Palmitoylation in Alzheimer's disease and other neurodegenerative diseases.

Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications, in various aspects of neuronal functions. Major players regulating palmitoylation are the enzymes that mediate palmitoylation and depalmitoylation which are palmitoyl acyltransferases (PATs) and protein thioesterases, respectively. In this review, we will provide and discuss current understandings on palmitoyation/depalmitoylation control mediated by PATs and/or protein thioesterases for neuronal functions in general and also for Alzheimer's disease in particular, and other neurodegenerative diseases such as Huntington's disease, schizophrenia and intellectual disability.

• Publication year

  2016

• Venue

  Pharmacological Research

• Publication date

  2016-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.phrs.2016.06.008PMID 27293050
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sequence

  2018cited by this paper
• Purification

  2018cited by this paper
• Physiological and Pathophysiological Implications of Synaptic Tau

  2017cited by this paper
• Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1)

  2016cited by this paper
• Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases.

  2016cited by this paper
• Phosphorylation modifies the molecular stability of β-amyloid deposits

  2016cited by this paper
• Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.

  2016cited by this paper
• Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

  2016cited by this paper
• Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation

  2016cited by this paper
• Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

  2015cited by this paper
• Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases

  2015cited by this paper
• Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

  2015cited by this paper
• The Palmitoyl Acyltransferase DHHC2 Regulates Recycling Endosome Exocytosis and Synaptic Potentiation through Palmitoylation of AKAP79/150

  2015cited by this paper
• Palmitoylation and depalmitoylation defects

  2015cited by this paper
• Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.

  2015cited by this paper
• Selenoprotein K and Protein Palmitoylation

  2015cited by this paper
• Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability

  2015cited by this paper
• X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

  2015cited by this paper
• Palmitoylation of δ-catenin by DHHC5 Mediates Activity-Induced Synapse Plasticity

  2014cited by this paper
• Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

  2014cited by this paper
• Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.

  2014cited by this paper
• Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms

  2014cited by this paper
• Expanding the clinical phenotype of patients with a ZDHHC9 mutation

  2014cited by this paper
• Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn

  2014cited by this paper
• The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

  2014cited by this paper
• The Role of Flotillins in Regulating Aβ Production, Investigated Using Flotillin 1-/-, Flotillin 2-/- Double Knockout Mice

  2014cited by this paper
• Identification of Binding Sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L

  2014cited by this paper
• Mutations in the X-linked Intellectual Disability Gene, zDHHC9, Alter Autopalmitoylation Activity by Distinct Mechanisms*

  2014cited by this paper
• SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

  2014cited by this paper
• A systematic analysis of protein palmitoylation in Caenorhabditis elegans

  2014cited by this paper
• Flotillins bind to the dileucine sorting motif of β‐site amyloid precursor protein‐cleaving enzyme 1 and influence its endosomal sorting

  2014cited by this paper
• Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

  2014cited by this paper
• The palmitoyl acyltransferase HIP 14 shares a high proportion of interactors with huntingtin : implications for a role in the pathogenesis of Huntington ’ s disease

  2014cited by this paper
• miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

  2014cited by this paper
• Putative DHHC-Cysteine-Rich Domain S-Acyltransferase in Plants

  2013cited by this paper
• DHHC8-Dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-Term Synaptic Depression

  2013cited by this paper
• Memory and synaptic deficits in Hip14/DHHC17 knockout mice

  2013cited by this paper
• Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.

  2013cited by this paper
• Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

  2013influential reference
• In Silico Screening for Palmitoyl Substrates Reveals a Role for DHHC1/3/10 (zDHHC1/3/11)-mediated Neurochondrin Palmitoylation in Its Targeting to Rab5-positive Endosomes*

  2013cited by this paper
• Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43*

  2013cited by this paper
• PROTEIN S-ACYL TRANSFERASE10 Is Critical for Development and Salt Tolerance in Arabidopsis[W]

  2013cited by this paper
• Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners.

  2013influential reference
• DHHC17 Palmitoylates ClipR-59 and Modulates ClipR-59 Association with the Plasma Membrane

  2013cited by this paper
• SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface.

  2013influential reference
• Local palmitoylation cycles define activity-regulated postsynaptic subdomains

  2013cited by this paper
• SUMO and Alzheimer’s Disease

  2013cited by this paper
• Apolipoprotein e sets the stage: response to injury triggers neuropathology.

  2012cited by this paper
• Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease

  2012cited by this paper
• Palmitoylated calnexin is a key component of the ribosome–translocon complex

  2012cited by this paper
• Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant

  2012cited by this paper
• Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease

  2012cited by this paper
• Posttranslational regulation of AMPA receptor trafficking and function.

