Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  1992-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/jcbfm.1992.103PMID 1506440
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Disturbances of cerebral protein synthesis and ischemic cell death.

  1993influential reference
• Cerebral Blood Flow and Oxygen Consumption in Cortical Spreading Depression

  1991cited by this paper
• Mechanism Underlying Protective Effect of MK-801 against NMDA-Induced Neuronal Injury in vivo

  1991cited by this paper
• Ischemic Thresholds of Cerebral Protein Synthesis and Energy State following Middle Cerebral Artery Occlusion in Rat

  1991cited by this paper
• Differences in ischemia-induced accumulation of amino acids in the cat cortex

  1991cited by this paper
• Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat.

  1990cited by this paper
• Protection by NMDA Antagonists against Selective Cell Loss following Transient Ischaemia

  1990cited by this paper
• Differences in ischemia-induced accumulation of amino acids in the cat cortex.

  1990cited by this paper
• Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

  1990cited by this paper
• Regional Neuroprotective Effects of the NMDA Receptor Antagonist MK-801 (Dizocilpine) in Hypoglycemic Brain Damage

  1990cited by this paper
• MK-801 reduced cerebral ischemic injury by inducing hypothermia.

  1990cited by this paper
• Ischemic threshold of brain protein synthesis after unilateral carotid artery occlusion in gerbils.

  1989cited by this paper
• The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.

  1989cited by this paper
• Effect of the NMDA Antagonist MK-801 on Local Cerebral Blood Flow in Focal Cerebral Ischaemia in the Rat

  1989cited by this paper
• Comparative electroencephalographic and behavioral effects of phencyclidine, (+)-SKF-10,047 and MK-801 in rats.

  1989cited by this paper
• Spreading depression is not associated with neuronal injury in the normal brain.

  1988cited by this paper
• Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

  1988cited by this paper
• Behavioral changes after focal cerebral ischemia by left middle cerebral artery occlusion in rats.

  1988cited by this paper
• Brain ion homeostasis in cerebral ischemia.

  1988cited by this paper
• Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.

  1988cited by this paper
• MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period.

  1988cited by this paper
• The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

  1988cited by this paper
• Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [14C]2-Deoxyglucose Phosphorylation

  1986cited by this paper
• Regional changes of blood flow, glucose, and ATP content determined on brain sections during a single passage of spreading depression in rat brain cortex.

  1984cited by this paper
• Functional recovery of cortical neurons as related to degree and duration of ischemia

  1983cited by this paper
• Barbiturate Therapy in the Management of Cerebral Ischaemia

  1982cited by this paper
• The time courses of intracellular free calcium and related electrical effects after injection of CaCl2 into neurons of the snail,Helix pomatia

  1981cited by this paper
• Thresholds in cerebral ischemia - the ischemic penumbra.

  1981cited by this paper
• Barbiturate therapy in the management of cerebral ischaemia

  1980cited by this paper
• Cerebral glucose utilization: local changes during and after recovery from spreading cortical depression.

  1979cited by this paper
• On the mechanism of the inhibitory effect of potasium ions on amino acid incorporation into rat cerebral cortex proteins in vivo.

  1978cited by this paper
• Cortical Evoked Potential and Extracellular K+ and H+ at Critical Levels of Brain Ischemia

  1977cited by this paper
• Double labelling study of the spreading depression effect on the incorporation of labelled leucine into the proteins of the brain mitochondrial subfractions

  1973cited by this paper
• Mechanisms involved in spreading depression.

  1973cited by this paper
• Journal of Cerebral Blood Flow and Metabolism Metabolic and Hemodynamic Activation of Postischemic Rat Brain by Cortical Spreading Depression

  year unknowncited by this paper

• A Scientometrics Analysis and Visualization of Ischemic Stroke

  2025cites this paper
• Gain-of-function PPM1D mutations attenuate ischemic stroke.

  2025cites this paper
• Role of microglia in stroke

  2024cites this paper
• Assessing donor-recipient arterial pressure dynamics in STA-MCA bypass for moyamoya disease

  2024cites this paper
• Current Paradigms in Understanding Neuron Fluctuations, Factors, Regulation, Pathophysiology of Epilepsy: Advancements in Diagnosis, Treatment and Management—An Update

  2024cites this paper
• Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome

  2023cites this paper
• Mild hypothermia reduces spreading depolarizations and infarct size in a swine model

  2023cites this paper
• Post-stroke epileptic seizures: risk factors, clinical presentation, principles of diagnosis and treatment

  2023cites this paper
• Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization

  2022cites this paper
• Spreading Depolarization as a Therapeutic Target in Severe Ischemic Stroke: Physiological and Pharmacological Strategies

  2022cites this paper
• Frequency selective neuronal modulation triggers spreading depolarizations in the rat endothelin-1 model of stroke

  2021cites this paper
• Influence of glutamate and GABA transport on brain excitatory/inhibitory balance

  2021cites this paper
• [Risk factors for post stroke epilepsy].

