Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/ATVBAHA.113.302249PMID 23968976PMCID PMC4009978
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

  2012cited by this paper
• Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet

  2012cited by this paper
• Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1

  2012cited by this paper
• Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.

  2012cited by this paper
• Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease.

  2011cited by this paper
• Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate

  2011cited by this paper
• Direct effects of phosphate on vascular cell function.

  2011cited by this paper
• The Phosphate Transporter PiT1 (Slc20a1) Revealed As a New Essential Gene for Mouse Liver Development

  2010cited by this paper
• The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload.

  2010cited by this paper
• Phosphate homeostasis and the renal-gastrointestinal axis.

  2010cited by this paper
• Cellular ATP Synthesis Mediated by Type III Sodium-dependent Phosphate Transporter Pit-1 Is Critical to Chondrogenesis*

  2010cited by this paper
• Ultrastructural analysis of vascular calcifications in uremia.

  2010cited by this paper
• Generation of mouse conditional and null alleles of the type III sodium‐dependent phosphate cotransporter PiT‐1

  2009cited by this paper
• Identification of a Novel Function of PiT1 Critical for Cell Proliferation and Independent of Its Phosphate Transport Activity*♦

  2009cited by this paper
• Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: effects of PDGF, TNF-α, and Pi

  2009cited by this paper
• Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis.

  2009cited by this paper
• Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: effects of PDGF, TNF‐alpha and Pi

  2009influential reference
• Familial idiopathic basal ganglia calcification: a challenging clinical–pathological correlation

  2009cited by this paper
• Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality

  2009cited by this paper
• Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin.

  2009cited by this paper
• Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis

  2008cited by this paper
• Clinical Outcome and Mechanism of Soft Tissue Calcification in Werner Syndrome

  2008cited by this paper
• BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.

  2008cited by this paper
• Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community.

  2007cited by this paper
• Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.

  2007cited by this paper
• Characterization of Phosphate Transport in Rat Vascular Smooth Muscle Cells: Implications for Vascular Calcification

  2007cited by this paper
• Phosphate transporters: a tale of two solute carrier families.

  2007cited by this paper
• Osteoblast Autonomous Pi Regulation via Pit1 Plays a Role in Bone Mineralization

  2007cited by this paper
• Enhanced Expression of the Inorganic Phosphate Transporter Pit‐1 Is Involved in BMP‐2–Induced Matrix Mineralization in Osteoblast‐Like Cells

  2006cited by this paper
• Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.

  2006cited by this paper
• Role of the Sodium-Dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Cell Calcification

  2006influential reference
• Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin.

  2004cited by this paper
• Organic anion transport is the primary function of the SLC17/type I phosphate transporter family

  2004cited by this paper
• Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

  2002cited by this paper
• Smooth Muscle Cell Phenotypic Transition Associated With Calcification: Upregulation of Cbfa1 and Downregulation of Smooth Muscle Lineage Markers

  2001cited by this paper
• Vascular calcification and inorganic phosphate.

  2001cited by this paper
• Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

  2001cited by this paper
• New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.

  2001cited by this paper
• Arterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal Disease

  2001cited by this paper
• Molecular cloning of a murine type III sodium-dependent phosphate cotransporter (Pit-2) gene promoter.

  2001cited by this paper
• Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis.

  2000cited by this paper
• Phosphate regulation of vascular smooth muscle cell calcification.

  2000cited by this paper
• Heparin proteoglycans released from rat serosal mast cells inhibit proliferation of rat aortic smooth muscle cells in culture.

  1999cited by this paper
• Na+-dependent phosphate cotransporters: the NaPi protein families.

  1998cited by this paper
• Phosphate depletion enhances the stability of the amphotropic murine leukemia virus receptor mRNA.

  1998cited by this paper
• SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis.

  1996cited by this paper
• Developmental-stage-specific expression and regulation of an amphotropic retroviral receptor in hematopoietic cells

  1996influential reference
• The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.

  1994cited by this paper
• Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters.

  1994cited by this paper
• Arterial calcification and pathology in uremic patients undergoing dialysis.

