New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2016-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbcan.2016.09.004PMID 27663420PMCID PMC5138100
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling*

  2016cited by this paper
• FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

  2016cited by this paper
• pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner

  2016cited by this paper
• Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

  2016cited by this paper
• Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

  2016influential reference
• The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

  2016influential reference
• Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

  2015cited by this paper
• Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases*

  2015cited by this paper
• PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

  2015cited by this paper
• pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation.

  2015cited by this paper
• Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications

  2015cited by this paper
• OH, the Places You'll Go! Hydroxylation, Gene Expression, and Cancer.

  2015cited by this paper
• A lactate-induced response to hypoxia.

  2015cited by this paper
• PHD1 regulates p53-mediated colorectal cancer chemoresistance

  2015influential reference
• An ID2-dependent mechanism for VHL inactivation in cancer

  2015cited by this paper
• MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.

  2014cited by this paper
• Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

  2014influential reference
• The ID proteins: master regulators of cancer stem cells and tumour aggressiveness

  2014cited by this paper
• Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury

  2014influential reference
• CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis.

  2014cited by this paper
• PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

  2014cited by this paper
• JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation

  2014cited by this paper
• Mechanism and function of oxidative reversal of DNA and RNA methylation.

  2014cited by this paper
• Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

  2013cited by this paper
• Loss of Epithelial Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Accelerates Skin Wound Healing in Mice

  2013influential reference
• Regulation of erythropoiesis by hypoxia-inducible factors.

  2013cited by this paper
• Histone lysine demethylases as targets for anticancer therapy

  2013cited by this paper
• Targeting the HIF pathway in inflammation and immunity.

  2013cited by this paper
• (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

  2013cited by this paper
• PHD–2 KNOCKOUT PROMOTES PLAQUE PROGRESSION VIA HIFla AND INCREASES THE EXPRESSION OF MAC–1, PSGL–1 AND VLA–4 ON MONOCYTES AND GRANULOCYTES IN MICE

  2013cited by this paper
• What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

  2013cited by this paper
• Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)*

  2013cited by this paper
• HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

  2013cited by this paper
• PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

  2013influential reference
• Deletion of Phd2 in Myeloid Lineage Attenuates Hypertensive Cardiovascular Remodeling

  2013cited by this paper
• Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription

  2013cited by this paper
• Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.

  2013cited by this paper
• Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation

  2012cited by this paper
• Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

  2012cited by this paper
• 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

  2012cited by this paper
• Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

  2012cited by this paper
• Hypoxia-inducible factors in physiology and medicine.

  2012cited by this paper
• Histone methylation: a dynamic mark in health, disease and inheritance

  2012cited by this paper
• IDH mutation impairs histone demethylation and results in a block to cell differentiation

  2012cited by this paper
• Identification of novel potential HIF-prolyl hydroxylase inhibitors by in silico screening

  2012cited by this paper
• The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

  2011cited by this paper
• The Erythropoietin Receptor

  2011cited by this paper
• Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance

  2011cited by this paper
• HIF-1-dependent Expression of Angiopoietin-like 4 and L1CAM Mediates Vascular Metastasis of Hypoxic Breast Cancer Cells to the Lungs

  2011cited by this paper
• Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

  2011cited by this paper
• Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ.

  2011cited by this paper
• Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).

  2011cited by this paper
• Aberrant Promoter CpG Methylation Is a Mechanism for Impaired PHD3 Expression in a Diverse Set of Malignant Cells

  2011cited by this paper
• Eukaryotic elongation factor‐2 (eEF2): its regulation and peptide chain elongation

  2011cited by this paper
• Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

  2011cited by this paper
• The N‐myc downstream regulated gene (NDRG) family: diverse functions, multiple applications

  2010cited by this paper
• Evidence for the slow reaction of hypoxia‐inducible factor prolyl hydroxylase 2 with oxygen

  2010cited by this paper
• Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.

  2010cited by this paper
• Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

  2010cited by this paper
• The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.

  2010cited by this paper
• Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity.

  2010cited by this paper
• The Actin Gene Family: Function Follows Isoform

  2010cited by this paper
• Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins*S⃞

  2009cited by this paper
• Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

  2009cited by this paper
• Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.

  2009cited by this paper
• Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.