  2021cites this paper
• Spreading depolarization evoked by endothelin-1 is inhibited by octanol but not by carbenoxolone

  2020cites this paper
• The role of spreading depolarizations and electrographic seizures in early injury progression of the rat photothrombosis stroke model

  2020cites this paper
• Cerebrospinal fluid influx drives acute ischemic tissue swelling

  2020cites this paper
• The role of Toll-like receptor signaling pathways in cerebrovascular disorders: the impact of spreading depolarization

  2020cites this paper
• Correlates of Spreading Depolarization, Spreading Depression, and Negative Ultraslow Potential in Epidural Versus Subdural Electrocorticography

  2019influential citation
• MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis

  2019cites this paper
• Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury

  2019cites this paper
• Brain injury and neural stem cells

  2018cites this paper
• Stroke‐related epilepsy

  2018cites this paper
• NADH fluorescence imaging and the histological impact of cortical spreading depolarization during the acute phase of subarachnoid hemorrhage in rats.

  2018cites this paper
• Systematic review of the pharmacological agents that have been tested against spreading depolarizations

  2018cites this paper
• The EEG in acute ischaemic cerebrovascular disease

  2018cites this paper
• Modulation of Post-Stroke Plasticity and Regeneration by Stem Cell Therapy and Exogenic Factors

  2018cites this paper
• Mechanisms of neuronal swelling during spreading depolarization

  2018cites this paper
• Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

  2018cites this paper
• Early EEG predicts poststroke epilepsy

  2018cites this paper
• Incidence of seizures following initial ischemic stroke in a community-based cohort: The Framingham Heart Study.

  2017cites this paper
• The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

  2017cites this paper
• Spreading depolarization monitoring in neurocritical care of acute brain injury

  2017cites this paper
• ‘Spreading depression of Leão’ and its emerging relevance to acute brain injury in humans

  2017cites this paper
• Mechanisms of spreading depolarization in vertebrate and insect central nervous systems.

  2016cites this paper
• Science Journals — AAAS

  2016cites this paper
• Science Journals — AAAS

  2016cites this paper
• Extracellular pH Modulation of Spreading Depression by Changes in

  2016cites this paper
• Evaluation of voxel-based analysis in stroke using multiparametric MR imaging. (Évaluation d'une analyse voxel à voxel dans l'accident vasculaire cérébral à partir d'images IRM multiparamétriques)

  2016cites this paper
• EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA

  2016cites this paper
• Post Stroke Seizure in Group of Hospitalized Patient in Baghdad Teaching Hospital

  2015cites this paper
• Preconditioning Cortical Lesions Reduce the Incidence of Peri-Infarct Depolarizations during Focal Ischemia in the Spontaneously Hypertensive Rat: Interaction with Prior Anesthesia and the Impact of Hyperglycemia

  2015cites this paper
• The stroke-migraine depolarization continuum.

  2015cites this paper
• Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.

  2015cites this paper
• Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.

  2015influential citation
• Suppression of spreading depolarization and stabilization of dendritic spines by GLYX-13, an NMDA receptor glycine-site functional partial agonist.

  2015cites this paper
• Promoting stroke recovery using delayed growth factor delivery: Contribution of ipsilesional versus contralesional pyramidal tract plasticity

  2014cites this paper
• Spreading depolarization in the ischemic brain: does aging have an impact?

  2014cites this paper
• Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective.

  2013cites this paper
• Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel HCN2 affect the outcome after stroke in mice?

  2013cites this paper
• Hypoxia Limits Inhibitory Effects of Zn2+ on Spreading Depolarizations

  2013cites this paper
• Synaptic Zn2+ release during spreading depolarizations : implications for ischemic brain injury

  2013cites this paper
• Impact of Poststroke Seizures on Neurological Deficits: Magnetic Resonance Diffusion-Weighted Imaging Study

  2013cites this paper
• Effect of lidocaine on dynamic changes in cortical reduced nicotinamide adenine dinucleotide fluorescence during transient focal cerebral ischemia in rats.

  2013cites this paper
• Responses to Cortical Spreading Depression under Oxygen Deficiency

  2012cites this paper
• Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury.

  2012cites this paper
• Studies on spreading depolarization in healthy and metabolically compromised brain tissues

  2012cites this paper
• Aquaporin-4 in Cerebral Edema Following Ischemia/Reperfusion Injury: Exploration of Novel Therapeutic Strategies

  2012cites this paper
• Peri-infarct blood-brain barrier dysfunction facilitates induction of spreading depolarization associated with epileptiform discharges.

