Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Virology

• Publication date

  1993-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.67.9.5139-5145.1993PMID 8394441PMCID PMC237911
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modifications of the 5' untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture.

  1992cited by this paper
• Creating chimeric molecules by PCR directed homologous DNA recombination.

  1991cited by this paper
• Chimeric cDNA clones: a novel PCR artifact.

  1991cited by this paper
• Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA

  1990influential reference
• Attenuation of Mengo virus through genetic engineering of the 5′ noncoding poly(C) tract

  1990influential reference
• Gross rearrangements within the 5'-untranslated region of the picornaviral genomes.

  1990cited by this paper
• Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability.

  1990cited by this paper
• An improved method for directly sequencing PCR amplified material using dimethyl sulphoxide.

  1989cited by this paper
• Production of single-stranded DNA templates by exonuclease digestion following the polymerase chain reaction.

  1989cited by this paper
• Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts

  1989cited by this paper
• Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus.

  1989cited by this paper
• An improved method for directly sequencing PCR amplified material using dimethyl sulphoxide.

  1989cited by this paper
• Heterogeneity of the polyribocytidilic acid tract in aphthovirus: changes in the size of the poly(C) of viruses recovered from persistently infected cattle.

  1988cited by this paper
• Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

  1988cited by this paper
• A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

  1988cited by this paper
• Subtyping of European foot-and-mouth disease virus strains by nucleotide sequence determination

  1987cited by this paper
• Proteolytic processing of foot-and-mouth disease virus polyproteins expressed in a cell-free system from clone-derived transcripts

  1987cited by this paper
• Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus.

  1987influential reference
• Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates.

  1987cited by this paper
• Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase.

  1986cited by this paper
• The mechanism of RNA recombination in poliovirus

  1986cited by this paper
• The sequence of foot-and-mouth disease virus RNA to the 5' side of the poly(C) tract.

  1985cited by this paper
• Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

  1985cited by this paper
• Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

  1985cited by this paper
• Nucleotide and amino acid sequence coding for polypeptides of foot-and-mouth disease virus type A12

  1985cited by this paper
• Comparison of the Nucleotide Sequence at the 5′ End of RNAs from Nine Aphthoviruses, Including Representatives of the Seven Serotypes

  1980cited by this paper
• Foot-and-mouth disease virion RNA: studies on the relation between the length of its 3'-poly(A) segment and infectivity.

  1979cited by this paper
• Sequence and location of the poly C tract in aphtho- and cardiovirus RNA.

  1979cited by this paper
• More precise location of the polycytidylic acid tract in foot and mouth disease virus RNA

  1978cited by this paper
• Biochemical analysis of a virulent and an avirulent strain of foot-and-mouth disease virus.

  1977cited by this paper
• The genomic RNA of mengovirus. I. Location of the poly(C) tract.

  1977cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Poly(C) sequence is located near the 5'-end of encephalomyocarditis virus RNA.

  1976cited by this paper
• The location of the ploy(C) tract in the RNA of foot-and-mouth disease virus.

  1976cited by this paper
• The Location of the Poly(C) Tract in the RNA of Foot-and-Mouth Disease Virus

  1976cited by this paper
• Presence of a large poly(rC) tract within the RNA of encephalomyocarditis virus

  1974cited by this paper
• Poly(C) in animal viral RNAs

  1974cited by this paper
• A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS

  1938cited by this paper

• The pseudoknot region and poly-(C) tract comprise an essential RNA packaging signal for assembly of foot-and-mouth disease virus

  2024cites this paper
• Virulence and Immune Evasion Strategies of FMDV: Implications for Vaccine Design

  2024cites this paper
• Developments in Negative-Strand RNA Virus Reverse Genetics

  2024cites this paper
• Molecular Basis of the Pathogenicity of the Foot-and-Mouth Disease Virus Isolated in Japan

  2024cites this paper
• Structural diversity and biological role of the 5’ untranslated regions of picornavirus

  2023cites this paper
• The Application of the Gibson Assembly Method in the Production of Two pKLS3 Vector-Derived Infectious Clones of Foot-and-Mouth Disease Virus

  2023cites this paper
• Mutation of FMDV Lpro H138 residue drives viral attenuation in cell culture and in vivo in swine

  2022cites this paper
• Polycytidine tract deletion from microRNA-detargeted oncolytic Mengovirus optimizes the therapeutic index in a murine multiple myeloma model

  2022cites this paper
• The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus

  2022cites this paper
• DDX60 selectively reduces translation off viral type II internal ribosome entry sites

  2022cites this paper
• Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites

  2022cites this paper
• The rescue and selection of thermally stable type O vaccine candidate strains of foot-and-mouth disease virus

  2021cites this paper
• The long-lasting enigma of polycytidine (polyC) tract

  2021influential citation
• A Novel Plasmid DNA-Based Foot and Mouth Disease Virus Minigenome for Intracytoplasmic mRNA Production

  2021influential citation
• The Rescue and the Selection of the Thermally Stabled Type O Vaccine Candidate Strains of Foot-and-mouth Disease Virus

  2021cites this paper
• Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines

  2020cites this paper
• Modification of the second translation initiation site restricts the replication of foot-and-mouth disease virus in PK-15 cells

  2020cites this paper
• Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

  2020cites this paper
• Symmetrical arrangement of positively charged residues around the 5-fold axes of SAT type foot-and-mouth disease virus enhances cell culture of field viruses

  2020cites this paper
• Impairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation In Vitro and In Vivo

  2020cites this paper
• Pathogenesis, biophysical stability and phenotypic variance of SAT2 foot-and-mouth disease virus.