  2009cited by this paper
• Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

  2009cited by this paper
• Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

  2009cited by this paper
• Increased activated Akt expression in renal cell carcinomas and prognosis

  2009cited by this paper
• Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

  2008cited by this paper
• Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.

  2008cited by this paper
• Mucosal protection by hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibition

  2008cited by this paper
• ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

  2008cited by this paper
• Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

  2008cited by this paper
• Biology of hypoxia-inducible factor-2α in development and disease

  2008cited by this paper
• Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.

  2008cited by this paper
• Biology of HIF-1α

  2008cited by this paper
• Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region.

  2008cited by this paper
• Expanding chemical biology of 2-oxoglutarate oxygenases.

  2008cited by this paper
• The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.

  2008cited by this paper
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

  2008cited by this paper
• Essential Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis of the Adult Vascular System

  2007influential reference
• Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

  2007cited by this paper
• Sulfasalazine-Induced Reduction of Glutathione Levels in Breast Cancer Cells: Enhancement of Growth-Inhibitory Activity of Doxorubicin

  2007cited by this paper
• Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.

  2007cited by this paper
• HIF-1 and HIF-2: working alone or together in hypoxia?

  2007cited by this paper
• Prolyl Hydroxylase Domain 2 Protein Suppresses Hypoxia-Induced Endothelial Cell Proliferation

  2007cited by this paper
• ASB4 Is a Hydroxylation Substrate of FIH and Promotes Vascular Differentiation via an Oxygen-Dependent Mechanism

  2007cited by this paper
• Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor*

  2007cited by this paper
• FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

  2007cited by this paper
• IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a (PII:S0092-8674(04)00302-2)

  2007cited by this paper
• MEKK4 signaling regulates filamin expression and neuronal migration.

  2006cited by this paper
• JmjC-domain-containing proteins and histone demethylation

  2006cited by this paper
• HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

  2006cited by this paper
• Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

  2006cited by this paper
• Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2

  2006cited by this paper
• Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.

  2006cited by this paper
• Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

  2006cited by this paper
• FOXO transcription factors at the interface between longevity and tumor suppression

  2005cited by this paper
• Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

  2005cited by this paper

• Small-molecule degron mimetics for targeted protein degradation

  2025cites this paper
• α-Ketoglutaric acid as a promising platform chemical for sustainable bio-based industries.

  2025cites this paper
• HIF1α-PHD1-FOXA1 Axis Orchestrates Hypoxic Reprogramming and Androgen Signaling Suppression in Prostate Cancer

  2025cites this paper
• 2‐Oxoglutarate Analog‐Based Biomolecular Tools for Exploring Structure–Activity Relationships in Nonheme Iron Enzymes

  2025cites this paper
• The new insight into the role of hydroxyproline in metabolism of cancer cells

  2025cites this paper
• Single-Molecule SERS Discrimination of Proline from Hydroxyproline Assisted by a Deep Learning Model

  2025cites this paper
• TRIM21 and OTUD6A orchestrate AKT K27-linked atypical ubiquitination to modulate cancer chemoresistance

  2025cites this paper
• Hist-i-fy—a multiple histidine post-translational-modification (PTM) prediction server based on protein sequences using convolution neural network: a case study on mass spectroscopy data

  2024cites this paper
• Procollagen-lysine 2-oxoglutarate 5-dioxygenases are responsible for 5R-hydroxylysine modification of therapeutic T-cell bispecific monoclonal antibodies produced by Chinese hamster ovary cells

  2024cites this paper
• Preparation and Characterization of Hydroxylated Recombinant Collagen by Incorporating Proline and Hydroxyproline in Proline-Deficient Escherichia coli

  2024cites this paper
• Cellular and epigenetic perspective of protein stability and its implications in the biological system.

  2024cites this paper
• Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH

  2024cites this paper
• Tumor hypoxia: From basic knowledge to therapeutic implications.

  2023cites this paper
• Hist-i-fy: Multiple histidine function prediction based on protein sequences using deep neural network

  2023cites this paper
• Citrullinated human and murine MOG35-55 display distinct biophysical and biochemical behavior.

