcement Learning Impairments in Schizophrenia

  2014cited by this paper
• Associations among smoking, anhedonia, and reward learning in depression.

  2014cited by this paper
• Imaging studies on dopamine transporter and depression: a review of literature and suggestions for future research.

  2014cited by this paper
• Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment.

  2014cited by this paper
• Neuroreceptor imaging in depression.

  2013cited by this paper
• Striatal presynaptic dopamine in schizophrenia, part II: meta-analysis of [(18)F/(11)C]-DOPA PET studies.

  2013cited by this paper
• Neural computations underlying arbitration between model-based and model-free learning.

  2013cited by this paper
• Blunted neural response to rewards prospectively predicts depression in adolescent girls.

  2013cited by this paper
• Impairments in both reward and punishment guided reinforcement learning in schizophrenia.

  2013cited by this paper
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  2013cited by this paper
• Biomarkers of threat and reward sensitivity demonstrate unique associations with risk for psychopathology.

  2013cited by this paper
• Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making.

  2013cited by this paper
• Proactive and reactive cognitive control and dorsolateral prefrontal cortex dysfunction in first episode schizophrenia☆

  2013cited by this paper
• The neural correlates of reward-related processing in major depressive disorder: a meta-analysis of functional magnetic resonance imaging studies.

  2013cited by this paper
• Depression impairs learning, whereas the selective serotonin reuptake inhibitor, paroxetine, impairs generalization in patients with major depressive disorder.

  2013cited by this paper
• Learning from negative feedback in patients with major depressive disorder is attenuated by SSRI antidepressants

  2013cited by this paper
• Neural response to reward as a predictor of increases in depressive symptoms in adolescence.

  2013cited by this paper
• Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation

  2013cited by this paper
• Blunted reward responsiveness in remitted depression.

  2013cited by this paper
• A psychophysiological investigation of threat and reward sensitivity in individuals with panic disorder and/or major depressive disorder.

  2013cited by this paper
• Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression

  2013cited by this paper
• Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression

  2013cited by this paper
• Negative symptoms of schizophrenia are associated with abnormal effort-cost computations.

  2013cited by this paper
• Constructing constructs for psychopathology: the NIMH research domain criteria.

  2013cited by this paper
• Spared and impaired aspects of motivated cognitive control in schizophrenia.

  2013cited by this paper
• Influence of depression symptoms on history-independent reward and punishment processing.

  2013cited by this paper
• Reduced reward learning predicts outcome in major depressive disorder.

  2013cited by this paper
• The expected value of control: an integrative theory of anterior cingulate cortex function.

  2013cited by this paper
• The Iowa Gambling Task in depression – what have we learned about sub-optimal decision-making strategies?

  2013cited by this paper
• Cognitive impairment in depression: a systematic review and meta-analysis

  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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• Neural correlates of emotion regulation deficits in remitted depression: The influence of regulation strategy, habitual regulation use, and emotional valence

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• The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond.

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• Reduced striatal activation during reward anticipation due to appetite-provoking cues in chronic schizophrenia: a fMRI study.

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• Anticipatory pleasure predicts motivation for reward in major depression.

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• Neural encoding of competitive effort in the anterior cingulate cortex

  2012cited by this paper
• Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder.

  2012cited by this paper
• Emerging drugs for major depressive disorder

  2012cited by this paper
• Reduced reward-related probability learning in schizophrenia patients

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• Neural processing of reward and punishment in young people at increased familial risk of depression.

  2012cited by this paper
• Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making

  2012cited by this paper
• Effects of depression on reward-based decision making and variability of action in probabilistic learning.

  2012cited by this paper
• Ventral Striatal Activation during Reward Processing in Subjects with Ultra-High Risk for Schizophrenia

  2012cited by this paper
• The mysterious motivational functions of mesolimbic dopamine.

  2012cited by this paper
• Alterations of the brain reward system in antipsychotic naïve schizophrenia patients.

  2012cited by this paper
• Sensitivity to reward and punishment in major depressive disorder: Effects of rumination and of single versus multiple experiences

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  2012cited by this paper
• Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia.

  2012cited by this paper
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  2012cited by this paper
• Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram

  2012cited by this paper
• Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients.

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• Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia.

  2012cited by this paper
• Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence.

  2012cited by this paper
• Cognition in schizophrenia: core psychological and neural mechanisms.

  2012cited by this paper
• The ubiquity of model-based reinforcement learning.

  2012cited by this paper
• Amygdala response and functional connectivity during emotion regulation: a study of 14 depressed adolescents.

  2012cited by this paper
• Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes.

  2012cited by this paper
• Pavlovian Reward Prediction and Receipt in Schizophrenia: Relationship to Anhedonia

  2012influential reference
• Neural Mechanisms Underlying Motivation of Mental Versus Physical Effort

  2012cited by this paper
• Cognitive remediation for schizophrenia: current status, biological correlates and predictors of response

  2012cited by this paper

• Parsing Reward Processing Substages With Multimodal EEG–fMRI

  2026cites this paper
• Targeting Positive Affect as a Way to Improve Social Anhedonia in Schizophrenia.