  2012cited by this paper
• Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated by N-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation*

  2012cited by this paper
• Human DHHC proteins: a spotlight on the hidden player of palmitoylation.

  2012cited by this paper
• Phosphatidylinositol 4-Kinase IIα Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner*

  2012cited by this paper
• Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

  2012cited by this paper
• Palmitoylation of A-Kinase Anchoring Protein 79/150 Regulates Dendritic Endosomal Targeting and Synaptic Plasticity Mechanisms

  2012cited by this paper
• Genomics and Localization of the Arabidopsis DHHC-Cysteine-Rich Domain S-Acyltransferase Protein Family1[C][W]

  2012cited by this paper
• Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.

  2012cited by this paper
• Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

  2012cited by this paper
• Small molecule inhibition of protein depalmitoylation as a new approach towards downregulation of oncogenic Ras signalling.

  2011cited by this paper
• FKBP12 binds to acylated H-ras and promotes depalmitoylation.

  2011cited by this paper
• Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

  2011cited by this paper
• The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain

  2011cited by this paper
• The metabolic serine hydrolases and their functions in mammalian physiology and disease.

  2011cited by this paper
• Introducing Human APOE into Aβ Transgenic Mouse Models

  2011cited by this paper
• Apolipoprotein E in Alzheimer's disease and other neurological disorders.

  2011cited by this paper
• Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.

  2011cited by this paper
• DHHC palmitoyl transferases: substrate interactions and (patho)physiology.

  2011cited by this paper
• Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

  2011cited by this paper
• Ion Channel Regulation by Protein Palmitoylation

  2011cited by this paper
• Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases

  2011influential reference
• S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95.

  2011cited by this paper
• Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

  2011cited by this paper
• DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells*

  2011influential reference
• The palmitoyl transferase DHHC 2 targets a dynamic membrane cycling pathway : regulation by a C-terminal domain

  2011cited by this paper
• Endoplasmic Reticulum Localization of DHHC Palmitoyltransferases Mediated by Lysine-based Sorting Signals*

  2011influential reference
• Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

  2010cited by this paper
• DHHC5 Interacts with PDZ Domain 3 of Post-synaptic Density-95 (PSD-95) Protein and Plays a Role in Learning and Memory*

  2010cited by this paper
• Fyn-tau-amyloid: a toxic triad.

  2010cited by this paper
• The Clinical and Genetic Features of Huntington Disease

  2010cited by this paper
• Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity

  2010cited by this paper
• Regulation of SNAP-25 trafficking and function by palmitoylation.

  2010cited by this paper
• Acyl-Protein Thioesterase 2 Catalizes the Deacylation of Peripheral Membrane-Associated GAP-43

  2010cited by this paper
• Testing for genetic association between the ZDHHC8 gene locus and susceptibility to schizophrenia: An integrated analysis of multiple datasets

  2010cited by this paper
• Association of ZDHHC8 polymorphisms with smooth pursuit eye movement abnormality

  2010cited by this paper
• Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box.

  2010cited by this paper
• Protein palmitoylation in neuronal development and synaptic plasticity

  2010influential reference
• The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.

  2010cited by this paper
• Reduced Alzheimer's Disease β-Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin

  2010cited by this paper
• Palmitoylation of the SNAP25 Protein Family

  2010influential reference
• Multiple Palmitoyltransferases Are Required for Palmitoylation-dependent Regulation of Large Conductance Calcium- and Voltage-activated Potassium Channels*

  2010influential reference
• Small-molecule inhibition of APT1 affects Ras localization and signaling.

  2010cited by this paper
• Huntington's disease: a clinical review

  2010cited by this paper
• Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

  2010cited by this paper
• A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

  2009cited by this paper
• Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts*

  2009cited by this paper
• S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1*

  2009cited by this paper
• A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation

  2009cited by this paper

• The palmitoylation code in cell death signaling: from molecular mechanisms to therapeutic opportunities

  2026cites this paper
• Lipidomic Comparison of Detergent‐Soluble and Detergent‐Resistant Lipid Domains Isolated From Rat Cerebellum and the Effect of Hypoxia–Ischemia Using UPLC‐HDMSE

  2026cites this paper
• Network-phenotype key gene screening (NPKG) identifies therapeutically relevant targets for neurodegenerative diseases

  2026cites this paper
• Liraglutide attenuates doxorubicin-induced cardiomyocyte ferroptosis via DHHC7-mediated STAT3 palmitoylation.