  2020cites this paper
• The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus

  2020cites this paper
• Immunogenicity and protective efficacy of 3A truncated negative marker foot-and-mouth disease virus serotype A vaccine

  2020cites this paper
• Inherent biophysical stability of foot-and-mouth disease SAT1, SAT2 and SAT3 viruses.

  2019cites this paper
• Stepping Stones in Foot-and-Mouth Research: A Personal View

  2019cites this paper
• Reverse Genetic Approaches for the Generation of Recombinant Zika Virus

  2018cites this paper
• Investigating the foot-and-mouth disease virus 3A protein

  2018cites this paper
• Epidémiologie moléculaire de la fièvre aphteuse en Afrique Subsaharienne : cas du Tchad

  2018cites this paper
• Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation

  2018cites this paper
• Improvement of foot-and-mouth disease virus vaccines and diagnostics through structural design

  2018cites this paper
• The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity

  2018cites this paper
• SAT2 Foot-and-Mouth Disease Virus Structurally Modified for Increased Thermostability

  2017cites this paper
• Evaluation of immune responses of stabilised SAT2 antigens of foot-and-mouth disease in cattle.

  2017cites this paper
• Improved stability of foot-and-mouth disease virus (FMDV) SAT2 capsid

  2017cites this paper
• Interaction between FMDV Lpro and transcription factor ADNP is required for optimal viral replication.

  2017cites this paper
• Proof-of-concept study: profile of circulating microRNAs in Bovine serum harvested during acute and persistent FMDV infection

  2017cites this paper
• Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells

  2016cites this paper
• Conserved elements within the genome of foot-and mouth disease virus; their influence on virus replication

  2016influential citation
• Novel 6xHis tagged foot-and-mouth disease virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity.

  2016cites this paper
• The rescue and evaluation of FLAG and HIS epitope-tagged Asia 1 type foot-and-mouth disease viruses.

  2016cites this paper
• Construction and characterization of a full-length infectious cDNA clone of foot-and-mouth disease virus strain O/JPN/2010 isolated in Japan in 2010.

  2016cites this paper
• A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses

  2016cites this paper
• Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: Impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of inoculation.

  2016cites this paper
• Comparative Proteomic Analysis of Wild-Type and SAP Domain Mutant Foot-and-Mouth Disease Virus-Infected Porcine Cells Identifies the Ubiquitin-Activating Enzyme UBE1 Required for Virus Replication.

  2015cites this paper
• Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design

  2015cites this paper
• Construction and characterization of 3A-epitope-tagged foot-and-mouth disease virus.

  2015cites this paper
• Development of a foot-and-mouth disease virus replicon system for the study of RNA replication

  2015cites this paper
• Synonymous Deoptimization of Foot-and-Mouth Disease Virus Causes Attenuation In Vivo while Inducing a Strong Neutralizing Antibody Response

  2015cites this paper
• Recovery of infectious type Asia1 foot-and-mouth disease virus from suckling mice directly inoculated with an RNA polymerase I/II-driven unidirectional transcription plasmid.

  2015cites this paper
• Genetic and phenotypic characterisation of selected african foot-and-mouth disease virus isolates

  2015cites this paper
• Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: role of Jumonji C-domain containing protein 6 in RHA demethylation.

  2014cites this paper
• Evaluation of a 3A-truncated foot-and-mouth disease virus in pigs for its potential as a marker vaccine

  2014cites this paper
• Construction and characterization of an infectious cDNA clone of encephalomyocarditis virus from pigs in China

  2014cites this paper
• RNA structure disrupting G320-T transversion within the short fragment of the 5' untranslated region prevents rescue of infectious foot-and-mouth disease virus.

  2014cites this paper
• Determining the Epitope Dominance on the Capsid of a Serotype SAT2 Foot-and-Mouth Disease Virus by Mutational Analyses

  2014cites this paper
• Type III Interferon Protects Swine Against Foot-and-Mouth Disease

  2014cites this paper
• Foot-and-Mouth Disease Virus Replication IRF 7 / 3 ( 5 D ) Efficiently Controls Expression of Porcine Fusion Protein

  2014cites this paper
• Expression of Porcine Fusion Protein IRF7/3(5D) Efficiently Controls Foot-and-Mouth Disease Virus Replication

  2014cites this paper
• Enhancement of Innate Immunity to Control Viral Infections in Livestock Species

  2014cites this paper
• Enhanced IRES activity by the 3'UTR element determines the virulence of FMDV isolates.

  2014cites this paper
• Sequences outside that of residues 93-102 of 3A protein can contribute to the ability of foot-and-mouth disease virus (FMDV) to replicate in bovine-derived cells.

