Regulation of dendritic cell differentiation and function by Notch and Wnt pathways

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Immunological Reviews

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.0105-2896.2009.00871.xPMID 20193015
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Jagged1 on Dendritic Cells and Notch on CD4+ T Cells Initiate Lung Allergic Responsiveness by Inducing IL-4 Production12

  2009cited by this paper
• Lipopolysaccharide-induced Maturation of Bone Marrow-derived Dendritic Cells Is Regulated by Notch Signaling through the Up-regulation of CXCR4*

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• Regulation of T Cell Activation by Notch Ligand, DLL4, Promotes IL-17 Production and Rorc Activation

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• Notch Regulates Cytolytic Effector Function in CD8+ T Cells1

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• JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.

  2009cited by this paper
• Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

  2009cited by this paper
• Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.

  2009cited by this paper
• Responsiveness by Inducing IL-4 Production T Cells Initiate Lung Allergic +Jagged1 on Dendritic Cells and Notch on CD4

  2009cited by this paper
• Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands.

  2009influential reference
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  2009cited by this paper
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  2009cited by this paper
• Notch and wingless signaling cooperate in regulation of dendritic cell differentiation.

  2009cited by this paper
• Notch regulates IL-10 production by T helper 1 cells

  2008influential reference
• TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4.

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• Notch3 Inhibition in Myelin-Reactive T Cells Down-Regulates Protein Kinase Cθ and Attenuates Experimental Autoimmune Encephalomyelitis1

  2008influential reference
• Wnt signalling and its impact on development and cancer

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• Human Mesenchymal Stem Cells License Adult CD34+ Hemopoietic Progenitor Cells to Differentiate into Regulatory Dendritic Cells through Activation of the Notch Pathway1

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• Notch-dependent control of myelopoiesis is regulated by fucosylation.

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• Signaling pathways governing stem-cell fate.

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• Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53

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• WNT signalling in the immune system: WNT is spreading its wings

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• Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma

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• Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction.

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• Cutting Edge: Notch Signaling Induces a Distinct Cytokine Profile in Dendritic Cells That Supports T Cell-Mediated Regulation and IL-2-Dependent IL-17 Production1

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• Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells1

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• Wnt signaling and stem cell control

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• The many facets of Notch ligands

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• Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection1

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• Contrasting Responses of Lymphoid Progenitors to Canonical and Noncanonical Wnt Signals1

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• Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity

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• Up-Regulation of Gene Related to Anergy in Lymphocytes Is Associated with Notch-Mediated Human T Cell Suppression1

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• CBP/p300 are bimodal regulators of Wnt signaling

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• SnapShot: Wnt/β-Catenin Signaling

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• Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.

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• Development of dendritic-cell lineages.

  2007cited by this paper
• Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.

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• The making of Wnt: new insights into Wnt maturation, sorting and secretion

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• Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF

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• Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands.

  2007cited by this paper
• Notch ligand Delta‐1 differentially modulates the effects of gp130 activation on interleukin‐6 receptor α‐positive and ‐negative human hematopoietic progenitors

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• Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines

  2007influential reference
• Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation

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• The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.

  2007cited by this paper
• Jagged1 and Delta1 Differentially Regulate the Outcome of Experimental Autoimmune Encephalomyelitis1

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• SnapShot: Wnt/beta-catenin signaling.

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• The Interaction of the Wnt and Notch Pathways Modulates Natural Killer Versus T Cell Differentiation

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• GSK-3 mediates differentiation and activation of proinflammatory dendritic cells.

  2007cited by this paper
• CD8− DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

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• WNT Signaling Pathway and Stem Cell Signaling Network

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• Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities.

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• Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation.

  2007cited by this paper
• Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen

  2007influential reference
• plasmacytoid dendritic cells The Notch ligand delta-1 is a hematopoietic development cofactor for

  2006influential reference
• Notch signalling regulates stem cell numbers in vitro and in vivo

  2006cited by this paper
• Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity1

  2006influential reference
• The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.

  2006cited by this paper
• Wnt/beta-catenin signaling in development and disease.

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• Notch signalling: a simple pathway becomes complex

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• Delta-4 expression on a stromal cell line is augmented by interleukin-6 via STAT3 activation.

  2006influential reference
• Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

  2006cited by this paper
• Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B.

  2006influential reference
• Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

  2006cited by this paper
• Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors*

  2006cited by this paper
• Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4+ T Cells and Dendritic Cells Enhances Cytokine Production

  2006cited by this paper
• Delta-4 Notch ligand promotes erythroid differentiation of human umbilical cord blood CD34+ cells.

  2006cited by this paper
• Wnt signaling: is the party in the nucleus?

  2006cited by this paper
• Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis

  2006cited by this paper
• Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

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• Wnt signalling in stem cells and cancer

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• WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

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• Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells

  2005cited by this paper
• Notch ligands Delta‐like1, Delta‐like4 and Jagged1 differentially regulate activation of peripheral T helper cells

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• Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling1

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• The nervous system and innate immunity: the neuropeptide connection.

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• Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

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• WNT signalling and haematopoiesis: a WNT–WNT situation

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• Notch/Delta4 Interaction in Human Embryonic Liver CD34+ CD38− Cells: Positive Influence on BFU‐E Production and LTC‐IC Potential Maintenance

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• Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells.

  2005cited by this paper
• Constitutively active beta-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors.

  2005cited by this paper
• Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species1

  2004cited by this paper
• Notch 1 signaling regulates peripheral T cell activation.

  2004cited by this paper
• WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos.

  2004cited by this paper
• Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

  2004cited by this paper
• Membrane-bound Delta-4 Notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential

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• Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.

  2004cited by this paper
• Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

  2004influential reference
• Deregulated expression of LRBA facilitates cancer cell growth

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• β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

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• Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling

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• Wnt signaling in the stem cell niche

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• Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8⁺ cell–dependent mechanism

  2003cited by this paper
• Notch signaling is necessary but not sufficient for differentiation of dendritic cells.

  2003cited by this paper
• Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

  2003cited by this paper
• Notch Signaling Induces Multilineage Myeloid Differentiation and Up-Regulates PU.1 Expression1

  2003cited by this paper
• TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells.

  2003influential reference
• Dendritic-cell control of pathogen-driven T-cell polarization

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• Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells.

  2003cited by this paper
• Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

  2003cited by this paper

• Phagocytosis of necroptotic cells optimizes type 1 conventional dendritic cells for induction of a cytotoxic T-cell response.

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• [Research progress on moxibustion therapy for improving chemotherapy-induced bone marrow suppression].

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• Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.

  2024cites this paper
• Specific Notch receptor and its ligand Delta interactions control antibacterial immunity by regulating hemocyte proliferation in Eriocheir sinensis

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• Progression of Notch signaling regulation of B cells under radiation exposure

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