The increasing complexity of the ubiquitin code

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Nature Cell Biology

• Publication date

  2016-05-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb3358PMID 27230526
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome‐wide turnover

  2015cited by this paper
• Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

  2015cited by this paper
• Substrate degradation by the proteasome: A single-molecule kinetic analysis

  2015cited by this paper
• The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy.

  2015cited by this paper
• USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

  2015cited by this paper
• Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

  2015cited by this paper
• Mechanism of phospho-ubiquitin induced PARKIN activation

  2015cited by this paper
• Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages

  2015cited by this paper
• Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

  2015cited by this paper
• Cell fate determination by ubiquitin-dependent regulation of translation

  2015cited by this paper
• The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

  2015cited by this paper
• Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition

  2015cited by this paper
• University of Dundee Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

  2015cited by this paper
• The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains

  2015cited by this paper
• RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage.

  2015cited by this paper
• Expanding the ubiquitin code through post‐translational modification

  2015cited by this paper
• RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

  2015cited by this paper
• K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

  2015cited by this paper
• Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

  2015cited by this paper
• Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.

  2014cited by this paper
• Enhanced protein degradation by branched ubiquitin chains.

  2014cited by this paper
• Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

  2014cited by this paper
• Ubiquitin acetylation inhibits polyubiquitin chain elongation

  2014cited by this paper
• Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation.

  2014cited by this paper
• K63 polyubiquitination is a new modulator of the oxidative stress response

  2014cited by this paper
• Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

  2014cited by this paper
• Ubiquitin is phosphorylated by PINK1 to activate parkin

  2014cited by this paper
• PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

  2014cited by this paper
• Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

  2014cited by this paper
• Molecular Basis and Regulation of OTULIN-LUBAC Interaction

  2014cited by this paper
• K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.

  2014cited by this paper
• Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner

  2014cited by this paper
• Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

  2014cited by this paper
• USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin

  2014cited by this paper
• The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

  2014cited by this paper
• Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

  2014cited by this paper
• RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms

  2014cited by this paper
• Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains

  2014cited by this paper
• Microtubule-dependent regulation of mitotic protein degradation.

  2014cited by this paper
• A two-step mechanism for TRF2-mediated chromosome end protection

  2013cited by this paper
• The linear ubiquitin-specific deubiquitinase Gumby/Fam105b regulates angiogenesis

  2013cited by this paper
• Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains.

  2013cited by this paper
• Mixed-linkage ubiquitin chains send mixed messages.

  2013cited by this paper
• PINK1 is degraded through the N-end rule pathway

  2013cited by this paper
• OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

  2013cited by this paper
• Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

  2013cited by this paper
• The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification.

  2013cited by this paper
• Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

  2013cited by this paper
• Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

  2013cited by this paper
• Conformational switching of the 26S proteasome enables substrate degradation

  2013cited by this paper
• The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesisThe linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

  2013cited by this paper
• Assembly, analysis and architecture of atypical ubiquitin chains

  2013cited by this paper
• Lysine 63-linked polyubiquitination is required for EGF receptor degradation

  2013cited by this paper
• OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

  2013cited by this paper
• VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.

  2013cited by this paper
• Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

  2013cited by this paper
• Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.

  2013cited by this paper
• RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

  2012cited by this paper
• Ubiquitin chain conformation regulates recognition and activity of interacting proteins

  2012cited by this paper
• Ubiquitin-dependent regulation of COPII coat size and function

  2012cited by this paper
• APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1

  2012cited by this paper
• Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair.

  2012cited by this paper
• TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.

  2012cited by this paper
• SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.

  2012cited by this paper
• The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

  2012cited by this paper
• The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.

  2012cited by this paper
• The ubiquitin code.

  2012cited by this paper
• Engineering and structural characterization of a linear polyubiquitin-specific antibody.

  2012cited by this paper
• Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions.

  2012cited by this paper
• Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells.