  2025cites this paper
• Understanding cognitive control in depression: the interactive role of emotion, expected efficacy and reward

  2025cites this paper
• Indirect effects of psychiatric symptoms on the association between childhood trauma and motivation orientation.

  2025cites this paper
• Characterizing the Profile of Anhedonia in Individuals With Schizotypal Traits, Subthreshold Depression and Autistic Traits

  2025cites this paper
• Advancing scientific understanding of the drive to socially engage: from broad constructs to transdiagnostic ‘building blocks’

  2025cites this paper
• The Critical Value of High-Risk Designs and Developmental Psychopathology Frameworks for Understanding Affective Psychopathology: Insights from Research on Anhedonia.

  2025cites this paper
• Common Neural Deficits in Social and Monetary Reinforcement Learning in Schizophrenia.

  2025cites this paper
• Personalized neural responses to self and filial reward: Functional and structural responses to motivational cues

  2025cites this paper
• Model-based planning in structured foraging environments.

  2025cites this paper
• Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference?

  2025cites this paper
• Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia

  2025cites this paper
• Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC)

  2025cites this paper
• Reward Processing in Mood Disorders and Schizophrenia: A Neurodevelopmental Framework.

  2025cites this paper
• The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach

  2025cites this paper
• Improving depressive symptoms in patients with schizophrenia using bilateral bipolar-nonbalanced prefrontal tDCS: Results from a double-blind sham-controlled trial.

  2024cites this paper
• Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation.

  2024cites this paper
• Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making

  2024cites this paper
• Research Progress on Non-Biological Mechanisms of Depression

  2024cites this paper
• Discriminative analysis of schizophrenia and major depressive disorder using fNIRS.

  2024cites this paper
• Dampened motivation in schizophrenia: evidence from a novel effort-based decision-making task in social scenarios

  2024cites this paper
• Kappa opioid receptor availability predicts severity of anhedonia in schizophrenia

  2024cites this paper
• Anhedonia Across and Beyond the Schizophrenia Spectrum

  2024cites this paper
• The Underestimated Role of the Sports Psychiatrist in Athletic Performance Restoration, Maintenance, and Enhancement in Sports

  2024cites this paper
• Two-year trajectories of anhedonia in adolescents at transdiagnostic risk for severe mental illness: Association with clinical symptoms and brain-symptom links.

  2024cites this paper
• Abnormal hedonic process in patients with stable schizophrenia: Relationships to negative symptoms and social functioning

  2024cites this paper
• Investigating the Prevalence and Predictors of Apathy among the Canadian Long-Term Care Residents: A Secondary Data Analysis

  2024cites this paper
• Approach and withdrawal from cognitively effortful activities: Development, validation, and transdiagnostic clinical utility of a cognitive motivation scale.

  2024cites this paper
• Brain stimulation over the left DLPFC enhances motivation for effortful rewards in patients with major depressive disorder.

  2024cites this paper
• Cognitive Effort Deficits in Depression: Autonomic Correlates and Clues to Potential Rescue.

  2023cites this paper
• Revisiting reward impairments in schizophrenia spectrum disorders: a systematic review and meta-analysis for neuroimaging findings

  2023cites this paper
• History of major depressive disorder is associated with differences in implicit learning of emotional faces.

  2023cites this paper
• Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making

  2023cites this paper
• Probing apathy in children and adolescents with the Apathy Motivation Index–Child version

  2023cites this paper
• Altered Associations Between Motivated Performance and Frontostriatal Functional Connectivity During Reward Anticipation in Schizophrenia.

  2023cites this paper
• Apathy and Motivation: Biological Basis and Drug Treatment.

  2023cites this paper
• Belief Updating in Psychosis, Depression and Anxiety Disorders: A Systematic Review Across Computational Modelling Approaches.

  2023cites this paper
• Increased cortical structural covariance correlates with anhedonia in schizophrenia

  2023cites this paper
• Efficacy of Serotonin and Dopamine Activity Modulators in the Treatment of Negative Symptoms in Schizophrenia: A Rapid Review

  2023cites this paper
• Inattentive responding can induce spurious associations between task behaviour and symptom measures

  2023cites this paper
• Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior.

  2023cites this paper
• Range adaptation in schizophrenia: A one-year longitudinal study

  2023cites this paper
• Childhood trauma, perceived stress and anhedonia in individuals at clinical high risk for psychosis: multigroup mediation analysis

  2023cites this paper
• Exploring expected reward and efficacy in enhancing cognitive control in patients with depression

  2023cites this paper
• Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis

  2023cites this paper
• Perceived chronic stress and impulsivity are associated with reduced learning about the costs and benefits of actions

  2023cites this paper
• The associations of Positive and Negative Valence Systems, Cognitive Systems and Social Processes on disease severity in anxiety and depressive disorders

  2023cites this paper
• The contextual goal dependent attentional flexibility (CoGoDAF) framework: A new approach to attention bias in depression.

