Exploring the therapeutic space around NAD+

NAD+ is a central metabolite in the cell. Changes in NAD+ abundance and the activity of NAD+-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD+ levels can improve metabolism and prevent age-related functional decline and associated disease, and how basic scientific discoveries in the NAD+ signaling pathway are being translated to the clinic.

• Publication year

  2012

• Venue

  Journal of Cell Biology

• Publication date

  2012-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201207019PMID 23071150PMCID 3471225
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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