Rationally improving LOV domain–based photoswitches

Genetically encoded protein photosensors are promising tools for engineering optical control of cellular behavior; we are only beginning to understand how to couple these light detectors to effectors of choice. Here we report a method that increases the dynamic range of an artificial photoswitch based on the LOV2 domain of Avena sativa phototropin 1 (AsLOV2). This approach can potentially be used to improve many AsLOV2-based photoswitches.

• Publication year

  2010

• Venue

  Nature Methods

• Publication date

  2010-06-03

• Fields of study

  Biology, Chemistry, Computer Science, Engineering, Medicine

• Identifiers
  DOI 10.1038/nmeth.1473PMID 20562867PMCID 2914111
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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