The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Oncogene

• Publication date

  1995-12-21

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8545124
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

  1995cited by this paper
• The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells.

  1995cited by this paper
• Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

  1994cited by this paper
• Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

  1994cited by this paper
• PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells

  1994cited by this paper
• AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.

  1994cited by this paper
• Characterization of a cell-type-restricted negative regulatory activity of the human granulocyte-macrophage colony-stimulating factor gene

  1994cited by this paper
• Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide.

  1994cited by this paper
• PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials

  1994cited by this paper
• Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting.

  1994cited by this paper
• Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors

  1994cited by this paper
• The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.

  1993cited by this paper
• The Runt domain identifies a new family of heteromeric transcriptional regulators.

  1993cited by this paper
• E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

  1993cited by this paper
• Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha.

  1993cited by this paper
• Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

  1993cited by this paper
• The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT

  1993cited by this paper
• Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.

  1993cited by this paper
• Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

  1993cited by this paper
• Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

  1993cited by this paper
• PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

  1993cited by this paper
• Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

  1993cited by this paper
• The t(8;21) translocation in acute myeloid leukemia results in production of an AML1‐MTG8 fusion transcript.

  1993cited by this paper
• The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

  1993cited by this paper
• Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.

  1992cited by this paper
• Leukaemia/Drosophila homology

  1992cited by this paper
• Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers.

  1992cited by this paper
• Transcription factors, translocations, and leukemia.

  1992cited by this paper
• t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

  1991cited by this paper
• Molecular physiology of granulocyte-macrophage colony-stimulating factor.

  1991cited by this paper
• A transcriptional enhancer of the mouse T cell receptor delta gene locus.

  1991cited by this paper
• Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity.

  1990cited by this paper
• The repeated sequence CATT(A/T) is required for granulocyte-macrophage colony-stimulating factor promoter activity

  1990cited by this paper
• Endogenous interleukin-1 can regulate the autonomous growth of the blast cells of acute myeloblastic leukemia by inducing autocrine secretion of GM-CSF.

  1990cited by this paper
• Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes

  1990cited by this paper
• A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.

  1990cited by this paper
• Control of granulocyte-macrophage colony-stimulating factor production in normal endothelial cells by positive and negative regulatory elements.

  1989cited by this paper
• Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.

  1989cited by this paper
• Multiple mechanisms control the expression of granulocyte-macrophage colony-stimulating factor by human fibroblasts.

  1989cited by this paper
• A simple phase-extraction assay for chloramphenicol acyltransferase activity.

  1988cited by this paper
• Characterization of the human granulocyte-macrophage colony-stimulating factor promoter region by genetic analysis: correlation with DNase I footprinting

  1988cited by this paper
• Primary human myeloid leukemia cells: comparative responsiveness to proliferative stimulation by GM-CSF or G-CSF and membrane expression of CSF receptors.

  1987cited by this paper
• Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.

  1986cited by this paper
• Regulation of expression of human granulocyte/macrophage colony-stimulating factor.

  1986cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983cited by this paper

• Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

  2025cites this paper
• Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

  2022cites this paper
• AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms

  2021cites this paper
• Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response.

  2021cites this paper
• The telomere complex and the origin of the cancer stem cell

  2021cites this paper
• Tumor necrosis factor-related apoptosis-inducing ligand is a novel transcriptional target of runt-related transcription factor 1

  2021cites this paper
• Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

  2020cites this paper
• Histone deacetylase 3 preferentially binds and collaborates with the transcription factor RUNX1 to repress AML1–ETO–dependent transcription in t(8;21) AML

  2020cites this paper
• Clinical Presentation, Diagnosis, and Classification of Acute Myeloid Leukemia

  2020cites this paper
• Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome

  2020influential citation
• A transcriptional landscape of 28 porcine tissues obtained by super deepSAGE sequencing

  2020cites this paper
• Development and Characterisation of an AML1/ETO Murine Bone Marrow Transplantation Leukaemia Model

  2019cites this paper
• MicroRNAs as regulators and effectors of hematopoietic transcription factors

  2019cites this paper
• Dissecting the role of lymphoid enhancer factor 1 (LEF1) in acute myeloid leukemia

  2019cites this paper
• Identification of porcine RUNX1 as an LPS-dependent gene expression regulator in PBMCs by Super deepSAGE sequencing of multiple tissues

  2019cites this paper
• ZFP36L2, a novel AML1 target gene, induces AML cells apoptosis and inhibits cell proliferation.

