The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Development

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10631182
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity.

  2000cited by this paper
• GDF5 coordinates bone and joint formation during digit development.

  1999cited by this paper
• Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud.

  1999cited by this paper
• Sox9 is required for cartilage formation

  1999cited by this paper
• Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-β Family Receptors*

  1999cited by this paper
• Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling.

  1998cited by this paper
• Specific Activation of Smad 1 Signaling Pathways by the BMP 7 Type I Receptor , ALK 2 *

  1998cited by this paper
• Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2*

  1998cited by this paper
• The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors.

  1998cited by this paper
• Compressive force promotes sox9, type II collagen and aggrecan and inhibits IL-1beta expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells.

  1998cited by this paper
• Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV.

  1998cited by this paper
• Determinants of specificity in TGF-beta signal transduction.

  1998cited by this paper
• Signal transduction by bone morphogenetic proteins.

  1998cited by this paper
• Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning.

  1998cited by this paper
• Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages

  1998cited by this paper
• Bone Morphogenetic Protein Signaling Is Required for Maintenance of Differentiated Phenotype, Control of Proliferation, and Hypertrophy in Chondrocytes

  1998cited by this paper
• Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage.

  1997influential reference
• Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

  1997cited by this paper
• Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development.

  1997cited by this paper
• SOX9 directly regulates the type-ll collagen gene

  1997cited by this paper
• Osteoblasts Express Types I and II Activin Receptors During Early Intramembranous and Endochondral Bone Formation

  1997influential reference
• BMP signaling during bone pattern determination in the developing limb.

  1996cited by this paper
• Requirement for BMP Signaling in Interdigital Apoptosis and Scale Formation

  1996cited by this paper
• Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.

  1996cited by this paper
• Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5*

  1996influential reference
• MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

  1996cited by this paper
• Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

  1995cited by this paper
• A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

  1995cited by this paper
• Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

  1995cited by this paper
• Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.

  1995cited by this paper
• The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos

  1995cited by this paper
• Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs

  1995cited by this paper
• BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

  1995cited by this paper
• Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb.

  1994cited by this paper
• Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

  1994influential reference
• Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

  1994cited by this paper
• A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4.

  1994cited by this paper
• Gene targeting in embryonic stem cells.

  1993cited by this paper
• Guide to techniques in mouse development

  1993cited by this paper
• Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse.

  1991cited by this paper
• Gene targeting in embryonic stem cells.

  1991cited by this paper
• Temporal and spatial analysis of cartilage proteoglycan core protein gene expression during limb development by in situ hybridization.

  1988cited by this paper
• Manipulating the mouse embryo: A laboratory manual

  1986cited by this paper
• Developmental and cellular skeletal biology

  1978cited by this paper
• Brachypodism in the mouse.

  1977cited by this paper
• The anatomy and development of brachypodism in the mouse.

  1973cited by this paper

• TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease

  2026influential citation
• Atypical Fibrodysplasia Ossificans Progressiva with G328E Variant and Digit Reduction Abnormalities: A Report of 2 Cases.

  2025cites this paper
• Self-organized BMP signaling dynamics underlie the development and evolution of digit segmentation patterns in birds and mammals

  2024cites this paper
• The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

  2024influential citation
• The modulatory role of bone morphogenetic protein signaling in cerebellar synaptic plasticity

  2024cites this paper
• Acromesomelic Dysplasia With Homozygosity for a Likely Pathogenic BMPR1B Variant: Postaxial Polydactyly as a Novel Clinical Finding

  2024cites this paper
• Influence of DNA-methylation at multiple stages of limb chondrogenesis.

  2024cites this paper
• Impaired 1,25-dihydroxyvitamin D3 action underlies enthesopathy development in the Hyp mouse model of X-linked hypophosphatemia

  2023cites this paper
• Enhanced BMP signaling leads to enlarged nasal cartilage formation in mice.

  2023cites this paper
• Self-organized BMP signaling dynamics underlie the development and evolution of tetrapod digit patterns

  2023cites this paper
• Optogenetic manipulation of BMP signaling to drive chondrogenic differentiation of hPSCs.

  2023cites this paper
• A human embryonic limb cell atlas resolved in space and time

  2023cites this paper
• Proteoglycan inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification

  2023cites this paper
• BMP Signaling Pathway in Dentin Development and Diseases

  2022cites this paper
• The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function

  2022cites this paper
• Mechanical feedback defines organizing centers to drive digit emergence.

  2022cites this paper
• Adverse effects of prenatal dexamethasone exposure on fetal development.

  2022cites this paper
• A human embryonic limb cell atlas resolved in 1 space and time 2

  2022cites this paper
• Anti-Müllerian Hormone Signal Transduction involved in Müllerian Duct Regression

  2022cites this paper
• BMPR-IB gene disruption causes severe limb deformities in pigs

  2022cites this paper
• BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis

  2021cites this paper
• Rethinking positional information and digit identity: The role of late interdigit signaling

  2021cites this paper
• Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates.

  2021cites this paper
• Interspecies transcriptomics identify genes that underlie disproportionate foot growth in jerboas.

  2021cites this paper
• Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate

  2021cites this paper
• THE ROLE OF THE MICROENVIRONMENT IN GROWTH PLATE AND ARTICULAR CHONDROCYTE DIFFERENTIATION

  2021cites this paper
• Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development

  2021cites this paper
• Know Your Model: Recombinase-expressing mice

  2020cites this paper
• LTP of inhibition at PV interneuron output synapses requires developmental BMP signaling

  2020cites this paper
• New Perspectives on Bone Morphogenetic Protein Signaling in Chondrogenic Differentiation During Skeletogenesis

  2020cites this paper
• A dot-stripe Turing model of joint patterning in the tetrapod limb

  2020cites this paper
• Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis

  2020cites this paper
• A sense of place, many times over – pattern formation and evolution of repetitive morphological 1 structures 2

  2020cites this paper
• An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 50Hoxd–Gli3 antagonism

  2020cites this paper
• Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture.