  1979cited by this paper
• Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein–deficient Mice: Evidence for Osteopontin as an Inducible Inhibitor of Vascular Calcification In Vivo

  year unknowncited by this paper

• Calciphylaxis diagnosis, management and future directions: a comprehensive update on behalf of the European Renal Association CKD-MBD Working Group

  2025cites this paper
• Whole-genome sequencing GWAS reveals bovine genomic effects on enteric methane emissions in beef cattle

  2025cites this paper
• LARP7 Protects Vascular Smooth Muscle Cell Contractile Phenotype in CKD by Coupling with P300.

  2025cites this paper
• Vascular calcification inhibitors in chronic kidney disease.

  2025cites this paper
• Enamel Maturation as a Systems Physiology: Ion Transport and Pi Flux

  2025cites this paper
• Dysregulation of bone and myocardial inorganic phosphate transporters and downstream cell signals in early-stage mild chronic kidney disease-mineral and bone disorder: An experimental study.

  2025cites this paper
• Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model.

  2024cites this paper
• SGK3 promotes vascular calcification via Pit-1 in chronic kidney disease

  2024cites this paper
• Zinc Action in Vascular Calcification

  2024cites this paper
• In Vitro Models of Cardiovascular Calcification

  2024cites this paper
• Inhibition of XPR1‐dependent phosphate efflux induces mitochondrial dysfunction: A potential molecular target therapy for hepatocellular carcinoma?

  2024cites this paper
• Phosphate overload via the type III Na-dependent Pi transporter represses aortic wall elastic fiber formation

  2024influential citation
• SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis

  2023cites this paper
• Phosphate Control in Peritoneal Dialysis Patients: Issues, Solutions, and Open Questions

  2023cites this paper
• Role of transporters in regulating mammalian intracellular inorganic phosphate

  2023cites this paper
• Phosphate and Cellular Senescence.

  2022cites this paper
• Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings?

  2022cites this paper
• MiR‐708‐5p/Pit‐1 axis mediates high phosphate‐induced calcification in vascular smooth muscle cells via Wnt8b/β‐catenin pathway

  2022cites this paper
• Insights Into the Role of Mitochondria in Vascular Calcification

  2022cites this paper
• Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification

  2022cites this paper
• CALCIFIC AORTIC VALVE DISEASE- A NARRATIVE REVIEW

  2022cites this paper
• Hyperglycemic environment disrupts phosphate transporter function and promotes calcification processes in podocytes and isolated glomeruli

  2022influential citation
• Oxidative Stress Related to Plasmalemmal and Mitochondrial Phosphate Transporters in Vascular Calcification

  2022cites this paper
• Phosphate Absorption and Hyperphosphatemia Management in Kidney Disease: A Physiology-Based Review

  2021cites this paper
• Klotho deficiency‐induced arterial calcification involves osteoblastic transition of VSMCs and activation of BMP signaling

  2021cites this paper
• Valvular Calcific Deposits and Mortality in Peritoneal Dialysis Patients: A Propensity Score-Matched Cohort Analysis

  2021cites this paper
• The impact of type III sodium‐dependent phosphate transporters (Pit 1 and Pit 2) on podocyte and kidney function

  2021cites this paper
• Case Report: Two Novel Frameshift Mutations in SLC20A2 and One Novel Splice Donor Mutation in PDGFB Associated With Primary Familial Brain Calcification

  2021cites this paper
• The emerging role of phosphorus in human health.

  2021cites this paper
• RAGE Differentially Altered in vitro Responses in Vascular Smooth Muscle Cells and Adventitial Fibroblasts in Diabetes-Induced Vascular Calcification

  2021cites this paper
• Phosphate Control: The Next Frontier in Dialysis Cardiovascular Mortality

  2021cites this paper
• Inorganic phosphate‐induced cytotoxicity

  2021cites this paper
• Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation

  2021cites this paper
• Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

  2021influential citation
• Intestinal epithelial ablation of Pit‐2/Slc20a2 in mice leads to sustained elevation of vitamin D3 upon dietary restriction of phosphate

  2020cites this paper
• Rare Co-occurrence of Beta-Thalassemia and Pseudoxanthoma elasticum: Novel Biomolecular Findings

  2020cites this paper
• Inhibition of tissue‐nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD‐MBD mouse model

  2020cites this paper
• Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival

  2020cites this paper
• Magnesium to prevent kidney disease–associated vascular calcification: crystal clear?