  2023cites this paper
• Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review

  2023cites this paper
• A transdiagnostic approach to negative symptoms: exploring factor structure and negative symptoms in bipolar disorders

  2023cites this paper
• The organization of frontostriatal brain wiring in non-affective early psychosis compared with healthy subjects using a novel diffusion imaging fiber cluster analysis

  2023cites this paper
• Range adaptive value representations in schizophrenia and major depression.

  2023cites this paper
• A three-dimensional model of neural activity and phenomenal-behavioral patterns

  2023cites this paper
• Behavioral responses to natural rewards in developing male and female rats.

  2023cites this paper
• Depression mediated the relationships between precentral-subcortical causal links and motor recovery in spinal cord injury patients.

  2023cites this paper
• Early life interpersonal stress and depression: Social reward processing as a potential mediator.

  2023cites this paper
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  2023cites this paper
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  2022cites this paper
• Learned industriousness as a translational mechanism in anorexia nervosa

  2022cites this paper
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  2022cites this paper
• MDMA for the Treatment of Negative Symptoms in Schizophrenia

  2022cites this paper
• Encore: Behavioural animal models of stress, depression and mood disorders

  2022cites this paper
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  2022cites this paper
• A transdiagnostic meta-analysis of physical and social Anhedonia in major depressive disorder and schizophrenia spectrum disorders.

  2022cites this paper
• Responses to positive affect and unique resting-state connectivity in individuals at clinical high-risk for psychosis

  2022cites this paper
• Motivational disturbances in rodent models of neuropsychiatric disorders

  2022cites this paper
• Are the measurement structures of the Traditional Chinese Dispositional Flow Scale-2 equivalent between schizophrenic patients and healthy subjects?

  2022cites this paper
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  2022cites this paper
• State-of-the-art diagnostic and treatment modalities for anxiety and depression

  2021cites this paper
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  2021cites this paper
• Schizophrenia and bipolar disorder are associated with opposite brain reward anticipation-associated response

  2021cites this paper
• Correlates of real-world goal-directed behavior in schizophrenia

  2021cites this paper
• Aversive Motivation and Cognitive Control.

  2021cites this paper
• Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder.

  2021cites this paper
• Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns

  2021cites this paper
• Mechanisms Underlying Motivational Dysfunction in Schizophrenia

  2021cites this paper
• Associations between different white matter properties and reward-based performance modulation

  2021cites this paper
• Differential reinforcement learning responses to positive and negative information in unmedicated individuals with depression.

  2021cites this paper
• Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study

  2021cites this paper
• Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study.

  2021cites this paper
• The Many Faces of Negative Symptoms in Schizophrenia

  2021cites this paper
• Understanding Emotions: Origins and Roles of the Amygdala

  2021cites this paper
• Exploring the relationship between recency and frequency of cannabis use and diminished expression and apathy as two dimensions of negative symptoms in first episode psychosis. A one-year follow-up study.

  2021cites this paper
• Implicit and Explicit Beliefs About the Effectiveness of Psychotherapy vs. Medication

  2021cites this paper
• Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

  2021cites this paper
• The perception of well-being: Do people with severe psychiatric conditions and their therapists put themselves in each other’s shoes?

  2021cites this paper
• Neuroplastic effects of a selective serotonin reuptake inhibitor in relearning and retrieval

  2021cites this paper
• Using Computational Modelling to Capture Schizophrenia-Specific Reinforcement Learning Differences and Their Implications on Patient Classification.

  2021cites this paper
• Inattentive responding can induce spurious associations between task behavior and symptom measures

  2021cites this paper
• MindTick: Case Study of a Digital System for Mental Health Clinicians to Monitor and Support Patients Outside Clinics

  2021cites this paper
• Avolition as the core negative symptom in schizophrenia: relevance to pharmacological treatment development

  2021cites this paper
• Biobehavioral correlates of an fMRI index of striatal tissue iron in depressed patients

  2021cites this paper
• Generalizable brain network markers of major depressive disorder across multiple imaging sites

  2020cites this paper
• Investigating Associations Between Early Life Stress, Neural Response to Reward, and Depression

  2020cites this paper
• Enhancing Psychosis Risk Prediction Through Computational Cognitive Neuroscience

  2020cites this paper
• Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders

  2020cites this paper
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  2020cites this paper
• Alterations of oscillatory neuronal activity during reward processing in schizophrenia.

  2020cites this paper
• Learning and Motivation for Rewards in Schizophrenia: Implications for Behavioral Rehabilitation

  2020cites this paper
• Depression history as a predictor of outcomes during buprenorphine-naloxone treatment of prescription opioid use disorder.

  2020cites this paper