  2020cites this paper
• Elucidating the early signaling cues involved in zebrafish chondrogenesis and cartilage morphology.

  2020cites this paper
• Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice

  2020cites this paper
• BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation

  2020cites this paper
• Association of growth performance and body conformational traits with BMP4 gene variation in Barki lambs

  2019cites this paper
• Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion

  2019cites this paper
• Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation.

  2019cites this paper
• Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip

  2019cites this paper
• Specification of BMP Signaling

  2019influential citation
• Mechanisms of synovial joint and articular cartilage development

  2019cites this paper
• Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation C

  2019cites this paper
• The Development and Evolution of Cartilage

  2019cites this paper
• BMPs, TGFβ, and border security at the interzone.

  2019cites this paper
• A sense of place, many times over ‐ pattern formation and evolution of repetitive morphological structures

  2019cites this paper
• Course-, dose-, and stage-dependent toxic effects of prenatal dexamethasone exposure on fetal articular cartilage development.

  2018cites this paper
• The TGF‐β Superfamily in Bone Formation and Maintenance

  2018cites this paper
• Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice

  2018cites this paper
• TGF-β Family Signaling in Mesenchymal Differentiation.

  2018cites this paper
• Correlating interfacial water dynamics with protein-protein interaction in complex of GDF-5 and BMPRI receptors.

  2018cites this paper
• Bone morphogenetic protein receptor signal transduction in human disease

  2018cites this paper
• Phenotypic Analyses of Genetically Modified Mice for BMP Receptors.

  2018cites this paper
• Disruption of bone morphogenetic protein type IA receptor in osteoblasts impairs bone quality and bone strength in mice

  2018cites this paper
• The BMP Pathway and Its Inhibitors in the Skeleton.

  2018cites this paper
• Identification of satellite cells from anole lizard skeletal muscle and demonstration of expanded musculoskeletal potential.

  2018cites this paper
• Molecular Regulation Mechanism of Biomineralization of Pinctada fucata

  2018cites this paper
• Associations between variants of bone morphogenetic protein 7 gene and growth traits in chickens

  2018cites this paper
• Role of BMP Signaling for the Formation of Auditory Brainstem Nuclei and Large Auditory Relay Synapses

  2018cites this paper
• Generation and Identification of Genetically Modified Mice for BMP Receptors.

  2018cites this paper
• An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 50Hoxd–Gli3 antagonism

  2018cites this paper
• Generation of gene-edited sheep with a defined Booroola fecundity gene (FecBB) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9.

  2018cites this paper
• Bone morphogenetic protein-2 and -7 mediate the anabolic function of nucleus pulposus cells with discrete mechanisms

  2017cites this paper
• Jussi Heinonen: Role of Snorc, a Novel Cartilage Transmembrane Proteoglycan, in Skeletal Tissue Homeostasis

  2017cites this paper
• Differential molecular regulation of processing and membrane expression of Type-I BMP receptors: implications for signaling

  2017cites this paper
• BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.

  2017cites this paper
• TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.

  2017cites this paper
• Microscopic Evaluations of Bone in Equine and Muroid Models

  2017cites this paper
• Enhancer Composition and Dosage Control Developmental Gene Expression at theIhh Locus

  2017cites this paper
• Bone Morphogenetic Protein Signaling in Pulmonary Arterial Hypertension

  2017cites this paper
• Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.

  2017cites this paper
• The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders

  2016cites this paper
• Challenging the Dogma of Canonical BMP signaling in the absence of Smad4 during Endochondral Bone Formation

  2016cites this paper
• A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal

  2016cites this paper
• receptor decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.

  2016cites this paper
• BMP signalling in skeletal development, disease and repair

  2016cites this paper
• Getting a handle on embryo limb development: Molecular interactions driving limb outgrowth and patterning.

  2016cites this paper
• Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK.

  2016cites this paper
• The biological function of type I receptors of bone morphogenetic protein in bone

  2016cites this paper
• Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication

  2016cites this paper
• An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism

  2016cites this paper
• Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors

  2016cites this paper
• Roof plate mediated morphogenesis of the forebrain: New players join the game.

  2016cites this paper
• Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development

  2016cites this paper
• TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

  2016cites this paper
• An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension

  2016cites this paper
• Transforming Growth Factor Beta Super Family Signaling in Development of Colorectal Cancer

  2016cites this paper
• BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse.

  2015influential citation
• The role of GDF5 in the developing vertebrate nervous system

  2015cites this paper
• Role of the Bone Morphogenetic Protein Pathway in Definitive Endoderm Patterning

  2015cites this paper
• UC San Francisco UC San Francisco Previously Published Works Title Targeting BMP signalling in cardiovascular disease and anaemia

  2015cites this paper
• The impact of angelicae sinensis radix and its herb-pairs in embryonic development

  2015cites this paper
• Mechanisms of BMP-Receptor Interaction and Activation.

  2015cites this paper
• GDF-5 can act as a context-dependent BMP-2 antagonist

  2015cites this paper
• eview etting a handle on embryo limb development : Molecular nteractions driving limb outgrowth and patterning

  2015cites this paper
• The Type I BMP Receptor ACVR1/ALK2 is Required for Chondrogenesis During Development

  2015influential citation
• Two novel disease-causing variants in BMPR1B are associated with brachydactyly type A1

  2015cites this paper
• Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation.

  2015cites this paper