The Production of IFN-γ by IL-12/IL-18-Activated Macrophages Requires STAT4 Signaling and Is Inhibited by IL-41

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Immunology

• Publication date

  2001-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.166.5.3075PMID 11207258
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• A Signal Transducer and Activator of  Transcription (Stat)4-independent Pathway for the Development of  T Helper Type 1 Cells

  1998influential reference
• Type 1 Interferon (IFNα/β) and Type 2 Nitric Oxide Synthase Regulate the Innate Immune Response to a Protozoan Parasite

  1998cited by this paper
• Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

  1998cited by this paper
• Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite.

  1998cited by this paper
• IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

  1998cited by this paper
• Interleukin-4 and interleukin-13: their similarities and discrepancies.

  1998cited by this paper
• IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

  1998cited by this paper
• Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis

  1997cited by this paper
• IL-11 regulates macrophage effector function through the inhibition of nuclear factor-kappaB.

  1997cited by this paper
• IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.

  1997cited by this paper
• Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

  1997cited by this paper
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• Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.

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• IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6.

  1996cited by this paper
• Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

  1996cited by this paper
• Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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  1995cited by this paper
• Autoregulation by interferons provides an endogenous 'priming' signal for LPS-responsive macrophages

  1995cited by this paper
• Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

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• Interferon gamma upregulates its own gene expression in mouse peritoneal macrophages

  1994cited by this paper
• Interferon-gamma and host antimicrobial defense: current and future clinical applications.

  1994cited by this paper
• Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major

  1994cited by this paper
• The molecular cell biology of interferon-gamma and its receptor.

  1993cited by this paper
• Induction of IFN-γ in macrophages by lipopolysaccharide

  1993cited by this paper
• Induction of IFN-gamma in macrophages by lipopolysaccharide.

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• Modulation of Macrophage Function by Transforming Growth Factor β, Interleukin‐4, and Interleukin‐10 a

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• Analysis of cytokine mRNA levels in interleukin‐4‐transgenic mice by quantitative polymerase chain reaction

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