  2018cites this paper
• The leukemogenic t ( 8 ; 21 ) fusion protein AML 1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes

  2017cites this paper
• Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation

  2017cites this paper
• Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm

  2017cites this paper
• Preview : Published ahead of advance online publication Heterodimerization of AML 1 / ETO with CBF b is required for leukemogenesis but not for myeloproliferation

  2017cites this paper
• Identification of common and distinct epigenetic re-programming properties of Core-Binding Factor (CBF) Fusion Proteins

  2016cites this paper
• Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors

  2016cites this paper
• New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins

  2016cites this paper
• Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity

  2016cites this paper
• Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock*

  2016cites this paper
• Loss of RUNX1/AML1 arginine‐methylation impairs peripheral T cell homeostasis

  2015cites this paper
• Antiproliferating Activity of Esculetin on Acute Myeloid Leukemic Cell Line Potential Role in Therapy

  2015cites this paper
• MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1

  2015cites this paper
• Cells via Targeting Runx1 and Function of Myeloid-Derived Suppressor MicroRNA-9 Regulates the Differentiation

  2015cites this paper
• Epigenetic Modifications Mediated by the AML1/ETO and MLL Leukemia Fusion Proteins

  2014cites this paper
• The role of hypoxia signalling pathways in normal and leukaemic haemopoiesis

  2014cites this paper
• Oridonin, a promising antitumor natural product in the chemotherapy of hematological malignancies.

  2014cites this paper
• The leukemogenic t ( 8 ; 21 ) fusion protein AML 1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes

  2014cites this paper
• AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia

  2013cites this paper
• The rate of spontaneous mutations in human myeloid cells.

  2013cites this paper
• Redistribution of H3K27me3 and acetylated histone H4 upon exposure to azacitidine and decitabine results in de-repression of the AML1/ETO target gene IL3

  2013cites this paper
• Long and Short Non-Coding RNAs as Regulators of Hematopoietic Differentiation

  2013cites this paper
• implications for mechanisms of pathogenesis familial platelet disorder with predisposition to acute myelogenous leukemia: In vitro analyses of known and novel RUNX1/AML1 mutations in dominant

  2013cites this paper
• University of Birmingham Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

  2012cites this paper
• Caractérisation clinique et moléculaire de nouvelles translocations chromosomiques ciblant le gène RUNX1 dans les leucémies aiguës de l’adulte

  2012cites this paper
• Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

  2012cites this paper
• PIG7, transactivated by AML1, promotes apoptosis and differentiation of leukemia cells with AML1–ETO fusion gene

  2012cites this paper
• with the Wilms tumor gene, WT1 AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation

  2012cites this paper
• AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

  2012cites this paper
• Regulation of the LIFR and gp130 genes by the RUNX1 transcription factor

  2012cites this paper
• Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation

  2011cites this paper
• SERPINB13 is a novel RUNX1 target gene.

  2011cites this paper
• Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation

  2011influential citation
• Genetic abnormalities and challenges in the treatment of acute myeloid leukemia.

  2011cites this paper
• Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer

  2010cites this paper
• of the maturation block mediated by the leukemia specific fusion oncoprotein AML 1 / ETO

  2010cites this paper
• Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1.

  2010cites this paper
• The molecular signature of oncofusion proteins in acute myeloid leukemia

  2010cites this paper
• Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.

  2010cites this paper
• AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2.

