Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0145-2126(99)00158-7PMID 10634644
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene.

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• Homozygous deletion of the p16/MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome.

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• Deletion map of chromosome 9 and p16 (CDKN2A) gene alterations in neuroblastoma.

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• Tumor-suppressive pathways in pancreatic carcinoma.

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• Alterations of p16 and p15 genes in acute leukemia with MLL gene rearrangements and their correlation with clinical features

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• Frequent hypermethylation of p16 and p15 genes in multiple myeloma.

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• Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia.

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• Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.

  1997influential reference
• Rb and p16INK4a expression in resected non-small cell lung tumors.

  1996cited by this paper
• Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

  1996cited by this paper
• Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity.

  1996cited by this paper
• High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.

  1996cited by this paper
• Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

  1996cited by this paper
• The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.

  1996cited by this paper
• Hypermethylation of the p16 gene in nasopharyngeal carcinoma.

  1996cited by this paper
• Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia.

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• Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.

  1996cited by this paper
• Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood.

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• High frequency of homozygous deletions of CDK4I gene in childhood acute lymphoblastic leukaemia

  1995cited by this paper
• 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

  1995cited by this paper
• Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia.

  1995cited by this paper
• Detection of DNA methylation in the calcitonin gene in human leukemias using differential polymerase chain reaction.

  1995cited by this paper
• Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

  1995cited by this paper
• Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.

  1995cited by this paper
• Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

  1995cited by this paper
• Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia.

  1995cited by this paper
• Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features.

  1995cited by this paper
• Genomic structure, expression and mutational analysis of the P15 (MTS2) gene.

  1995cited by this paper
• CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.

  1994cited by this paper
• Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB.

  1994cited by this paper
• A cell cycle regulator potentially involved in genesis of many tumor types.

  1994cited by this paper
• pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

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• Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

  1994cited by this paper
• Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.

  1994cited by this paper
• Rates of p16 (MTS1) mutations in primary tumors with 9p loss.

  1994cited by this paper
• Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

  1994cited by this paper
• Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

  1994cited by this paper
• Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias.

  1994cited by this paper
• CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

  1994cited by this paper
• Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias.

  1994cited by this paper
• p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

  1994cited by this paper
• Mammalian G1 cyclins.

  1993cited by this paper
• Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

  1993cited by this paper
• A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

  1993cited by this paper
• Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group

  1976cited by this paper

• Unraveling the role of long non-coding RNAs in therapeutic resistance in acute myeloid leukemia: New prospects & challenges

  2024cites this paper
• Therapeutic targeting of DNA methylation alterations in cancer.

  2024cites this paper
• Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax

  2024cites this paper
• PCR-Based Study for Molecular Documentation of Human Herpes Virus Type – 8 and P15 Polymorphism in a Group of lymphoma Patients.

  2023cites this paper
• Organochlorine pesticides may induce leukemia by methylation of CDKN2B and MGMT promoters and histone modifications.

  2022cites this paper
• Cyclin-dependent kinase inhibitors in malignant hematopoiesis

  2022cites this paper
• Regulation of the epigenetic landscape by immune cell oxidants.

  2021cites this paper
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• Use of DNA Methylation Profiling in Translational Oncology.

  2020cites this paper
• Purity estimation from differentially methylated sites using Illumina Infinium methylation microarray data

  2020cites this paper
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• HDL-AuNPs-BMS nanoparticle conjugates as molecularly targeted therapy for leukemia

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• Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

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• Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocols

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• CpG island methylator phenotype and its relationship with prognosis in adult acute leukemia patients

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• Association between MTR A2756G polymorphism and childhood acute lymphoblastic leukemia: a meta-analysis

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• Strain-Specific Allele Loss: An Important Clue to Tumor Suppressors Involved in Tumor Susceptibility

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• Epigenesis in acute myeloid leukemia: an update.

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• Inactivation of P16 (INK4a) Gene by Promoter Hypermethylation is Associated with Disease Progression in Chronic Myelogenous Leukaemia

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• Lack of Increased P 15 INK 4 B Protein Expression in Basal Cell Carcinomas

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• Specific small nucleolar RNA expression profiles in acute leukemia

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• Epigenetics in Pediatric Cancers

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• SETD1 HISTONE 3 LYSINE 4 METHYLTRANSFERASE COMPLEX COMPONENTS IN EPIGENETIC REGULATION

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• p15INK4b, a Tumor Suppressor in Acute Myeloid Leukemia

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• Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability

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• Aberrant promoter methylation of p16 in colorectal adenocarcinoma in North Indian patients.

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• Role of p16 in the pathogenesis of Langerhans cell histiocytosis

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• Epigenetic mechanisms in AML - a target for therapy.

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• Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning.

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• High-resolution analysis of aberrant regions in autosomal chromosomes in human leukemia THP-1 cell line

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• Promoter methylation of P15INK4B gene is possibly associated with parvovirus B19 infection in adult acute leukemias

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• Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins.

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• Significance of mitotic spindle checkpoint genes in leukemia

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• Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia

  2009influential citation
• Overexpression of nucleolin in engrafted acute myelogenous leukemia cells

  2009cites this paper
• p15Ink4b: dual function in myelopoiesis and inactivation in myeloid disease.

  2008cites this paper
• Role of epigenetic therapy in myelodysplastic syndrome

  2008cites this paper
• Genetic polymorphism of GST, NAT2, and MTRR and susceptibility to childhood acute leukemia

  2008cites this paper
• Flavopiridol displays preclinical activity in acute lymphoblastic leukemia

  2008cites this paper
• Wilms' tumor gene (WT1) is predominantly expressed in clonal hematopoietic cells in myelodysplastic syndromes

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
• Retinoblastoma gene family expression in lymphoid tissues

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• Expression of the cell cycle regulators p14(ARF) and p16(INK4a) in chronic myeloid leukemia.

  2006cites this paper
• Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia.

  2005cites this paper
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  2005cites this paper
• The silence of the genes: epigenetic disturbances in haematopoietic malignancies

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• Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia.

  2005cites this paper
• Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia

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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• [Investigations to the influence of tumor supressor gene p16 inactivation on the prognosis of head and neck squamous cell carcinoma].

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  2003cites this paper