Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Current Hypertension Reports

• Publication date

  2016-01-05

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1007/s11906-015-0609-2PMID 26733189
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

  2015cited by this paper
• 4D flow cardiovascular magnetic resonance consensus statement

  2015cited by this paper
• Three-dimensional, soft neotissue arrays as high throughput platforms for the interrogation of engineered tissue environments.

  2015cited by this paper
• Right Intraventricular Dyssynchrony in Idiopathic, Heritable, and Anorexigen-Induced Pulmonary Arterial Hypertension: Clinical Impact and Reversibility.

  2015cited by this paper
• Noninvasive Imaging in the Assessment of the Cardiopulmonary Vascular Unit

  2015cited by this paper
• Right ventricular remodeling in idiopathic pulmonary arterial hypertension: adaptive versus maladaptive morphology.

  2015cited by this paper
• Right Heart Score for Predicting Outcome in Idiopathic, Familial, or Drug- and Toxin-Associated Pulmonary Arterial Hypertension.

  2015cited by this paper
• Pulmonary Artery Enlargement Is Associated With Right Ventricular Dysfunction and Loss of Blood Volume in Small Pulmonary Vessels in Chronic Obstructive Pulmonary Disease

  2015cited by this paper
• Four‐dimensional flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: Results from two institutions

  2015cited by this paper
• [Relevant issues in the pathology and pathobiology of pulmonary hypertension].

  2014cited by this paper
• 4D flow imaging with MRI.

  2014cited by this paper
• RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension

  2014cited by this paper
• Arterial stiffness and hypertension: chicken or egg?

  2014cited by this paper
• Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction An Individual Participant Meta-Analysis of Prospective Observational Data From 17,635 Subjects

  2014influential reference
• Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.

  2014cited by this paper
• "Inflammation and arterial stiffness in humans".

  2014cited by this paper
• Vascular Stiffening in Pulmonary Hypertension: Cause or Consequence? (2013 Grover Conference Series)

  2014cited by this paper
• Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway

  2014cited by this paper
• Review of MRI-based measurements of pulse wave velocity: a biomarker of arterial stiffness.

  2014cited by this paper
• Pulmonary arterial hypertension

  2013cited by this paper
• Mechano-transduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer associated fibroblasts

  2013cited by this paper
• A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

  2013cited by this paper
• High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression.

  2013cited by this paper
• High Pulsatility Flow Induces Acute Endothelial Inflammation Through Overpolarizing Cells to Activate NF-κB

  2013cited by this paper
• Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review

  2013cited by this paper
• Influence of Distal Resistance and Proximal Stiffness on Hemodynamics and RV Afterload in Progression and Treatments of Pulmonary Hypertension: A Computational Study with Validation Using Animal Models

  2013cited by this paper
• Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of p38 Mitogen-Activated Protein Kinase

  2013cited by this paper
• Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.

  2013cited by this paper
• Non-invasive indices of right ventricular function are markers of ventricular-arterial coupling rather than ventricular contractility: insights from a porcine model of chronic pressure overload.

  2013cited by this paper
• Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques

  2013cited by this paper
• Pulmonary artery pulse wave velocity in idiopathic pulmonary arterial hypertension.

  2013cited by this paper
• Venous and arterial flow quantification are equally accurate and precise with parallel imaging compressed sensing 4D phase contrast MRI

  2013cited by this paper
• Assessment of normal flow patterns in the pulmonary circulation by using 4D magnetic resonance velocity mapping.

  2013cited by this paper
• Noninvasive estimation of PA pressure, flow, and resistance with CMR imaging: derivation and prospective validation study from the ASPIRE registry.

  2013cited by this paper
• Intracardiac flow visualization: current status and future directions.

  2013cited by this paper
• Relevant issues in the pathology and pathobiology of pulmonary hypertension.

  2013cited by this paper
• Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure.

  2013cited by this paper
• Cellular, Pharmacological, and Biophysical Evaluation of Explanted Lungs from a Patient with Sickle Cell Disease and Severe Pulmonary Arterial Hypertension

  2013cited by this paper
• Pulmonary Arterial Hypertension: Challenges in Translational Research and a Vision for Change

  2013cited by this paper
• Elastin in Large Artery Stiffness and Hypertension

  2012cited by this paper
• The REVEAL Registry risk score calculator in patients newly diagnosed with pulmonary arterial hypertension.

  2012cited by this paper
• Compressive elasticity of three-dimensional nanofiber matrix directs mesenchymal stem cell differentiation to vascular cells with endothelial or smooth muscle cell markers.