  2009cites this paper
• Multilevel targeting of hematopoietic stem cell self-renewal, differentiation and apoptosis for leukemia therapy.

  2009cites this paper
• MicroRNA‐27 enhances differentiation of myeloblasts into granulocytes by post‐transcriptionally downregulating Runx1

  2009cites this paper
• adverse effects on t(8;21) leukemia in vitro and in vivo AML1-ETO fusion protein and shows potent antitumor activity with low Oridonin, a diterpenoid extracted from medicinal herbs, targets

  2009cites this paper
• Post-translational modifications of Runx1 regulate its activity in the cell.

  2009cites this paper
• Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.

  2008cites this paper
• Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.

  2008cites this paper
• Gene expression profiling for the diagnosis and prognosis of acute myeloid leukaemia.

  2008cites this paper
• Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins

  2008cites this paper
• Oncoproteins, heterochromatin silencing and microRNAs: a new link for leukemogenesis

  2008cites this paper
• Transcriptional repression of the RUNX 3 / AML 2 gene by the t ( 8 ; 21 ) and inv ( 16 ) fusion proteins in acute myeloid leukemia

  2008cites this paper
• AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets

  2008cites this paper
• Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: a report from the Children's Oncology Group

  2008cites this paper
• The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes

  2008cites this paper
• Aus der Medizinischen Klinik und Poliklinik III Großhadern der Ludwig-Maximilians-Universität München

  2008cites this paper
• Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

  2008cites this paper
• Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia.

  2008cites this paper
• HDAC3: taking the SMRT-N-CoRrect road to repression

  2007cites this paper
• Proteomics of Acute Myeloid Leukemia

  2007influential citation
• leukemia in vitro and in vivo AML 1-ETO fusion protein and shows potent antitumor activity with low Oridonin , a diterpenoid extracted from medicinal herbs , targets

  2007cites this paper
• Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.

  2007cites this paper
• MicroRNAs 17-5p–20a–106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation

  2007cites this paper
• Targeting transcription factors in acute leukemia in children.

  2007cites this paper
• Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.

  2007cites this paper
• c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression.

  2007cites this paper
• From dissection of disease pathogenesis to elucidation of mechanisms of targeted therapies: leukemia research in the genomic era

  2007cites this paper
• Cell type dependent regulation of multidrug resistance-1 gene expression by AML1-ETO.

  2007cites this paper
• RUNX1-RUNX1 Homodimerization Modulates RUNX1 Activity and Function*

  2007cites this paper
• p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death.

  2007cites this paper
• Discovery and Characterization of Recurrent Gene Fusions in Prostate Cancer.

  2007cites this paper
• Characterisation of the leukaemia-associated ETO homologues

  2006cites this paper
• Project Title: Principal Investigator: Award Period: "Control of ELF4-gene expression"

  2006cites this paper
• Charakterisierung der Funktion des Transkriptionsfaktors Gfi1 während der T-Zell-vermittelten Immunantwort in Gfi1-defizienten Mäusen

  2006cites this paper
• Evidence of recurrent gene fusions in common epithelial tumors.

  2006cites this paper
• Promoter analysis of interleukin 19.

  2006cites this paper
• AML 1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene , WT 1

  2006cites this paper
• The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells.

  2006cites this paper
• A study for evaluation of different diagnostic approaches in acute leukemia in Egypt

  2006cites this paper
• RUNX expression and function in human B cells.

  2006cites this paper
• The role of the leukemia-associated ETO homologue repressors in hematopoiesis

  2006cites this paper
• AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

  2006cites this paper
• Phosphorylation of AML1/RUNX1 Regulates Its Degradation and Nuclear Matrix Association

  2005influential citation
• The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia

  2005cites this paper
• Interplay of RUNX 1 / MTG 8 and DNA Methyltransferase 1 in Acute Myeloid Leukemia

  2005cites this paper
• The molecular pathogenesis of acute myeloid leukemia.

  2005cites this paper
• Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.

  2005cites this paper