  2023cites this paper
• Rapid intestinal and systemic metabolic reprogramming in an immunosuppressed environment

  2023cites this paper
• Rapid intestinal and systemic metabolic reprogramming in an immunosuppressed environment

  2023cites this paper
• Enhancement of Collagen-I Levels in Human Gingival Fibroblasts by Small Molecule Activation of HIF-1α

  2023cites this paper
• Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9

  2022cites this paper
• VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma

  2022cites this paper
• JMJD family proteins in cancer and inflammation

  2022cites this paper
• ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

  2022cites this paper
• Impact of Reactive Species on Amino Acids—Biological Relevance in Proteins and Induced Pathologies

  2022cites this paper
• Potensi Mesenchymal Stromal Cells (MSCs) sebagai Terapi Novel pada Penyakit Kritis

  2022cites this paper
• Hypoxia-induced factor and its role in liver fibrosis

  2022cites this paper
• Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies

  2022cites this paper
• Unraveling post-translational modifications in Echinococcus granulosus sensu lato.

  2022cites this paper
• Epigenetics in Necrotizing Enterocolitis.

  2021cites this paper
• Redox signaling in heart failure and therapeutic implications.

  2021cites this paper
• Mass Spectrometry Imaging of Fibroblasts: Promise and Challenge

  2021cites this paper
• Contrasting Local and Macroscopic Effects of Collagen Hydroxylation

  2021cites this paper
• P 4 HA 2-induced prolyl hydroxylation suppresses YAP 1-mediated prostate cancer cell migration , 1 invasion , and metastasis 2

  2021cites this paper
• Crosstalk between Proline Hydroxylation and Histidine Methylation Regulates Actin-Dependent Cell Mobility Control

  2021cites this paper
• Current Status of the Use of Multifunctional Enzymes as Anti-Cancer Drug Targets

  2021cites this paper
• Zonal Regulation of Collagen Types and Post-Translational Modifications In Prostatic Benign and Cancer Tissues By Imaging Mass Spectrometry

  2021cites this paper
• P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis

  2021influential citation
• The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancer.

  2021cites this paper
• Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

  2020cites this paper
• The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer.

  2020cites this paper
• Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC

  2020cites this paper
• Microbial Engineering for Production of N‐Functionalized Amino Acids and Amines

  2020cites this paper
• Understanding the Oxygen Sensing Pathway and Its Therapeutic Implications in Diseases.

  2020cites this paper
• Argonaute proteins: Structural features, functions and emerging roles

  2020cites this paper
• Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry.

  2020cites this paper
• Transcriptional Programs Underlying Cold Acclimation of Common Carp (Cyprinus carpio L.)

  2020cites this paper
• Hydroxylation of Proteins

  2019cites this paper
• Epigenetics

  2019cites this paper
• CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis

  2019cites this paper
• Mechanisms of hypoxia signalling: new implications for nephrology

  2019cites this paper
• Current Trends in the Analysis of Post-translational Modifications

  2019cites this paper
• Hypoxia-adaptive pathways: A pharmacological target in fibrotic disease?

  2019cites this paper
• Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression.

  2019cites this paper
• Exceptionally versatile – arginine in bacterial post-translational protein modifications

  2019cites this paper
• Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

  2019influential citation
• Epigenetic Mechanisms and Posttranslational Modifications in Systemic Lupus Erythematosus

  2019influential citation
• Label-free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2.

  2019cites this paper
• Heat shock protein 47 (HSP47) binds to discoidin domain–containing receptor 2 (DDR2) and regulates its protein stability

  2019cites this paper
• PLOD3 promotes lung metastasis via regulation of STAT3

  2018cites this paper
• Identification of substrates for the conserved prolyl hydroxylase Ofd1 using quantitative proteomics in fission yeast

  2018cites this paper
• Skeletal Muscle Metabolism: from Tissue to Stem Cell

  2018influential citation
• VHL and Hypoxia Signaling: Beyond HIF in Cancer

  2018cites this paper
• Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury

  2018influential citation
• Role of the Facial Triad in Factor Inhibiting HIF (FIH): Ligand Binding, Substrate Selectivity, and Coupling

  2018cites this paper
• Studies on the PDHA1 protein expression and its correlation with clinicopathological characteristics and prognosis in NSCLC

  2017cites this paper