Hydroxysteroid Dehydrogenases – Localization, Function and Regulation in the Testis

© 2012 Kotula-Balak et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hydroxysteroid Dehydrogenases – Localization, Function and Regulation in the Testis

• Publication year

  2012

• Venue

  Unknown venue

• Publication date

  2012-11-14

• Fields of study

  Biology, Medicine, Business

• Identifiers
  DOI 10.5772/47740
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• 46,XY Disorders of Sexual Development

  2013cited by this paper
• Antiandrogenic and Estrogenic Compounds: Effect on Development and Function of Male Reproductive System

  2011cited by this paper
• Relaxin family peptides in the male reproductive system--a critical appraisal.

  2011cited by this paper
• Effects of 4-tert-octylphenol on the testes and seminal vesicles in adult male bank voles.

  2011cited by this paper
• Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats.

  2011cited by this paper
• Octylphenol affects morphology and steroidogenesis in mouse tumor Leydig cells.

  2011cited by this paper
• Expression of steroidogenic enzymes during equine testicular development.

  2011cited by this paper
• Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A.

  2011cited by this paper
• Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine.

  2010cited by this paper
• Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine.

  2010cited by this paper
• Immunohistochemical localization of steroidogenic enzymes in the testis of the sika deer (Cervus nippon) during developmental and seasonal changes.

  2010cited by this paper
• Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors

  2010cited by this paper
• Stem Leydig cells: from fetal to aged animals.

  2010influential reference
• Androgens and spermatogenesis: lessons from transgenic mouse models

  2010cited by this paper
• 46,XY DSD due to impaired androgen production.

  2010cited by this paper
• Where Do Adult Leydig Cells Come From?1

  2010influential reference
• Effects of genistein and equol on human and rat testicular 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities.

  2010cited by this paper
• The Clinical and Molecular Heterogeneity of 17βHSD-3 Enzyme Deficiency

  2010cited by this paper
• Effect of estradiol benzoate on rat testis and adrenal.

  2009cited by this paper
• Leydig cells: From stem cells to aging.

  2009cited by this paper
• Differentiation of Leydig cells in the Mongolian gerbil

  2009cited by this paper
• Leydig cell aging and the mechanisms of reduced testosterone synthesis.

  2009cited by this paper
• Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds.

  2009cited by this paper
• Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice.

  2009cited by this paper
• The effect of testicular macrophages, macrophage-conditioned medium and interleukin-1alpha on bank vole Leydig cell steroidogenesis.

  2009cited by this paper
• Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice.

  2009cited by this paper
• Complementary approaches demonstrate that cellular aromatization in the bank vole testis is related to photoperiod.

  2009cited by this paper
• Effects of photo stimulation and nonstimulation of golden hamsters (Mesocricetus auratus) from birth to early puberty on testes structure and function.

  2009cited by this paper
• Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan.

  2009cited by this paper
• Gonadotrophin-releasing hormone-I and -II stimulate steroidogenesis in prepubertal murine Leydig cells in vitro.

  2008cited by this paper
• Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study

  2008cited by this paper
• The effects of cryptorchidism on the regulation of steroidogenesis and gap junctional communication in equine testes.

  2008cited by this paper
• Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis

  2008cited by this paper
• Morphofunctional alterations in testicular cells of deslorelin-treated boars: an immunohistochemical study.

  2008cited by this paper
• Gene Expression During Development of Fetal and Adult Leydig Cells

  2007cited by this paper
• Expression and localization of estrogenic type 12 17β-hydroxysteroid dehydrogenase in the cynomolgus monkey

  2007cited by this paper
• The development of rat Leydig cell progenitors in vitro: how essential is luteinising hormone?

  2007influential reference
• Key factors in the regulation of fetal and postnatal leydig cell development

  2007cited by this paper
• Dynamics of Leydig Cell Regeneration After EDS

  2007cited by this paper
• Expression of connexin 43 protein in testes, epididymides and prostates of stallions.

  2007cited by this paper
• Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17beta-hydroxysteroid dehydrogenase.

  2007cited by this paper
• Steroidogenic Enzymes in Leydig Cells

  2007cited by this paper
• Corticosterone impairs the mRNA expression and activity of 3β- and 17β-hydroxysteroid dehydrogenases in adult rat Leydig cells

  2006cited by this paper
• Effects of experimental cryptorchidism on sperm motility and testicular endocrinology in adult male rats.

  2006cited by this paper
• Corticosterone impairs the mRNA expression and activity of 3beta- and 17beta-hydroxysteroid dehydrogenases in adult rat Leydig cells.

  2006cited by this paper
• Aromatization and antioxidant capacity in the testis of seasonally breeding bank voles: Effects of LH, PRL and IGF-I.

  2006cited by this paper
• Consensus Statement on Management of Intersex Disorders

  2006cited by this paper
• Triphenyltin and Tributyltin inhibit pig testicular 17beta-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis.

  2005cited by this paper
• Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system.

  2005cited by this paper
• Estrogens in Testis Biology

  2005cited by this paper
• Expression of aromatase and oestrogen receptors in reproductive tissues of the stallion and a single cryptorchid visualised by means of immunohistochemistry.

  2005cited by this paper
• Molecular Biology of the 3-Hydroxysteroid Dehydrogenase/5-4 Isomerase Gene Family

  2005influential reference
• Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.

  2004cited by this paper
• Cell biology of Leydig cells in the testis.

  2004influential reference
• Progesterone: the forgotten hormone in men?

  2004cited by this paper
• Dose- and photoperiod-dependent effects of 17beta-estradiol and the anti-estrogen ICI 182,780 on testicular structure, acceleration of spermatogenesis, and aromatase immunoexpression in immature bank voles.