  2014cites this paper
• transfection.direct intrahepatic nucleic acid nontranslated RNA remains virulent in primates the first pyrimidine-rich tract of the 5' A hepatitis A virus deletion mutant which lacks

  2013cites this paper
• Analysis of SAT Type Foot-And-Mouth Disease Virus Capsid Proteins and the Identification of Putative Amino Acid Residues Affecting Virus Stability

  2013cites this paper
• Genetic heterogeneity in the leader and P1-coding regions of foot-and-mouth disease virus serotypes A and O in Africa

  2013cites this paper
• Rescue of infective virus from a genome-length cDNA clone of the FMDV serotype O (IND-R2/75) vaccine strain and its characterization.

  2013cites this paper
• Engineering Foot-and-Mouth Disease Viruses with Improved Growth Properties for Vaccine Development

  2013cites this paper
• Repeated exposure to 5 D 9 , an inhibitor of 3 D polymerase , effectively limits the replication

  2013cites this paper
• Characterization of a chimeric foot-and-mouth disease virus bearing a bovine rhinitis B virus leader proteinase.

  2013cites this paper
• Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.

  2013cites this paper
• Examination of soluble integrin resistant mutants of foot-and-mouth disease virus

  2013cites this paper
• Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis.

  2013cites this paper
• proteinase of foot-and-mouth disease virus. Identification of the active-site residues of the L

  2013cites this paper
• Theiler's murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism.

  2013cites this paper
• Mapping of antigenic determinants on a SAT2 foot-and-mouth disease virus using chicken single-chain antibody fragments.

  2012cites this paper
• Foot and Mouth Disease Virus Genome

  2012cites this paper
• A Safe Foot-and-Mouth Disease Vaccine Platform with Two Negative Markers for Differentiating Infected from Vaccinated Animals

  2012cites this paper
• Dissecting the molecular basis of foot-and-mouth disease virus evolution

  2012cites this paper
• Foot-and-mouth disease: Global status and Indian perspective

  2012cites this paper
• Role of arginine-56 within the structural protein VP3 of foot-and-mouth disease virus (FMDV) O1 Campos in virus virulence.

  2012cites this paper
• The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells.

  2012cites this paper
• Capsid coding sequences of foot-and-mouth disease viruses are determinants of pathogenicity in pigs

  2012cites this paper
• Evaluation of a genetically modified foot-and-mouth disease virus vaccine candidate generated by reverse genetics

  2012cites this paper
• Expression and Stability of Foreign Epitopes Introduced into 3A Nonstructural Protein of Foot-and-Mouth Disease Virus

  2012cites this paper
• Construction of genome-length cDNA for foot-and-mouth disease virus serotype Asia 1 IND 63/72 vaccine strain

  2011cites this paper
• Antiviral activity of bovine type III interferon against foot-and-mouth disease virus.

  2011cites this paper
• Analysis of SAT1 type foot-and-mouth disease virus capsid proteins: influence of receptor usage on the properties of virus particles.

  2011cites this paper
• Custom-engineered chimeric foot-and-mouth disease vaccine elicits protective immune responses in pigs.

  2011cites this paper
• Inoculation of Swine with Foot-and-Mouth Disease SAP-Mutant Virus Induces Early Protection against Disease

  2011cites this paper
• Increased efficacy of an adenovirus-vectored foot-and-mouth disease capsid subunit vaccine expressing nonstructural protein 2B is associated with a specific T cell response.

  2011cites this paper
• Isolation, identification and complete genome sequence analysis of a strain of foot-and-mouth disease virus serotype Asia1 from pigs in southwest of China

  2011cites this paper
• Capsid proteins from field strains of foot-and-mouth disease virus confer a pathogenic phenotype in cattle on an attenuated, cell-culture-adapted virus.

  2011cites this paper
• In-vitro and in-vivo phenotype of type Asia 1 foot-and-mouth disease viruses utilizing two non-RGD receptor recognition sites

  2011cites this paper
• ncreased efficacy of an adenovirus-vectored foot-and-mouth disease capsid ubunit vaccine expressing nonstructural protein 2 B is associated with a specific cell response auro

  2011cites this paper
• Infectivity of Asia1 type foot-and-mouth disease virus was increased via an alternative RDD motif

  2010cites this paper
• Mapping of amino acid residues responsible for adhesion of cell culture-adapted foot-and-mouth disease SAT type viruses.

  2010cites this paper
• The region between the two polyprotein initiation codons of foot-and-mouth disease virus is critical for virulence in cattle.

  2010cites this paper
• Investigating the specificity of the Foot-and-mouth diesease leader protease using mutational analysis

  2010cites this paper
• A mutant of infectious Asia 1 serotype foot-and-mouth disease virus with the deletion of 10-amino-acid in the 3A protein

  2010cites this paper
• Strategy for Novel Vaccine and Antivirals Against Foot-and-Mouth Disease

  2010cites this paper
• Domain disruptions of individual 3B proteins of foot-and-mouth disease virus do not alter growth in cell culture or virulence in cattle.

  2010cites this paper