Cardiovascular autonomic and hormonal dysregulation in ischemic stroke with an emphasis on survival

Abstract Ischemic stroke is associated with cardiovascular autonomic nervous system (ANS) disturbances, including reduced heart rate (HR) variability and acute phase neurohumoral activation with elevated stress hormone levels. The impact of HR variability and neurohumoral factors such as natriuretic peptides on the long-term survival of patients with ischemic stroke has not been studied previously. This study was designed to evaluate cardiovascular autonomic regulation in ischemic stroke patients by assessing HR dynamics and various neurohumoral factors. The values of the assessed variables in predicting mortality were evaluated.

• Publication year

  2005

• Venue

  International Journal of Circumpolar Health

• Publication date

  2005-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3402/ijch.v64i5.18034
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of cerebral vascular accident on the level of 17-hydroxycorticosteroids in plasma.

  2009cited by this paper
• Autonomic nervous system disorders in stroke

  2006cited by this paper
• N-terminal pro-B-type natriuretic peptide and long-term mortality in stable coronary heart disease.

  2005cited by this paper
• Cardiac Troponins and N-Terminal Pro-Brain Natriuretic Peptide in Acute Ischemic Stroke Do Not Relate to Clinical Prognosis

  2005influential reference
• Trends in Fatal and Nonfatal Strokes Among Persons Aged 35 to ≥85 Years During 1991–2002 in Finland

  2005cited by this paper
• Morbidity and Mortality After Stroke, Eprosartan Compared With Nitrendipine for Secondary Prevention: Principal Results of a Prospective Randomized Controlled Study (MOSES)

  2005cited by this paper
• Plasma levels of N-terminal pro-brain natriuretic peptide in patients with coronary artery disease and relation to clinical presentation, angiographic severity, and left ventricular ejection fraction.

  2005cited by this paper
• Blood Pressure and Vessel Recanalization in the First Hours After Ischemic Stroke

  2005cited by this paper
• Effects of short-term glucocorticoids on cardiovascular biomarkers.

  2005cited by this paper
• Heart Rate Turbulence: A New Predictor for Risk of Sudden Cardiac Death

  2005cited by this paper
• Blood Pressure Course In Patients With Acute Stroke and Matched Controls

  2005cited by this paper
• Left-insular cortex lesions perturb cardiac autonomic tone in humans

  2005cited by this paper
• Mapping of the cardiac sympathetic nervous system by single photon emission tomography with technetium-99m-labelled fluorobenzylpiperidine derivative (99mTc-FBPBAT): result of a feasibility study in a porcine model and an initial dosimetric estimation in humans

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• Physiological Background of the Loss of Fractal Heart Rate Dynamics

  2005cited by this paper
• Mortality and Cause of Death after Hospital Discharge in 10,981 Patients with Ischemic Stroke and Transient Ischemic Attack

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• Physiological characteristics of low‐threshold mechanoreceptors in joints, muscle and skin in human subjects

  2005cited by this paper
• Fractal and Complexity Measures of Heart Rate Variability

  2005cited by this paper
• Trends in Fatal and Nonfatal Strokes Among Persons Aged 35 to ≥85 Years During 1991–2002 in Finland

  2005cited by this paper
• Heart rate turbulence after atrial premature beats before spontaneous onset of atrial fibrillation.

  2005cited by this paper
• Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies

  2004cited by this paper
• Essential biochemistry and physiology of (NT‐pro)BNP

  2004cited by this paper
• Cardiac 123I-MIBG scintigraphy can assess the disease severity and phenotype of PD.

  2004cited by this paper
• Genetic targeting of the brain renin-angiotensin system in transgenic rats: impact on stress-induced renin release.

  2004cited by this paper
• Central Disorders of Autonomic Function

  2004cited by this paper
• A systematic review of the diagnostic accuracy of natriuretic peptides for heart failure.

  2004cited by this paper
• Insular Cortical Ischemia Is Independently Associated With Acute Stress Hyperglycemia

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• Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides.

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• The Relative Impact of Inadequate Primary and Secondary Prevention on Cardiovascular Mortality in the United States

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• Continuous 15-Year Decrease in Incidence and Mortality of Stroke in Finland: The FINSTROKE Study

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• N-Terminal Pro-Brain Natriuretic Peptide on Admission Has Prognostic Value Across the Whole Spectrum of Acute Coronary Syndromes

  2004cited by this paper
• Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke

  2004cited by this paper
• Declining incidence and mortality of stroke in persons aged ≥ 75 years in Finland; the FINSTROKE study

  2004cited by this paper
• Plasma natriuretic peptide levels and the risk of cardiovascular events and death.

  2004influential reference
• Atrial natriuretic peptide, B-type natriuretic peptide, and serum collagen markers after acute myocardial infarction.

  2004cited by this paper
• Loss of circadian rhythm of blood pressure following acute stroke

  2004cited by this paper
• Is B-type natriuretic peptide-guided heart failure management cost-effective?

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• Long-Term Prognosis, by Stroke Subtypes, after a First-Ever Stroke: A Hospital-Based Study over a 20-Year Period

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• Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

  2004cited by this paper
• Serum Cardiac Troponin I in Acute Stroke Is Related to Serum Cortisol and TNF-α

  2004cited by this paper
• Cardiac effects of stroke

  2004cited by this paper
• International Comparison of Stroke Cost Studies

  2004cited by this paper
• Cardiac Autonomic Derangement and Arrhythmias in Right-Sided Stroke With Insular Involvement

  2004cited by this paper
• Serum-cortisol reflects severity and mortality in acute stroke.