  2012cited by this paper
• Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.

  2012cited by this paper
• Pulmonary Capillary Wedge Pressure Augments Right Ventricular Pulsatile Loading

  2012cited by this paper
• Pulmonary Hypertension Secondary to COPD

  2012cited by this paper
• Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.

  2012cited by this paper
• Mechanics and Function of the Pulmonary Vasculature: Implications for Pulmonary Vascular Disease and Right Ventricular Function.

  2012cited by this paper
• A new flow co-culture system for studying mechanobiology effects of pulse flow waves

  2012cited by this paper
• Molecular mechanisms of arterial stiffness: new insights.

  2012cited by this paper
• RV dysfunction in pulmonary hypertension is independently related to pulmonary artery stiffness.

  2012cited by this paper
• Pulmonary vascular wall stiffness: An important contributor to the increased right ventricular afterload with pulmonary hypertension

  2011cited by this paper
• Right ventriculo-arterial coupling in pulmonary hypertension: a magnetic resonance study

  2011cited by this paper
• Pulmonary vascular stiffness: measurement, modeling, and implications in normal and hypertensive pulmonary circulations.

  2011cited by this paper
• Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study.

  2011cited by this paper
• Role of YAP/TAZ in mechanotransduction

  2011cited by this paper
• Critical Roles of Macrophages in the Formation of Intracranial Aneurysm

  2011cited by this paper
• Intrinsic extracellular matrix properties regulate stem cell differentiation.

  2010cited by this paper
• The arterial load in pulmonary hypertension

  2010cited by this paper
• Time course of carotid artery growth and remodeling in response to altered pulsatility.

  2010cited by this paper
• Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study

  2010cited by this paper
• CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses

  2010cited by this paper
• Ventricular Geometry, Strain, and Rotational Mechanics in Pulmonary Hypertension

  2010cited by this paper
• Harnessing Traction-Mediated Manipulation of the Cell-Matrix Interface to Control Stem Cell Fate

  2010cited by this paper
• A comprehensive histopathological evaluation of vascular medial fibrosis: insights into the pathophysiology of arterial stiffening.

  2010cited by this paper
• Reduced Ascending Aortic Strain and Distensibility: Earliest Manifestations of Vascular Aging in Humans

  2010cited by this paper
• Effects of Extracellular Matrix on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Smooth Muscle Cell Lineage: Utility for Cardiovascular Tissue Engineering

  2009cited by this paper
• Evaluation of pulmonary artery stiffness in pulmonary hypertension with cardiac magnetic resonance.

  2009cited by this paper
• Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications.

  2009cited by this paper
• Effects of extracellular matrix on differentiation of human bone marrow-derived mesenchymal stem cells into smooth muscle cell lineage : utility for cardiovascular tissue engineering

  2009cited by this paper
• Arterial-ventricular coupling: Mechanistic insights into cardiovascular performance at rest and during exercise (Journal of Applied Physiology (2008) 105, (1342-1351) DOI: 10.1152/japplphysiol.90600.2008)

  2009cited by this paper
• Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension.

  2009cited by this paper
• Effects of Pathological Flow on Pulmonary Artery Endothelial Production of Vasoactive Mediators and Growth Factors

  2009cited by this paper
• Importance of pulsatility in hypertensive carotid artery growth and remodeling

  2009cited by this paper
• Right atrial volume index in chronic systolic heart failure and prognosis.

  2009cited by this paper
• High Pulsatility Flow Induces Adhesion Molecule and Cytokine mRNA Expression in Distal Pulmonary Artery Endothelial Cells

  2009cited by this paper
• Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

  2009cited by this paper
• Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension.

  2008cited by this paper
• Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves.

  2008cited by this paper
• Magnetic Resonance–Derived 3-Dimensional Blood Flow Patterns in the Main Pulmonary Artery as a Marker of Pulmonary Hypertension and a Measure of Elevated Mean Pulmonary Arterial Pressure

  2008cited by this paper
• Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise.

  2008cited by this paper
• Vascular stiffness is related to superoxide generation in the vessel wall

  2008cited by this paper
• Relations of Inflammatory Biomarkers and Common Genetic Variants With Arterial Stiffness and Wave Reflection

  2008cited by this paper
• In Search of the In Vivo Identity of Mesenchymal Stem Cells

  2008cited by this paper
• Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension.

  2008cited by this paper
• Development and evaluation of microdevices for studying anisotropic biaxial cyclic stretch on cells

  2008cited by this paper
• Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension.