  2025cites this paper
• Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential

  2025cites this paper
• SARM1: The Checkpoint of Axonal Degeneration in the Nervous System Disorders

  2025cites this paper
• Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases

  2025cites this paper
• ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk

  2025cites this paper
• Palmitoylation in cancer: decoding its roles in signal transduction, tumor immunity, and emerging therapeutic opportunities

  2025cites this paper
• Deciphering protein long-chain S-acylation using mass spectrometry proteomics strategies

  2025cites this paper
• Palmitoylation Code and Endosomal Sorting Regulate ABHD17A Plasma Membrane Targeting and Activity

  2025cites this paper
• DHHC-1-dependent modulation of CED-1 protein stability regulates apoptotic cell clearance in C. elegans.

  2025cites this paper
• S-acylation and neuroinflammation: the therapeutic potential of zDHHC and deacylase modulation.

  2025cites this paper
• A Novel Palmitoylation-Related Molecular Signature for Predicting and Therapeutically Targeting Alzheimer’s Disease

  2025cites this paper
• ZDHHC5 and ZDHHC14 promote depression via the mediation of double-negative T cells

  2025cites this paper
• S-palmitoylation: An oily modification guardinggenome stability.

  2025cites this paper
• Protein palmitoylation: biological functions, disease, and therapeutic targets

  2025cites this paper
• PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy

  2025cites this paper
• Neuronal Ceroid Lipofuscinosis—Concepts, Classification, and Avenues for Therapy

  2025cites this paper
• Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility

  2025cites this paper
• Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer’s disease: insights from machine learning analyses and WGCNA

  2025cites this paper
• Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases

  2025cites this paper
• Role of S-palmitoylation in digestive system diseases

  2025cites this paper
• Computational exploration of palmitoyl-protein thioesterase 1 inhibition by Juniperus phoenicea L. for anti-dementia treatment

  2024cites this paper
• Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer’s disease

  2024cites this paper
• Haploinsufficiency of lysosomal enzyme genes in Alzheimer’s disease

  2024cites this paper
• Palmitoylation regulates norepinephrine transporter uptake, surface localization, and total expression with pathogenic implications in postural orthostatic tachycardia syndrome

  2024cites this paper
• Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders

  2024cites this paper
• Palmitoylation of synaptic proteins: roles in functional regulation and pathogenesis of neurodegenerative diseases

  2024influential citation
• Thyroid hormone T3 induces Fyn modification and modulates palmitoyltransferase gene expression through αvβ3 integrin receptor in PC12 cells during hypoxia

  2024cites this paper
• Protein lipidation in health and disease: molecular basis, physiological function and pathological implication

  2024cites this paper
• The role of s-palmitoylation in neurological diseases: implication for zDHHC family

  2024cites this paper
• Amino acid and protein specificity of protein fatty acylation in C. elegans

  2024cites this paper
• A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability

  2024cites this paper
• Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage

  2023cites this paper
• Mechanistic Insights into S-Depalmitolyse Activity of Cln5 Protein Linked to Neurodegeneration and Batten Disease: A QM/MM Study.

  2023cites this paper
• Deep Learning of Speech Data for Early Detection of Alzheimer’s Disease in the Elderly

  2023cites this paper
• BACE1 and SCD1 are associated with neurodegeneration

  2023cites this paper
• S-acylation of the Wnt receptor Frizzled-5 by zDHHC5 controls its cellular localization and synaptogenic activity in the rodent hippocampus.

  2023cites this paper
• Palmitoylation of Solute Carriers.

  2023cites this paper
• S-Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells

  2023cites this paper
• Palmitoylation in apoptosis

  2023cites this paper
• Lost in traffic: consequences of altered palmitoylation in neurodegeneration

  2023cites this paper
• Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

  2023cites this paper
• Effect of apigenin on neurodegenerative diseases.

  2023cites this paper
• Control of mitochondria-associated endoplasmic reticulum membranes by protein S-palmitoylation：novel therapeutic targets for neurodegenerative diseases.

  2023cites this paper
• Inhibition of hippocampal palmitoyl acyltransferase activity impairs spatial learning and memory consolidation.

  2023cites this paper
• S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains

  2023cites this paper
• Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins

  2022cites this paper
• Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer’s disease

  2022cites this paper
• Myristoylation-dependent palmitoylation of cyclin Y modulates long-term potentiation and spatial learning.

  2022cites this paper
• PTMs: A Missing Piece for Schizophrenia Studies.

