A Temporospatial Map That Defines Specific Steps at Which Critical Surfaces in the Gag MA and CA Domains Act during Immature HIV-1 Capsid Assembly in Cells

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Virology

• Publication date

  2014-03-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.03609-13PMID 24623418PMCID PMC4019110
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
• HIV-1 assembly, budding, and maturation.

  2012cited by this paper
• Assembly and architecture of HIV.

  2012cited by this paper
• Structural and Functional Insights into the HIV-1 Maturation Inhibitor Binding Pocket

  2012cited by this paper
• Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

  2012influential reference
• HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly

  2012cited by this paper
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  2011cited by this paper
• New insights into HIV assembly and trafficking.

  2011cited by this paper
• Molecular determinants that regulate plasma membrane association of HIV-1 Gag.

  2011cited by this paper
• Conserved and Variable Features of Gag Structure and Arrangement in Immature Retrovirus Particles

  2010cited by this paper
• Analysis of the Initiating Events in HIV-1 Particle Assembly and Genome Packaging

  2010cited by this paper
• Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function.

  2009cited by this paper
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  2009cited by this paper
• Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles

  2009cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Point mutations in the HIV-1 matrix protein turn off the myristyl switch.

  2007cited by this paper
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  2006cited by this paper
• Mutation of Dileucine-Like Motifs in the Human Immunodeficiency Virus Type 1 Capsid Disrupts Virus Assembly, Gag-Gag Interactions, Gag-Membrane Binding, and Virion Maturation

  2006influential reference
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  2006cited by this paper
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  2006influential reference
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  2005cited by this paper
• Association of Human Immunodeficiency Virus Type 1 Gag with Membrane Does Not Require Highly Basic Sequences in the Nucleocapsid: Use of a Novel Gag Multimerization Assay

  2005cited by this paper
• Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane.

  2004cited by this paper
• Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

  2004cited by this paper
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  2004cited by this paper
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  2003influential reference
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  2002cited by this paper
• Identification of a host protein essential for assembly of immature HIV-1 capsids

  2002cited by this paper
• Effect of mutations in Gag on assembly of immature human immunodeficiency virus type 1 capsids in a cell-free system.

  2001cited by this paper
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  2000cited by this paper
• Basic Residues in Human Immunodeficiency Virus Type 1 Nucleocapsid Promote Virion Assembly via Interaction with RNA

  2000cited by this paper
• Relationship between Human Immunodeficiency Virus Type 1 Gag Multimerization and Membrane Binding

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Opposing Effects of Human Immunodeficiency Virus Type 1 Matrix Mutations Support a Myristyl Switch Model of Gag Membrane Targeting

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Binding of Human Immunodeficiency Virus Type 1 Gag to Membrane: Role of the Matrix Amino Terminus

  1999cited by this paper
• In Vitro Assembly Properties of Human Immunodeficiency Virus Type 1 Gag Protein Lacking the p6 Domain

  1999cited by this paper
• The I Domain Is Required for Efficient Plasma Membrane Binding of Human Immunodeficiency Virus Type 1 Pr55Gag

  1998cited by this paper
• Analysis of the Assembly Function of the Human Immunodeficiency Virus Type 1 Gag Protein Nucleocapsid Domain

  1998cited by this paper
• The role of nucleocapsid of HIV-1 in virus assembly.

  1998cited by this paper
• A Putative α-Helical Structure Which Overlaps the Capsid-p2 Boundary in the Human Immunodeficiency Virus Type 1 Gag Precursor Is Crucial for Viral Particle Assembly

  1998cited by this paper
• HIV-1 gag proteins: diverse functions in the virus life cycle.

  1998cited by this paper
• Effects of nucleocapsid mutations on human immunodeficiency virus assembly and RNA encapsidation

  1997cited by this paper
• Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.

  1997influential reference
• Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism

  1997cited by this paper
• A Multistep, ATP-dependent Pathway for Assembly of Human Immunodeficiency Virus Capsids in a Cell-free System

  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Crystal structure of dimeric HIV-1 capsid protein

  1996cited by this paper
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  1996cited by this paper
• Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production

  1994cited by this paper
• Comparative morphology of Gag protein structures produced by mutants of the gag gene of human immunodeficiency virus type 1.

  1994cited by this paper
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  1994cited by this paper
• Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

  1992influential reference
• Distinct signals in human immunodeficiency virus type 1 Pr55 necessary for RNA binding and particle formation.

  1992cited by this paper
• Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.

  1990cited by this paper
• Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells.

  1989cited by this paper
• Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.

  1989cited by this paper
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  year unknowncited by this paper

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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2015cites this paper
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