  2007cited by this paper
• The value of approved therapies for pulmonary arterial hypertension.

  2007cited by this paper
• A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology.

  2007cited by this paper
• Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.

  2006cited by this paper
• The current treatment of pulmonary arterial hypertension: time to redefine success.

  2006cited by this paper
• Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension.

  2006cited by this paper
• Matrix elasticity directs stem cell lineage specification.

  2006cited by this paper
• Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage.

  2006cited by this paper
• Pulmonary arterial hypertension

  2006cited by this paper
• Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.

  2006cited by this paper
• Tissue Cells Feel and Respond to the Stiffness of Their Substrate

  2005cited by this paper
• Overexpression of Hyaluronan in the Tunica Media Promotes the Development of Atherosclerosis

  2005cited by this paper
• Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy.

  2005cited by this paper
• Mechanisms, pathophysiology, and therapy of arterial stiffness.

  2005cited by this paper
• Pathologic assessment of vasculopathies in pulmonary hypertension.

  2004cited by this paper

• Relationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic.

  2026cites this paper
• Assessment of Right Ventricular‐Pulmonary Arterial Coupling in Heart Failure With Preserved Ejection Fraction Using Three‐Dimensional Speckle‐Tracking Echocardiography and Pulmonary Artery Stiffness

  2026cites this paper
• 5-Hydroxytryptamine Limits Pulmonary Arterial Hypertension Progression by Regulating Th17/Treg Balance.

  2025cites this paper
• Identification of pulmonary artery stiffening due to left heart disease by ultrasonography.

  2025cites this paper
• Design and Optimization of LOXL2 and sGC Dual-Target Regulators Targeting Extracellular Matrix Dysregulation and Vasodilation for the Treatment of Pulmonary Arterial Hypertension.

  2025cites this paper
• A Lifelong Journey in the Field of the Pulmonary Circulation: Perspectives Through the Lens of the Cardiovascular Pulmonary Research Laboratory

  2025cites this paper
• Pulmonary arterial stiffness as the main correlate of effective arterial elastance in pre- and post-capillary pulmonary hypertension.

  2025cites this paper
• Dissecting contributions of pulmonary arterial remodeling to right ventricular afterload in pulmonary hypertension

  2025cites this paper
• Preoperative serum LOXL2 levels are elevated in patients with pulmonary hypertension undergoing mitral valve surgery in a prospective observational cohort study.

  2025cites this paper
• A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation.

  2024cites this paper
• Dissecting contributions of pulmonary arterial remodeling to right ventricular afterload in pulmonary hypertension

  2024cites this paper
• LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension.

  2024cites this paper
• Pulmonary Hemodynamic Parameters Derived from 4D Flow MR Imaging Can Provide Sensitive Markers for Chronic Obstructive Pulmonary Disease (COPD) Patients with Right Ventricular Dysfunction

  2024cites this paper
• Galectin-3 Expression Promotes Pulmonary Hypertension Through Multiple Mechanisms

  2023cites this paper
• Isolation of vasa vasorum endothelial cells from pulmonary artery adventitia: Implementation to vascular biology research.

  2023cites this paper
• Evaluation of pulmonary artery stiffness and right ventricle functions in polycythemia vera patients by transthoracic echocardiography

  2023cites this paper
• Characterization of pulmonary arterial stiffness using cardiac MRI

  2023cites this paper
• MRI pulmonary artery flow detects lung vascular pathology in preterms with lung disease

  2023cites this paper
• Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

  2023cites this paper
• Extracellular Matrix Stiffness in Lung Health and Disease.

  2022cites this paper
• Substrate stiffness modulates migration and local inter-cellular membrane motion in pulmonary endothelial cell monolayers.

  2022cites this paper
• The relationship between bioelectrical impedance parameters and pulmonary artery stiffness in obese subjects

  2022cites this paper
• Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

  2021cites this paper
• Pulsatile pulmonary artery pressure in a large animal model of chronic thromboembolic pulmonary hypertension: Similarities and differences with human data

  2021cites this paper
• Cardiopulmonary Monitoring of Patients with Pulmonary Hypertension and Right Ventricular Failure

  2021cites this paper
• Effect of Supervised Training Therapy on Pulmonary Arterial Compliance and Stroke Volume in Severe Pulmonary Arterial Hypertension and Inoperable or Persistent Chronic Thromboembolic Pulmonary Hypertension

  2021cites this paper
• Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data

  2021cites this paper
• Galectin-3 Promotes ROS, Inflammation, and Vascular Fibrosis in Pulmonary Arterial Hypertension.