  2022cites this paper
• Bioconjugation Strategies for Revealing the Roles of Lipids in Living Cells.

  2022cites this paper
• Protein palmitoylation in cancer: molecular functions and therapeutic potential

  2022cites this paper
• Palmitoylation of Voltage-Gated Ion Channels

  2022cites this paper
• Exploring the expression patterns of palmitoylating and de-palmitoylating enzymes in the mouse brain using the curated RNA-seq database BrainPalmSeq

  2022cites this paper
• Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation

  2022cites this paper
• Characterization of gene expression patterns in mild cognitive impairment using a transcriptomics approach and neuroimaging endophenotypes

  2022cites this paper
• Protein Lipidation by Palmitate Controls Macrophage Function

  2022cites this paper
• Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

  2022cites this paper
• Golgi Apparatus Regulates Plasma Membrane Composition and Function

  2022cites this paper
• Altered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson’s Disease

  2022cites this paper
• BrainPalmSeq: A curated RNA-seq database of palmitoylating and de-palmitoylating enzyme expression in the mouse brain

  2021influential citation
• Roles of palmitoylation in structural long-term synaptic plasticity

  2021cites this paper
• Loss of PIKfyve drives the spongiform degeneration in prion diseases

  2021cites this paper
• Protein S‐Palmitoylation: advances and challenges in studying a therapeutically important lipid modification

  2021cites this paper
• Post-translational modifications: Regulators of neurodegenerative proteinopathies.

  2021cites this paper
• Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity

  2021cites this paper
• A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications.

  2021cites this paper
• DHHC21 deficiency attenuates renal dysfunction during septic injury

  2021cites this paper
• MRMD-palm: A novel method for the identification of palmitoylated protein

  2021cites this paper
• A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors

  2021cites this paper
• Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6.

  2021cites this paper
• Insights into auto-S-fatty acylation: targets, druggability, and inhibitors

  2021cites this paper
• A sticky situation: regulation and function of protein palmitoylation with a spotlight on the axon and axon initial segment

  2021cites this paper
• Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis

  2021cites this paper
• How palmitoylation affects trafficking and signaling of membrane receptors

  2021cites this paper
• APP palmitoylation is involved in the increase in Aβ1-42 induced by aluminum.

  2021cites this paper
• Sodium hydrogen exchanger (NHE1) palmitoylation and potential functional regulation.

  2021cites this paper
• Synaptic Activity-Dependent Changes in the Hippocampal Palmitoylome

  2021cites this paper
• Investigating the Endo-Lysosomal System in Major Neurocognitive Disorders Due to Alzheimer’s Disease, Frontotemporal Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a Cross-Disease Gene

  2021cites this paper
• Regulation of T cell receptor signaling by protein acyltransferase DHHC21

  2020cites this paper
• Palmitoylation: A Fatty Regulator of Myocardial Electrophysiology

  2020cites this paper
• Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance

  2020cites this paper
• Androgen‐dependent miR‐125a‐5p targets LYPLA1 and regulates global protein palmitoylation level in late‐onset hypogonadism males

  2020cites this paper
• Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time

  2020cites this paper
• A Molecular Perspective on Sirtuin Activity

  2020cites this paper
• Machine learning methods in prediction of protein palmitoylation sites: A brief review.

  2020cites this paper
• Protein Palmitoylation in Leukocyte Signaling and Function

  2020cites this paper
• Protein palmitoylation and its pathophysiological relevance

  2020influential citation
• Regulatory effects of post-translational modifications on zDHHC S-acyltransferases

  2020cites this paper
• Endosomal Trafficking in Alzheimer's Disease, Parkinson's Disease, and Neuronal Ceroid Lipofuscinosis

  2020cites this paper
• Structure and mechanism of DHHC protein acyltransferases.

  2020cites this paper
• Cysteine in Alzheimer's Disease

  2020cites this paper
• Drug design targeting active posttranslational modification protein isoforms

  2020cites this paper
• SPalmitoylC-PseAAC: A sequence-based model developed via Chou's 5-steps rule and general PseAAC for identifying S-palmitoylation sites in proteins.

  2019cites this paper
• Understanding the role of AKAP150 palmitoylation in synaptic plasticity

  2019cites this paper
• Molecular crosstalk between cancer and neurodegenerative diseases

  2019cites this paper
• Therapeutic targeting of protein S-acylation for the treatment of disease.

  2019cites this paper
• Role of Post‐translational Modifications in Alzheimer's Disease

  2019cites this paper