Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Journal of Neurosurgery

• Publication date

  1997-05-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.3171/FOC.1997.2.5.3PMID 9384404
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

  1996cited by this paper
• Spreading Depression—A Gap Junction Mediated Event?

  1996cited by this paper
• Excitotoxic mechanisms in focal ischemia.

  1996cited by this paper
• Review : Neuroprotection in Brain Ischemia: An Update (Part II

  1995cited by this paper
• Glutamate, calcium, and free radicals as mediators of ischemic brain damage.

  1995cited by this paper
• Gap junctions are required for the propagation of spreading depression.

  1995cited by this paper
• Neural Signalling: Neuromodulatory astrocytes

  1994cited by this paper
• Direct signaling from astrocytes to neurons in cultures of mammalian brain cells.

  1994cited by this paper
• Viability thresholds and the penumbra of focal ischemia

  1994cited by this paper
• Glutamate-mediated astrocyte–neuron signalling

  1994cited by this paper
• Characterization of Cortical Depolarizations Evoked in Focal Cerebral Ischemia

  1993cited by this paper
• Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat.

  1993cited by this paper
• Gap junctions in the brain: where, what type, how many and why?

  1993cited by this paper
• Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

  1992cited by this paper
• Intercellular calcium signaling via gap junctions in glioma cells

  1992cited by this paper
• Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology.

  1992cited by this paper
• Calcium waves in astrocytes-filling in the gaps.

  1992cited by this paper
• The Effect of Glutamate Receptor Blockade on Anoxic Depolarization and Cortical Spreading Depression

  1992cited by this paper
• Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment.

  1992cited by this paper
• Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling.

  1990cited by this paper
• Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [14C]2-Deoxyglucose Phosphorylation

  1986cited by this paper
• Effect of anoxia on ion distribution in the brain.

  1985cited by this paper
• Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

  1981cited by this paper
• The Application of ion-selective microelectrodes

  1981cited by this paper
• Thresholds in cerebral ischemia - the ischemic penumbra.

  1981cited by this paper
• Mechanism of spreading cortical depression.

  1956cited by this paper

• Licorice extract and carbenoxolone protect PC12 cells against serum/glucose deprivation-induced apoptosis through modulation of caspase-3 and PARP activation

  2025cites this paper
• Ca2+-dependent rapid uncoupling of astrocytes upon brief metabolic stress

  2023cites this paper
• Interactive mechanism between connexin43 and Cd-induced autophagic flux blockage and gap junctional intercellular communication dysfunction in rat hepatocytes

  2023cites this paper
• Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome

  2023cites this paper
• Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury

  2022cites this paper
• HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: a potential mechanism of bystander damage and viral reservoir survival.

  2021cites this paper
• Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

  2021cites this paper
• Oleamide Induces Cell Death in Glioblastoma RG2 Cells by a Cannabinoid Receptor–Independent Mechanism

  2020cites this paper
• Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

  2020cites this paper
• The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions

  2020cites this paper
• Gap Junction Channels of Innexins and Connexins: Relations and Computational Perspectives

  2019cites this paper
• Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

  2019cites this paper
• Targeting Gap Junctions: New Insights in the Treatment of Major Depressive Disorder.

  2019cites this paper
• Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases

  2019cites this paper
• Gap junctions in liver disease: Implications for pathogenesis and therapy.

  2019cites this paper
• Connexins and Pannexins in cerebral ischemia.

  2018cites this paper
• Mitochondrial Cx43, an important component of cardiac preconditioning.

  2018cites this paper
• Mechanisms of neuronal swelling during spreading depolarization

  2018cites this paper
• The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

  2017cites this paper
• Cardioprotection with halogenated gases: how does it occur?

  2017cites this paper
• Phosphorylation of astrocytic connexin43 by ERK1/2 impairs blood–brain barrier in acute cerebral ischemia

  2017cites this paper
• Dispelling myths about connexins, pannexins and P2X7 in hypoxic-ischemic central nervous system.