  2020cites this paper
• Isolation and Characterization of Three Sodium-Phosphate Cotransporter Genes and Their Transcriptional Regulation in the Grass Carp Ctenopharyngodon idella

  2020cites this paper
• Oxidative Stress by Ca2+ Overload is Critical forPhosphate-Induced Vascular Calcification.

  2020cites this paper
• IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

  2020cites this paper
• The Effects of Progenitor and Differentiated Cells on Ectopic Calcification of Engineered Vascular Tissues.

  2020cites this paper
• Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease

  2020cites this paper
• TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells

  2020cites this paper
• Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis

  2020cites this paper
• Phosphate Transport in Epithelial and Nonepithelial Tissue.

  2020cites this paper
• New insights into endogenous mechanisms of protection against arterial calcification.

  2020cites this paper
• The Need of a Paradigm Shift to Better Understand PiT1 and PiT2 Biology: Response to “Why Is There No PiT1/SLC20A1 Pathogenic Variants Yet Linked to Primary Familial Brain Calcification?”

  2020cites this paper
• Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.

  2019cites this paper
• Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia

  2019cites this paper
• Would acetazolamide inhibit progression of atheromatous vascular calcification?

  2019cites this paper
• Atherosclerosis in Chronic Kidney Disease.

  2019cites this paper
• Suppression of Lysophosphatidylcholine-Induced Human Aortic Smooth Muscle Cell Calcification by Protein Kinase A Inhibition.

  2019cites this paper
• Exploring the Frontiers of Regenerative Cardiovascular Medicine

  2019cites this paper
• Vascular Calcification in Patients with Chronic Kidney Disease

  2019cites this paper
• Several phosphate transport processes are present in vascular smooth muscle cells.

  2019cites this paper
• Chronic kidney disease and coronary atherosclerosis: evidences from intravascular imaging

  2019cites this paper
• Extracellular vesicles in vascular calcification.

  2019cites this paper
• Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

  2019influential citation
• The role of sodium phosphate cotransporters in ectopic calcification.

  2019cites this paper
• Crosstalk between the nervous system and the kidney.

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• Warfarin accelerated vascular calcification and worsened cardiac dysfunction in remnant kidney mice

  2018cites this paper
• Research Progress on the Relationship between Coronary Artery Calcification and Chronic Renal Failure

  2018cites this paper
• Cell Phenotype Transitions in Cardiovascular Calcification

  2018cites this paper
• Genome-wide association study and functional analysis of feet and leg conformation traits in Nellore cattle.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway‐Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification

  2017cites this paper
• Phosphate imbalance in patients with heart failure

  2017cites this paper
• Association of arterial calcification with chronic limb ischemia in patients with peripheral artery disease.

  2017cites this paper
• Development of a novel chronic kidney disease mouse model to evaluate the progression of hyperphosphatemia and associated mineral bone disease

  2017cites this paper
• Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells

  2017cites this paper
• Vascular Calcification in Rat Cultured Smooth Muscle Cells: a Role for Nitric Oxide

  2016cites this paper
• L’influenza del fosforo, del calcio e del magnesio sulla proteina Gla di matrice e sul processo di calcificazione vascolare: una review sistematica

  2016cites this paper
• The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification: a systematic review.

  2016cites this paper
• Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells.

  2016cites this paper
• The type III transporters (PiT-1 and PiT-2) are the major sodium-dependent phosphate transporters in the mice and human brains.

  2016cites this paper
• Kidney Research

  2016cites this paper
• Calcium Homeostasis in Health and in Kidney Disease.

  2016cites this paper
• Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing.

  2016cites this paper
• Vascular Calcification in Uremia: New-Age Concepts about an Old-Age Problem.

  2016cites this paper
• The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms

  2016cites this paper
• Prevalence and risk factors of vascular calcification in pre-dialysis patients with Balkan endemic nephropathy.

  2016cites this paper
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  2016cites this paper
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  2016cites this paper