A Putative α-Helical Structure Which Overlaps the Capsid-p2 Boundary in the Human Immunodeficiency Virus Type 1 Gag Precursor Is Crucial for Viral Particle Assembly

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Virology

• Publication date

  1998-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.72.3.2072-2078.1998PMID 9499062PMCID PMC109501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.

  1997influential reference
• A direct comparison of helix propensity in proteins and peptides.

  1997cited by this paper
• In vitro assembly properties of purified bacterially expressed capsid proteins of human immunodeficiency virus.

  1997cited by this paper
• Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences

  1997cited by this paper
• Crystal structure of dimeric HIV-1 capsid protein

  1996cited by this paper
• The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811

  1996influential reference
• Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.

  1996cited by this paper
• Structure of the Amino-Terminal Core Domain of the HIV-1 Capsid Protein

  1996influential reference
• Protein Design: A Hierarchic Approach

  1995cited by this paper
• Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity

  1995influential reference
• Differential proteolytic processing leads to multiple forms of the CA protein in avian sarcoma and leukemia viruses

  1995influential reference
• The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity

  1995influential reference
• Intrinsic secondary structure propensities of the amino acids, using statistical ϕ–ψ matrices: Comparison with experimental scales

  1994cited by this paper
• Specific incorporation of cyclophilin A into HIV-1 virions

  1994cited by this paper
• Functional association of cyclophilin A with HIV-1 virions

  1994cited by this paper
• Specificity and sequence requirements for interactions between various retroviral Gag proteins

  1994cited by this paper
• Intrinsic secondary structure propensities of the amino acids, using statistical phi-psi matrices: comparison with experimental scales.

  1994cited by this paper
• Functional domains of the capsid protein of human immunodeficiency virus type 1

  1994influential reference
• Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis

  1994cited by this paper
• Combining evolutionary information and neural networks to predict protein secondary structure

  1994cited by this paper
• Amino acid sequence analysis of the proteolytic cleavage products of the bovine immunodeficiency virus Gag precursor polypeptide

  1994cited by this paper
• Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein

  1994cited by this paper
• The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions

  1994influential reference
• Prediction of protein secondary structure at better than 70% accuracy.

  1993cited by this paper
• Improved prediction of protein secondary structure by use of sequence profiles and neural networks.

  1993cited by this paper
• Necessity of the spacer peptide between CA and NC in the Rous sarcoma virus gag protein

  1993cited by this paper
• Structural basis of amino acid alpha helix propensity.

  1993cited by this paper
• Identification of proteolytic processing sites within the Gag and Pol polyproteins of feline immunodeficiency virus

  1993cited by this paper
• Identification of a region in the Pr55gag-polyprotein essential for HIV-1 particle formation.

  1993cited by this paper
• Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis

  1993cited by this paper
• Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants

  1993cited by this paper
• Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions

  1993cited by this paper
• Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequences

  1992cited by this paper
• The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions

  1992cited by this paper
• Spatial Visualization of the Maturing HIV-1 Core and Its Linkage to the Envelope

  1992influential reference
• Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acid.

  1991cited by this paper
• Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.

  1991cited by this paper
• Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus

  1990cited by this paper
• Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.

  1990cited by this paper
• Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA

  1990cited by this paper
• Retroviral RNA packaging: sequence requirements and implications.

  1990cited by this paper
• Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells.

  1989cited by this paper
• Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.

  1989influential reference
• Unusually stable helix formation in short alanine-based peptides.

  1989cited by this paper
• Molecular characterization of gag proteins from simian immunodeficiency virus (SIVMne)

  1988cited by this paper
• Human retroviruses and AIDS.

  1988cited by this paper
• The gag gene products of human immunodeficiency virus type 1: alignment within the gag open reading frame, identification of posttranslational modifications, and evidence for alternative gag precursors

  1988cited by this paper
• Human retroviruses and AIDS.

  1988cited by this paper
• Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins.

  1987influential reference
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1987cited by this paper
• Chemical and immunological characterizations of equine infectious anemia virus gag-encoded proteins

  1987cited by this paper
• Use of eukaryotic expression technology in the functional analysis of cloned genes.

  1987cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1985cited by this paper
• Immunoglobulin gene transcription is activated by downstream sequence elements.

  1983cited by this paper

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• HIV-1 assembly - when virology meets biophysics.

  2024cites this paper
• Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice

  2024cites this paper
• Unconventional stabilization of the human T-cell leukemia virus type 1 immature Gag lattice

  2023cites this paper
• Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal

  2023cites this paper
• Intrinsic resistance of HIV-2 and SIV to the maturation inhibitor GSK2838232

  2023cites this paper
• Relationship between HIV-1 Gag Multimerization and Membrane Binding

  2022cites this paper
• Advances in HIV-1 Assembly

  2022cites this paper
• Initiation of HIV-1 Gag lattice assembly is required for cytoplasmic recognition of the viral genome packaging signal

  2022cites this paper
• Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice

  2021cites this paper
• Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus

  2021cites this paper
• CryoET structures of immature HIV Gag reveal six-helix bundle

  2021cites this paper
• Rotten to the core: antivirals targeting the HIV-1 capsid core

  2021cites this paper
• HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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• Structural analysis of pleomorphic and asymmetric viruses using cryo-electron tomography and subtomogram averaging.

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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2016cites this paper
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  2016influential citation
• Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396

  2016cites this paper
• Retrovirus maturation-an extraordinary structural transformation.

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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• Retroviral proteases and their roles in virion maturation.

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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle.

  2014cites this paper
• Role of Mason-Pfizer Monkey Virus CA-NC Spacer Peptide-Like Domain in Assembly of Immature Particles

  2014cites this paper
• 3D molecular models of whole HIV-1 virions generated with cellPACK

  2014cites this paper
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  2014cites this paper
• HIV-1 Maturation

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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• HIV Type 1 Gag as a Target for Antiviral Therapy

  2012cites this paper
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  2011cites this paper
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