  2017cites this paper
• An implantable multimodal sensor for oxygen, neurotransmitters, and electrophysiology during spreading depolarization in the deep brain.

  2017cites this paper
• Excitotoxic injury mechanisms in central white matter

  2017cites this paper
• Connexin43 in retinal injury and disease.

  2016cites this paper
• Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke.

  2016cites this paper
• EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA

  2016cites this paper
• Traumatic Brain Injury and Blood-Brain Barrier Cross-Talk.

  2016cites this paper
• Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior.

  2016cites this paper
• Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo

  2015cites this paper
• Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.

  2015cites this paper
• Gap Junction Intercellular Communication Mediates Ammonia-Induced Neurotoxicity

  2015cites this paper
• Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury

  2015cites this paper
• Neuroprotection in the treatment of glaucoma--A focus on connexin43 gap junction channel blockers.

  2015cites this paper
• Involvement of Connexin40 in the Protective Effects of Ginsenoside Rb1 Against Traumatic Brain Injury

  2015cites this paper
• Astrocytes and microglia in acute cerebral injury underlying cerebral palsy associated with preterm birth

  2014cites this paper
• Intercellular Communication and Heterosynaptic Metaplasticity in the Rodent Hippocampus

  2014cites this paper
• Intravitreal injection of connexin43 mimetic peptides for the treatment of optic neuropathy using an in vivo retinal ischaemia-reperfusion rat model

  2014cites this paper
• A surgical model of middle cerebral artery occlusive stroke in the sheep.

  2014cites this paper
• Inhibition of the Connexin 43 Elevation May be Involved in the Neuroprotective Activity of Leptin Against Brain Ischemic Injury

  2014cites this paper
• Relevance of gap junctions and large pore channels in traumatic brain injury

  2014cites this paper
• Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases

  2014cites this paper
• Opposite effects of the gap junction blocker octanol on focal cerebral ischemia occluded for different durations.

  2014cites this paper
• Propagation of Spreading Depression: A Review of Different Hypothesis

  2014cites this paper
• Role of Astrocyte Network in Edema after Juvenile Traumatic Brain Injury

  2014cites this paper
• The dual face of connexin-based astroglial Ca(2+) communication: a key player in brain physiology and a prime target in pathology.

  2014cites this paper
• Role of connexins and pannexins in ischemic stroke.

  2014cites this paper
• Connexin hemichannel induced vascular leak suggests a new paradigm for cancer therapy

  2014cites this paper
• Effective protection of rabbits' explosive brain injury through blocking gap junction communication.

  2013cites this paper
• Protective effects of carbenoxolone are associated with attenuation of oxidative stress in ischemic brain injury

  2013cites this paper
• Gap junctions and Bystander Effects: Good Samaritans and executioners.

  2013cites this paper
• Connexin-based therapeutic approaches to inflammation in the central nervous system

  2013cites this paper
• Roles of glial cells in neuroinflammation and neurodegeneration

  2013cites this paper
• Connexin pathology in chronic multiple sclerosis and experimental autoimmune encephalomyelitis

  2013cites this paper
• The use of connexin-based therapeutic approaches to target inflammatory diseases.

  2013cites this paper
• A New and Reliable Guide for Studies of Neuronal Loss Based on Focal Lesions and Combinations of In Vivo and In Vitro Approaches

  2013cites this paper
• A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke

  2013cites this paper
• Regulation and dysregulation of astrocyte activation and implications in tumor formation

  2013cites this paper
• Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia.

  2012cites this paper
• POSSÍVEL RELAÇÃO ENTRE ACOPLAMENTO E CICLO CELULAR NA NEURODENERAÇÃO DA RETINA

  2012cites this paper
• Regulation of Connexin43 Gap Junction Protein Triggers Vascular Recovery and Healing in Human Ocular Persistent Epithelial Defect Wounds

  2012cites this paper
• Calcium Dyshomeostasis in Astrocytes After Ischemia

  2012cites this paper
• POSSÍVEL RELAÇÃO ENTRE ACOPLAMENTO E CICLO CELULAR NA NEURODEGENERAÇÃO DA RETINA

  2012cites this paper
• Deleterious Effects of High Dose Connexin 43 Mimetic Peptide Infusion After Cerebral Ischaemia in Near-Term Fetal Sheep

  2012cites this paper
• A key role for connexin hemichannels in spreading ischemic brain injury.