  2004cited by this paper
• Predictors of Neurocardiogenic Injury After Subarachnoid Hemorrhage

  2004cited by this paper
• Lateralization in autononic dysfunction in ischemic stroke involving the insular cortex

  2004cited by this paper
• Effect of cardiac vagal outflow on complexity and fractal correlation properties of heart rate dynamics.

  2003cited by this paper
• Differences between natriuretic peptide receptors in the olfactory bulb and hypothalamus from spontaneously hypertensive and normotensive rat brain.

  2003cited by this paper
• Role of brain natriuretic peptide in cerebral vasospasm

  2003cited by this paper
• Location-Dependent Patterns in Cardio-Autonomic Dysfunction in Ischaemic Stroke

  2003cited by this paper
• Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease

  2003cited by this paper
• Community-Based Thrombolytic Therapy of Acute Ischemic Stroke in Helsinki

  2003cited by this paper
• Changes in Brain Natriuretic Peptide and Norepinephrine Over Time and Mortality and Morbidity in the Valsartan Heart Failure Trial (Val-HeFT)

  2003cited by this paper
• Anatomy and histology

  2003cited by this paper
• Neuroendocrine changes in patients with acute space occupying ischaemic stroke

  2003cited by this paper
• Temporal changes and prognostic significance of measures of heart rate dynamics after acute myocardial infarction in the beta-blocking era.

  2003cited by this paper
• Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression

  2003cited by this paper
• B-Type Natriuretic Peptides and Ejection Fraction for Prognosis After Myocardial Infarction

  2003cited by this paper
• Cardiac rhythm disorders and muscle changes with cerebral lesions.

  2003cited by this paper
• Predictors of outcome after acute ischemic stroke *

  2003cited by this paper
• N‐Terminal Pro‐Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease: A Global Utilization of Strategies To Open occluded arteries (GUSTO)‐IV Substudy

  2003cited by this paper
• Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18.

  2003cited by this paper
• Use of ramipril in preventing stroke: double blind randomised trial

  2002cited by this paper
• Fractal analysis of heart rate variability and mortality after an acute myocardial infarction.

  2002cited by this paper
• BNP and congestive heart failure.

  2002cited by this paper
• Risk stratification using a combination of cardiac troponin T and brain natriuretic peptide in patients hospitalized for worsening chronic heart failure.

  2002cited by this paper
• Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.

  2002cited by this paper
• Hypercortisolemia in acute stroke is related to the inflammatory response.

  2002cited by this paper
• Electrocardiographic Changes in Patients with Acute Stroke: A Systematic Review

  2002cited by this paper
• N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation.

  2002cited by this paper
• Multimarker Approach to Risk Stratification in Non-ST Elevation Acute Coronary Syndromes: Simultaneous Assessment of Troponin I, C-Reactive Protein, and B-Type Natriuretic Peptide

  2002cited by this paper
• Cardiovascular Autonomic Dysregulation

  2002cited by this paper
• Aivoverisuonisairauksien aiheuttamat suorat ja epäsuorat kustannukset Suomessa

  2001cited by this paper
• Prognostic relevance of pathological sympathetic activation after acute thromboembolic stroke

  2001cited by this paper
• Long-Term Survival and Causes of Death After Stroke

  2001cited by this paper
• Fractal analysis and time- and frequency-domain measures of heart rate variability as predictors of mortality in patients with heart failure.

  2001cited by this paper
• Epidemiology of Ischemic Stroke Subtypes According to TOAST Criteria: Incidence, Recurrence, and Long-Term Survival in Ischemic Stroke Subtypes: A Population-Based Study

  2001cited by this paper
• Immunohistochemistry of Atrial Natriuretic Peptide in Brain Infarction

  2001cited by this paper
• Clinical trials report

  2001cited by this paper
• Blood-pressure reduction and cardiovascular risk in HOPE study.

  2001cited by this paper
• Effects of intravenous brain natriuretic peptide on regional sympathetic activity in patients with chronic heart failure as compared with healthy control subjects.

  2001cited by this paper
• Improving the Reliability of Stroke Subgroup Classification Using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Criteria

  2001cited by this paper
• Mortality and causes of death after first ischemic stroke

  2001cited by this paper
• Pain-autonomic interactions: A selective review

  2001cited by this paper
• Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population

  2001cited by this paper
• Eprosartan reduces cardiac hypertrophy, protects heart and kidney, and prevents early mortality in severely hypertensive stroke-prone rats.

  2001cited by this paper
• Acute Stroke in Very Old People: Clinical Features and Predictors of In‐Hospital Mortality

  2000cited by this paper
• The insula and cerebrogenic sudden death.

  2000cited by this paper
• Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations.

  2000cited by this paper
• Variations in Stroke Incidence and Survival in 3 Areas of Europe

  2000cited by this paper
• Transient autonomic nervous system dysfunction during hyperacute stroke

  2000cited by this paper
• Gene Expression of Brain Natriuretic Peptide in Isolated Atrial and Ventricular Human Myocardium: Influence of Angiotensin II and Diastolic Fiber Length

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Decreased severity of brain infarct can in part explain the decreasing case fatality rate of stroke.

  2000cited by this paper
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• Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.

  2000cited by this paper
• Ischemic stroke subtypes : a population-based study of functional outcome, survival, and recurrence.

  2000cited by this paper
• Relation between troponin T concentration and mortality in patients presenting with an acute stroke: observational study

  2000cited by this paper
• Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease prevention.

  2000cited by this paper

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