Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Gene Therapy

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.gt.3301626PMID 11857072
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Olfactory Ensheathing Cells

  2002cited by this paper
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  2002cited by this paper
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• Adenoviral vector-mediated gene transfer for human gene therapy.

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• Inhibitory proteoglycan immunoreactivity is higher at the caudal than the rostral Schwann cell graft-transected spinal cord interface.

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• Neurotrophic and migratory properties of an olfactory ensheathing cell line

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• Regulation of Neuregulin Expression in the Injured Rat Brain and Cultured Astrocytes

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• Regulation of Trk receptors following contusion of the rat spinal cord.

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• Olfactory ensheathing cells — another miracle cure for spinal cord injury?

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• Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors.

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• Peripheral nerve injury fails to induce growth of lesioned ascending dorsal column axons into spinal cord scar tissue expressing the axon repellent Semaphorin3A

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• Mitogenic response of adult rat olfactory ensheathing glia to four growth factors

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• Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function.

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• Labeling and Identifying Grafted Cells

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• Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes

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• Limits to the capacity of transplants of olfactory glia to promote axonal regrowth in the CNS

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• Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia.

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• Adenoviral gene transfer to the injured spinal cord of the adult rat

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• Lentiviral vectors: regulated gene expression.

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• Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

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• Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons.

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• Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

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• Redistribution of bisbenzimide Hoechst 33342 from transplanted cells to host cells

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• Transplantation of the rat suprachiasmatic nucleus. Functional studies and ex vivo adenoviral vector-mediated gene transfer

  1999cited by this paper
• Neuregulin is a mitogen and survival factor for olfactory bulb ensheathing cells and an isoform is produced by astrocytes

  1999cited by this paper
• ‘Autoreplication’ of the vector genome in recombinant adenoviral vectors with different E1 region deletions and transgenes

  1999cited by this paper
• Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism.

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• Inhibition of collagen IV deposition promotes regeneration of injured CNS axons

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• Enhanced Expression of Transgenes from Adeno-Associated Virus Vectors with the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element: Implications for Gene Therapy

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• Retinal axon regeneration in peripheral nerve, tectal, and muscle grafts in adult rats

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• Adenoviral vector-mediated expression of a foreign gene in peripheral nerve tissue bridges implanted in the injured peripheral and central nervous system.

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• Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2

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• Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.

  1999cited by this paper
• Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2

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• Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: Differential regulation of GAP‐43, tubulins, and neurofilament‐M

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• Purification of Recombinant Adeno-Associated Virus by Iodixanol Gradient Ultracentrifugation Allows Rapid and Reproducible Preparation of Vector Stocks for Gene Transfer in the Nervous System

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• Erratum: Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2 (Nature Medicine (1999) 5 (1052-1056))

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  1998cited by this paper
• Woodchuck Hepatitis Virus Contains a Tripartite Posttranscriptional Regulatory Element

  1998cited by this paper
• Olfactory ensheathing glia: properties and function.

  1998cited by this paper
• Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord

  1998cited by this paper
• Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination.

  1998cited by this paper
• Regeneration of Adult Rat Corticospinal Axons Induced by Transplanted Olfactory Ensheathing Cells

  1998cited by this paper
• Factors Influencing Recombinant Adeno-Associated Virus Production

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• Adenoviral Vector-Mediated Gene Delivery to Injured Rat Peripheral Nerve

  1998cited by this paper
• Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

  1998cited by this paper
• Viral vectors, tools for gene transfer in the nervous system.

  1998cited by this paper
• Long-Distance Axonal Regeneration in the Transected Adult Rat Spinal Cord Is Promoted by Olfactory Ensheathing Glia Transplants

  1998cited by this paper
• Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.

  1997cited by this paper
• Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury

  1997cited by this paper
• Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters

  1997cited by this paper
• Transient gene transfer to neurons and glia: analysis of adenoviral vector performance in the CNS and PNS.

  1997cited by this paper
• Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

  1997cited by this paper
• Long-term transgene expression in fetal rat suprachiasmatic nucleus neurografts following ex vivo adenoviral vector-mediated gene transfer.