  2004cited by this paper
• Androgen aromatization in cryptorchid mouse testis.

  2003cited by this paper
• Amplified androstenedione enzymeimmunoassay for the diagnosis of cryptorchidism in the male horse: comparison with testosterone and estrone sulphate methods.

  2003cited by this paper
• Hormonal regulation of oestrogen formation by Leydig cells in vitro: immunocytochemical approach.

  2003cited by this paper
• Estrogen Receptor-α Gene Deficiency Enhances Androgen Biosynthesis in the Mouse Leydig Cell

  2003cited by this paper
• Stimulatory Effect of Progesterone on the Expression of Steroidogenic Acute Regulatory Protein in MA-10 Leydig Cells1

  2003cited by this paper
• THYROID HORMONES: THEIR ROLE IN TESTICULAR STEROIDOGENESIS

  2003cited by this paper
• The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway.

  2003cited by this paper
• Inhibition of rat testis microsomal 3-hydroxysteroid dehydrogenase activity by tributyltin

  2003cited by this paper
• Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells.

  2003cited by this paper
• Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide.

  2003cited by this paper
• Comparison of the hamster and human adrenal P450c17 (17 alpha-hydroxylase/17,20-lyase) using site-directed mutagenesis and molecular modeling.

  2002cited by this paper
• Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.

  2002cited by this paper
• Influence of Cytokines and Growth Factors on Distinct Steroidogenic Enzymes in Vitro

  2002cited by this paper
• Effect of prenatal exposure to hydroxyprogesterone on steroidogenic enzymes in male rats

  2002cited by this paper
• Andropause: clinical implications of the decline in serum testosterone levels with aging in men.

  2002cited by this paper
• Failure of normal adult Leydig cell development in androgen-receptor-deficient mice.

  2002cited by this paper
• Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro.

  2002cited by this paper
• Photoperiod-dependent capability of androgen aromatization and the role of estrogens in the bank vole testis visualized by means of immunohistochemistry.

  2001cited by this paper
• Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function?

  2001cited by this paper
• Seasonal Changes in Testicular Steroidogenesis and Spermatogenesis in a Northern Fur Seal, Callorhinus ursinus

  2001cited by this paper
• Ontogenesis of Oxidative Reaction of 17β-hydroxysteroid Dehydrogenase and 11β-hydroxysteroid Dehydrogenase in Rat Leydig Cells, a Histochemical Study

  2001cited by this paper
• Differentiation of the adult Leydig cell population in the postnatal testis.

  2001cited by this paper
• Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads.

  2001cited by this paper
• Substitution Mutation C268Y Causes 17β-Hydroxysteroid Dehydrogenase 3 Deficiency1

  2001cited by this paper
• Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects

  2001cited by this paper
• Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.

  2001cited by this paper
• Abnormal Germ Cell Development in Cryptorchidism

  2001cited by this paper
• The site of aromatization in the mouse cryptorchid testis.

  2001cited by this paper
• Localization of 17β-Hydroxysteroid Dehydrogenase/17-Ketosteroid Reductase Isoform Expression in the Developing Mouse Testis-Androstenedione Is the Major Androgen Secreted by Fetal/Neonatal Leydig Cells.

  2000cited by this paper
• Localization of 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase isoform expression in the developing mouse testis--androstenedione is the major androgen secreted by fetal/neonatal leydig cells.

  2000cited by this paper
• Ultrastructural study of the boar seminiferous epithelium: Changes in cryptorchidism

  2000cited by this paper
• Changes in the Testis Interstitium of Sprague Dawley Rats from Birth to Sexual Maturity1

  2000cited by this paper
• Progesterone action in a murine Leydig tumor cell line (mLTC-1), possibly through a nonclassical receptor type.

  2000cited by this paper
• Localization of androgen and estrogen receptors in rat and primate tissues.

  2000cited by this paper
• Regulation of Leydig Cell Steroidogenic Function During Aging1

  2000cited by this paper
• Localization of cytochrome P450 aromatase and estrogen receptors alpha and beta in testicular cells--an immunohistochemical study of the bank vole.

  2000cited by this paper
• Progesterone Action in a Murine Leydig Tumor Cell Line (mLTC-1), Possibly through a Nonclassical Receptor Type1.

  2000cited by this paper
• Influence of age and photoperiod on steroidogenic function of the testis in the golden hamster.

  1999cited by this paper
• Function of contralateral testis after artificial unilateral cryptorchidism in dogs.

  1999cited by this paper
• New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes.

  1999cited by this paper
• Immunolocalization of androgen receptors in testicular cells during postnatal development of the bank vole (Clethrionomys glareolus, S.).

  1999cited by this paper
• 17 b -Hydroxysteroid Dehydrogenase-3 Deficiency: Diagnosis, Phenotypic Variability, Population Genetics, and Worldwide Distribution of Ancient and de Novo Mutations*

  1999cited by this paper
• Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development.

  1999cited by this paper
• Differentiation of adult Leydig cells in the neonatal rat testis is arrested by hypothyroidism.

  1998cited by this paper

• Identification of a novel candidate HSD3B2 gene variant for familial hypospadias by whole-exome sequencing

  2023cites this paper
• A REVIEW OF PARACETAMOL: MECHANISM OF ACTION AND THE EFFECTS ON SPERMATOGENESIS

  2023cites this paper
• A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function

  2022cites this paper
• Interrelationship between NO and androgenic activity in mice, Mus musculus, following temporal phase relation of serotonergic and dopaminergic neural oscillations

  2014cites this paper
• Leydig Cell Androgen Synthesis

  2014cites this paper