Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells

Relatively little is known about how receptor tyrosine kinase ligands can positively cooperate with BMP signaling. Primary cultures of lens cells were used to reveal an unprecedented type of cross-talk between the canonical FGF and BMP signaling pathways that regulates lens cell differentiation and intercellular coupling.

• Publication year

  2015

• Venue

  Molecular Biology of the Cell

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E15-02-0117PMID 25947138PMCID 4571308
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular mediators of transforming growth factor β superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo

  2015influential reference
• The lens equator: A platform for molecular machinery that regulates the switch from cell proliferation to differentiation in the vertebrate lens

  2014cited by this paper
• Frs2&agr; and Shp2 signal independently of Gab to mediate FGF signaling in lens development

  2014cited by this paper
• Link Protein N-terminal Peptide Binds to Bone Morphogenetic Protein (BMP) Type II Receptor and Drives Matrix Protein Expression in Rabbit Intervertebral Disc Cells*

  2013cited by this paper
• Essential role of Bmp signaling and its positive feedback loop in the early cell fate evolution of chordates.

  2013cited by this paper
• Identification and Characterization of FGF2-Dependent mRNA: microRNA Networks During Lens Fiber Cell Differentiation

  2013cited by this paper
• Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development

  2012cited by this paper
• A balance of FGF and BMP signals regulates cell cycle exit and Equarin expression in lens cells

  2012cited by this paper
• Primary Cultures of Embryonic Chick Lens Cells as a Model System to Study Lens Gap Junctions and Fiber Cell Differentiation

  2012influential reference
• Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes

  2012cited by this paper
• MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.

  2011cited by this paper
• Understanding the role of growth factors in embryonic development: insights from the lens

  2011cited by this paper
• Id Gene Regulation and Function in the Prosensory Domains of the Chicken Inner Ear: A Link between Bmp Signaling and Atoh1

  2010influential reference
• Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity*

  2010cited by this paper
• Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade.

  2010cited by this paper
• De-regulated FGF receptors as therapeutic targets in cancer.

  2010cited by this paper
• Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates

  2010cited by this paper
• The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.

  2009influential reference
• Upregulation and maintenance of gap junctional communication in lens cells.

  2009influential reference
• Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

  2008influential reference
• Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.

  2008influential reference
• Essential role of BMPs in FGF-induced secondary lens fiber differentiation.

  2008influential reference
• Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells.

  2008influential reference
• Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis IVA.

  2008cited by this paper
• Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.

  2008cited by this paper
• FGF-mediated induction of ciliary body tissue in the chick eye.

  2007cited by this paper
• Oligonucleotide microarray analysis of human lens epithelial cells: TGFbeta regulated gene expression.

  2007cited by this paper
• Balancing BMP signaling through integrated inputs into the Smad1 linker.

  2007cited by this paper
• Time of exposure to BMP signals plays a key role in the specification of the olfactory and lens placodes ex vivo.

  2007cited by this paper
• A rapid and sensitive bioassay to measure bone morphogenetic protein activity

  2007cited by this paper
• Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.

  2007cited by this paper
• Intracellular mediators of transforming growth factor β superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo

  2007cited by this paper
• An assay for the determination of biologically active bone morphogenetic proteins using cells transfected with an inhibitor of differentiation promoter-luciferase construct.

  2006cited by this paper
• An essential role for FGF receptor signaling in lens development.

  2006cited by this paper
• BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways

  2006cited by this paper
• Regulation of αA‐crystallin via Pax6, c‐Maf, CREB and a broad domain of lens‐specific chromatin

  2006influential reference
• Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development

  2006cited by this paper
• Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction.

  2006cited by this paper
• Fibroblast Growth Factor-1 Induces Heme Oxygenase-1 via Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) in Spinal Cord Astrocytes CONSEQUENCES FOR MOTOR NEURON SURVIVAL*

  2005cited by this paper
• Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells

  2005cited by this paper
• Regulation of Twist, Snail, and Id1 is conserved between the developing murine palate and tooth

  2005cited by this paper
• Fibroblast Growth Factor-1 Induces Heme Oxygenase-1 via Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) in Spinal Cord Astrocytes

  2005cited by this paper
• Growth factor regulation of lens development.

  2005cited by this paper
• Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.

  2005cited by this paper
• Cellular signaling by fibroblast growth factor receptors.

  2005cited by this paper
• BMP and activin receptor expression in lens development.

  2004cited by this paper
• FGF18 Represses Noggin Expression and Is Induced by Calcineurin*

  2004cited by this paper
• Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia.

  2004cited by this paper
• Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins

  2004cited by this paper
• Alterations in Receptor Expression or Agonist Concentration Change the Pathways Gastrin-Releasing Peptide Receptor Uses to Regulate Extracellular Signal-Regulated Kinase

  2004cited by this paper
• Contributions by members of the TGFbeta superfamily to lens development.

  2004cited by this paper
• Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 Tyrosine Phosphorylation and Subsequent ERK Activation*

  2003cited by this paper
• The BMP antagonist noggin regulates cranial suture fusion

  2003cited by this paper
• Fibroblast growth factors and their receptors in the central nervous system

  2003cited by this paper
• Controlling cell fate by bone morphogenetic protein receptors.

  2003cited by this paper
• Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells.

  2003cited by this paper
• Movement of cysteine in intact monkey lenses: the major site of entry is the germinative region.

  2003cited by this paper
• Integration of Smad and MAPK pathways: a link and a linker revisited.