  1997cited by this paper
• Adenoviral Vector-Mediated Gene Expression in the Nervous System of Immunocompetent Wistar and T Cell-Deficient nude Rats: Preferential Survival of Transduced Astroglial Cells in nude Rats

  1997cited by this paper
• The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord.

  1997cited by this paper
• Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord

  1997cited by this paper
• Regeneration of adult axons in white matter tracts of the central nervous system

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• Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

  1997cited by this paper
• Improved Green Fluorescent Protein by Molecular Evolution Using DNA Shuffling

  1996cited by this paper
• Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

  1996cited by this paper
• Characterization of 911: A New Helper Cell Line for the Titration and Propagation of Early Region 1-Deleted Adenoviral Vectors

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• Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.

  1996cited by this paper
• In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

  1996cited by this paper
• Regeneration into the spinal cord of transected dorsal root axons is promoted by ensheathing glia transplants.

  1994cited by this paper
• A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration.

  1994cited by this paper
• Characterization of a Neurite Outgrowth Inhibitor Expressed After CNS Injury

  1993cited by this paper
• Transfer of a foreign gene into the brain using adenovirus vectors

  1993cited by this paper
• Gelatin embedding to preserve lesion-damaged hypothalami and intracerebroventricular grafts for vibratome slicing and immunocytochemistry.

  1992cited by this paper
• Manipulation of adenovirus vectors.

  1991cited by this paper
• Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats.

  1981cited by this paper
• Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat

  1975cited by this paper

• Transplantation of Olfactory Ensheathing Cells: Properties and Therapeutic Effects after Transplantation into the Lesioned Nervous System

  2022cites this paper
• Characterization of an immune-evading doxycycline-inducible lentiviral vector for gene therapy in the spinal cord.

  2022cites this paper
• Cell transplantation to repair the injured spinal cord.

  2022cites this paper
• Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury

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• Transplantation of cultured olfactory mucosal cells rescues optic nerve axons in a rat glaucoma model.

  2019cites this paper
• Selective Cre‐mediated gene deletion identifies connexin 43 as the main connexin channel supporting olfactory ensheathing cell networks

  2019cites this paper
• Viral Transduction of Schwann Cells for Peripheral Nerve Repair.

  2018cites this paper
• Partial Recovery of Proprioception in Rats with Dorsal Root Injury after Human Olfactory Bulb Cell Transplantation

  2017cites this paper
• Olfactory Ensheathing Cells Inhibit Gliosis in Retinal Degeneration by Downregulation of the Müller Cell Notch Signaling Pathway

  2017cites this paper
• A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells.

  2017cites this paper
• Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury

  2017cites this paper
• Transplantation of Cultured Olfactory Bulb Cells Prevents Abnormal Sensory Responses during Recovery from Dorsal Root Avulsion in the Rat

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  2016cites this paper
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  2016cites this paper
• (2016). Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC. Journal of the Neurological Sciences, 367, 311-318.

  2016cites this paper
• Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC.

  2016cites this paper
• Functional Repair of Rat Corticospinal Tract Lesions Does Not Require Permanent Survival of an Immunoincompatible Transplant

  2016cites this paper
• Modulación de las propiedades migratorias de las células de la glia envolvente

  2015cites this paper
• Transplantation of Olfactory Ensheathing Cells for Neural Repair

  2015cites this paper
• Comparison of Olfactory Bulbar and Mucosal Cultures in a Rat Rhizotomy Model

  2014cites this paper
• Embryonic-Derived Olfactory Ensheathing Cells Remyelinate Focal Areas of Spinal Cord Demyelination more Efficiently than Neonatal or Adult-Derived Cells

  2013cites this paper
• Combined treatment with platelet-rich plasma and brain-derived neurotrophic factor-overexpressing bone marrow stromal cells supports axonal remyelination in a rat spinal cord hemi-section model.

  2013cites this paper
• Olfactory ensheathing cell transplantation for spinal cord injury: An 18-year bibliometric analysis based on the Web of Science

  2013cites this paper
• Tissue sparing, behavioral recovery, supraspinal axonal sparing/regeneration following sub-acute glial transplantation in a model of spinal cord contusion

  2013influential citation
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010influential citation
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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