  2012cites this paper
• High pressure-induced retinal ischaemia reperfusion causes upregulation of gap junction protein connexin43 prior to retinal ganglion cell loss.

  2012cites this paper
• Connexin hemichannel blockade improves outcomes in a model of fetal ischemia

  2012cites this paper
• Biological role of connexin intercellular channels and hemichannels.

  2012cites this paper
• Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice.

  2012cites this paper
• Gap junction protein connexin43 (GJA1) in the human glaucomatous optic nerve head and retina.

  2011cites this paper
• Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

  2011cites this paper
• Expression und Lokalisation von Pannexinen und Connexinen in der äußeren Retina der Maus

  2011cites this paper
• Role of Connexin Hemichannels in Neurodegeneration

  2011cites this paper
• Reactive gliosis in the injured brain: The effect of cell communication and Nrf2-mediated cellular defence

  2011cites this paper
• Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

  2011cites this paper
• Trauma-induced reactive gliosis is reduced after treatment with octanol and carbenoxolone

  2011cites this paper
• Adaptive calcified matrix response of dental pulp to bacterial invasion is associated with establishment of a network of glial fibrillary acidic protein+/glutamine synthetase+ cells.

  2010cites this paper
• Immunolocalization of gap junction protein connexin43 (GJA1) in the human retina and optic nerve.

  2010cites this paper
• Reorganization of Gap Junctions after Focused Ultrasound Blood–Brain Barrier Opening in the Rat Brain

  2010cites this paper
• Role of gap junctions in early brain injury following subarachnoid hemorrhage.

  2010influential citation
• Role of connexin43 in central nervous system injury.

  2010influential citation
• Mitochondrial potassium sequestration and neuroprotection is mediated by connexin43

  2010cites this paper
• New concepts regarding cerebral vasospasm: glial-centric mechanisms

  2010cites this paper
• Connexin-related signaling in cell death: to live or let die?

  2009cites this paper
• Effect of gap junction inhibition on intracerebral hemorrhage-induced brain injury in mice

  2009influential citation
• MODULAÇÃO DA EXPRESSÃO DE CONEXINAS NA RETINA: UM ESTUDO MORFOLÓGICO, BIOQUÍMICO E FUNCIONAL

  2009cites this paper
• Hemichannels in cerebral ischemia.

  2009cites this paper
• Pathophysiology of Ischemia-Reperfusion Injury: New Therapeutic Options for Acute Myocardial Infarction

  2009cites this paper
• Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

  2009cites this paper
• Translational cardiovascular medicine (II). Pathophysiology of ischemia-reperfusion injury: new therapeutic options for acute myocardial infarction.

  2009cites this paper
• Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.

  2009cites this paper
• Fisiopatología del daño miocárdico por isquemia-reperfusión: nuevas oportunidades terapéuticas en el infarto agudo de miocardio

  2009cites this paper
• Connexin43 antisense oligodeoxynucleotide treatment down-regulates the inflammatory response in an in vitro interphase organotypic culture model of optic nerve ischaemia.

  2008cites this paper
• Clinical connexions

  2008cites this paper
• Emerging Role of Astrocytes in Cerebral Ischemia/Reperfusion Injury

  2008cites this paper
• A Central Role of Connexin 43 in Hypoxic Preconditioning

  2008influential citation
• Glial connexins and gap junctions in CNS inflammation and disease

  2008cites this paper
• Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury.

  2008cites this paper
• ASTROCYTIC COMMUNICATION AND CELL DEATH DURING METABOLIC DEPRESSION AND OXIDATIVE STRESS

  2008cites this paper
• Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury.

  2008cites this paper