  2021cites this paper
• The isobaric pulmonary arterial compliance in pulmonary hypertension

  2021cites this paper
• The Arterial Load and Right Ventricular-Vascular Coupling in Pulmonary Hypertension.

  2021cites this paper
• Metalloproteinases and Their Inhibitors Are Associated with Pulmonary Arterial Stiffness and Ventricular Function in Pediatric Pulmonary Hypertension.

  2021cites this paper
• Impact of mechanical and fluid mechanisms in the development and severity of pulmonary hypertension

  2021cites this paper
• The Mechanobiology of Vascular Remodeling in the Aging Lung.

  2021cites this paper
• Right Heart Size and Right Ventricular Reserve in Pulmonary Hypertension: Impact on Management and Prognosis

  2020cites this paper
• Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension

  2020cites this paper
• Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling

  2020cites this paper
• A machine learning cardiac magnetic resonance approach to extract disease features and automate pulmonary arterial hypertension diagnosis

  2020cites this paper
• Precision Medicine in Pulmonary Hypertension

  2020cites this paper
• Update on noninvasive imaging of right ventricle dysfunction in pulmonary hypertension.

  2020cites this paper
• Cardiovascular disease in young People with Type 1 Diabetes: Search for Cardiovascular Biomarkers.

  2020cites this paper
• LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension.

  2020cites this paper
• Pulmonary Artery Endovascular Device Compensates for Loss of Vascular Compliance in Pulmonary Arterial Hypertension.

  2020cites this paper
• Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension

  2019cites this paper
• The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension

  2019cites this paper
• Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies

  2019cites this paper
• Galectin-3: A Harbinger of Reactive Oxygen Species, Fibrosis, and Inflammation in Pulmonary Arterial Hypertension

  2019cites this paper
• Use of a right ventricular continuous flow pump to validate the distensible model of the pulmonary vasculature.

  2019cites this paper
• Clinical and Hemodynamic Correlates of Pulmonary Arterial Stiffness in Incident, Untreated Patients With Idiopathic Pulmonary Arterial Hypertension

  2018cites this paper
• Effect of electrical dyssynchrony on left and right ventricular mechanics in children with pulmonary arterial hypertension.

  2018cites this paper
• Proximal pulmonary arterial wall disease in patients with persistent pulmonary hypertension after successful left-sided valve replacement according to the hemodynamic phenotype

  2018cites this paper
• Simulation of unsteady blood flows in a patient‐specific compliant pulmonary artery with a highly parallel monolithically coupled fluid‐structure interaction algorithm

  2018cites this paper
• Noninvasive wave intensity analysis predicts functional worsening in children with pulmonary arterial hypertension.

  2018influential citation
• Mechanobiological Feedback in Pulmonary Vascular Disease

  2018cites this paper
• Computational Fluid Dynamics Modeling of the Human Pulmonary Arteries with Experimental Validation

  2018cites this paper
• Obstructive sleep apnea syndrome is associated with impaired pulmonary artery distensibility and right ventricular systolic dysfunction

  2018cites this paper
• Pulmonary vascular dysfunction secondary to pulmonary arterial hypertension: insights gained through retrograde perfusion.

  2018cites this paper
• Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations

  2017cites this paper
• Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency?

  2017cites this paper
• Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease

  2017cites this paper
• Galectin‐3 contributes to vascular fibrosis in monocrotaline‐induced pulmonary arterial hypertension rat model

  2017cites this paper
• mTOR‐Notch3 signaling mediates pulmonary hypertension in hypoxia‐exposed neonatal rats independent of changes in autophagy

  2017cites this paper
• Vascular Calcification in Pulmonary Hypertension. Another Brick in the Wall.

  2016cites this paper
• Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension.

  2016cites this paper
• RhoA ACTIVITY IS SPATIALLY ASSOCIATED WITH BARRIER DISRUPTING DISTANT CONTRACTILE F-ACTIN FIBERS OR RE-ANNEALING MEMBRANE PROTRUSIONS DEPENDENT ON THE ACTIVATION STATUS OF THE ENDOTHELIUM

  2016influential citation
• Static and dynamic components of right ventricular afterload are negatively associated with calf survival at high altitude.

  2016cites this paper
• Update on novel targets and potential treatment avenues in pulmonary hypertension.

  2016cites this paper
• From Here to There, Progenitor Cells and Stem Cells Are Everywhere in Lung Vascular Remodeling

  2016cites this paper
• Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling.

  2016cites this paper