  2003cited by this paper
• Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter*

  2002cited by this paper
• Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation ofId1 Gene*

  2002cited by this paper
• FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl

  2002cited by this paper
• Retinal ablation and altered lens differentiation induced by ocular overexpression of BMP7.

  2002cited by this paper
• Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

  2002cited by this paper
• Identification of a BMP‐responsive element in Id1, the gene for inhibition of myogenesis

  2002cited by this paper
• BMP signaling is required for development of the ciliary body.

  2002cited by this paper
• Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations.

  2002cited by this paper
• A novel role for FGF and extracellular signal–regulated kinase in gap junction–mediated intercellular communication in the lens

  2001influential reference
• FGF signaling in chick lens development.

  2001influential reference
• Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation.

  2001cited by this paper
• Neural induction: toward a unifying mechanism

  2001cited by this paper
• Fgf receptor signaling plays a role in lens induction.

  2001cited by this paper
• Molecular solutions to mammalian lens transparency.

  2001cited by this paper
• FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling.

  2001cited by this paper
• A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens.

  2001cited by this paper
• Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo.

  2000cited by this paper
• The Homeodomain Transcription Factor Xvent-2 Mediates Autocatalytic Regulation of BMP-4 Expression in XenopusEmbryos*

  2000cited by this paper
• Peter Bishop Lecture: Growth factors in lens development and cataract: key roles for fibroblast growth factor and TGF‐β

  2000cited by this paper
• Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.

  2000cited by this paper
• FGF and genes encoding transcription factors in early limb specification.

  2000cited by this paper
• Lens development

  1999cited by this paper
• Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme.

  1999cited by this paper
• Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells*

  1999cited by this paper
• BMP7 acts in murine lens placode development.

  1999influential reference
• Expression of transforming growth factor-beta superfamily receptors in rat eyes.

  1999cited by this paper
• Normal differentiation of cultured lens cells after inhibition of gap junction-mediated intercellular communication.

  1998influential reference
• Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice.

  1998cited by this paper
• Smads and early developmental signaling by the TGFbeta superfamily.

  1998cited by this paper
• Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice.

  1998cited by this paper
• BMP4 is essential for lens induction in the mouse embryo.

  1998influential reference
• Human Smad3 and Smad4 are sequence-specific transcription activators.

  1998cited by this paper
• Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

  1998influential reference
• Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

  1997cited by this paper
• Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene.

  1997cited by this paper
• Physiological properties of the normal lens.

  1997cited by this paper
• Osmoreceptors in the central nervous system.

  1997cited by this paper
• Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf*

  1996cited by this paper
• The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.

  1996cited by this paper
• Lens-specific expression of PDGF-A alters lens growth and development.

  1996cited by this paper
• Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1

  1996influential reference
• IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages.

  1993cited by this paper

• Analysis of mouse lens morphological and proteomic abnormalities following deletion of the βB3-crystallin promoter.

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• TGFβ overcomes FGF-induced transinhibition of EGFR in lens cells to enable fibrotic secondary cataract

  2024cites this paper
• TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells

  2024influential citation
• Lens Epithelial Explants Treated with Vitreous Humor Undergo Alterations in Chromatin Landscape with Concurrent Activation of Genes Associated with Fiber Cell Differentiation and Innate Immune Response

  2023cites this paper
• Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency

  2023cites this paper
• BMP-4 and BMP-7 Inhibit EMT in a Model of Anterior Subcapsular Cataract in Part by Regulating the Notch Signaling Pathway

  2023cites this paper
• Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology

  2022cites this paper
• Insights into Bone Morphogenetic Protein—(BMP-) Signaling in Ocular Lens Biology and Pathology

  2021cites this paper
• Protective Effect and Mechanism of Bone Morphogenetic Protein-4 on Apoptosis of Human Lens Epithelium Cells under Oxidative Stress

  2021cites this paper
• Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development

  2021cites this paper
• Fibronectin has multifunctional roles in posterior capsular opacification (PCO).

  2020cites this paper
• Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3

  2019cites this paper
• Reduced NGF Level Promotes Epithelial–Mesenchymal Transition in Human Lens Epithelial Cells Exposed to High Dexamethasone Concentrations

  2019cites this paper
• A comprehensive spatial‐temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cells

  2018cites this paper
• Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens

  2018cites this paper
• Crim1 is required for maintenance of the ocular lens epithelium

  2018cites this paper
• TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition.

  2018cites this paper
• Dual release of growth factor from nanocomposite fibrous scaffold promotes vascularisation and bone regeneration in rat critical sized calvarial defect.

  2018cites this paper
• Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract

  2017influential citation
• Signaling and Gene Regulatory Networks in Mammalian Lens Development.

  2017cites this paper
• The Progress of BMP4 on the Role of Ocular Development and Eye Diseases

  2017cites this paper
• TGF- b Family Signaling in Epithelial Differentiation and Epithelial – Mesenchymal Transition

  2017cites this paper
• The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma

  2016cites this paper
• β1-integrin controls cell fate specification in early lens development.

  2016cites this paper
• Control of lens development by Lhx2-regulated neuroretinal FGFs

  2016cites this paper
• Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling*

  2015cites this paper
• Prox1 and fibroblast growth factor receptors form a novel regulatory loop that promotes lens fiber differentiation and regulates global gene expression

  2015cites this paper
• The role of β1-integrin and its ligands in lens development and disease

  2015cites this paper
• Research progress on the regulation of BMP 4 on ocular cells

  year unknowncites this paper