Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract

TGFβ signaling is linked to posterior capsule opacification (PCO), the most common complication of cataract surgery. TGFβ can induce primary lens epithelial cells to differentiate into two disparate, PCO-causing abnormal cell phenotypes, a variation of the TGFβ paradox. Analysis of the signaling pathways downstream of TGFβ reveals novel therapeutic targets for PCO.

• Publication year

  2017

• Venue

  Molecular Biology of the Cell

• Publication date

  2017-02-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E16-12-0865PMID 28209733PMCID 5385940
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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