  2012cited by this paper
• SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

  2011cited by this paper
• The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

  2011cited by this paper
• SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

  2011cited by this paper
• Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

  2011cited by this paper
• An Ankyrin-repeat ubiquitin binding domain determines TRABID’s specificity for atypical ubiquitin chains

  2011cited by this paper
• Global identification of modular cullin-RING ligase substrates.

  2011cited by this paper
• Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.

  2011cited by this paper
• Linear ubiquitination prevents inflammation and regulates immune signalling

  2011cited by this paper
• PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.

  2011cited by this paper
• Systematic and quantitative assessment of the ubiquitin-modified proteome.

  2011cited by this paper
• Regulation of ubiquitin chain initiation to control the timing of substrate degradation.

  2011cited by this paper
• Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

  2010cited by this paper
• The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.

  2010cited by this paper
• The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

  2010cited by this paper
• K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.

  2010cited by this paper
• Regulated degradation of spindle assembly factors by the anaphase-promoting complex.

  2010cited by this paper
• UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

  2010cited by this paper
• Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

  2010cited by this paper
• Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase.

  2010cited by this paper
• Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

  2010cited by this paper
• Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

  2010cited by this paper
• PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

  2010cited by this paper
• Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

  2010cited by this paper
• K 63-specific deubiquitination by two JAMM / MPN þ complexes : BRISC-associated Brcc 36 and proteasomal Poh 1

  2009cited by this paper
• Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains

  2009cited by this paper
• K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

  2009cited by this paper
• Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.

  2009cited by this paper
• Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains

  2009cited by this paper
• Building ubiquitin chains: E2 enzymes at work

  2009cited by this paper
• The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

  2009cited by this paper

• The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.

  2026cites this paper
• The role of ER-associated degradation and ER-phagy in health and disease

  2026cites this paper
• Construction of a robust sepsis prognostic classifier based on E3 ubiquitin ligase-related genes.

  2026cites this paper
• The role of ubiquitination in regulating secondary metabolism in plants: mechanistic insights and biological significance

  2026cites this paper
• FBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome

  2026cites this paper
• Ubiquitin recognition integrates plant immune signaling by cell-surface and intracellular receptors

  2026cites this paper
• PRRSV Nsp11 antagonizes host antiviral immune response by reducing OAS1 and RNase L expressions

  2026cites this paper
• LINC01963 promotes pancreatic ductal adenocarcinoma proliferation via METTL3/IGF2BP2 axis-mediated m⁶A modification of c-Myc.

  2026cites this paper
• Modulation of Ube2R1 activity by a nanobody that binds near its N-terminus.

  2026cites this paper
• Investigating Enzyme-Substrate Interactions in the Assembly of K48/K63 Heterotypic Ubiquitin Chains.

  2026cites this paper
• Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

  2026cites this paper
• Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism

  2025cites this paper
• USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytes.

  2025cites this paper
• From molecular logic to therapeutic modulation: advances in Ub/UBL signalling.

  2025cites this paper
• Synergizing Structure-Guided Photocaged Linear Diubiquitin-Dha with Biotinylated Linear-Fab for Time-Resolved Profiling of Interactors in Living Cells.

  2025cites this paper
• Deciphering USP8’s pivotal role in cancer: mechanisms, clinical insights and contrasts with its function in pituitary adenomas

  2025cites this paper
• Complexes Formed by the K63-Specific Deubiquitinating Enzyme BRCC36: New Promising Therapeutic Targets in Human Disease

  2025cites this paper
• Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells

  2025cites this paper
• Deciphering the Mechanism of Interactions between Polyubiquitin Chains and Caspase Activation and Recruitment Domains Using Protein-Polymer-Engineering-Assisted Native Mass Spectrometry.

  2025cites this paper
• Roles of Deubiquitinases OTUD3 and OTUD5 in Inflammatory Bowel Diseases

  2025cites this paper
• Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

  2025cites this paper
• Interplay between ubiquitination and ADP-ribosylation and the case of dual modification ADPr-Ub

  2025cites this paper
• TRIM11 potentiates antitumor immunity via inhibition of the IFN-γ/PD-L1 axis.

