Update on novel targets and potential treatment avenues in pulmonary hypertension.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  American Journal of Physiology - Lung cellular and Molecular Physiology

• Publication date

  2016-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajplung.00302.2016PMID 27591245PMCID PMC5130539
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Riociguat: Mode of Action and Clinical Development in Pulmonary Hypertension

  2017cited by this paper
• Metformin Reverses Development of Pulmonary Hypertension via Aromatase Inhibition

  2016cited by this paper
• Haemodynamic unloading reverses occlusive vascular lesions in severe pulmonary hypertension.

  2016cited by this paper
• 2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension.

  2016cited by this paper
• Lung Circulation.

  2016cited by this paper
• Challenges and opportunities in treating inflammation associated with pulmonary hypertension

  2016cited by this paper
• Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension.

  2016cited by this paper
• Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.

  2016cited by this paper
• Galectin-3 levels are associated with right ventricular functional and morphologic changes in pulmonary arterial hypertension

  2016cited by this paper
• Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double‐Blind, Placebo‐controlled Trial

  2016cited by this paper
• Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.

  2016cited by this paper
• Interleukin-18 disruption suppresses hypoxia-induced pulmonary artery hypertension in mice.

  2016cited by this paper
• Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment

  2016cited by this paper
• Limiting collagen turnover via collagenase‐resistance attenuates right ventricular dysfunction and fibrosis in pulmonary arterial hypertension

  2016cited by this paper
• Higher Estradiol and Lower Dehydroepiandrosterone-Sulfate Levels Are Associated with Pulmonary Arterial Hypertension in Men.

  2016cited by this paper
• The Critical Role of Pulmonary Arterial Compliance in Pulmonary Hypertension.

  2016cited by this paper
• HIF2α–arginase axis is essential for the development of pulmonary hypertension

  2016cited by this paper
• Estrogen Metabolite 16&agr;-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II–Associated Pulmonary Arterial Hypertension Through MicroRNA-29–Mediated Modulation of Cellular Metabolism

  2016cited by this paper
• SIRT3–AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

  2016cited by this paper
• Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension.

  2016cited by this paper
• Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy.

  2016cited by this paper
• The Serotonin Transporter Promotes a Pathological Estrogen Metabolic Pathway in Pulmonary Hypertension via Cytochrome P450 1B1

  2016cited by this paper
• Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension.

  2015cited by this paper
• Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction.

  2015cited by this paper
• Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.

  2015cited by this paper
• Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia.

  2015cited by this paper
• Prevention of pulmonary hypoplasia and pulmonary vascular remodeling by antenatal simvastatin treatment in nitrofen-induced congenital diaphragmatic hernia.

  2015cited by this paper
• Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure.

  2015cited by this paper
• Peripheral Blood Signature of Vasodilator-Responsive Pulmonary Arterial Hypertension

  2015cited by this paper
• Lung matrix and vascular remodeling in mechanically ventilated elastin haploinsufficient newborn mice.

  2015cited by this paper
• Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis.

  2015cited by this paper
• Recent Advances in Pulmonary Hypertension

  2015cited by this paper
• Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension.

  2015cited by this paper
• Antagonism of Stem Cell Factor/c-kit Signaling Attenuates Neonatal Chronic Hypoxia-Induced Pulmonary Vascular Remodeling

  2015cited by this paper
• Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells.

  2015cited by this paper
• Maternal-pup interaction disturbances induce long-lasting changes in the newborn rat pulmonary vasculature.

  2015cited by this paper
• RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.

  2015cited by this paper
• Collagen Metabolism Biomarkers and Health Related Quality of Life in Pulmonary Arterial Hypertension.

  2015cited by this paper
• Biomarkers in Lung Diseases : from Pathogenesis to Prediction to New Therapies Utility of large-animal models of BPD : chronically ventilated preterm lambs

  2015cited by this paper
• Bioengineering the Lung : Molecules , Materials , Matrix , Morphology , and Mechanics Intrauterine endotoxin-induced impairs pulmonary vascular function and right ventricular performance in infant rats and improvement with early vitamin D therapy

  2015cited by this paper
• Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

  2015cited by this paper
• The pathophysiology of pulmonary hypertension in left heart disease.

  2015cited by this paper
• Modulating the dysregulated migration of pulmonary arterial hypertensive smooth muscle cells with motif mimicking cell permeable peptides.

  2015cited by this paper
• Therapeutic potential of soluble guanylate cyclase modulators in neonatal chronic lung disease.

  2015cited by this paper
• Persistent pulmonary hypertension of the newborn: Advances in diagnosis and treatment.

  2015cited by this paper
• Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.

  2015cited by this paper
• Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage.

  2015cited by this paper
• The reversal of pulmonary vascular remodeling through inhibition of p38 MAPK-alpha: a potential novel anti-inflammatory strategy in pulmonary hypertension

  2015influential reference
• Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.

  2015cited by this paper
• Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.

  2015cited by this paper
• The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.

  2015cited by this paper
• Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones.

  2015cited by this paper
• CALL FOR PAPERS Biomarkers in Lung Diseases: From Pathogenesis to Prediction to New Therapies Plasma vascular endothelial growth factor A and placental growth factor: novel biomarkers of pulmonary hypertension in congenital diaphragmatic hernia

  2015cited by this paper
• Resolvin E1 normalizes contractility, Ca2+ sensitivity and smooth muscle cell migration rate in TNF-α- and IL-6-pretreated human pulmonary arteries.

  2015influential reference
• PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.

  2015cited by this paper
• Iloprost reverses established fibrosis in experimental right ventricular failure

  2015cited by this paper
• BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.