  2012cites this paper
• Seizures after stroke.

  2012cites this paper
• Optical Approaches to Study Metabolic Consequences of Spreading Depression In Vivo

  2012cites this paper
• Peri-infarct flow transients predict outcome in rat focal brain ischemia.

  2012cites this paper
• Uncrossed cortical and thalamic circuits to mediate sensory processing weeks after stroke

  2011influential citation
• Oxygen therapy improves energy metabolism in focal cerebral ischemia.

  2011cites this paper
• Ischemic Stroke: Basic Pathophysiology and Neuroprotective Strategies

  2011cites this paper
• Role of PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries following stroke

  2011cites this paper
• Regulation of spreading depression events in brain slices by astrocyte metabolism

  2011influential citation
• Relative contributions of zinc and calcium to acute injury to hippocampal CA1 neurons

  2010influential citation
• Acute pathophysiological processes after ischaemic and traumatic brain injury.

  2010cites this paper
• Epigenetic chromatin modifications in the cortical spreading depression.

  2010cites this paper
• Generation of sustained field potentials by gradients of polarization within single neurons: a macroscopic model of spreading depression.

  2010cites this paper
• A new model for the study of high-K(+)-induced preconditioning in cultured neurones: role of N-methyl-d-aspartate and alpha7-nicotinic acetylcholine receptors.

  2009cites this paper
• Post-stroke seizures.

  2009cites this paper
• Characterization of periinfarct flow transients with laser speckle and Doppler after middle cerebral artery occlusion in the rat

  2009cites this paper
• Preliminary Evidence That Ketamine Inhibits Spreading Depolarizations in Acute Human Brain Injury

  2009cites this paper
• The ischemic cascade and mediators of ischemic injury.

  2009cites this paper
• Dynamic changes in cortical NADH fluorescence in rat focal ischemia: evaluation of the effects of hypothermia on propagation of peri-infarct depolarization by temporal and spatial analysis.

  2009cites this paper
• Mitochondrial activity and brain functions during cortical depolarization

  2008cites this paper
• Two-Photon Imaging during Prolonged Middle Cerebral Artery Occlusion in Mice Reveals Recovery of Dendritic Structure after Reperfusion

  2008cites this paper
• Flow-dependent versus spreading-like impairment of brain tissue integrity during focal cerebral ischemia and its consequences for neuroprotective strategies.

  2008cites this paper
• Two-Photon Imaging of Stroke Onset In Vivo Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines

  2008cites this paper
• Spreading depolarizations occur in human ischemic stroke with high incidence

  2008cites this paper
• Spreading depression and brain preconditioning: A short review

  2008cites this paper
• Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors.

  2008cites this paper
• Slow Waves Associated with Seizure Activity

  2008cites this paper
• Extrazelluläre Ionenänderungen während Cortical Spreading Ischaemia im zerebralen Kortex der Ratte

  2008cites this paper
• Metabolic Challenge to Glia Activates an Adenosine-Mediated Safety Mechanism that Promotes Neuronal Survival by Delaying the Onset of Spreading Depression Waves

  2008cites this paper
• Physiological studies of cortical spreading depression.

  2007cites this paper
• Cortical spreading depression: an adverse but treatable factor in intensive care?

  2007cites this paper
• Métabolisme et circulation cérébrale: modifications liées à l’agression cérébrale

  2007cites this paper
• Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia.

  2007cites this paper
• Fine Mapping of the Spatial Relationship between Acute Ischemia and Dendritic Structure Indicates Selective Vulnerability of Layer V Neuron Dendritic Tufts within Single Neurons in Vivo

  2007cites this paper
• Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance.

  2007cites this paper
• Experimental focal cerebral ischemia

  2007cites this paper
• NEURAL STEM/PROGENITOR CELLS IN THE POST-ISCHEMIC ENVIRONMENT: Proliferation, Differentiation and Neuroprotection

  2007cites this paper
• Examination of the Parameter Space of a Computational Model of Acute Ischaemic Stroke Using Rough Sets

  2007cites this paper
• Chapter 5.4 Online glucose and lactate monitoring during physiological and pathological conditions

  2006cites this paper
• Métabolisme énergétique et agression cérébrale

  2006cites this paper
• Vasoconstrictive Neurovascular Coupling during Focal Ischemic Depolarizations

  2006cites this paper
• Pathophysiology and Therapy of Experimental Stroke

  2006cites this paper
• Therapeutic Approaches to the Treatment of Acute Ischemic Stroke

  2006cites this paper