  2025cites this paper
• Electrochemically-generated ferricyanide enables thiol-ene capture of protein-protein binding.

  2025cites this paper
• A multi-omics atlas of testicular development in Leiocassis longirostris: dynamic regulation of spermatogenesis.

  2025cites this paper
• Encoding and Decoding Ubiquitin Chain Architectures: Fine-Tuning the Fate of Proteins.

  2025cites this paper
• Conformation-specific Antibody Deciphers K27-linked Ubiquitination in Chaperone-Mediated Proteostasis

  2025cites this paper
• Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases

  2025cites this paper
• Teleost-specific TLR25/MyD88 signaling promotes K63-linked ubiquitination of IRF1 to induce IFNa gene expression.

  2025cites this paper
• Rheb ubiquitination drives LC3 lipidation via non-canonical autophagy to promote porcine sperm acrosome reaction.

  2025cites this paper
• Overview of RING gene family in maize (Zea mays L.): ZmRING-93 enhances drought tolerance in transgenic Arabidopsis

  2025cites this paper
• TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy

  2025cites this paper
• RNF149 modulates the type I IFN innate antiviral immune responses through degrading IRF3

  2025cites this paper
• TRIM55 suppresses inflammatory response after spinal cord injury by accelerating the ubiquitination and degradation of TLR4

  2025cites this paper
• Understanding the Role of RING‐Between‐RING E3 Ligase of the Human Malaria Parasite

  2025cites this paper
• DUBA sustains the stability of NOD2 and RIPK2 to enhance innate immune responses

  2025cites this paper
• MARCH8 promotes the proteasomal degradation of foot-and-mouth disease virus VP1, VP2, and VP3 to negatively regulate viral replication

  2025cites this paper
• Interferon and immunity: the role of microRNA in viral evasion strategies

  2025cites this paper
• Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms

  2025cites this paper
• The ribosome ubiquitination code: fine-tuning translation under stress.

  2025cites this paper
• Membrane Contact Sites in Proteostasis and ER Stress Response

  2025cites this paper
• Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

  2025cites this paper
• The ubiquitin-proteasome system in circadian regulation

  2025cites this paper
• SpyTag/SpyCatcher-mediated protein ubiquitination to investigate 20S and 26S proteasomal degradation

  2025cites this paper
• OsEHD1 and OsEHD2, two EH domain proteins targeted by E3 ubiquitin ligase OsBBI1, negatively modulate rice immunity against blast and bacterial blight diseases

  2025cites this paper
• Recent progress in histone post-translational modifications as regulator of metabolic diseases: A review.

  2025cites this paper
• WNK kinase regulates plasma membrane levels of the WNT inhibitor RNF43

  2025cites this paper
• USP32 promotes temporomandibular joint osteoarthritis by modulating PKM2 stability and glycolytic metabolism in chondrocytes

  2025cites this paper
• Ubiquitin choreography in nasopharyngeal carcinoma: USP18 scaffolds radioresistance.

  2025cites this paper
• USP7 restricts lineage potency in human embryonic stem cells through modulating mTOR activity

  2025cites this paper
• Molecular mechanisms of the lysosomal damage response and its roles in aging and disease.

  2025cites this paper
• OTU deubiquitinases in cancer pathogenesis and precision therapy.

  2025cites this paper
• Hydrophobic tagging: A promising paradigm for targeted protein degradation

  2025cites this paper
• E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

  2025cites this paper
• Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors.

  2025cites this paper
• E3 ubiquitin ligase WWP2 regulates stability of the chromatin remodeler ARID1B

  2025cites this paper
• Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo

  2025cites this paper
• Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities

  2025cites this paper
• JOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7

  2025cites this paper
• USP37 as a novel regulator of NRF2 protein stability and chemoresistance in HCC

  2025cites this paper
• The deubiquitinase USP7 stabilizes HER2 expression and promotes breast cancer progression

  2025cites this paper
• Human clearance systems have a layered architecture across tissues and cell types that supports varied proteome compositions

  2025cites this paper
• Protein quality control machinery: regulators of condensate architecture and functionality.