  2015cited by this paper
• Redox Biology in Pulmonary Arterial Hypertension (2013 Grover Conference Series)

  2015cited by this paper
• Circulating biomarkers in pulmonary arterial hypertension: update and future direction.

  2015cited by this paper
• 15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.

  2015cited by this paper
• Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension.

  2015cited by this paper
• Fatty Acid Metabolism in Pulmonary Arterial Hypertension: Role in Right Ventricular Dysfunction and Hypertrophy

  2015cited by this paper
• Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension.

  2015cited by this paper
• Translational Research in Acute Lung Injury and Pulmonary Fibrosis Arginase inhibition prevents bleomycin-induced pulmonary hypertension , vascular remodeling , and collagen deposition in neonatal rat lungs

  2015cited by this paper
• PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21

  2015cited by this paper
• Nonclassical resident macrophages are important determinants in the development of myocardial fibrosis.

  2015cited by this paper
• Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery: a randomised-controlled trial

  2015cited by this paper
• Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation.

  2015cited by this paper
• Serotonin transporter is not required for the development of severe pulmonary hypertension in the Sugen hypoxia rat model.

  2015cited by this paper
• Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK

  2015cited by this paper
• Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension.

  2015cited by this paper
• Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension

  2015cited by this paper
• Estimation of the number of alveolar capillaries by the Euler number (Euler-Poincaré characteristic).

  2015cited by this paper
• Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

  2014cited by this paper
• Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.

  2014cited by this paper
• Angiotensin II type 2 receptor ligand PD123319 attenuates hyperoxia-induced lung and heart injury at a low dose in newborn rats.

  2014cited by this paper
• High proliferative potential endothelial colony-forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization.

  2014cited by this paper
• Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators.

  2014cited by this paper
• Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats.

  2014cited by this paper
• Novel Dual Endothelin Receptor Antagonist Macitentan Reverses Severe Pulmonary Arterial Hypertension in Rats

  2014cited by this paper
• Alterations of mouse lung tissue dimensions during processing for morphometry: a comparison of methods.

  2014cited by this paper
• Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs.

  2014cited by this paper
• Transgelin as a therapeutic target to prevent hypoxic pulmonary hypertension.

  2014cited by this paper
• Circulating collagen biomarkers as indicators of disease severity in pulmonary arterial hypertension.

  2014cited by this paper
• Thromboxane-induced actin polymerization in hypoxic neonatal pulmonary arterial myocytes involves Cdc42 signaling.

  2014cited by this paper
• Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling.

  2014cited by this paper
• Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension.

  2014cited by this paper
• Peroxisome proliferator activated receptor-γ-Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension.

  2014cited by this paper
• Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge

  2014cited by this paper
• Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension.

  2014cited by this paper
• Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.

  2014cited by this paper
• Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus Infection

  2014cited by this paper
• Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice.

  2014cited by this paper
• The Ratio of 18F-FDG Activity Uptake Between the Right and Left Ventricle in Patients With Pulmonary Hypertension Correlates With the Right Ventricular Function

  2014cited by this paper
• Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle.

  2014cited by this paper
• Upregulation of Steroidogenic Acute Regulatory Protein by Hypoxia Stimulates Aldosterone Synthesis in Pulmonary Artery Endothelial Cells to Promote Pulmonary Vascular Fibrosis

  2014cited by this paper
• Bioengineering the Lung : Molecules , Materials , Matrix , Morphology , and Mechanics Chronic intrauterine pulmonary hypertension increases main pulmonary artery stiffness and adventitial remodeling in fetal sheep

  2014cited by this paper
• Animal models of bronchopulmonary dysplasia. The term mouse models.

  2014cited by this paper
• Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity.

  2014cited by this paper
• Therapeutic Potential of p38 MAP Kinase Inhibition in the Management of Cardiovascular Disease

  2014cited by this paper

• Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms

  2024cites this paper
• Enhanced lung endothelial glycolysis is implicated in the development of severe pulmonary hypertension in type 2 diabetes.

  2024cites this paper
• Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells

  2023cites this paper
• Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III.

  2023cites this paper
• Hypertension: Potential Player in Cardiovascular Disease Incidence in Preeclampsia

  2022cites this paper
• Established pulmonary hypertension in rats was reversed by a combination of a HIF‐2α antagonist and a p53 agonist

  2021cites this paper
• A predictive model for dilated cardiomyopathy with pulmonary hypertension

  2021cites this paper
• Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition

  2020cites this paper
• Comprehensive network analysis to identify the molecular pathogenesis of pulmonary hypertension.

  2020cites this paper
• Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension

  2020cites this paper
• NTP42 , a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension CURRENT STATUS: UNDER REVIEW

  2019cites this paper
• Pulmonary Hypertension

  2019cites this paper
• Towards improved pharmacotherapy in pulmonary arterial hypertension. Can diet play a role?

  2019cites this paper
• Fasudil dichloroacetate (FDCA), an orally available agent with potent therapeutic efficiency on monocrotaline-induced pulmonary arterial hypertension rats.

  2019cites this paper
• NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension

  2019cites this paper
• Accepting the challenge: maintaining AJP-Lung as the best place to publish basic and translational studies in lung biology and pathophysiology.

  2018cites this paper
• Gestational Hypoxia and Developmental Plasticity.

  2018cites this paper
• Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition.

  2018cites this paper
• Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium

  2018cites this paper
• Pharmacological activation of PPARγ inhibits hypoxia-induced proliferation through a caveolin-1-targeted and -dependent mechanism in PASMCs.

  2018cites this paper
• A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017.

  2018cites this paper
• Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both.

  2018cites this paper