  2025cites this paper
• E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells

  2025cites this paper
• Structure and Dynamics of Monoclonal Antibody Domains Using Spins, Scattering, and Simulations

  2025cites this paper
• Ubiquitin-A structural perspective.

  2025cites this paper
• Chemical- and photo-activation of protein-protein thiol-ene coupling for protein profiling

  2025cites this paper
• Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia

  2025cites this paper
• Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance.

  2025cites this paper
• Regulatory mechanisms of connexin26.

  2025cites this paper
• APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons

  2025cites this paper
• Ubiquitin-specific protease: an emerging key player in cardiomyopathy

  2025cites this paper
• Structural basis for the ubiquitin chain recognition of the human 26S proteasome

  2025cites this paper
• A nanobody that binds to the backside of the ubiquitin conjugating enzyme Ube2G2 differentially affects interactions with its partner E3 Ligases

  2025cites this paper
• Examining the Role of Threonine Phosphorylation in Ubiquitin’s Function Using Chemical Protein Synthesis

  2025cites this paper
• Thioether-mediated protein ubiquitination in constructing affinity- and activity-based ubiquitinated protein probes

  2025cites this paper
• Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors

  2025cites this paper
• Discovery of Artesunate (ARS) PROTACs as GPX4 protein degraders for the treatment of bladder cancer.

  2025cites this paper
• Ubiquitination in cancer: mechanisms and therapeutic opportunities

  2025cites this paper
• Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination.

  2025cites this paper
• Decoding polyubiquitin regulation of KV7. 1 (KCNQ1) surface expression with engineered linkage-selective deubiquitinases

  2025cites this paper
• Making FAT10 with a Reactive C-terminus for E3 Ligase Screening

  2025cites this paper
• Degrons: defining the rules of protein degradation

  2025cites this paper
• Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice

  2025cites this paper
• BBSome-Mediated Clearance of Ubiquitinated IMPG2 Defines a Constitutive Ciliary Retrieval Pathway in Photoreceptors

  2025cites this paper
• Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole

  2025cites this paper
• Ubiquitinome profiling identifies USP13-CMAS axis as critical regulator of hair follicular melanogenesis via K48-linked polyubiquitination.

  2025cites this paper
• Biotinylation Interferes with Protein Ubiquitylation and Turnover in Arabidopsis—A Cautionary Insight for Proximity Labeling in Ubiquitylation Proteome Studies

  2025cites this paper
• Novel post-translational modifications in bone remodeling: potential therapeutic strategies for osteoporosis

  2025cites this paper
• K29‐Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response

  2025cites this paper
• Mechanism of Ferroptosis and Its Role in Disease Development

  2025cites this paper
• DYRK1A Overexpression Drives Muscle Wasting by Impeding Myogenesis via a USP7‐Axin1‐β‐Catenin Regulatory Axis in Mice

  2025cites this paper
• Solution NMR Structure and NMR-based Molecular Backbone Dynamics of UbKEKS: A Ubiquitin Variant Encoded in the UBB4 Pseudogene with Emerging Specific and New Functions.

  2025cites this paper
• Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology.

  2025cites this paper
• Phase Separation Clustering of Poly Ubiquitin Cargos on Ternary Mixture Lipid Membranes by Synthetically Cross-Linked Ubiquitin Binder Peptides

  2025cites this paper
• The functional landscape of the human ubiquitinome

  2025influential citation
• RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B

  2025cites this paper
• Intracellular dynamics of ubiquitin-like 3 visualized using an inducible fluorescent timer expression system

  2024cites this paper
• Comparative Proteome-Wide Abundance Profiling of Yeast Strains Deleted for Cdc48 Adaptors

  2024cites this paper
• Proteome Profiling of S. cerevisiae Strains Lacking the Ubiquitin-Conjugating Enzymes Ubc4 and Ubc5 During Exponential Growth and After Heat Shock Treatment

  2024cites this paper